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ALTERATION IN ENTEROCYTE GENE EXPRESSION MAY EXPLAIN STRUCTURAL AND FUNCTIONAL CHANGES FOLLOWING GLUTAMINE SUPPLEMENTED PARENTERAL NUTRITION

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Chinese Medical Sciences Journal 1999年第2期14卷 112-116页

作者： JiangZhuming,md LiuYuewu,md,phd MaYongxian,md baimanxi,md,phd QiangBoqing,phd RobertSmith,md DepartmentofSurgery PekingUnionMedicalCollegeHospitalBeijing100730 MolecularBiologyLaboratoryofChineseAcademyofMedicalSciences Beijing100730 JoslinDiabeticCenter DepartmentofSurgeryMassachusettsGeneralHospitalandBrighamandWomen＇sHospitalHarvardMedicalSchool

Following extensive bowel resection, the intestinal tract undergoes a variety of adaptive responses to enhance bowel function. The purpose of this study was to determine the effect of glutamine-supplemented parenteral nutrition on mucosal cellularity and gut function. In addition, enterocyte gene expression of two relevant systems was also characterized and related to the structural and functional changes that occurred. Male Wistar rats underwent a 60% small bowel resection and jugular vein catheterization and were randomized into two groups. The control group (n = 10) received a standard intravenous nutritional solution and the study group (n = 10) received a similar solution but enriched with alanylglutamine dipeptide. After 7 days blood was taken for amino acid analysis, and bowel was harvested to determine mucosal morphology and expression of mucosal cell glutaminase and IGF-I mRNA. Mesentery lymphnodes were cultured to determine the presence of bacteria and thus access bacteria translocation. Serum glutamine concentration and mucosal architecture were maintained in the study group compared to the controls. Seventy percent of lymphnodes were cultured positive in control vs. only 20% in the study group (P

关键词： Parenteral Nutrition Animals Dipeptides Enterocytes Gene Expression Glutaminase Ileum Insulin-Like Growth Factor I Intestinal Mucosa Intestine, Small Jejunum Male RNA, Messenger Rats Rats, Wistar Research Support, Non-U.S. Gov't

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Regeneration mechanisms and therapeutic strategies for neuromuscular junctions in aging and diseases

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Neural Regeneration Research 2025年第1期20卷 193-194页

作者： Masashi Fujitani Abu md Mamun Tarif Yoshinori Otani Department of Anatomy and Neuroscience Faculty of MedicineShimane UniversityShimaneJapan

The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout *** NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).

关键词： aging structure Figure

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Rhabdomyolysis-related acute kidney injury in COVID-19:A critical concern

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World Journal of Virology 2025年第1期14卷 127-129页

作者： md Safiullah Sarker Virology Laboratory Infectious Diseases DivisionDhaka 1212Bangladesh

Rhabdomyolysis is a severe condition characterized by the breakdown of muscle tissue leading to the release of intracellular components into the *** condition,when associated with acute kidney injury(AKI),can result in significant morbidity and mortality,particularly in the context of coronavirus disease 2019(COVID-19).This editorial discusses a retrospective study on patients with COVID-19 who developed rhabdomyolysis-related *** study highlights that patients with rhabdomyolysis exhibited higher inflammatory markers,such as Creactive protein,ferritin,and procalcitonin,and experienced worse clinical outcomes compared to those with other causes of *** findings underscore the importance of early recognition and management of rhabdomyolysis in COVID-19 patients to improve prognosis and reduce mortality rates.

关键词： Rhabdomyolysis Acute kidney injury COVID-19 SARS-CoV-2 Creatine kinase Inflammation Prognosis Mortality

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ALTERATION IN ENTEROCYTE GENE EXPRESSION MAY EXPLAIN STRUCTURAL AND FUNCTIONAL CHANGES FOLLOWING GLUTAMINE SUPPLEMENTED PARENTERAL NUTRITION

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Chinese Medical Sciences Journal 1999年第2期 49-53页

作者： $$$$ Jiang Zhuming, md Liu Yuewu, md, phd , Ma Yongxian, md , Bai Manxi,md, phd , Qiang Boqing, phd  ,Robert Smith, md Wlley Souba, md , ScD and Douglas Wilmore, md Department of Surgery, Peking

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期 125-143页

作者： md Al Raihan C.Adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

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Inherited Wolff–Parkinson–White Syndrome

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Cardiovascular Innovations and Applications 2016年第B02期1卷 187-197页

作者： Yang Liu,md,phd Yumei Xue,md,phd Shulin Wu,md,FACC,FHRS Dan Hu,md,phd,FHRS Guangdong Cardiovascular Institute Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Molecular Genetics and Experimental Cardiology Masonic Medical Research LaboratoryUticaNY 13501USA

Wolff-Parkinson-White(WPW)syndrome is a congenital disorder of cardiac conduction system characterized by electrocardiographic preexcitation and episodes of paroxysmal supraventricular *** is caused by a cardiac developmental defect in the electrical insulation between the atria and the ventricles due to the presence of an accessory *** syndrome is a common cause of supraventricular tachycardia with benign ***,this clinical entity also predisposes patients to an increased risk of sudden cardiac death,especially in the setting of preexcited atrial *** syndrome is usually sporadic and of unknown etiology in most *** the past10years,a signifi cant heritable factor is increasingly *** cation of the genetic basis among patients with WPW syndrome has important implications for understanding the molecular mechanism of ventricular preexcitation and the development of therapeutic strategies for risk stratifi cation and *** goal of this review is to examine the previous studies on hereditary variants,as well as to outline potential future avenues toward defi ning the heritability of WPW syndrome.

关键词： Wolff-Parkinson-White syndrome ventricular preexcitation genetics

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“Eye Science” in 2011

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Eye Science 2011年第1期26卷 1-2页

作者： Jian Ge md phd Zhongshan Ophthalmic Center Guangzhou

2011 is an opportune time for Yanke Xuebao (Eye Science) to launch its bilingual edition as a platform for cooperation between Chinese and international vision *** yearly research output of Chinese investigators in all fields of science, but particularly biomedicine, has been growing recently by leaps and *** an example, the American Journal of Ophthalmology (AJO), one of the most prestigious clinical journals in our field,received more submissions from East Asian authors (Japan, China and Korea alone)than they did from the United States in *** investigators ranked third on the list, climbing rapidly, only after the US and *** vision research centers in China, such as Zhongshan Ophthalmic Center, where Eye Science is published, now rank alongside Moorfields and Johns Hopkins as among the most prolific institutions in the world, measured by articles appearing annually in peer-reviewed SCI journals.

关键词：《眼科学报:英文版》期刊编辑部 2011年

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Capturing transition and non-transition flows with a new shear stress transport model

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Chinese Journal of Aeronautics 2023年第3期36卷 121-136页

作者： md Mizanur RAHMAN School of Mechanical Engineering Hangzhou Dianzi UniversityHangzhou 310018China

A new Shear Stress Transport(SST)k-ω model is devised to integrate salient features of both the non-transitional SST k-ω model and correlation-based γ-Re_(θ) transition *** exceptionally simplified approach is applied to extend the New SST(NSST)model capabilities toward transition/non-transition ***’s stress-intensity factor R_(b)=|-uv|/k can be parameterized with the wall-distance dependent Reynolds number Re_(y)=√ky/v;however,as the Re_(y)is replaced by a“flow-structure-adaptive”parameter R_(μ)=v_(T)/v,the resulting R_(b)is capable of capturing various transition phenomena *** prospective stress-intensity parameter R_(b)=R_(b)(Re_(y),R_(μ))is incorporated in the constitutive relations for eddy-viscosity v_(T) and production term P_(k).The proposed formulation is intrinsically plausible,having a dramatic impact on the prediction of bypass,separation-induced and natural transitions together with non-transitional *** extra viscous-production term P_(k)^(lim) is added with the k-equation to ensure proper generation of k at the viscous sublayer when computing separation-induced transition over a Low-Reynolds Number(LRN)*** demonstrate that the NSST k-ω model maintains an excellent consistency with both SST k-ω and γ-Re_(θ) models.

关键词： γ-Re_(θ)model Non-transition Stress-intensity parameter SST model Transition

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Pressure-dependent physical properties of cubic SrΒO3(Β=Cr,Fe)perovskites investigated by density functional theory

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Chinese Physics B 2020年第12期29卷 212-220页

作者： md Zahid Hasan md Rasheduzzaman Khandaker Monower Hossain Department of Electrical and Electronic Engineering International Islamic University ChittagongKumiraChittagong-4318Bangladesh Department of Materials Science and Engineering University of RajshahiRajshahi-6205Bangladesh

We perform the first-principles investigations of the structural,elastic,electronic,and optical properties of SrBO3(B=Cr,Fe)perovskites under pressure based on density functional theory(DFT).This is the first detailed pressure-dependent study of the physical properties for these *** calculated structural parameters are consistent with the existing experimental results and slightly decrease with the application of *** mechanical properties are discussed in detail and reveal that the SrCrO3 is harder than *** pressure,these compounds behave like half-metals,confirmed by their band structure and density of *** the SrCrO3 retains its half-metallic nature under pressure,SrFeO3 becomes metallic for both up-spin and down-spin *** charge density and bond overlap population reveal the covalent nature of Cr–O bond and Fe–O bond in the studied *** optical properties of SrBO3,also discussed for the first time,reveal some interesting results.

关键词： density functional theory(DFT) effects of pressure electronic band structure optical properties

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Antiplatelet Therapy Considerations in Women

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Cardiovascular Innovations and Applications 2019年第B02期3卷 363-373页

作者： Khadeeja Esmail,md Dominick J.Angiolillo,md,phd University of Florida College of MedicineJacksonvilleFLUSA

Coronary artery disease(CAD)is the leading cause of death worldwide,but because of several factors,one of which is antiplatelet therapy,the mortality rates have steadily ***,women continue to experience higher CAD mortality rates than *** may be explained by differences in comorbidities,increased time to presentation,higher bleeding rates,and differences in *** are numerous landmark trials in the field of antiplatelet therapy;however,women are consistently underrepresented in these *** results of these trials reveal that women experience the same benefit as men from antiplatelet therapy but experience higher bleeding rates;therefore bleeding-reduction strategies are imperative in this patient *** review provides an overview of the available evidence on CAD in women and its implications for antiplatelet medications.

关键词： antiplatelet therapy women atherosclerosis

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