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Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory

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Neural Regeneration Research 2024年第5期19卷 1133-1141页

作者： baicheng zhao Hang Zhang Ying Liu Gaoyu Zu Yuxiao Zhang Jiayi Hu Shuai Liu Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghaiChina Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) Affiliated Mental Health Center(ECNU)School of Psychology and Cognitive ScienceEast China Normal UniversityShanghaiChina Shanghai Changning Mental Health Center ShanghaiChina NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai ShanghaiChina Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai ShanghaiChina

Bromodomain and plant homeodomain(PHD)finger containing protein 1(Brpf1)is an activator and scaffold protein of a multiunit complex that includes other components involving lysine acetyltransferase(KAT)6A/6B/***1,KAT6A,and KAT6B mutations were identified as the causal genes of neurodevelopmental disorders leading to intellectual *** previous work revealed strong and specific expression of Brpf1 in both the postnatal and adult forebrain,especially the hippocampus,which has essential roles in learning and ***,we hypothesized that Brpf1 plays critical roles in the function of forebrain excitatory neurons,and that its deficiency leads to learning and memory *** test this,we knocked out Brpf1 in forebrain excitatory neurons using *** found that Brpf1 deficiency reduced the frequency of miniature excitatory postsynaptic currents and downregulated the expression of genes Pcdhgb1,Slc16a7,Robo3,and Rho,which are related to neural development,synapse function,and memory,thereby damaging spatial and fear memory in *** findings help explain the mechanisms of intellectual impairment in patients with BRPF1 mutation.

关键词： behavioral test Brpf1 CAMKIIa-Cre intellectual disability miniature excitatory postsynaptic current mRNA-Seq

STUDY ON MACRO AND MICRO MODELING ON SOLIDIFICATION PROCESS OF SHAPED CASTING

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Chinese Journal of Mechanical Engineering 2002年第3期15卷 252-256页

作者： Liu baicheng Kang Jinwu zhao Haidong Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China Department of Mechanical Engineering Tsinghua University 北京 100084

Facing the market economy and global challenge the development ofmanufacturing industry especially casting industry is critical to the national economy. To reformthe traditional casting industry by using computer technology is one of the hottest researchfrontiers studied by many researchers and engineers. Computer simulation of solidification processof shaped casting can assure the quality of casting, optimize the casting technology, shorten thelead time and therefore decrease the developing and manufacturing cost. Recently, numericalsimulation of mold-filling and solidification processes of shaped casting and prediction ofmicrostructure and property as well are extensively studied and put into application in many castingplants with many successful simulation cases.

关键词： Shaped casting Solidification Mold filling Stress analysis Modelingand simulation

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白城市地下水质量现状与发展趋势

吉林地质 1994年第3期13卷 76-83,54页

作者：隋永顺赵永锋白城市节约用水办公室白城市地质环境监测站

通过白城市地下水环境地质调查和多年地下水动态监测工作，对白城市１９９３年地下水污染，地下水质量作出评价。并对多年资料作趋势分析。结果表明：白城市地下水受到不同程度污染、地下水质量濒临恶化，化学组分中Ｃｌ￣－、ＳＯ、Ｎ... 详细信息

通过白城市地下水环境地质调查和多年地下水动态监测工作，对白城市１９９３年地下水污染，地下水质量作出评价。并对多年资料作趋势分析。结果表明：白城市地下水受到不同程度污染、地下水质量濒临恶化，化学组分中Ｃｌ￣－、ＳＯ、ＮＯ、总硬度、矿化度呈上升趋势。针对上述问题，提出防治措施。

关键词：地下水污染地下水质量发展趋势

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高频超声在烧伤创面深度诊断中的应用

中华超声影像学杂志 2000年第8期9卷 478-481页

作者：赵柏程周启昌钱利徐俊章鸣周宇鲁青湖南医科大学第二附属医院烧伤整形外科长沙410011 湖南医科大学第二附属医院超声诊断科长沙410011

目的　探讨应用高频超声检测烧伤部位真皮肿胀度和真度皮下界面是否失去连续性与烧伤创面深度的关系。方法　以病理组织学检查作为烧伤创面深度的诊断标准 ,应用 13MHz高频超声检测 41例烧伤患者 62个烧伤部位的真皮肿胀度和真皮皮... 详细信息

目的　探讨应用高频超声检测烧伤部位真皮肿胀度和真度皮下界面是否失去连续性与烧伤创面深度的关系。方法　以病理组织学检查作为烧伤创面深度的诊断标准 ,应用 13MHz高频超声检测 41例烧伤患者 62个烧伤部位的真皮肿胀度和真皮皮下界面是否失去连续性。结果　烧伤后 6h内 ,2 7个部位浅Ⅱ度烧伤创面真皮肿胀度为 ( 3 2 .75± 13 .2 3 ) % ,2 0个部位深Ⅱ度烧伤创面真皮肿胀度为 ( 76.0 9± 15 .88) % ,Ⅱ度烧伤创面真皮皮下界面完整 ,15个部位Ⅲ度创面真皮肿胀度为 ( 15 0 .46± 2 4.0 6) % ,且部分Ⅲ度创面 ( 13 /15 )真皮皮下界面被破坏。经统计学处理 ,三组间真皮肿胀度差异有显著性 (P <0 .0 1)。结论　随着烧伤深度增加 ,真皮肿胀度亦增加 ,部分Ⅲ度创面真皮皮下界面被破坏。高频超声作为一种无创、准确、客观的方法 ,可望在烧伤创面深度的诊断中得到广泛应用。

关键词：超声检查烧伤诊断

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烧伤合并急性肾功能衰竭的临床研究

中国医药导报 2011年第31期8卷 42-44页

作者：贺斌赵柏程钱利戴永恒谢利平胡佳湖南省宁乡县人民医院湖南宁乡410600 中南大学湘雅二医院湖南长沙410011

目的：探讨烧伤合并急性肾功能衰竭（ARF）的早期指标检测以及各种危险因素和疗效。方法：选择2008年1月～2009年6月所收治的中重度热烧伤患者75例，Ⅱ度或Ⅲ度烧伤面积累计达20％～70％TBSA。所有患者在入院时、入院后3d、7d、14d和21... 详细信息

目的：探讨烧伤合并急性肾功能衰竭（ARF）的早期指标检测以及各种危险因素和疗效。方法：选择2008年1月～2009年6月所收治的中重度热烧伤患者75例，Ⅱ度或Ⅲ度烧伤面积累计达20％～70％TBSA。所有患者在入院时、入院后3d、7d、14d和21d检测血清肌酐（Scr）、血尿素氮（BUN）、肌酐清除率（Ccr）、24h尿量、尿蛋白、尿微量白蛋白（mALB）。结果：75例烧伤患者中有14例（18．7％）并发ARF。烧伤合并ARF组平均Scr、Ccr和尿蛋白水平在住院7d后明显高于烧伤未合并ARF组（P均〈0．05），平均BUN水平在住院14d后明显高于烧伤未合并ARF组（P〈0．05），平均尿量在住院21d后明显高于烧伤未合并ARF组（P〈0．05）。烧伤合并ARF组在入院时mALB水平已达正常值3-4倍，在观察期均高于烧伤未合并ARF组（P均〈0．05）。烧伤面积与脓毒症是烧伤并发ARF的主要危险因素（负相关系数r分别为0．52和0．23，P均〈0．05）。14例ARF患者中有10例患者行血液净化治疗，其他4例患者给予相应治疗。12例患者痊愈，2例患者（14.3％）分别死于严重脓毒症和多器官功能衰竭。结论：本组资料显示．mALB是早期监测ARF的敏感指标，烧伤合并ARF与烧伤面积与脓毒症相关，连续性静脉－静脉血液滤过（CVVH）治疗烧伤合并ARF疗效较好．

关键词：烧伤肾功能衰竭尿微量白蛋白危险因素

光伏材料转运车承载平台模块化设计及有限元分析

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时代汽车 2024年第1期 120-122页

作者：陈进辉赵柏程冯文明温炜鹏罗彪陆军装备部驻衡阳地区军代室湖南省衡阳市421001 衡阳泰豪通信车辆有限公司湖南省衡阳市421001 南华大学机械工程学院湖南省衡阳市421001

为了解决光伏电站施工现场的材料转运问题,本文设计了一种新的多功能光伏材料转运承载平台。该平台采用模块化设计,通过不同模块的快速切换实现不同光伏材料的高效转运;同时为了保证光伏板等易碎件的安全运输,在相应模块中增加了减震和... 详细信息

为了解决光伏电站施工现场的材料转运问题,本文设计了一种新的多功能光伏材料转运承载平台。该平台采用模块化设计,通过不同模块的快速切换实现不同光伏材料的高效转运;同时为了保证光伏板等易碎件的安全运输,在相应模块中增加了减震和防倾覆等功能;最后利用有限元方法对平台的强度进行了校核。

关键词：模块化设计平稳性安全性有限元分析

Aerophilic Triphase Interface Tuned by Carbon Dots Driving Durable and Flexible Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2023年第2期15卷 238-258页

作者： Kuixing Ding Yu Ye Jiugang Hu Liming zhao Wei Jin Jia Luo Shan Cai baicheng Weng Guoqiang Zou Hongshuai Hou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China College of Standardization China Jiliang UniversityHangzhou 310018People’s Republic of China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009People’s Republic of China

Efficient bifunctional catalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)are vital for rechargeable Zn-air batteries(ZABs).Herein,an oxygen-respirable sponge-like Co@C–O–Cs catalyst with oxygen-rich active sites was designed and constructed for both ORR and OER by a facile carbon dot-assisted *** aerophilic triphase interface of Co@C–O–Cs cathode efficiently boosts oxygen diffusion and *** theoretical calculations and experimental studies revealed that the Co–C–COC active sites can redistribute the local charge density and lower the reaction energy *** Co@C–O–Cs catalyst displays superior bifunctional catalytic activities with a half-wave potential of 0.82 V for ORR and an ultralow overpotential of 294 mV at 10 mA cm^(−2) for ***,it can drive the liquid ZABs with high peak power density(106.4 mW cm^(−2)),specific capacity(720.7 mAh g^(−1)),outstanding long-term cycle stability(over 750 cycles at 10 mA cm^(−2)),and exhibits excellent feasibility in flexible all-solid-state *** findings provide new insights into the rational design of efficient bifunctional oxygen catalysts in rechargeable metal-air batteries.

关键词： Aerophilic triphase interface Oxygen-rich active sites O2 diffusion Bifunctional oxygen catalyst Flexible rechargeable Zn-air battery

Generation of transgenic cucumbers with expression of a ten-tandem repeat long-acting GLP-1 analogue and their biological function on diabetic rats

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Chinese Science Bulletin 2009年第24期54卷 4658-4663页

作者： zhao Lei LIAO Fang WANG CuiYan CHEN Miao WEI AiMin DU ShengLi MA baicheng HU XiaoYu WU ZhiQiang WANG RuiJu LI MingGang Key Laboratory for Bioactive Materials of the Ministry of Education Institute of Molecular Biology College of Life Science Nankai University Tianjin 300071 China Chemical Engineering College of Inner Mongolia University of Technology Hohhot 010000 China Tianjin Kernel Cucumber Research Institute Tianjin 300071 China

Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone, which has the regulatory function of stimulating the secretion of insulin to balance blood glucose levels. In this study, marker-free expression vector pX6 with a fusion gene of ten tandem repeated GLP-1 analog ([Ser8, Gln26 and Asp34]-GLP-1) genes was constructed and transformed into cucumbers by Agrobacterium tumefaciens-mediated transformation method. Four transgenic lines were obtained by PCR and Southern blotting analysis and two transgenic lines successfully expressed the fusion protein (named GLP-T), which was revealed by Western blotting analysis. The biological activity test results showed that the serum glucose level of diabetic rats was significantly decreased after oral administration of the fusion protein GLP-T extracted from the transgenic cucumber fruitage. These results suggest that this may provide a brand-new strategy to prevent and cure the diabetes with no pain.

关键词：转基因表达糖尿病大鼠生物学功能串联重复 GLP 黄瓜模拟年表

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铝合金三维枝晶生长相场模拟

金属学报 2005年第5期41卷 491-495页

作者：赵红兆荆涛柳百成清华大学机械工程系北京100084

以相场模型为基础,耦合热噪声,对三维铝合金枝晶生长进行模拟计算.考虑到三维模拟计算量大,赋值计算单元界面标志,在界面处引入噪声,而不是全局引入噪声,加快了计算速度.在多相场模型中选用了不同的生长最优方向,与实际情况更加符合.计... 详细信息

以相场模型为基础,耦合热噪声,对三维铝合金枝晶生长进行模拟计算.考虑到三维模拟计算量大,赋值计算单元界面标志,在界面处引入噪声,而不是全局引入噪声,加快了计算速度.在多相场模型中选用了不同的生长最优方向,与实际情况更加符合.计算结果表明,加入热噪声是二次枝晶臂产生的原因之一,加入热噪声不影响尖端的稳态行为.

关键词：铝合金枝晶生长相场模型