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Responsive hyperbranched poly(formyl-1,2,3-triazole)s toward quadruple-modal information security protection

Science China Chemistry 2022年第4期65卷 771-777页

作者： baixue Li Zhen Li Kai You Anjun Qin Ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation Induced EmissionSouth China University of TechnologyGuangzhou 510640China Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China Foshan Nanhai Guangdong Technology University CNC Equipment Cooperative Innovation Institute Foshan 528225China

Secrecy has received tremendous attention in modern information society. Innovative polymer-based fluorescent materials with multiple mode emission are quite desirable to achieve multistage data security. Herein, a series of soluble and thermally stable hyperbranched poly(formyl-1,2,3-triazole)s(hb-PFTAs) with high molecular weights were facilely prepared by catalyst-free polycycloaddition of aldehyde-activated internal triyne and diazides. Functional moieties of triphenylamine and binaphthyl could be incorporated into the polymers to offer them with unique fluorescence and circular dichroism properties, respectively.By taking advantage of activated ethynyl and aldehyde groups on their peripheries and in the internal branch chains, the hbPFTAs can undergo efficient single-and double-stage post-functionalization. More importantly, based on the remarkable fluorescence responses to hydrazine and hydrochloric acid, the hyperbranched polymers are featured with triple-mode fluorescent patterns and have been applied in quadruple-modal information encryption and storage with enhanced security and density. Collectively, this work not only enriches the structural diversity of the existing triazole-based material library, but also provides new polymeric materials for data and information security application.

关键词： activated internal triyne hyperbranched poly(formyl-1,2,3-triazole)s post-polymerization modification multilevel information security

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Injectable bone marrow microniches by co-culture of HSPCs with MSCs in 3D microscaffolds promote hematopoietic reconstitution from acute lethal radiation

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Bioactive Materials 2023年第4期22卷 453-465页

作者： Haiwei Liang Yanxiao Ao Wenjing Li Kaini Liang Baixue Tang Junyang Li Jianwei Wang Xiaoyu Zhu Yanan Du Department of Biomedical Engineering School of MedicineTsinghua-PekingCenter for Life SciencesTsinghua UniversityBeijing100084China School of Pharmaceutical Sciences Tsinghua UniversityBeijing100084China Department of Hematology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina

Hematopoietic syndrome of acute radiation syndrome(h-ARS)is an acute illness resulted from the damage of bone marrow(BM)microenvironment after exposure to radiation.Currently,the clinical management of h-ARS is limited to medication-assisted treatment,while there is still no specific therapy for the hematopoietic injury from high-dose radiation exposure.Our study aimed to assemble biomimetic three-dimensional(3D)BM microniches by co-culture of hematopoietic stem and progenitor cells(HSPCs)and mesenchymal stem cells(MSCs)in porous,injectable and viscoelastic microscaffolds in vitro.The biodegradable BM microniches were then transplanted in vivo into the BM cavity for the treatment of h-ARS.We demonstrated that the maintenance of HSPCs was prolonged by co-culture with MSCs in the porous 3D microscaffolds with 84μm in pore diameter and 11.2 kPa in Young’s modulus compared with 2D co-culture system.Besides,the minimal effective dose and therapeutic effects of the BM microniches were investigated on a murine model of h-ARS,which showed that the intramedullary cavity-injected BM microniches could adequately promote hematopoietic reconstitution and mitigate death from acute lethal radiation with a dose as low as 1000 HSPCs.Furthermore,the mRNA expression of Notch1 and its downstream target gene Hes1 of HSPCs were increased when co-cultured with MSCs,while the Jagged1 expression of the co-cultured MSCs was upregulated,indicating the significance of Notch signaling pathway in maintenance of HSPCs.Collectively,our findings provide evidence that biomimetic and injectable 3D BM microniches could maintain HSPCs,promote hematopoiesis regeneration and alleviate post-radiation injury,which provides a promising approach to renovate conventional HSPCs transplantation for clinical treatment of blood and immune disorders.

关键词： Hematopoietic syndrome of acute radiation syndrome Bone marrow Hematopoietic stem cells Mesenchymal stem cells 3D microscaffolds

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Aging-disturbed FUS Phase Transition Impairs Hematopoietic Stem Cell

Aging-disturbed FUS Phase Transition Impairs Hematopoietic S...

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2021年全国生物相分离和相变学术研讨会

作者： Baixue Tang Jianwei Wang School of Pharmaceutical Sciences Tsinghua University

Hematopoietic stem cells(HSCs) build up the blood system throughout life-span and aged HSCs exhibit compromised reconstitution capacity and differentiation bias towards myeloid lineage,which is a key factor resulting in myeloproliferative disease and immunosenescence.While,the molecular mechanism behind this phenomenon is still not fully understood.In this study,we observed that the RNA-binding protein fused in sarcoma(FUS) is increased in aged HSCs and enforced FUS impairs HSCs.FUS undergoes liquid-liquid phase separation(LLPS) in HSCs,which is mediated by RGG domain.FUS HSCs display aberrant dynamic FUS condensates compared to FUS HSCs,and exhibit compromised reconstitution capacity.Molecular analysis reveals that that HSC fingerprint genes are enriched in FUS HSCs.Knockdown of aging-declined Tnpol results in increased FUS and perturbed LLPS of FUS in HSCs,and furthermore leads to the impairment of HSC function.Replacing FUS’s RGG domain with Arabidopsis FLL2 and ELF3 PLD domains,which mediate phase separation,significantly disturbs the LLPS of FUS and then severely impairs HSC in vitro and in vivo.Collectively,our results provides important molecular insights into a previously unknown character of FUS phase transition in HSC aging.

关键词： Hematopoietic stem cell Aging FUS Phase separation

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Multi-features fusion for short-term photovoltaic power prediction

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Intelligent and Converged Networks 2022年第4期3卷 311-324页

作者： Ming Ma Xiaorun tang Qingquan Lv Jun Shen baixue Zhu Jinqiang Wang Binbin Yong State Grid Gansu Electric Power Research Institute Lanzhou 730000China School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China School of Computing and Information Technology University of WollongongWollongong 2522Australia

In recent years,in order to achieve the goal of“carbon peaking and carbon neutralization”,many countries have focused on the development of clean energy,and the prediction of photovoltaic power generation has become a hot research topic.However,many traditional methods only use meteorological factors such as temperature and irradiance as the features of photovoltaic power generation,and they rarely consider the multi-features fusion methods for power prediction.This paper first preprocesses abnormal data points and missing values in the data from 18 power stations in Northwest China,and then carries out correlation analysis to screen out 8 meteorological features as the most relevant to power generation.Next,the historical generating power and 8 meteorological features are fused in different ways to construct three types of experimental datasets.Finally,traditional time series prediction methods,such as Recurrent Neural Network(RNN),Convolution Neural Network(CNN)combined with eXtreme Gradient Boosting(XGBoost),are applied to study the impact of different feature fusion methods on power prediction.The results show that the prediction accuracy of Long Short-Term Memory(LSTM),stacked Long Short-Term Memory(stacked LSTM),Bi-directional LSTM(Bi-LSTM),Temporal Convolutional Network(TCN),and XGBoost algorithms can be greatly improved by the method of integrating historical generation power and meteorological features.Therefore,the feature fusion based photovoltaic power prediction method proposed in this paper is of great significance to the development of the photovoltaic power generation industry.

关键词： meteorological factors multi-features fusion time series prediction photovoltaic power prediction

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Activated Internal Alkyne-Based Polymerization

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Chinese Journal of Chemistry 2022年第16期40卷 2001-2013页

作者： baixue Li Jia Wang Benzhao He Anjun Qin Ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation Induced EmissionAIE InstituteSouth China University of TechnologyGuangzhouGuangdong510640 China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhenGuangdong518172 China Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Center for Advanced Materials Research Advanced Institute of Natural SciencesBejing Normal University at ZhuhaiZhuhaiGuangdong 519085China

As an emerging and efficient polymerization methodology,activated internal alkyne-based polymerization has been considered as a powerful tool for the construction of polymers with diverse architectures and versatile functions.This review focuses on the recent progresses in the polymerization using mono-activated,di-activated,in-situ generated,ring-strained ethynyl groups as substrates,coupling with post-modification on premade polymers containing activated internal ethynyl moieties.Representative examples are used to illustrate the fundamental design strategy,the development of polymerization and post-functionalization,along with the properties and potential applications of the prepared polymers.Moreover,the challenges and perspectives in terms of new-type active alkynes,green polymerization methodology,tailored regio-/stereoselectivity modulation,and potentially expanded application in this area are also discussed.

关键词： Alkynes Polymerization Polymers Post-functionalization Property and application

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可同化阿拉伯糖的木糖还原酿酒酵母菌株构建

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微生物学报 2020年第12期60卷 2705-2716页

作者：黄河浪刁于真杨白雪夏子渊汤岳琴四川大学建筑与环境学院四川成都610065 四川省环境保护有机废弃物资源化利用重点实验室四川成都610065

【目的】以秸秆等木质纤维素类生物质为原料生产液体生物燃料乙醇,目前生产成本高,大规模工业化生产尚有较大难度。构建能同化阿拉伯糖进行木糖还原生产木糖醇的重组酿酒酵母菌株,以实现原料中全糖利用、生产高附加值产品,实现产品多元... 详细信息

【目的】以秸秆等木质纤维素类生物质为原料生产液体生物燃料乙醇,目前生产成本高,大规模工业化生产尚有较大难度。构建能同化阿拉伯糖进行木糖还原生产木糖醇的重组酿酒酵母菌株,以实现原料中全糖利用、生产高附加值产品,实现产品多元化。【方法】首先,利用CRISPR/Cas9基因编辑技术依次向出发菌株中导入阿拉伯糖代谢途径和木糖还原酶基因,使菌株获得代谢阿拉伯糖和将木糖转化为木糖醇的能力;其次,通过适应性驯化的进化工程手段,提高重组菌株对阿拉伯糖的利用效率;最后,通过混合糖发酵验证重组菌株利用阿拉伯糖和还原木糖产木糖醇的能力。【结果】通过导入植物乳杆菌的阿拉伯糖代谢途径,酿酒酵母菌株获得了较好的利用阿拉伯糖生长繁殖的能力;进一步导入假丝酵母的木糖还原酶基因后,重组菌株在葡萄糖作为辅助碳源条件下可高效还原木糖产木糖醇,但阿拉伯糖的利用能力下降。利用以阿拉伯糖为唯一碳源的培养基进行反复批次驯化,阿拉伯糖的利用能力得以恢复和提升,得到表型较好的重组菌株KAX3-2。该菌株在木糖(50 g/L)和阿拉伯糖(20 g/L)混合糖发酵条件下发酵72 h时,对阿拉伯糖和木糖利用率分别达到42.1%和65.9%,木糖醇的收率为64%。【结论】本研究成功构建了一株能有效利用阿拉伯糖并能将木糖转化为木糖醇的重组酿酒酵母菌株KAX3-2,为后续构建、获得阿拉伯糖代谢能力更强、木糖醇积累效率更高菌株的工作奠定了基础。

关键词：酿酒酵母木糖醇木糖阿拉伯糖 CRISPR/Cas9 进化工程

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外泌体在脓毒症心肌病中的研究进展

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健康研究 2023年第4期43卷 448-452页

作者：姚白雪王磊唐泽文徐宇璇张丽楠林乐清杭州师范大学临床医学院浙江杭州311121 杭州师范大学附属医院重症医学科浙江杭州310015

脓毒症是严重感染引起的宿主反应失调导致的致命性器官功能障碍,脓毒症相关的心功能不全即脓毒症心肌病,其发病机制尚未明确。外泌体是细胞外囊泡的一种,在细胞间通讯中发挥着重要作用,影响心血管及炎症相关疾病的发展。近年来研究表明... 详细信息

脓毒症是严重感染引起的宿主反应失调导致的致命性器官功能障碍,脓毒症相关的心功能不全即脓毒症心肌病,其发病机制尚未明确。外泌体是细胞外囊泡的一种,在细胞间通讯中发挥着重要作用,影响心血管及炎症相关疾病的发展。近年来研究表明,外泌体参与了脓毒症心肌病的发病过程,对疾病的发展、诊断、治疗具有重要的作用。文章就脓毒症心肌病与不同细胞来源的外泌体之间的联系进行综述。

关键词：脓毒症心肌病外泌体非编码RNA

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不同海拔高度青年军人工作记忆刷新功能的影响因素分析

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陆军军医大学学报 2022年第23期44卷 2360-2367页

作者：张颖王菲菲郑莹灿张振铭詹小青唐映丹白雪吕恬歌郭桦杨国愉陆军军医大学(第三军医大学)医学心理系军人发展心理学教研室重庆400038 解放军第73141部队卫生连福建泉州362308

目的探讨不同海拔高度青年军人工作记忆刷新功能的变化特点及其影响因素。方法于2021年12月至2022年5月采用方便抽样的方法,将收集到的426名青年军人的数据分为3组:4000 m组(n=151)。采用N-back(0-back,1-back,2-back)任务测量青年军人... 详细信息

目的探讨不同海拔高度青年军人工作记忆刷新功能的变化特点及其影响因素。方法于2021年12月至2022年5月采用方便抽样的方法,将收集到的426名青年军人的数据分为3组:4000 m组(n=151)。采用N-back(0-back,1-back,2-back)任务测量青年军人工作记忆的刷新功能,采用自制的一般资料调查表分析刷新功能可能存在的影响因素。结果(1)不同海拔组的青年官兵在0-back任务和1-back任务的正确反应时、1-back任务和2-back任务的正确率方面均存在显著差异(P<0.01)。(2)经单因素分析筛选变量后,多元线性回归分析显示,家庭结构是青年军人0-back任务正确率的显著影响因素(P<0.05);海拔高度、工作期间是否经历过较严重的心理创伤、家庭结构是青年军人1-back任务正确率的显著影响因素(P<0.05);海拔高度、军龄是青年军人0-back和1-back任务正确反应时的显著影响因素(P<0.01);海拔高度、家庭结构是青年军人2-back任务正确率的显著影响因素(P<0.05)。(3)两因素方差分析显示,刷新功能的影响因素之间不存在交互作用。结论高原地区青年军人的工作记忆刷新功能低于平原地区青年军人。海拔高度、军龄、家庭结构以及工作期间是否经历过较严重的心理创伤可能影响青年军人的工作记忆刷新功能。

关键词：高海拔青年军人工作记忆刷新功能

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The landscape of aging

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Science China(Life Sciences) 2022年第12期65卷 2354-2454页

作者： Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Frontier Science Center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International Laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

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基于TI DM6437的视频图像增强算法实现

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微型机与应用 2014年第7期33卷 44-47,50页

作者：施白雪陈芬张陈梅黄逸飞陈仁涛汤颛顼宁波大学信息科学与工程学院浙江宁波315211

采用基于TI公司高性能Davinci系列TMS320DM6437处理器的SEED-DEC6437 EVM板作为主要硬件平台,在DSP集成开发环境CCS3.3中实现图像增强算法,并在设计过程中成功地完成了增强算法从软件到硬件平台的移植,搭建了一个视频图像增强的DSP应用... 详细信息

采用基于TI公司高性能Davinci系列TMS320DM6437处理器的SEED-DEC6437 EVM板作为主要硬件平台,在DSP集成开发环境CCS3.3中实现图像增强算法,并在设计过程中成功地完成了增强算法从软件到硬件平台的移植,搭建了一个视频图像增强的DSP应用系统。设计结果表明,本系统具有算法简单、性能稳定、实时性好的特点。

关键词：图像增强 DSP TMS320DM6437

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