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First report on chlorophyllin to protect mammalian and fish muscle cells from pesticide toxicity via activation of p53 and PARP

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Aquaculture and Fisheries 2021年第4期6卷 393-399页

作者： Asmita Samadder Swatilekha Das bakul pal Sweta Das Anindita Mandal Priyanka Biswas Sujoy Ghosh Shamim Hossain Mandal Priyanka Sow Ruchira Das Souvik Biswas Ashis Kumar Panigrahi Cytogenetics and Molecular Biology Laboratory Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Cell and Developmental Biology Special Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Department of Zoology Dum Dum Motijheel CollegeKolkata700074India Eco-Toxicology Fisheries and Aquaculture Extn.LaboratoryDepartment of ZoologyUniversity of KalyaniKalyaniNadia741235India

Objectives:Pesticide toxicity has become one of the major environmental menaces affecting all types of life forms of the *** get washed off from agricultural fields into nearby water bodies and enter the aquatic *** bio-accumulated form finally reaches the human race,through consumption of pesticide infested aquatic animals,causing several physiological *** it becomes necessary to find a therapeutic cure/a preventive measure to stop the health hazard issues of *** this projection a search for a phyto-based-product was made whose primary objective would be to lower the pesticidal toxicity in fish and simultaneously in the human ***:In this study we tried to check whether the phyto-chemical,Chlorophyllin(CHL),known for its anti-genotoxic,anti-oxidant activities,could render any kind of protection against Cypermethrin(CM)induced-toxicity in fish model and mammalian cell line *** the model L6 and fish were pre-treated with CHL prior to exposure of *** scientific parameters like%cellular cytotoxicity,reactive oxygen species(ROS)generation,nuclear condensation,etc were checked to validate the possibility of CHL in protecting CM-induced ***:The overall results revealed that pre-treatment with CHL could restrict the ROS generation leading to modulation in associated cytokine proteins expression NFkβand IFNγ.Further,CHL lowered nuclear condensation and elevated expression of DNA repair proteins p53 and PARP,showing a kind of pre-activation of signalling cascades for overall protection against the severity of pesticidal ***:Thus,this phyto-based preventive approach would possibly solve many areas of human health issues related to pesticide toxicity in future.

关键词： Cypermethrin Chlorophyllin Fish L6 cells DNA damage ROS generation

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