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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu Yu leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Progress in numerical modeling of subducting plate dynamics

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Science China Earth Sciences 2018年第12期61卷 1761-1774页

作者： Wei leng Liangzhi HUANG School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China National Geophysical Observatory at Mengcheng Hefei 230026China

The core concerns of plate tectonics theory are the dynamics of subducting plates, which can be studied by integrating multidisciplinary fields such as seismology, mineral physics, rock geochemistry, geological formation studies, sedimentology,and numerical simulations. By establishing a theoretical model and solving it with numerical methods, one can replicate the dynamic effects of a subducting plate, quantifying its evolution and the surface response. Simulations can also explain the observations and experimental results of other disciplines. Therefore, numerical models are among the most important tools for studying the dynamics of subducting plates. This paper provides a review on recent advances in the numerical modeling of subducting plate dynamics. It covers various aspects, namely, the origin of plate tectonics, the initiation process and thermal structure of subducting slab, and the main subduction slab dynamics in the upper mantle, mantle transition zone, and lower mantle. The results of numerical models are based on the theoretical equations of mass, momentum, and energy conservation. To better understand the dynamic progress of subducting plates, the simulation results must be verified in comparisons with the results from natural observations by geology, geophysics and geochemistry. With the substantial increase in computing power and continuous improvement of simulation methods, numerical models will become a more accurate and efficient means of studying the frontier issues of Earth sciences, including subducting plate dynamics.

关键词： Subducting plate Dynamics Numerical simulation

Progress in the numerical modeling of mantle plumes

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Science China Earth Sciences 2023年第4期66卷 685-702页

作者： Wei leng Hao LIU Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China State Key Laboratory of Geological Processes and Mineral Resources School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China CAS Center for Excellence in Comparative Planetology Hefei 230026China

The mantle plume model, as an integral part of the Earth’s internal convection system, is complementary to the theory of plate tectonics. They together constitute the key configuration of material circulation and energy transport in the Earth’s interior. Seismology, high-temperature and high-pressure mineralogy, geology, and geodynamic numerical modeling have conducted comprehensive studies on the mantle plume model since it was proposed. In particular, numerical simulation, which investigates the dynamic processes of mantle plumes by establishing a theoretical model, provides a quantitative description of possible mantle plume evolution and the responses of the Earth’s interior and surface, which can be used to explain observations and experimental results from other disciplines. Thus, it is one of the most important means to study plume dynamics. This paper summarizes the research progress in numerical modeling of mantle plumes in past decades, including the origin of mantle plumes, seismological evidence for the existence of plumes, interactions between mantle plumes and the lithosphere, mid-ocean ridges, subduction zones, and the mantle transition zone, as well as the relationship between plumes and large low shear wave velocity provinces. The theoretical results of numerical modeling combined with observations from other disciplines enable us to deeply understand the dynamic process of mantle plumes. With the continuing development of numerical methodology and the improvement of high-performance computing, geodynamic numerical modeling will become a more accurate and efficient approach for studying mantle plume dynamics and related frontier problems in geosciences.

关键词： Mantle plume Dynamics Numerical modeling

Mathematical method in optical molecular imaging

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Science China(Information Sciences) 2015年第3期58卷 4-16页

作者： leng ChengCai TIAN Jie School of Mathematics and Information Sciences Nanchang Hangkong University Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences

Optical molecular imaging is an important technique of studies at molecular level and provides promising tools to non-invasively delineate in vivo physiological and pathological activities at cellular and molecular levels,and it has been widely used for diagnosing,managing diseases,metastasis detection and drug *** a mathematical perspective,this paper mainly focuses on the forward problem and inverse problem in biological tissues based on the radiative transfer equation(RTE).The forward problem is accustomed to describing photon propagation in biological tissues and the inverse problem is used to reconstruct internal source distribution from the signal detected on the external *** also introduce the detailed derivation of the RTE and Robin boundary condition and discretization of the forward problem,along with the reconstruction methods and iterative solution algorithms summarized for the inverse ***,the current and future challenges of optical molecular imaging are *** survey aims to construct a mathematical method,a state-of-the-art framework for optical molecular imaging,from which future research may benefit.

关键词： radiative transfer equation(RTE) regularization method source reconstruction optical molecular imaging mathematical method

Infinite Horizon Backward Doubly Stochastic Differential Equations with Non-degenerate Terminal Functions and Their Stationary Property

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 407-422页

作者： Hui-nan leng Department of Mathematics East China University of Science and Technology

In this paper we consider infinite horizon backward doubly stochastic differential equations （BDS- DEs for short） coupled with forward stochastic differential equations, whose terminal functions are non-degenerate. For such kind of BDSDEs, we study the existence and uniqueness of their solutions taking values in weighted Lp（dx）¤L2（dx）space （p _〉 2）, and obtain the stationary property for the solutions.

关键词： backward doubly stochastic differential equations infinite horizon non-degenerate terminal func-tion stationary property

Aseismic ridge subduction and flat subduction:Insights from three-dimensional numerical models

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Earth and Planetary Physics 2023年第2期7卷 269-281页

作者： Hui Zhao Wei leng Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Hefei 230026China

Flat subduction can significantly influence the distribution of volcanism,stress state,and surface topography of the overriding ***,the mechanisms for inducing flat subduction remain *** two-dimensional(2-D)numerical models and laboratory analogue models suggested that a buoyant impactor(aseismic ridge,oceanic plateau,or the like)may induce flat ***,three-dimensional(3-D)systematic studies on the relationship between flat subduction and buoyant blocks are still ***,we use a 3-D numerical model to investigate the influence of the aseismic ridge,especially its width(which is difficult to consider in 2-D numerical models),on the formation of flat *** model results suggest that the aseismic ridge needs to be wide and thick enough to induce flat subduction,a condition that is difficult to satisfy on the *** also find that the subduction of an aseismic ridge parallel to the trench or a double aseismic ridge normal to the trench has a similar effect on super-wide aseismic ridge subduction in terms of causing flat subduction,which can explain the flat subduction observed beneath regions such as Chile and Peru.

关键词： flat subduction aseismic ridge oceanic plateau 3-D numerical simulation

GENERIC NEWTON POLYGON OF THE L-FUNCTION OF n VARIABLES OF THE LAURENT POLYNOMIAL I

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Acta Mathematica Scientia 2022年第6期42卷 2419-2436页

作者： Fusheng leng Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

The Hodge bound for the Newton polygon of L-functions of T-adic exponential sums associated to a Laurent polynomial is *** improve the lower bound and study the properties of this new *** also study when this new boun... 详细信息

关键词： exponential sum Hodge bound combinatorial Newton polygon

Thermal structure of continental subduction zone: high temperature caused by the removal of the preceding oceanic slab

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Earth and Planetary Physics 2021年第3期5卷 290-295页

作者： Ting Luo Wei leng Laboratory of Seismology and Physics of Earth’s Interior/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Center for Excellence in Comparative Planetology Beijing 100049China

The thermal structure of the continental subduction zone can be deduced from high-pressure and ultra-high-pressure rock samples or numerical ***,petrological data indicate that the temperature of subducted continental plates is generally higher than that derived from numerical *** this paper,a two-dimensional kinematic model is used to study the thermal structure of continental subduction zones,with or without a preceding oceanic *** results show that the removal of the preceding oceanic slab can effectively increase the slab surface temperature of the continental subduction zone in the early stage of *** can sufficiently explain the difference between the cold thermal structure obtained from previous modeling results and the hot thermal structure obtained from rock sample data.

关键词： thermal structure continental subduction zone slab breakoff numerical model

Shape Memory Epoxy Resin and Its Composites:From Materials to Applications

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Research 2022年第2期2022卷 345-369页

作者： Lan Luo Fenghua Zhang Jinsong leng Centre for Composite Materials and Structures Harbin Institute of Technology(HIT)Harbin 150080China

Shape memory polymers(SMPs)have historically attracted attention for their unique stimulation-responsive and variable stifness and have made notable progress in acrospace,civil industry,and other *** particular,epoxy resin(EP)has great potential due to its excellent mechanical properties,fatigue resistance,and radiation ***,we focus on the molecular design and network construction of shape memory epoxy resins(SMEPs)to provide opportunities for performance and functional *** and high-performance SMEPs are introduced in detail,including multiple SMEPs,two-way SMEPs,outstanding toughness,and termperature ***,emerging applications of SMEP's and their composites in aerospace,four-dimensional printing,and self-healing are *** on this,we point out the challenges ahead and how SMEPs can integrate performance and versatility to meet the needs of technological development.

关键词： composites printing resins