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Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model

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World Journal of Gastroenterology 2007年第48期13卷 6538-6548页

作者： Tridib Chakraborty Dipak Bhuniya Mary chatterjee Mosiur Rahaman Dipak Singha baidya nath chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra Malay chatterjee Chemical Carcinogenesis and Chemoprevention Laboratory Division of Biochemistry Department of Pharmaceutical Technology Jadavpur University Division of Medicinal Chemistry Indian Institute of Chemical Biology Jadavpur East Calcutta Girls' College Lake Town Cell Signaling Laboratory Cardiovascular and Cancer Research Institute College of Medicine The Texas A&M University System HSC Temple TX 76504 United States

AIM： To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma （EAC）- bearing murine model.METHODS： Male Swiss albino mice were divided into four groups： Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal （ip） inoculations of rapidly proliferating 2 × 10^5 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract （ALE） of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation （ALE control）; and Group D was the EAC ＋ ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein （MT） protein, sister-chromatid exchanges （SCEs）, and DNA alterations.RESULTS： Treatment of the EAC-bearing mice with the ALE significantly （P 〈 0.001） reduced viable tumour cell count by 68.34% （228.7 × 10^6 ± 0.53） when compared to EAC control mice （72.4 × 10^6 ± 0.49）, and restored body and organ weights almost to the normal values. ALE administration also increased （P 〈 0.001） mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC ＋ ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count （P 〈 0.001）, hemoglobin percent （P 〈 0.001）, and haematocrit value （P 〈 0.001） from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC ＋ ALE-treated group, along with concurrent de

关键词： Acanthus ilicifolius Chemoprevention DNA strand-breaks Ehrlich ascites carcinoma Haematological indices Medicinal plants Metallothionein Sister- chromatid exchange Transplantable tumour

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The effect of vaccination to dendritic cell and immune cell interaction in HIV disease progression

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International Journal of Biomathematics 2016年第1期9卷 91-110页

作者： Priti Kumar Roy Amar nath chatterjee Xue-Zhi Li Center for Mathematical Biology and EcologyDepartment of Mathematics Jadavpur UniversiSy Kolkata 700032 India College of Mathematics and Information Science Xinyang Normal University Xinyang 464000 P. R. China

In this research paper, our main objective is to find out the meticulous role of activated dendritic cells （DCs） during the human immunodeficiency virus （HIV） infection process. DCs play a dual role by enhancing both HIV infection progression, as well as antiviral immune response. To explore the implications of these dual roles, we have formulated our mathematical model and analyzed the model by both analytical and numerical approaches. By using an impulsive differential equation, we have studied the effect of DC-based vaccination. Analytically we have determined the threshold value of drug dosage and dosing interval for optimum levels of injection. We have also investigated the effect of perfect adherence of drug dose on the immune cell count in extreme cases and observed that, systematic drug dose of the immune cells leads to its maximum level.

关键词： HIV dendritic cell DC-based immune therapy first-order elimination Michaelis-Menten elimination.

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Saturation Effects on Immunopathogenic Mechanism of Psoriasis:A theoretical approach

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应用泛函分析学报 2011年第3期13卷 310-318页

作者： Priti Kumar Roy Abhirup Datta Amar nath chatterjee Center for Mathematical Biology and Ecology Department of MathematicsJadavpur University

Psoriasis vulgaris is a common chronic autoimmune inflammatory skin disease characterized by T-cell mediated hyper proliferation of *** type of skin disorder is characterized by macroscopic and also microscopic skin *** was observed that,psoriatic lesions are sharply demarcated,red and slightly raised lesions along with silver whitish *** striking feature of T-cell mediated chronic psoriatic lesions are the epidermal infiltration of predominantly oligoclonal CD8^+T-cells and probably also of CD4^+T-cells in the *** this research article we proposed a mathematical model for the chronic disease,psoriasis,consisting a set of differential equations, involving T-Lymphocytes cells,Dendritic cells and the epidermal Keratinocytes,incorporating half saturation constant through the T lymphocyte cells and also in that sense,it has been infiltrated in the activation process of keratinocytes in the course of the plaque of *** biological research on psoriasis has been established the suppression of epidermal T-cell *** we are interested to know how the cell biological system changes for introducing the half saturation constant in presence of suppression taking place DCs on the model *** analytical and numerical result reveal that due to control effect,the macrophages population density does not impede for the interaction between T-cell and keratinocytes.T-cell and keratinocyte population ultimately become stable after a certain period of time span.

关键词： dendritic cells helper T-cells Keratinocytes DCs dermis epidermis drug efficacy

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Insight of Viral Infection of Jatropha Curcas Plant(Future Fuel):A control based mathematical study

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应用泛函分析学报 2011年第4期13卷 366-374,412页

作者： Sumit Nandi Subhas Khajanchi Amar nath chatterjee Priti Kumar Roy Department of Chemistry Narula Institute of TechnologyKolkata-700109 Center for Mathematical Biology and Ecology Department of MathematicsJadavpur UniversityKolkata-700032 India

Jatropha Curcas Linnaeous(Jatropha Curcas L)is a wonder plant with a variety of applications and enormous economic ***,an alternative fuel from non edible vegetable oil of Jatropha Curcas plant,has the requisite potential of providing a promising and commercially viable alternative to diesel oil since it has the desirable physicochemical and performance characteristics comparable to *** alternative fuel is eco-friendly,cost effective and has the huge potentiality for the future generations throughout the *** effective cultivation of this plant, protection from different viral diseases is *** this paper,we describe the eco-epidemiological model of the plant Jatropha Curcas L for understanding the disease dynamics which helps to control the viral infection of the Jatropha Curcas plant *** this approach,this plant can grow ideally for the renewable green fuel of the future world.

关键词： Jatropha Curcas cell biodiesel asymptotic stability optimal control remedial application

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Cyclic Sedimentation of the Barakar Formation, Singrauli Coalfield, India: Statistical Assessment from Borehole Logs

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Open Journal of Geology 2012年第1期2卷 1-13页

作者： Rabindra nath Hota Pallavi chatterjee Adhikari Anketika Mohanty Wataru Maejima 不详

The succession of lithofacies of a part of the Barakar Formation of the Singrauli coalfield has been studied by statistical techniques. The lithologies have been grouped under five facies states viz. coarse-, medium-, and fine-grained sandstones, shale and coal for statistical analyses. Markov chain analysis indicates the arrangement of Barakar lithofacies in the form of fining-upward cycles. A complete cycle consists of conglomerate or coarse-grained sandstone at the base sequentially succeeded by medium- and fine-grained sandstones, shales and coal seam at the top. The entropy analysis puts the Barakar cycles in A-4 type of cyclicity, which consists of different proportions of lower-, side- and upper-truncated cycles of lithologic states. Regression analysis indicates a sympathetic relationship between total thickness of strata (net subsidence) and number of coal cycles and an antipathic relationship between average thickness and number of coal cycles. The cyclic sedimentation of the Barakar Formation was controlled by autocyclic process, which occurred due to the lateral migration of streams triggered by intrabasinal differential subsidence. In many instances, the clastic sediments issued from the laterally migrating rivers interrupted the sedimentation resulting in thinner cycles in areas where the numbers of cycles are more. Principal component and multivariate regression analyses suggest that the net subsidence of the basin is mostly controlled by number and thickness of sandstone beds and coal seams.

关键词： Cyclic Sedimentation Markov Chain Analysis Entropy Analysis Regression Analysis Principal Component Analysis Barakar Formation Singrauli Coalfield

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Human immunodeficiency virus/acquired immune deficiency syndrome: Using drug from mathematical perceptive

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World Journal of Virology 2015年第4期4卷 356-364页

作者： Amar nath chatterjee Shubhankar Saha Priti Kumar Roy Centre for Mathematical Biology and Ecology Department of Mathematics Jadavpur University

Entry of acquired immune deficiency syndrome virus into the host immune cell involves the participation of various components of host and viral cell unit. These components may be categorized as attachment of the viral surface envelope protein subunit, gp120, to the CD4+ receptor and chemokine coreceptors, CCR5 and CXCR4, present on T cell surface. The viral fusion protein, gp41, the second cleaved subunit of Env undergoes reconfiguration and the membrane fusion reaction itself. Since the CD4+ T cell population is actively involved; the ultimate outcome of human immunodeficiency virus infection is total collapse of the host immune system. Mathematical modeling of the stages in viral membrane protein-host cell receptor-coreceptor interaction and the effect of antibody vaccine on the viral entry into the susceptible host cell has been carried out using as impulsive differential equations. We have studied the effect of antibody vaccination and determined analytically the threshold value of drug dosage and dosing interval for optimum levels of infection. We have also investigated the effect of perfect adherence of drug dose on the immune cell count in extreme cases and observed that systematic drug dosage of the immune cells leads to longer and improved lives.

关键词： Human immunodeficiency virus Acquired immune deficiency syndrome Antibody vaccine Perfect drug adherence Impulsive differential equation

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Cyclic Sedimentation of the Barakar Formation, Singrauli Coalfield, India: Statistical Assessment from Borehole Logs

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Open Journal of Geology（地质学期刊） 2012年第1期

作者： Rabindra nath Hota Pallavi chatterjee Adhikari Anketika Mohanty Wataru Maejima

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Multiple quantitative trait loci contribute to resistance to bacterial canker incited by Pseudomonas syringae *** in kiwifruit(Actinidia chinensis)

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Horticulture Research 2019年第1期6卷 471-488页

作者： Jibran Tahir Stephen Hoyte Heather Bassett Cyril Brendolise Abhishek chatterjee Kerry Templeton Cecilia Deng Ross Crowhurst Mirco Montefiori Ed Morgan Andrew Wotton Keith Funnell Claudia Wiedow Mareike Knaebel Duncan Hedderley Joel Vanneste John McCallum Kirsten Hoeata Amardeep nath David Chagné Luis Gea Susan E.Gardiner The New Zealand Institute for Plant and Food Research Limited Private Bag 11030Manawatu Mail CentrePalmerston North 4442New Zealand The New Zealand Institute for Plant Food Research Limited HamiltonNew Zealand The New Zealand Institute for Plant and Food Research Limited Private Bag 92–169Auckland 1025New Zealand New Plant via Malpighi 5Forlì47122Italy The New Zealand Institute for Plant and Food Research Limited LincolnNew Zealand The New Zealand Institute for Plant and Food Research Limited 412 No 1 RoadRD2Te Puke 3182New Zealand

Pseudomonas syringae ***(Psa)biovar 3,a virulent,canker-inducing pathogen is an economic threat to the kiwifruit(Actinidia spp.)industry *** commercially grown diploid(2×)*** *** is more susceptible to Psa than tetraploid and hexaploid *** information on the genetic loci modulating Psa resistance in kiwifruit is not *** we report mapping of quantitative trait loci(QTLs)regulating resistance to Psa in a diploid kiwifruit population,derived from a cross between an elite Psa-susceptible‘Hort16A’and a resistant male breeding parent *** high-density genetic maps and intensive phenotyping,we identified a single QTL for Psa resistance on Linkage Group(LG)27 of‘Hort16A’revealing 16–19%phenotypic variance and candidate alleles for susceptibility and resistance at this *** addition,six minor QTLs were identified in P1 on distinct LGs,exerting 4–9%*** in the F1 population is improved by additive effects from‘Hort16A’and P1 QTLs providing evidence that divergent genetic pathways interact to combat the virulent Psa *** different bioassays further identified new QTLs for tissue-specific responses to *** genetic marker at LG27 QTL was further verified for association with Psa resistance in diploid Actinidia chinensis *** analysis of Psa-resistant and susceptible genotypes in field revealed hallmarks of basal defense and provided candidate RNA-biomarkers for screening for Psa resistance in greenhouse conditions.

关键词： breeding trait

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