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空肠间置术能快速改善非肥胖2型糖尿病大鼠的糖耐量并缓慢改善胰岛素抵抗

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Gastroenterology Report 2018年第4期6卷 291-297,I0002页

作者： Hengliang Zhu Huaiming Wang Zhihai Zheng bailiang ye Xiaojiao Ruan Xiaofeng Zheng Guoxin Li Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina Department of Gastrointestinal Surgery The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongChina Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina

背景:许多研究已证实,回肠间置术能改善2型糖尿病(T2DM),同时胰高血糖素样肽-1(GLP-1)水平上升。我们采用糖尿病大鼠模型进行研究,评估回肠间置术对糖代谢的影响及其机制。方法:20只GK大鼠被随机分为回肠间置组和假手术组。分别于术前... 详细信息

背景:许多研究已证实,回肠间置术能改善2型糖尿病(T2DM),同时胰高血糖素样肽-1(GLP-1)水平上升。我们采用糖尿病大鼠模型进行研究,评估回肠间置术对糖代谢的影响及其机制。方法:20只GK大鼠被随机分为回肠间置组和假手术组。分别于术前及术后1、4、8、16、24周检测大鼠体重、进食量、空腹血糖(FPG)、空腹胰岛素(F-ins)、口服葡萄糖耐量试验(OGTT)和GLP-1水平。计算稳态模型胰岛素抵抗指数(HOMA-IR)和OGTT曲线下面积(AUC)。术后24周处死大鼠,检测胰腺和回肠组织中GLP-1受体(GLP-1R)的表达水平。结果:与假手术组相比,回肠间置组大鼠术后4、8、16和24周血GLP-1水平更高(均P<0.05),术后8、16和24周FPG、F-ins和HOMAIR水平更低(均P<0.05)。与术前相比,回肠间置组术后各个时间点均可观察到血GLP-1、AUC和FPG水平的下降(均P<0.05);术后8、16和24周F-ins和HOMA-IR也显著下降(均P<0.05)。术后24周,无论是胰腺还是回肠组织,回肠间置组大鼠的GLP-1R表达水平均显著高于假手术组(均P<0.05)。结论:回肠间置可改善GK大鼠的糖代谢,且不会导致体重的下降和进食量的减少,这可能与GLP-1水平升高有关。而后期胰岛素抵抗的改善和胰岛素水平的下降可能并不直接受益于GLP-1水平的升高。

关键词： GK大鼠空肠间置术胰岛素抵抗进食量 FPG 糖尿病大鼠模型糖代谢糖耐量

Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer： a meta-analysis

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Chinese Medical Journal 2014年第3期127卷 538-546页

作者： Wang Ming Zheng Xiaofeng Ruan Xiaojiao ye bailiang Cai Long Lin Feizhuan Tu Jinfu Jiang Feizhao Li Shaotang Department of Laparoscopic Surgery First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China

Background What benefits and toxicities patients acquire from the use of bevacizumab combined with first-line chemotherapy remains controversial.This study was performed to evaluate the efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorectal cancer （mCRC）.Methods Several databases,including PubMed,Embase,and Cochrane Library,were searched up to April 30,2013.Eligible studies were only randomized,controlled trials （RCTs） with a direct comparison between mCRC patients treated with and without bevacizumab.Overall risk ratio （RR）,hazard ratio （HR）,odds ratio （OR）,and 95％ confidence intervals （CO were calculated employing fixed or random-effects models depending on the heterogeneity of the included trials.Results Six RCTs,including 1582 patients in chemotherapy plus bevacizumab group and 1484 patients in chemotherapyalone group,were included.Overall,the addition of bevacizumab to first-line chemotherapy increased overall response rate （ORR） by 4.5％,prolonged both progression-free survival （PFS） and overall survival （OS）,and increased the rate of total Grades 3 or 4 adverse events （G3/4AEs） by 6.9％.Significant differences were found in ORR （RR=1.22 （95％ CI 1.01-1.46）,P=0.03）,PFS （HR=0.60 （95％ Cl 0.47-0.77）,P ＜0.0001）,OS （HR=0.83 （95％ Cl 0.70-0.97）,P=0.02）,and any G3/4AEs （OR=1.56 （95％ Cl 1.29-1.89）,P ＜0.00001）.Conclusion Bevacizumab is a valuable addition to the current first-line chemotherapy regimens used in patients with mCRC,because of conferring a significant improvement in ORR,PFS,and OS,even though it increased adverse events.

关键词： antiangiogenesis bevacizumab metastatic colorectal cancer first-line chemotherapy meta-analysis

Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： Lina Tang Jianping ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy balance.The thermogenic function is under the influence of various tissues,including the brain,muscles,and liver.However,the breast t... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

A modified stochastic model for LS+AR hybrid method and its application in polar motion short-term prediction

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Geodesy and Geodynamics 2024年第1期15卷 100-105页

作者： Fei ye Yunbin Yuan State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430077China BeiDou High-precision Satellite Navigation and Location Service Hunan Engineering Research Center Hunan Institute of Geomatics Sciences and TechnologyChangsha 410007China Hunan Continuously Operating Reference Stations(HNCORS)Data Center Hunan Institute of Geomatics Sciences and TechnologyChangsha 410007China

Short-term(up to 30 days)predictions of Earth Rotation Parameters(ERPs)such as Polar Motion(PM:PMX and PMY)play an essential role in real-time applications related to high-precision reference frame conversion.Currently,least squares(LS)+auto-regressive(AR)hybrid method is one of the main techniques of PM prediction.Besides,the weighted LS+AR hybrid method performs well for PM short-term prediction.However,the corresponding covariance information of LS fitting residuals deserves further exploration in the AR model.In this study,we have derived a modified stochastic model for the LS+AR hybrid method,namely the weighted LS+weighted AR hybrid method.By using the PM data products of IERS EOP 14 C04,the numerical results indicate that for PM short-term forecasting,the proposed weighted LS+weighted AR hybrid method shows an advantage over both the LS+AR hybrid method and the weighted LS+AR hybrid method.Compared to the mean absolute errors(MAEs)of PMX/PMY sho rt-term prediction of the LS+AR hybrid method and the weighted LS+AR hybrid method,the weighted LS+weighted AR hybrid method shows average improvements of 6.61%/12.08%and 0.24%/11.65%,respectively.Besides,for the slopes of the linear regression lines fitted to the errors of each method,the growth of the prediction error of the proposed method is slower than that of the other two methods.

关键词： Stochastic model LS+AR Short-term prediction The earth rotation parameter(ERP) Observation model

Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body

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Acta Pharmaceutica Sinica B 2024年第1期14卷 433-435页

作者： Lin Wang Jianping ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft tissues1.Urate is an intermediate metabolite within the purine degradation pathway,predominantly derived from uric acid under physiological pH levels.Hyperuricemia occurs due to excessive uric acid production or insufficient excretion2,which is associated with various chronic diseases,including type 2 diabetes.

关键词： Uric acid Gout Microbiota Gut Uricase

Effects of microenvironment and biological behavior on the paracrine function of stem cells

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Genes & Diseases 2024年第1期11卷 135-147页

作者： Zhixin Xue Yunjun Liao ye Li The Department of Plastic and Cosmetic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal potential.MsC-based thera-pies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function.An increasing body of evidence demonstrates that paracrine func-tion is central to the effects of MsC-based therapy.Growth factors,cytokines,chemokines,extracellular matrix components,and extracellular vehicles all contribute to the beneficial ef-fects of MSCs on tissue regeneration and repair.The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior.In this review,we discuss the bioactive substances secreted by MsCs depending on the microenvironment and biological behavior and their regulatory mechanisms,which explain their potential to treat human diseases,to provide new ideas for further research and clinical cell-free therapy.

关键词： Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome

Building the toolbox for in vivo glia-to-neuron reprogramming

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Neural Regeneration Research 2024年第6期19卷 1171-1172页

作者： ye Xie Bo Chen Departments of Ophthalmology and Neuroscience Icahn School of Medicine at Mount Sinai

Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously, the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality. Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons,

关键词： CONVERSION DISEASE

Complicated target recognition by archaeal box C/D guide RNAs

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Science China(Life Sciences) 2024年第4期67卷 631-644页

作者： Jiayin Wang Songlin Wu Keqiong ye Key Laboratory of RNA Science and Engineering CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Box C/D RNAs guide the site-specific formation of 2′-O-methylated nucleotides(Nm)of RNAs in eukaryotes and archaea.Although C/D RNAs have been profiled in several archaea,their targets have not been experimentally determined.Here,we mapped Nm in r RNAs,t RNAs,and abundant small RNAs(s RNAs)and profiled C/D RNAs in the crenarchaeon Sulfolobus islandicus.The targets of C/D RNAs were assigned by analysis of base-pairing interactions,in vitro modification assays,and gene deletion experiments,revealing a complicated landscape of C/D RNA-target interactions.C/D RNAs widely use dual antisense elements to target adjacent sites in r RNAs,enhancing modification at weakly bound sites.Two consecutive sites can be guided with the same antisense element upstream of box D or D′,a phenomenon known as doublespecificity that is exclusive to internal box D′in eukaryotic C/D RNAs.Several C/D RNAs guide modification at a single non-canonical site.This study reveals the global landscape of RNA-guided 2′-O-methylation in an archaeon and unexpected targeting rules employed by C/D RNA.

关键词： C/D RNA 2′-O-methylation archaea guide RNA RNA modification

Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems

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Journal of Thermal Science 2024年第3期33卷 1055-1064页

作者： LI Jiawei ye Lin Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

In recent years,Enhanced Geothermal System(EGS)technologies have been applied to the geothermal resources production in the Hot Dry Rock(HDR).The core of EGS technologies is to adopt hydraulic fracturing in the reservoir to create a connected network of discrete fractures with the consideration of water as a working fluid for hydraulic fracturing and heat production.This paper investigates the characteristics of water flow behaviors through a single rough fracture under different temperature and pressure conditions.A single fracture model with rough fracture surfaces is constructed and then characterized,and influences of the anisotropic factor on the average tortuosity and frictional resistance coefficient of water flow through a single fracture with rough surfaces have been compared and analyzed.With consideration of other impacting factors(temperature,pressure,fracture roughness),the impact of mass flow rate has also been presented.Numerical simulation results present that changes of average tortuosity for water flow through a single rough facture are mainly affected by temperature.It can be observed that higher temperature leads to larger average tortuosity but the frictional resistance coefficient shows an opposite trend.As for pressure conditions,it is found that effects of pressure on average tortuosity and frictional resistance coefficient is very small,which can be neglected under high pressure conditions.Furthermore,the average tortuosity shows a progressively linear relationship with the mass flow rate.On the contrary,the frictional resistance coefficient has a negative relationship with the mass flow rate.It is revealed that when the mass flow rate reaches a critical point,the influences of temperature on the frictional resistance coefficient will be negligible.Comparisons of single rough fractures with different anisotropic factors show that values of average tortuosity and frictional resistance coefficient have positive relationships with the increase of anisotropic factors.

关键词： single rough fracture tortuosity frictional resistance enhanced geothermal system