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Human Digital Twin(HDT)Driven Human-Cyber-Physical Systems:Key Technologies and Applications

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Chinese Journal of Mechanical Engineering 2022年第1期35卷 1-6页

作者： baicun Wang Huiying Zhou Geng Yang Xingyu li Huayong Yang State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA

1 Introduction Traditional industrial systems,where physical systems,i.e.,robots and machines,replaced manual labor mostly,are often known as human-physical system(HPS)[1].Cyber system,a major outcome of the digitalization revolution,is increasingly adopted in HPS and continuously evolving with the development of advanced manufacturing technologies,leading to the human-cyber-physical system(HCPS)[2].

关键词： system mostly Key

Greentelligence:Smart Manufacturing for a Greener Future

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 159-164页

作者： Xingyu li baicun Wang Tao Peng Xun Xu Department of Mechanical Engineering University of MichiganAnn ArborMI48109USA State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310027China Department of Mechanical Engineering The University of AucklandAucklandNew Zealand1010

1 Introduction Global climate change has grown into one of the major concerns in global industrialization and economic development.Carbon dioxide(CO_(2)),one of the six Kyoto Protocol greenhouse gases(GHGs),is the most difficult to contain due to its closeness with energy generation and consumption^([1]).With an earlier awareness of climate change,developed countries tended to displace the resource-and energy-intensive industries to other countries,thus emissions have not been reduced but relocated^([2]),which can be further magnified if production shifts to countries using carbon-intensive energy or low-energyefficient technologies.Developing countries are responsible for 63%of GHGs emissions and get hit the hardest,i.e.,78%of the cost of climate change,and predicted to rise to 87%by 2035^([3]).

关键词： Smart gases emissions

Intelligent Manufacturing Systems in COVID‑19 Pandemic and Beyond:Framework and Impact Assessment

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Chinese Journal of Mechanical Engineering 2020年第4期33卷 1-5页

作者： Xingyu li baicun Wang Chao liu Theodor Freiheit Bogdan I.Epureanu Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA School of Engineering Cardiff UniversityCardiff CF243AAUK

Pandemics like COVID-19 have created a spreading and ever-higher healthy threat to the humans in the manufacturing system which incurs severe disruptions and complex issues to industrial networks.The intelligent manufacturing(IM)systems are promising to create a safe working environment by using the automated manufacturing assets which are monitored by the networked sensors and controlled by the intelligent decision-making algorithms.The relief of the production disruption by IM technologies facilitates the reconnection of the good and service flows in the network,which mitigates the severity of industrial chain disruption.In this study,we create a novel intelligent manufacturing framework for the production recovery under the pandemic and build an assessment model to evaluate the impacts of the IM technologies on industrial networks.Considering the constraints of the IM resources,we formulate an optimization model to schedule the allocation of IM resources according to the mutual market demands and the severity of the pandemic.

关键词： Intelligent manufacturing system COVID-19 pandemic Industrial network Supply chain disruption Optimization

Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1213-1224页

作者： Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona li Yuan liu Yitian Zhou Peiran Yang Tianhui Fan Ying liu Zhaoguo li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang State Key Laboratory of Medical Molecular Biology Department of PhysiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Tsinghua-Peking Center for life Sciences Department of BiologyCollege of MedicineTsinghua UniversityBeijing 100084China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China Peking Union Medical College MD ProgramBeijing 100730China Department of Respiratory the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Pulmonary and Critical Care Medicine the First Hospital of Shanxi Medical UniversityTaiyuan 030001China

Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis.

关键词： Silicosis Gasdermin D Pyroptosis Macrophage Pulmonary fibrosis

Toward New-Generation Intelligent Manufacturing

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Engineering 2018年第1期4卷 11-20页

作者： Zhou Ji li Peigen Zhou Yanhong Wang baicun Zang Jiyuan Meng liu Chinese Academy of Engineering Beijing 100088 China Huazhong University of Science and Technology Wuhan 430074 China Tsinghua University Beijing 100084 China

Intelligent manufacturing is a general concept that is under continuous development. It can be categorized into three basic paradigms: digital manufacturing, digital-networked manufacturing, and newgeneration intelligent manufacturing. New-generation intelligent manufacturing represents an indepth integration of new-generation artificial intelligence (AI) technology and advanced manufacturing technology. It runs through every link in the full life-cycle of design, production, product, and service. The concept also relates to the optimization and integration of corresponding systems; the continuous improvement of enterprises’ product quality, performance, and service levels; and reduction in resources consumption. New-generation intelligent manufacturing acts as the core driving force of the new industrial revolution and will continue to be the main pathway for the transformation and upgrading of the manufacturing industry in the decades to come. Human-cyber-physical systems (HCPSs) reveal the technological mechanisms of new-generation intelligent manufacturing and can effectively guide related theoretical research and engineering practice. Given the sequential development, cross interaction, and iterative upgrading characteristics of the three basic paradigms of intelligent manufacturing, a technology roadmap for ‘‘parallel promotion and integrated development” should be developed in order to drive forward the intelligent transformation of the manufacturing industry in China.

关键词： Advanced manufacturing New-generation intelligent manufacturing Human-cyber-physical systemNew-generation AIBasic paradigms Parallel promotionIntegrated development

Collagen fiber membrane-derived chemically and mechanically durable superhydrophobic membrane for high- performance emulsion separation

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Journal of Leather Science and Engineering 2021年第1期3卷 214-223页

作者： Huifang li Wan Zheng Hanzhong Xiao baicun Hao Yujia Wang Xin Huang Bi Shi National Engineering Research Center of Clean Technology in Leather Industry Sichuan University610065 ChengduP.R.China

Developing high-performance separation membrane with good durability is a highly desired while challenging issue.Herein,we reported the successful fabrication of chemically and mechanically durable superhydrophobic membrane that was prepared by embedding UiO-66 as size-sieving sites within the supramolecular fiber structure of collagen fiber membrane(CFM),followed by the polydimethylsiloxane(PDMS)coating.The as-prepared CFM/UiO-66(12)/PDMS membrane featured capillary effect-enhanced separation flux and homogeneous porous channels guaranteed high separation efficiency.When utilized as double-layer separation membranes,this new type of composite membranes separated various surfactant stabilized water-in-oil microemulsions and nanoemulsions,with the separation efficiency high up to 99.993%and the flux as high as 973.3 L m−2 h−1.Compared with commercial polytetrafluoro ethylene(PTFE)membrane,the advantage of the double-layer CFM/UiO-66(12)/PDMS membranes in separation flux was evident,which exhibited one order of magnitude higher than that of commercial PTFE membrane.The CFM/UiO-66(12)/PDMS membrane was acid-alkali tolerant,UV-aging resistant and reusable for emulsion separation.Notably,the CFM/UiO-66(12)/PDMS membrane was mechanically durable against strong mechanical abrasion,which was still capable of separating diverse water-in-oil emulsions after the abrasion with sandpaper and assembled as double-layer separation membranes.We anticipate that the combination of CFM and metal organic frameworks(MOFs)is an effective strategy for fabricating high-performance separation membrane with high mechanical and chemical durability.

关键词： collagen fiber membrane metal organic frameworks superhydrophobic composite membrane emulsion separation mechanical and chemical durability

针灸足三里对佐剂性关节炎模型大鼠胃肠动力的调节作用

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中国组织工程研究 2022年第26期26卷 4141-4146页

作者：李佳李柏村蔡国伟李静湖北中医药大学针灸骨伤学院/针灸治未病湖北省协同创新中心湖北省武汉市430061 华中科技大学同济医学院附属协和医院针灸科湖北省武汉市430022

背景:类风湿关节炎患者存在胃肠动力不足的问题逐渐受到关注,针灸作为类风湿关节炎的一种治疗方法,是否能够改善其胃肠动力不足的问题,值得进一步探究。目的:制备佐剂性关节炎大鼠模型,探讨针灸足三里对大鼠胃肠动力的影响。方法:将60... 详细信息

背景:类风湿关节炎患者存在胃肠动力不足的问题逐渐受到关注,针灸作为类风湿关节炎的一种治疗方法,是否能够改善其胃肠动力不足的问题,值得进一步探究。目的:制备佐剂性关节炎大鼠模型,探讨针灸足三里对大鼠胃肠动力的影响。方法:将60只清洁级健康3月龄雌性SD大鼠随机分为5组,即正常组、模型组、针刺组、艾灸组和针+灸组,每组12只,除正常组外其余4组均采用弗氏完全佐剂建立佐剂性关节炎模型。针刺组、艾灸组和针+灸组于造模第1天取足三里穴治疗,15 min/次,1次/d,一共14 d。针刺组大鼠采用针刺干预,艾灸组大鼠则用艾灸干预,而针+灸组大鼠在使用针刺的基础上联合使用艾灸方法。所有大鼠于相应处理结束后,采用跖围法测大鼠跖围长度,采用苏木精-伊红染色观察其膝关节的病理形态变化,运用结肠蠕动波测定方法检测大鼠肠蠕动波次数,应用活性炭悬液灌胃法观察首粒黑便排出时间,计算大鼠的胃排空率和肠推进率,以离体灌流装置检测大鼠空肠平滑肌肌条收缩水平,应用免疫荧光染色法观察空肠神经纤维。结果与结论:①针灸足三里治疗后,大鼠跖关节肿胀程度明显降低,软骨破坏和炎性细胞明显减少,肠蠕动波次数增加,全胃肠活性炭排出时间缩短,胃排空率和肠推进率得到提升,空肠平滑肌肌条收缩基础张力增强,空肠神经纤维减少;②3组针灸方法中针+灸干预最为明显;③提示针灸足三里对佐剂性关节炎大鼠肠动力障碍具有防治作用,并且针刺联合艾灸疗效优于单纯针刺或艾灸治疗。

关键词：针灸足三里针刺艾灸佐剂性关节炎类风湿关节炎肠动力

美国联邦政府资助和管理阿尔茨海默病研究项目的实践与启示

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中国科学院院刊 2023年第2期38卷 219-229页

作者：韩志凌李柏村肖小溪李晓轩中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049 福州大学经济与管理学院福州350108

如何资助和管理面向科学前沿或国家需求的重大科研项目(包括选题、资助、绩效评价等方面),是我国当前面临的一个紧迫问题。文章以美国联邦政府组织开展阿尔茨海默病的研究为对象,经案例研究发现,美国形成了一套有效的重大科研项目资助... 详细信息

如何资助和管理面向科学前沿或国家需求的重大科研项目(包括选题、资助、绩效评价等方面),是我国当前面临的一个紧迫问题。文章以美国联邦政府组织开展阿尔茨海默病的研究为对象,经案例研究发现,美国形成了一套有效的重大科研项目资助与管理机制,主要包括组织动员、目标管理、绩效评估、预算听证4个方面,以此实现对重大科研项目的绩效管理,保证财政科技投入效能。文章探讨了美国在重大科研项目资助和管理上的实践与经验,并提出对我国的启示。

关键词：财政科技投入阿尔茨海默病绩效管理

美国联邦政府多元化科研资助体系的特点和启示——基于NIH资助与产出数据的分析

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科学学与科学技术管理 2023年第12期44卷 3-16页

作者：李美娟李柏村姜靖阿儒涵福州大学经济与管理学院福州350108 中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049 科技日报社北京100038

科学、合理、有效、多元化的政府科研资助体系,是国家科技水平提升的重要动力和源泉。美国联邦政府自二战以来,逐步形成了以稳定拨款、竞争性项目补助和合作协议作为主要资助模式的科研资助体系。这三类资助模式在设立时出于不同的目的... 详细信息

科学、合理、有效、多元化的政府科研资助体系,是国家科技水平提升的重要动力和源泉。美国联邦政府自二战以来,逐步形成了以稳定拨款、竞争性项目补助和合作协议作为主要资助模式的科研资助体系。这三类资助模式在设立时出于不同的目的,其特点各有侧重,互为补充,有效地推动了美国科技水平的快速发展,对我国政府的科研资助实践具有重要的借鉴意义。美国国立卫生研究院(National Institutes of Health,NIH)作为美国联邦政府中专注于探索生命本质和行为学领域的基础知识的专业化机构,在美国联邦政府基础研究投入中占有重要的地位,具有资助总量大、资助模式类型齐全等特点。基于此,文章以NIH的资助、产出数据为样本,通过选题机制、经费配置机制和产出表现多维度的数据分析,得到关于美国联邦政府多元化科研资助体系在实践过程中所体现的具体特点,回答美国联邦政府以多元化资助体系实现自身使命定位的机制问题。基于分析结果,得到以下几点结论:(1)不同资助模式所形成的多元化选题机制,有利于从更多角度发掘有价值的研究问题。(2)差异化的经费配置机制有利于根据项目特点和需求灵活部署经费,提升资金使用效益。(3)项目的产出表现受到资助模式的影响,契合于资助模式的机制特点。进而,提出了相关的启示与建议:(1)实现机构使命定位、提升资金效益是遴选资助模式的出发点和落脚点。(2)政府资助机构角色多元化,与科学共同体形成良好互动。(3)基于资助模式的特点,确定合理的选题机制及支持强度。

关键词：美国联邦政府政府科研资助资助与产出数据分析