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Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population

Virologica Sinica 2021年第5期36卷 1241-1244页

作者： Raimonds Rescenko Raitis Peculis Monta Briviba Laura Ansone Anna Terentjeva Helena Daiga Litvina Liga Birzniece Kaspars Megnis Oksana Kolesova baiba Rozentale Ludmila Viksna Vita Rovite Janis Klovins Latvian Biomedical Research and Study Centre Riga 1067Latvia Riga Stradins University Riga 1007Latvia

Dear Editor,Clinical outcomes of SARS-CoV-2 infection are highly heterogeneous,ranging from symptoms-free infection to death of the patient(Park et al.2020).Although the outcome can be explained to some extent by age and comorbidities,genetic factors have also been linked to the prognosis of SARS-CoV-2 infection(Hu et al.2021;Liu et al.2020;Maya et al.2020;Pairo-Castineira et al.2021。

关键词： Replication Maya COV

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拉脱维亚农村地区的经济、社会和环境条件

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人类环境杂志 1997年第7期26卷 431-433页

作者： baiba Rivza 郑亚新拉脱维亚农业大学经济系

本文分析了自1990年至今拉脱维亚转型时期的经济系统。影响农村地区形势和影响就业因素的特征是:农业生产的下降;失业;失去东方的市场;以及人民物质福利水准的下降。对农业的环境影响进行分析,需要包括:使用农药和无机肥料地区的动态;... 详细信息

本文分析了自1990年至今拉脱维亚转型时期的经济系统。影响农村地区形势和影响就业因素的特征是:农业生产的下降;失业;失去东方的市场;以及人民物质福利水准的下降。对农业的环境影响进行分析,需要包括:使用农药和无机肥料地区的动态;拉脱维亚各流域的富营养化进程;土质;自流水的污染。本文还提出拉脱维亚向可持续农业迈进的初步措施。

关键词：拉脱维亚农村地区农业经济社会环境

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单倍型测序确认HLA新等位基因A~* 9217

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中国卫生工程学 2007年第3期6卷 154-156页

作者：张伯伟杜广有赵磊 baiba Poorer Debra Kukuruga 河南省红十字血液中心河南郑州450012 美国国家骨髓库马里兰大学HLA实验室

目的用单倍型测续方法判定骨髓库HLA分型检测中出现的模棱两可结果,以发现新的HLA基因序列。方法用DNA测序的方法确认HLA分型结果,用单倍型测序的方法分析常规测序方法无法确认的杂合子的新基因序列。结果9个常规SSO流式荧光微珠HLA分... 详细信息

目的用单倍型测续方法判定骨髓库HLA分型检测中出现的模棱两可结果,以发现新的HLA基因序列。方法用DNA测序的方法确认HLA分型结果,用单倍型测序的方法分析常规测序方法无法确认的杂合子的新基因序列。结果9个常规SSO流式荧光微珠HLA分型方法无法确认的结果中,有8个可以用常规测序方法得到确切分型结果(该8个结果均为近期报告的新的HLA等位基因),1个标本被确认为新的基因序列A*9217,已经在GENBANK注册(注册号:EF526712),并向HLA因子命名委员会进行新基因申报(申报号:WHS10004629),得到WHO HLA因子命名委员会的正式命名。结论DNA测序的方法是解决HLA分型的最直接方法;在遇到杂合子等位基因时,采用单倍型测续的方法简单有效。

关键词： DNA测序 HLA分型单倍型

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Association between inherited monogenic liver disorders and chronic hepatitis C

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World Journal of Hepatology 2014年第2期6卷 92-97页

作者： Linda Piekuse Madara Kreile Agnese Zarina Zane Steinberga Valentina Sondore Jazeps Keiss baiba Lace Astrida Krumina Scientific Laboratory of Molecular Genetics Riga Stradins University Latvian Centre of Infectious Diseases Riga East University Hospital Latvian Biomedical Research and Study Centre

AIM:To determine the frequencies of mutations that cause inherited monogenic liver disorders in patients with chronic hepatitis C. METHODS:This study included 86 patients with chronic hepatitis C(55 men, 31 women; mean age at diagnosis, 38.36 ± 14.52 years) who had undergone antiviral therapy comprising pegylated interferon and ribavirin. Viral load, biochemical parameter changes, and liver biopsy morphological data were evaluated in all patients. The control group comprised 271 unrelated individuals representing the general population of Latvia for mutation frequency calculations. The most frequent mutations that cause inherited liver disorders [gene(mutation): ATP7B(H1069Q), HFE(C282Y, H63D),UGT1A1(TA)7, and SERPINA1(PiZ)] were detected by polymerase chain reaction(PCR), bidirectional PCR allele-specific amplification, restriction fragment length polymorphism analysis, and sequencing. RESULTS: The viral genotype was detected in 80 of the 86 patients. Viral genotypes 1, 2, and 3 were present in 61(76%), 7(9%), and 12(15%) patients, respectively. Among all 86 patients, 50(58%) reached an early viral response and 70(81%) reached a sustained viral response. All 16 patients who did not reach a sustained viral response had viral genotype 1. Casecontrol analysis revealed a statistically significant difference in only the H1069Q mutation between patients and controls(patients, 0.057; controls, 0.012; odds ratio, 5.514; 95%CI: 1.119-29.827, P = 0.022). However, the H1069Q mutation was not associated with antiviral treatment outcomes or biochemical indices. The(TA) 7 mutation of the UGT1A1 gene was associated with decreased ferritin levels(beta regression coefficient =-295.7, P = 0.0087). CONCLUSION: Genetic mutations that cause inherited liver diseases in patients with hepatitis C should be studied in detail.

关键词： Hepatitis C Hepatolenticular degeneration(Wilson’s disease) ATP7B SERPINA1 UGT1A1 HFE

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Missed Opportunities for Prevention of Mother-to-Child Transmission of HIV (PMTCT) in Ibadan, Southwest Nigeria

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World Journal of AIDS 2014年第3期4卷 356-364页

作者： Babatunde O. Ogunbosi Regina E. Oladokun Olutosin Awolude Biobele J. Brown Olubukola A. Adeshina Modupe Kuti Babafemi Taiwo baiba berzin. Demetrious N. Kyriacou Ellen G. Chadwick Kikelomo Osinusi Isaac F. Adewole Robert L. Murphy Department of Paediatrics College of Medicine University of Ibadan Ibadan Nigeria Department of Paediatrics University College Hospital Ibadan Nigeria Department of Obstetrics and Gynecology College of Medicine University of Ibadan Ibadan Nigeria Department of Obstetrics and Gynecology University College Hospital Ibadan Nigeria Department of Chemical Pathology College of Medicine University of Ibadan Ibadan Nigeria Department of Internal Medicine Feinberg School of Medicine Northwestern University Chicago USA Center for Global Health Institute for Public Health and Medicine Feinberg School of Medicine Northwestern University Chicago USA Department of Emergency Medicine Feinberg School of Medicine Northwestern University Chicago USA Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago USA

Background: Nigeria has the largest paediatric HIV-infected population in the world. Missed opportunities for prevention of mother-to-child transmission of HIV (PMTCT) compromise efforts at eliminating new pediatric HIV infections. Methods: Six hundred children, aged < 15 years, presenting to the pediatric units of the University College Hospital (UCH), Ibadan Southwest Nigeria between June to December 2007 were studied. The demographics, HIV status and socioeconomic status of mothers and their children were studied. A 4-step hierarchy was used to assess the missed opportunities for PMTCT. Step 1: utilization of a health facility for antenatal care and delivery;Step 2: maternal HIV status determination during pregnancy;Step 3: provision of antiretroviral medication to HIV-infected mother and baby;and Step 4: avoidance of mixed feeding in HIV-exposed children. The rates of missed opportunities for PMTCT services at different steps in the PMTCT cascade, perinatal transmission rates, and associated factors were reported. Results: There were 599 mothers and 600 children (one set of twins), 60 (10%) were HIV infected and 56 (93.3%) of these were adjudged perinatally infected. Of 78 HIV-infected women, 7 (9.0%) accessed all interventions in the PMTCT cascade and 71 (91.0%) had missed opportunities for PMTCT. Missed opportunities for PMTCT occurred 42.9% in cascade Step 1, 64.2% in Step 2, 52.6% in step 3 and 73.7% in Step 4. All mother-baby pairs who accessed complete PMTCT interventions received care at a teaching hospital. Among infants with perinatal HIV infection, 53 (94.6%) were born to mothers who had missed opportunities for PMTCT. Most women with missed opportunities attended antenatal care outside the teaching hospital setting and belonged to low socioeconomic status. Conclusion: It is imperative to expand PMTCT access to women who receive antenatal care outside the teaching hospitals and to those of low socioeconomic status.

关键词： HIV Perinatal Prevention PMTCT Missed Opportunities

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Correction to: Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population

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Virologica Sinica 2021年第6期36卷 1692-1692页

Correction to:Virologica Sinica https://***/10.1007/s12250-021-00448-x Due to our oversight,the author list of reference“Promchan *** *** M(2020)Leucine zipper transcription factor-like I binds adaptor protein comple... 详细信息

关键词： Replication LZTFL1 traffic

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