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Prevalence of Extended-Spectrum Beta-Lactamase-Producing Strains Isolated at Zinder National Hospital (ZNH) in 2021 and Their Antibiotic Susceptibility Profile

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Open Journal of Medical Microbiology 2023年第1期13卷 43-51页

作者： Maman Sani Falissou Saïdou Abdoulaye Ousmane Abdoulaye Inoussa Abdoulaye Maman Bachir Hassane Boureima Lo Gora Alhousseini Maiga Daouda Doutchi Mahamadou bako saley mahaman laouali Sidi Maman Bacha Boukar Mamadou Saidou Faculté des Sciences de la Santé Université Dan Dicko Dankoulodo de Maradi Maradi Niger Hôpital National de Zinder Zinder Niger Centre de Recherche Médicale et Sanitaire Niamey Niger Faculté de Médecine de Pharmacie et d’odontostomatologie Université Cheikh Anta Diop de Dakar Dakar Sénégal Faculté des Sciences de la Santé Université Abdou Moumouni Niamey Niger Faculté des Sciences de la Santé Université de Zinder Zinder Niger

Purpose: Bacterial resistance to antibiotics has become a global public health problem. Enterobacteriaceae ESBL is among the most incriminated in this emergence which reduces the therapeutic possibilities. Thus, the objective of this study is to determine the prevalence of the extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae at ZNH and their antibiotic susceptibility profile. Materials and Methods: This is a prospective study carried out over 5 months in all hospitalized and non-hospitalized patients in whom a culture was taken for the diagnosis of an infection. The search for ESBL is done by the double disc diffusion method. Results: In total, 21 out of 45 of our strains are ESBL-producing, i.e. a frequency of 46.7%. The mean age is 41.62 (±22.90) with extremes of 2.6 - 78 years. The distribution of ESBL producing species showed a predominance of E. coli with 66.7% followed by K. pneumoniae and K. oxytoca each 9.5%. All ESBL strains were resistant to Amoxicillin, Cefalotin, Pipiracillin, Piperacillin + tazobactam, Ticarcillin, Ticarcillin + clavulanic acid. Resistance to C3G and Aztreonam was each 95.5%, to Amoxicillin/clavulanic acid 9.1%. All strains were sensitive to imipenem. E. coli strains showed resistance: 85.7% to ciprofloxacin, 50% to Amikacin, 57.1% to Gentamicin. For K. pneumoniae, it is 66.7% for Gentamicin and Ciprofloxacin. Conclusion: Our study reports a high prevalence of ESBL at the HNZ. This must be taken into account in order to monitor this phenomenon which constitutes a public health problem. The study also reports sensitivity to Amoxicillin/clavulanic acid and Aminoside which can be an alternative.

关键词： Bacterial Resistance ESBL Enterobacteriaceae Zinder Niger

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