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Comparison of the Efficacy of Two Commercial Coccidicidal Compounds on Experimentally Infected Dogs

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Pharmacology & Pharmacy 2014年第13期5卷 1163-1170页

作者： Froylan ibarra-Velarde Yolanda Vera-Montenegro Nelyda Saldana-Hernandez Pedro Ochoa-Galvan Department of Parasitology Veterinary FacultyNational University Autonomous of MexicoMexico CityMexico Department of Genetics Veterinary FacultyNational University Autonomous of MexicoMexico CityMexico

The aim of the present study was to compare the coccidicidal efficacy of two commercial compounds for artificially infected dogs. Eighteen cocccidia-free dogs, male and female aged between 2 and 4 months old, were infected each with 20,000 Cystoisospora oocists cultured under laboratory conditions. When the poppies showed high counts of oocysts per gramm (OPG) (McMaster method), they were divided into 3 groups (G). G1 was treated with a compound named One® (Lab. Bio Zoo) containing 150 mg of toltrazuril/tablet, administered daily/5days dosing 1 tablet per 10 kg b.w. G2 received Giacoccide® (Pet’s Pharma) containing 250 mg of sulfadimetoxine and 165 mg of dimetridazole dosing 1 tablet per 10 kg b.w. twice a day for 10 days. G3 served as an untreated control. The puppies were coprologically monitored on Days 0, 3, 5, 10, 15, 20 and 25 to determine the percentage of OPG. Efficacy was measured based on the OPG reduction on treated animals relative to the untreated control. The results indicated an efficacy for compound One of 78.4%, 100%, 100%, 100%, 100% and 100%, for Days 3, 5, 10, 15, 20 and 25, respectively and for Giacoccide 40.6%, 45.5%, 47.4%, 65.9%, 90.4% and 92.7%, for Days 3, 5, 10, 15, 20 and 25, respectively. No statistical difference was observed on the weight of the treated puppies (p < 0.764), but the control group was statistically different to the treated ones (p < 0.014). It was concluded that compound One showed greater efficacy than Giacoccide for the treatment of canine coccidiosis in artificially infected dogs.

关键词： Efficacy Coccidicides Experimentally Infected Dogs

Information Theory and Data-Mining Techniques for Network Traffic Profiling for Intrusion Detection

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Journal of Computer and Communications 2014年第11期2卷 24-30页

作者： Pablo Velarde-Alvarado Rafael Martinez-Pelaez Joel Ruiz-ibarra Victor Morales-Rocha Autonomous University of Nayarit Area of Basic Sciences and Engineering Ciudad de la Cultura “Amado Nervo” Tepic Nayarit Mexico Department of Electrical and Computer Engineering Autonomous University of Ciudad Juarez Ciudad Juarez Mexico

In this paper, information theory and data mining techniques to extract knowledge of network traffic behavior for packet-level and flow-level are proposed, which can be applied for traffic profiling in intrusion detection systems. The empirical analysis of our profiles through the rate of remaining features at the packet-level, as well as the three-dimensional spaces of entropy at the flow-level, provide a fast detection of intrusions caused by port scanning and worm attacks.

关键词： Intrusion Detection Traffic Profiling Entropy and Network Worms

跨步或不跨步下的前弓步和侧弓步动作中的髌股关节压力与应力（二）

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中华骨科杂志 2009年第7期29卷 697-700页

作者： Naiquan Zheng Rafael F escamilla Glenn S Fleisig Kevin E Wilk James R Andrews 美国北卡罗来纳大学机械工程和工程科学系生物医学工程中心美国加利福尼亚大学理疗系美国阿拉巴马州伯明翰市美国运动医学研究所美国阿拉巴马州伯明翰市冠军运动医学中心

结果髌股关节的压力与应力随膝关节屈曲角度的增加而升高，随膝关节屈曲角度的减小而降低（图3～8）。不同膝关节屈曲角度下弓步变化和跨步变化的髌股关节压力见表1。膝关节屈曲相内屈曲角度80°～90°及膝关节伸展相内屈曲90°时，侧... 详细信息

结果髌股关节的压力与应力随膝关节屈曲角度的增加而升高，随膝关节屈曲角度的减小而降低（图3～8）。不同膝关节屈曲角度下弓步变化和跨步变化的髌股关节压力见表1。膝关节屈曲相内屈曲角度80°～90°及膝关节伸展相内屈曲90°时，侧弓步的髌股关节应力大于前弓步。膝关节屈曲相内屈曲角度10°～50°及膝关节伸展相内屈曲角度50°～20°时，跨步的髌股关节应力明显大于不跨步。弓步与跨步之间无明显的交互作用。

关键词：髌股关节压力应力前弓膝关节屈曲屈曲角度交互作用伸展

Optimization of Zeaxanthin Production by Immobilized <i>Flavobacterium</i>sp. Cells in Fluidized Bed Bioreactor

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Advances in Microbiology 2012年第4期2卷 598-604页

作者： Ma Del Carmen Chavez-Parga Alejandro Munguia-Franco Mayanin Aguilar-Torres Eleazar M. escamilla-Silva Division de Estudios de Posgrado Facultad de Ingeniería Química Universidad Michoacana de San Nicolas de Hidalgo Morelia Mexico Laboratorio de Biotecnologia y Bioingenieria Departamento de Ingenieria Quimica Instituto Tecnologico de Celaya Celaya Mexico

From time immemorial, human beings have used pigments made from vegetables, fruits, superior plants, animal tissues and cereals. One of the greatest sources of pigments is the bacterium that, with the use of the modern technology, has increased the production of metabolites of interest. The microbiological production of carotenoids has not been optimized to obtain pigment production quantities of pigments and carotenoids recovery that lower production costs. The aim of this work was to design a Zeaxanthin production process with Flavobacterium sp. immobilized cells in a fluidized bed bioreactor. An optimum culture medium for Zeaxanthin production in stirred flasks (2.46 g·L–1) was obtained. Furthermore, optimum process conditions for a maximum yield of Zeaxanthin production, by fluidized bed bioreactor, were established. A statistical analysis showed that the most significant factors were air flow, pH and NaCl concentration (4.5 g·L–1). In this study a maximum Zeaxanthin production of 3.8 g·L–1 was reached. The highest reported yield to date was 0.329 g·L–1.

关键词： Fluidized Bed Bioreactor Orthogonal Design Flavobacterium sp. Zeaxanthin

Effect of laser shock processing on erosive resistance of 6061-T6 aluminum

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Transactions of Nonferrous Metals Society of China 2016年第6期26卷 1522-1530页

作者： J.ibarra E.RODRíGUEZ O.JIMéNEZ G.GóMEZ-ROSAS M.FLORES J.VERDUZCO J.CHáVEZ Universidad de Guadalajara Departamento de Ingeniería de Proyectos Universidad de Guadalajara Departamento de Física Centro Universitario de Ciencias Exactas e Ingenierías

Application of laser shock processing （LSP） on 6061-T6 aluminum was made in order to evaluate its response to the erosive wear by silica sand. Impact angles of 15° , 30° , 60° and 90° were tested, two particle speeds （37 and 58 m/s） and two LSP irradiation conditions were used. Erosion marks were characterized by 3D profilometry and SEM analysis was conducted to identify the erosion mechanisms for each tested angle. The results showed a maximum erosive wear at low impact angles （ductile type behavior）. Erosion strength and the erosion mechanisms were not affected by the application of LSP and they were attributed to the high strain rate of the erosion phenomena. A few differences encountered on the erosion plots were explained on the basis of the surface roughness left by the LSP process. The maximum mass loss and the maximum erosion penetration happened in different impact angles （15° and 30° , respectively）. Finally, a well-defined erosion mechanism transition was observed, from cutting action at low impact angle, to crater formation at 90° of incidence.

关键词： 6061-T6 aluminum erosive wear laser shock processing

Distribution of Candida Species and Molecular Typing of C. albicans Isolates in a Mexico City Tertiary Care Hospital from 2011 to 2013

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Open Journal of Medical Microbiology 2016年第2期6卷 66-79页

作者： Haydee Torres Guerrero Israel Martínez Espinosa Misael Gonzales ibarra Magdalena Aguirre García Unidad de Medicina Experimental Facultad de Medicina Universidad Nacional Autónoma de México México D.F. México Laboratorio de Inmunoalergología y Micología Médica División de Investigación Hospital Juárez de México México D.F. México

The incidence of yeast infections has increased significantly over the past few years, constituting a leading cause of morbidity and mortality among hospitalised patients. The rapid identification of candidiasis is important for the clinical management of patients and to facilitate tracing the sources of infections in hospitalized patients. Here, we report a retrospective, single-centre study of Candida spp. distribution and antifungal susceptibility from January 2011 to May 2013 at a hospital in México City, regarding the importance of elucidating the identity of the infection-causing Candida species in order to improve prophylactic measures and treatment. Clinical data were collected from patient medical records and the laboratory database. Isolates were initially identified using standard mycology techniques, and then confirmed by PCR-based system using amplification of intergenic spacers (rDNA ITS) and restriction length polymorphism of PCR products after sequence-specific enzymatic cleavage (PCR-RFLP). We observed no shift from C. albicans to non-albicans Candida species: Candida albicans (73.7%) was the most prevalent species isolated, while C. dubliniensis was not identified in this study. Antifungal susceptibility was determined using FUNGITEST®17.4% of C. albicans isolates were resistant to fluconazole and 21.7% to itraconazole. Multiplex PCR microsatellite analysis of the clinical C. albicans isolates using primers for the CAI, CAIII and CAVI loci identified 29 different alleles for CAI, 8 alleles for CAIII and 31 for CAVI. The combined discriminatory power of these three microsatellites was 0.98, which was considered reliable for molecular typing. Genetic analysis of these isolates revealed a clonal population with a total of 62 genotypes from the examined isolates

关键词： Candidiasis rDNA-ITS RFLP Microsatellites Molecular Typing CAI Candida spp.

跨步或不跨步下的前弓步和侧弓步动作中的髌股关节压力与应力(一)

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中华骨科杂志 2009年第6期29卷 605-608页

作者： Naiquan Zheng Rafael F escamilla Glenn S Fleisig Kevin E Wilk James R Andrews 美国北卡罗来纳大学机械工程和工程科学系生物医学工程中心美国阿拉巴马州伯明翰市美国运动医学研究所 4. 美国阿拉巴马州伯明翰市冠军运动医学中心美国加利福尼亚大学理疗系

背景:在髌股关节康复训练中经常进行负重的弓步动作,但这种动作下的髌股关节压力和应力状况尚不明确。方法:18名受试者在负重下做跨步和不跨步的前弓步和侧弓步动作,负重重量为可进行12次重复动作的最大负荷。将肌电学、测力平台以及运... 详细信息

背景:在髌股关节康复训练中经常进行负重的弓步动作,但这种动作下的髌股关节压力和应力状况尚不明确。方法:18名受试者在负重下做跨步和不跨步的前弓步和侧弓步动作,负重重量为可进行12次重复动作的最大负荷。将肌电学、测力平台以及运动学数据输入生物力学模型中,计算不同膝关节屈曲角度下的髌股关节压力和应力。结果:髌股关节的压力和应力随膝关节屈曲角度增加而增高,随膝关节屈曲角度减小而降低。膝关节屈曲80°～90°时.侧弓步下的髌股关节压力和应力大于前弓步;膝关节屈曲10°～50°时,跨步下的髌股关节压力和应力大于不跨步。弓步和跨步之间无明显的相互作用。膝关节屈曲0°～50°时髌股关节压力和应力小于膝关节屈曲60°～90°时的压力和应力,因此在髌股关节康复训练早期应限制膝关节屈曲在50°以内。解释:为了尽量减小髌股关节的压力和应力,应当在不跨步下进行前弓步和侧弓步练习,尤其是膝关节屈曲0°～50°时。了解不同弓步间髌股关节压力和应力的差异,可能有助于临床医生制定更加安全有效的康复训练方法。

关键词：侧弓动作髌股关节压力膝关节屈曲

Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer

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World Journal of Clinical Oncology 2015年第6期6卷 299-311页

作者： Michelle Bowie Patrick Pilie Julia Wulfkuhle Siya Lem Abigail Hoffman Shraddha Desai Emanuel Petricoin Amira Carter Adrian Ambrose Victoria Seewaldt Dihua Yu Catherine ibarra Drendall Department of Medicine Division of Medical OncologyDuke University Medical Center Department of Internal Medicine University of Michigan Center for Applied Proteomics and Molecular Medicine George Mason University Department of Molecular and Cellular Oncology University of Texas MD Anderson Cancer Center

AIM: To investigate the mechanism of action of lipophilic antidepressant fluoxetine(FLX) in representative molecular subtypes of breast ***: The anti-proliferative effects and mechanistic action of FLX in triple-negative(SUM149PT) and luminal(T47D and Au565) cancer cells and nontransformed MCF10 A were investigated. Reverse phase protein microarray(RPPM) was performed with and without 10 μmol/L FLX for 24 and 48 h to determine which proteins are significantly changed. Viability and cell cycle analysis were also performed to determine drug effects on cell growth. Western blotting was used to confirm the change in protein expression examined by RPPM or pursue other signaling proteins. RESULTS: The FLX-induced cell growth inhibition in all cell lines was concentration- and time-dependent but less pronounced in early passage MCF10 A. In comparison to the other lines,cell growth reduction in SUM149 PT coincided with significant induction of endoplasmic reticulum(ER) stress and autophagy after 24 and 48 h of 10 μmol/L FLX,resulting in decreased translation of proteins along the receptor tyrosine kinase/Akt/mammalian target of rapamycin pathways. The increase in autophagy marker,cleaved microtubule-associated protein 1 light chain 3,in SUM149 PT after 24 h of FLX was likely due to increased metabolic demands of rapidly dividing cells and ER stress. Consequently,the unfolded protein response mediated by double-stranded RNA-dependent protein kinase-like ER kinase resulted in inhibition of protein synthesis,growth arrest at the G1 phase,autophagy,and caspase-7-mediated cell ***: Our study suggests a new role for FLX as an inducer of ER stress and autophagy,resulting in death of aggressive triple negative breast cancer SUM149 PT.

关键词： Inflammatory breast cancer Endoplasmic reticulum stress Autophagy Apoptosis Fluoxetine

Ultrasonic Sensors with Mechanical Couplers： Simulation and Validation

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Journal of Mathematics and System Science 2012年第4期2卷 264-271页

作者： Monica Femendez Cristina Rodriguez Juan M. Perez Oria Manuel ibarra Luciano Alonso Department of Electronic Technology and Automatic Control Systems University of Cantabria Santander 39005 Spain

The use of ultrasonic sensors has varied applications, but the sensor operation frequency limits the operating distance. An easy way to increase this distance is to couple a mechanical element （horn）, but it is necessary to characterize this technique. In this paper the results obtained in a study of the behaviour of mechanical elements coupled to an ultrasonic sensor using finite element techniques are presented. These results have been obtained using Comsol Multiphysics modelling. Also, the effect caused by the sensor size on the radiation acoustic pressure has also been evaluated. In other way, in this paper it is presented the results obtained in the laboratory measurements. First, it is studied the influence of a straight horn attached to the ultrasonic sensor. Later, it is presented the variation in the sound pressure on the radiation axis when the sensor varies its size. In the final part of the paper, the experimental validation of the simulations is presented.

关键词： Ultrasounds sensors homs radiation pattem.