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A novel deep generative model for mRNA vaccine development: Designing 5′ UTRs with N1-methyl-pseudouridine modification

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Acta Pharmaceutica sinica B 2024年第4期14卷 1814-1826页

作者： Xiaoshan Tang Miaozhe Huo Yuting Chen Hai Huang shugang Qin Jiaqi Luo Zeyi Qin Xin Jiang Yongmei Liu Xing Duan Ruohan Wang Lingxi Chen Hao Li Na Fan Zhongshan He Xi He bairong s.en shuai Cheng Li Xiangrong song Institute of systems Genetics Department of Critical Care MedicineFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610000China Department of Computer science City University of Hong KongHong Kong 99907China Department of Biology Brandeis UniversityBostonMA 02453USA

Efficient translation mediated by the 5'untranslated region(5'UTR)is es.ential for the robust efficacy of mRNA ***,the N1-methyl-pseudouridine(m1)modification of mRNA can impact the translation efficiency of the 5'*** discovered that the optimal 5'UTR for m1y-modified mRNA(m1y-5'UTR)differs significantly from its unmodified counterpart,high-lighting the need for a specialized tool for designing mly-5'UTRs rather than directly utilizing high-expression endogenous gene 5'*** response,we developed a novel machine learning-based tool,smart5UTR,which employs a deep generative model to identify superior m1y-5'UTRs in *** tailored loss function and network architecture enable smart5UTR to overcome limitations inherent in existing *** a result,smart5UTR can successfully design superior 5'UTRs,greatly benefiting mRNA vaccine ***,smart5UTR-designed superior 5'UTRs significantly enhanced antibody titers induced by COVID-19 mRNA vaccines against the Delta and Omicron variants of sARs-CoV-2,surpassing the performance of vaccines using high-expression endogenous gene 5'UTRs.

关键词： mRNA vaccine Machine learning 5'UTR mRNA design sequence design N1-Methyl-pseudouridine COVID-19 sARs-CoV-2

包膜综合处理及假体置换联合大分子透明质酸注射治疗隆乳术后包膜挛缩

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中国美容医学 2024年第8期33卷 30-33页

作者：朱小平方柏荣中南大学湘雅二医院整形美容烧伤外科湖南长沙410011 长沙鹏爱医疗美容医院湖南长沙410011

目的:探讨包膜综合处理及假体置换联合大分子透明质酸注射治疗隆乳术后包膜挛缩的效果。方法:选择2014年5月-2021年4月笔者医院收治的29例假体隆乳后包膜挛缩患者为研究对象,患者年龄21~53岁,初次假体隆乳后1~6年,平均2.3年,其中Baker... 详细信息

目的:探讨包膜综合处理及假体置换联合大分子透明质酸注射治疗隆乳术后包膜挛缩的效果。方法:选择2014年5月-2021年4月笔者医院收治的29例假体隆乳后包膜挛缩患者为研究对象,患者年龄21~53岁,初次假体隆乳后1~6年,平均2.3年,其中Baker分级Ⅲ级21例,Ⅳ级8例,单侧3例,双侧26例。采用乳晕切口,完全去除乳房增厚包膜11例,包膜松解18例,均置换假体。在隆乳术后即刻或术后48 h内,每侧注入大分子透明质酸10~20 ml,用于预防包膜再次挛缩。结果:29例患者术后即刻均获得满意外形,随访1~5年,乳房外形保持良好,柔软度好,无乳房疼痛、硬块和乳头感觉缺失,Baker分级Ⅰ级22例,Ⅱ级7例,无假体破裂、乳房下垂及上移等并发症。结论:包膜综合处理及假体置换联合大分子透明质酸注射治疗隆乳术后包膜挛缩疗效好,且能有效降低乳房包膜再次挛缩的概率。

关键词：大分子透明质酸隆乳包膜挛缩假体置换复发

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Translational Informatics for Parkinson’s Disease:from Big Biomedical Data to small Actionable Alterations

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 415-429页

作者： bairong s.en Yuxin Lin Cheng Bi s.engrong Zhou Zhongchen Bai Guangmin Zheng Jing Zhou Institutes for systems Genetics West China HospitalSichuan UniversityChengdu 610041China Center for systems Biology Soochow UniversitySuzhou 215006China Center for Translational Biomedical Informatics Guizhou University School of MedicineGuiyang 550025China

Parkinson’s disease(PD)is a common neurological disease in elderly people,and its morbidity and mortality are increasing with the advent of global *** traditional paradigm of moving from small data to big data in biomedical research is shifting toward big data-based identification of small actionable *** highlight the use of big data for precision PD medicine,we review PD big data and informatics for the translation of basic PD research to clinical *** emphasize some key findings in clinically actionable changes,such as susceptibility genetic variations for PD risk population screening,biomarkers for the diagnosis and stratification of PD patients,risk factors for PD,and lifestyles for the prevention of *** challenges associated with the collection,storage,and modelling of diverse big data for PD precision medicine and healthcare are also *** perspectives on systems modelling and intelligent medicine for PD monitoring,diagnosis,treatment,and healthcare are discussed in the end.

关键词： Parkinson’s disease Healthcare Disease biomarker Translational informatics systems modelling

An Analysis of Market Competitiveness of World＇s Major Apple Export Countries

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Chinese Business Review 2005年第8期4卷 32-37页

作者： Pingfan Chang bairong Lu shanxi Agricultural University Planning Department of Foreign Cooperative Center of Agriculture Ministry

Market competitiveness of apple exports consists of export capacity and foreign currency earning ability. The strength and weakness of export competitiveness to some extent will determine each nation＇s position in the international apple market. Results indicate that apple export competitiveness of China is far below the world average level, and suggest that there are huge apple export potentials for China to exploit in the future. China has obvious comparative advantages both in apple production and apple marketing in aspects of labor, climate, soil, market, technology, etc.. Hence effective measures must be taken in order to speed up the quick transformation of resource advantages to export competitiveness.

关键词： apple exports export capacity competitiveness AECA FCEA AEC

社会团结的先声:皮埃尔·勒鲁的贫困治理思想

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学海 2023年第4期 88-96页

作者：张柏榕浙江大学城市学院马克思主义学院杭州310015

19世纪中期,产业工人贫困问题在法国社会凸显,社会主义者纷纷提出改革方案,限制自由市场竞争产生的破坏性影响。皮埃尔·勒鲁认为,贫困现象源于19世纪法国社会道德的衰落与统一共识的破碎;治理贫困不仅需要从实践上变革劳动组织和所有权... 详细信息

19世纪中期,产业工人贫困问题在法国社会凸显,社会主义者纷纷提出改革方案,限制自由市场竞争产生的破坏性影响。皮埃尔·勒鲁认为,贫困现象源于19世纪法国社会道德的衰落与统一共识的破碎;治理贫困不仅需要从实践上变革劳动组织和所有权,更要在社会智识中建设稳定的道德秩序,以个体间的世俗团结重塑慈善伦理。这一思想开启了法国社会团结理论的先声,促使19世纪法国慈善话语从以教会救济为主的慈善伦理,向以社会责任为主的世俗团结原则转换,对法国社会福利体系的构建产生深刻影响。

关键词：皮埃尔·勒鲁贫困社会团结社会主义慈善

site Testing at the Gaomeigu Village

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天文研究与技术 1999年第S1期 18-23页

作者： Tan Huisong, Zhang bairong (Yunnan Observatory, The Chinese Academy of sciences, Kunming 650011, China)

The work on the site testing at the Gaomeigu village Lijiang county in the northwest of Yunnan Province, was started in 1994 after the completion of the investigation on optical/infrared astronomical observatory site resources over Yunnan Province. The observation of the astro climate conditons has been made for more than two years. The major results are given as follows: The photometrical nights are 75, the half photometrical nights 39, the spectroscopic nights 99 5. the average of the temperature difference during night is 3 2℃, the average of the winding speed 3 6m/s, the precipitable water vapor at night is 13.0mm in the raining season and 4.3mm in the dry season respectively. The seeing measurement was made by a three subaperture DIMM. 20486 sets data obtained for 294 nights. The average of the Fried parameter is 15.53cm (FWHM=0.″71). The micro temperature sensors were used to determine the atmospheric turbulence distribution near the ground from 6 5cm to 27m. The typical value is about 0.″11 at night. The sky brightness and the extinction coefficient in B.V. colors was measured by a photometer. The means of the sky brightness B=22 m 34/◇″ and V=21 m.54/◇″. The extinction coefficients K′ v=0.135 and K′ bv =0.298.

关键词： site Testing at the Gaomeigu Village 110

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清末民初挽联与新文学的发生

中国文学研究 2017年第3期 88-92页

作者：肖百容湖南师范大学文学院湖南长沙410081

晚清以降,哀祭文体盛行于文坛,其中尤以挽联为胜,当时的知名人物,无论文人还是武将,均酷爱写作挽联。挽联被用来娱情、炫才、言志、抒怀,不一而足,其功能得到了极度扩展,其内涵和形式或隐或显也发生了巨大的变化。挽联在主题形态、生命... 详细信息

晚清以降,哀祭文体盛行于文坛,其中尤以挽联为胜,当时的知名人物,无论文人还是武将,均酷爱写作挽联。挽联被用来娱情、炫才、言志、抒怀,不一而足,其功能得到了极度扩展,其内涵和形式或隐或显也发生了巨大的变化。挽联在主题形态、生命观念、叙事方式、叙事情感,甚至语言形式等诸多方面与新文学的发生存在密切的关系。文章以详实的楹联文献为基础,具体细致地阐述了这个问题。

关键词：挽联新文学清末民初

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抗日根据地旧体诗词创作与中国形象塑造

中国社会科学 2021年第6期 98-115,206页

作者：肖百容张宁湖南师范大学文学院长沙410081 湖南城市学院人文学院益阳413000

与其他现代旧体诗词一样,抗日根据地旧体诗词一直没有得到研究者足够的重视,更不要说以现代性品质入史。其实,旧体诗词在抗日根据地是一个巨大的存在,特别是它对中国形象的塑造可谓情理交融、简约明快,反映了积极进取、健康向上而又自... 详细信息

与其他现代旧体诗词一样,抗日根据地旧体诗词一直没有得到研究者足够的重视,更不要说以现代性品质入史。其实,旧体诗词在抗日根据地是一个巨大的存在,特别是它对中国形象的塑造可谓情理交融、简约明快,反映了积极进取、健康向上而又自由雄健的价值观和审美风尚,诠释了国家民族的希冀与梦想。这既有助于对共产党领导人及广大人民群众精神风貌的艺术表达,也有利于新型军民鱼水关系与延安政治形象的形塑。抗日根据地旧体诗词塑造了全新的中国形象。这一形象传递出宏大的历史足音,体现了民心所向,也振奋了国人军人士气,展现出中华民族在危难之际乐观奋进的精神气象,打破了长久以来旧体诗词缺乏现代性和不能入史的"臆断",有助于重新认识旧体诗词的功能、价值及在整个抗战文艺和文学史中的地位。

关键词：抗日根据地旧体诗词中国形象文化自信精神气象

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林语堂英文小说二三论

湖南师范大学社会科学学报 2019年第3期48卷 87-92页

作者：肖百容钟新良湖南师范大学文学院

林语堂的小说都是用英文写成的,但是,它们的内涵与形式都和中国历史与文化息息相关。具体地说,林语堂的英文小说采用的是翻译性写作方法,他创造性地将中国元素注入其中。林语堂小说的独特形式为中国文化的输出和中国形象的塑造做出了贡... 详细信息

林语堂的小说都是用英文写成的,但是,它们的内涵与形式都和中国历史与文化息息相关。具体地说,林语堂的英文小说采用的是翻译性写作方法,他创造性地将中国元素注入其中。林语堂小说的独特形式为中国文化的输出和中国形象的塑造做出了贡献。不过,由于它们宣扬中国道德文化、讽喻美国等西方国家存在的现代文明弊病的意图太过强烈,以致忽略了小说的人物刻画和细节描写,因而在一定程度上损害了小说的形象魅力。

关键词：林语堂英文小说中国形象讽喻