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Plant trite.pe.oid saponins function as susce.tibility factors to promote.the.pathoge.icity of Botrytis cine.e.

Mole.ular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.e.caray Ame.ia Fe.ipo-Be.ave.t Cristian J.Antone.li Be.ona balaguer Maria Pilar Lope.-Gre.a Pablo Ve.a Instituto de.Biologia Mole.ular y Ce.ular de.Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The.gray mold fungus Botrytis cine.e. is a ne.rotrophic pathoge. that cause. dise.se. in hundre.s of plant spe.ie.,including high-value.*** polyxe.ous nature.and pathoge.ic succe.s are.due.to its ability to pe.ce.ve.host signals in its *** this study,we.found that laticife. ce.ls of e.phorbia lathyris are.a source.of susce.tibility factors re.uire. by *** to cause.***,poor-in-late.(pil)mutants,which lack laticife. ce.ls,show full re.istance.to this pathoge.,whe.e.s lot-of-late. mutants,which produce.more.laticife. ce.ls,are.*** S factors are.trite.pe.oid saponins,which are.wide.y distribute. natural products of vast structural *** downre.ulation of laticife.-spe.ific oxydosquale.e.cyclase.ge.e.,which e.code.the.first committe. ste. e.zyme. for trite.pe.e.and,the.e.ore.saponin biosynthe.is,confe.re. dise.se.re.istance.to ***,the.Me.icago truncatula Iha-1 mutant,compromise. in trite.pe.oid saponin biosynthe.is,showe. e.hance. ***,the.application of diffe.e.t purifie. trite.pe.oid saponins pharmacologically comple.e.te. the.dise.se.e.istant phe.otype.ofpil and hla-1 mutants and e.hance. dise.se.susce.tibility in diffe.e.t plant *** found that trite.pe.oid saponins function as plant cue. that signal transcriptional re.rogramming in ***,le.ding to a change.in its growth habit and infe.tion strate.y,culminating in the.abundant formation of infe.tion cushions,the.multice.lular appre.soria apparatus de.icate. to plant pe.e.ration and biomass de.truction in *** toge.he.,the.e.re.ults provide.an e.planation for how plant trite.pe.oid saponins function as dise.se.susce.tibility factors to promote.*** pathoge.icity.

关键词： e.phorbia lathyris laticife. ce.l late. appre.sorium infe.tion cushion ne.rotrophic fungi

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Se.e.tive.butyric acid production from CO_(2)and its upgrade.to butanol in microbial e.e.trosynthe.is ce.ls

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e.vironme.tal Scie.ce.and e.ote.hnology 2024年第1期17卷 119-127页

作者： Me.itxe.l Romans-Casas Laura Fe.iu-Parade.a Miche.e.Te.e.co Hube.tus V.M.Hame.e.s Lluis Bañe.as M.Dolors balaguer Se.astiàPuig Paolo De.sì Institute.of the.e.vironme.t University of Girona.Campus MontiliviCarrer Maria Aurélia Capmany 69E-17003GironaSpain Mole.ular Microbial e.ology Group Institute of Aquatic EcologyUniversity of GironaMaria Aurelia Capmany 4017003GironaSpain We.sus European Centre of Excellence for Sustainable Water TechnologyOostergoweg 98911MALeeuwardenthe Netherlands

Microbial e.e.trosynthe.is(Me.)is a promising carbon utilization te.hnology,but the.low-value.products(i.e.,ace.ate.or me.hane.and the.high e.e.tric powe. de.and hinde. its industrial *** this study,e.e.trically e.ficie.t Me. ce.ls with a low ohmic re.istance.of 15.7 mU m^(2)we.e.ope.ate. galvanostatically in fe.-batch mode.alte.nating pe.iods of high CO_(2)and H2 *** promote. ace.ic acid and e.hanol production,ultimate.y trigge.ing se.e.tive.78%on a carbon basis)butyric acid production via chain *** ave.age.production rate.of 14.5 g m^(-2)d^(-1)was obtaine. at an applie. curre.t of 1.0 or 1.5 mA cm^(-2),be.ng Me.asphae.a *** ke. chain e.ongating *** a se.ond ce.l with the.catholyte.containing the.e.riche. community re.ulte. in butyric acid production at the.same.rate.as the.pre.ious ce.l,but the.lag phase.was re.uce. by 82%.Furthe.more.inte.rupting the.CO_(2)fe.ding and se.ting a constant pH2 of 1.7e..8 atm in the.cathode.compartme.t trigge.e. solve.toge.ic butanol production at a pH be.ow *** e.ficie.t ce.l de.ign re.ulte. in ave.age.ce.l voltage. of 2.6e..8 V and a re.arkably low e.e.tric e.e.gy re.uire.e.t of 34.6 kWhe. kg1 of butyric acid produce.,de.pite.coulombic e.ficie.cie. be.ng re.tricte. to 45%due.to the.cross-ove. of O_(2)and H2 through the.*** conclusion,this study re.e.le. the.optimal ope.ating conditions to achie.e.e.e.gy-e.ficie.t butyric acid production from CO_(2)and sugge.te. a strate.y to furthe. upgrade.it to valuable.butanol.

关键词： Biocathode Bioe.e.troche.ical syste. Chain e.ongation Hydroge. partial pre.sure Me.asphae.a

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第一产程中应用哌替啶治疗难产:一项随机对照试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 8-8页

作者： Sosa C.G. balaguer e. Alonso J.G. 程广艳 De.t. Obste.. Gyne.ol. De.t. N. Pereira Rossell Hospital Sch. of Med. University of Uruguay Montevideo Uruguay Dr

Obje.tive.This study was unde.take. to e.aluate.whe.he. the.administration of me.e.idine.de.re.se. the.le.gth of labor in patie.ts with a diagnosis of dystocia during the.first stage.of labor. Study de.ign Wome. with te.m single.on pre.nancie. who re.e.ve. a diagnosis of dystocia and re.uire. an active.manage.e.t of labor we.e.randomly assigne. to re.e.ve.e.the. 100 mg of me.e.idine.or place.o. The.primary outcome.me.sure.was le.gth of labor. Re.ults Four hundre. se.e. pre.nant wome. we.e.include.. The.e.we.e.no significant statistical diffe.e.ce. be.we.n me.e.idine.and place.o groups in le.gth of labor and ope.ative.de.ive.y rate. such as force.s and ce.are.n se.tion by inte.tiontotre.t analysis. Low Apgar score., umbilical arte.y acidosis, and admission to ne.natal care.units we.e.incre.se. in the.me.e.idine.group. Conclusion Be.ause.of the.abse.ce.of any be.e.its in patie.ts with dystocia in labor and the.pre.e.ce.of harmful e.fe.ts on ne.natal outcome., me.e.idine.should not be.use. during labor for this spe.ific indication.

关键词：第一产程随机对照试验足月单胎产钳助娩手术分娩脐动脉剖宫产术新生儿监护病房安慰剂产时

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Ne. ge.e. e.e.ging for colore.tal cance. pre.isposition

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World Journal of Gastroe.te.ology 2014年第8期20卷 1961-1971页

作者： Clara e.te.an-Jurado Pilar Garre.Maria Vila Juan José Lozano Anna Pristoupilova Se.gi Be.trán Anna Abulí Je.ife. Muoz France.c balaguer Te.e.a Ocaa Antoni Caste.ls Jose. M Piqué Ange. Carrace.o Clara Ruiz-Ponte.Xavie. Be.sa Montse.rat Andre. Luis Bujanda Trinidad Caldés Se.gi Caste.lví-Be. De.artme.t of Gastroe.te.ology Hospital ClínicCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD)Institut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)University of Barcelona08036 BarcelonaCataloniaSpain Mole.ular Oncology Laboratory Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Bioinformatics platform Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain Ce.tre.Nacional d’Anàlisi Ge.òmica (CNAG) Parc Científic de Barcelona08028 BarcelonaSpain De.artme.t of Gastroe.te.ology Hospital del Mar-IMIM (Hospital del Mar Medical Research Centre)Pompeu Fabra University08003 BarcelonaSpain Galician Public Foundation of Ge.omic Me.icine.(FPGMX) Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER)Genomics Medicine GroupHospital ClínicoSantiago de CompostelaUniversity of Santiago de Compostela15706 GaliciaSpain Ce.te. of e.ce.le.ce.in Ge.omic Me.icine.Re.e.rch King Abdulaziz University21589 JeddahKingdom of Saudi Arabia Gastroe.te.ology De.artme.t Hospital DonostiaNetworked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD)Basque Country University20080 San SebastiánSpain

Colore.tal cance.(CRC)is one.of the.most fre.ue.t ne.plasms and an important cause.of mortality in the.de.e.ope. *** cance. is cause. by both ge.e.ic and e.vironme.tal factors although 35%of the.variation in CRC susce.tibility involve. inhe.ite. ge.e.ic *** syndrome. account for about5%of the.total burde. of CRC,with Lynch syndrome.and familial ade.omatous polyposis the.most common *** he.e.itary forms,the.e.is an important fraction of CRC case. that pre.e.t familial aggre.ation for the.dise.se.with an unknown ge.mline.ge.e.ic *** can be.also conside.e. as a comple. dise.se.taking into account the.common dise.se.ommom variant hypothe.is with a polyge.ic mode. of inhe.itance.whe.e.the.ge.e.ic compone.ts of common comple. dise.se. corre.pond mostly to variants of low/mode.ate.*** far,30 common,low-pe.e.rance.susce.tibility variants have.be.n ide.tifie. for ***,ne. se.ue.cing te.hnologie. including e.ome.nd whole.ge.ome.se.ue.cing have.pe.mitte. to add a ne. approach to facilitate.the.ide.tification of ne. ge.e. re.ponsible.for human dise.se.*** using whole.ge.ome.se.ue.cing,ge.mline.mutations in the.POLe.and POLD1 ge.e. have.be.n found to be.re.ponsible.for a ne. form of CRC ge.e.ic pre.isposition calle. polyme.ase.proofre.ding-associate. polyposis.

关键词： Colore.tal ne.plasm, ge.e.ic pre.isposition to dise.se Ne.t ge.e.ation se.ue.cing Ge.otype.phe.otype.corre.ation Ge.e.ic variant Single.nucle.tide.polymorphism

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