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Simulation on the dynamic stability derivatives of battle-structure-damaged aircrafts

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Defence Technology（防务技术） 2021年第3期17卷 987-1001页

作者： bai.gang mi School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

Accurately evaluating the aerodynamic performance of a battle-structure-damaged aircraft is essential to enable the pilot to optimize the flight control strategy. Based on CFD and rigid dynamic mesh techniques,a numerical method is developed to calculate the longitudinal and longitudinal-lateral coupling forces and moments with small amplitude sinusoidal pitch oscillation, and the corresponding dynamic derivatives of two fragment-structure-damaged and two continuous-rod-damaged models modified from the SACCON UAV. The results indicate that, at the reference point set in this paper, additional positive damping is generated in fragment-damaged configurations;thus, the absolute values of the negative pitch dynamic derivative increase. The missing wingtip induces negative pitch damping on the aircraft and decreases the value of the pitch dynamic derivative. The missing middle wing causes a noticeable increase in the absolute value of the pitch dynamic derivative;the missing parts on the right wing cause the aircraft to roll to the right side in the dynamic process, and the pitch-roll coupling cross dynamic derivatives are positive. Moreover, the values of these derivatives increase as the damaged area on the right wing increases, and an optimal case with the smallest cross dynamic derivative can be found to help improve the survivability of damaged aircraft.

关键词： Flying wing Fragment damage Continuous rod damage Combined dynamic derivative Computational fluid dynamics(CFD)

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing Zhao Xin min Yanghong Li Ruiyu mi Yangai Liu Xiaowen Wu minghao Fang Zhaohui Huang Engineering Research Center of ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu michael Chopp michael millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO2 Nanoparticles for Tetracycline Degradation

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 42-48页

作者：徐荣琪 mi Jianxin 王树林徐慢 ZHU Li bai Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and Engineering Wuhan Institute of Technology Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.

Cu-Mn co-doped CeO2photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO2without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO2nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18% and maintained a stable cycling performance.

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Design concept development of a variable magnetization motorwith improved efficiency and controllable stiffness for roboticapplications

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Science China(Technological Sciences) 2019年第1期62卷 39-46页

作者： bai Kun ZHU Lang YUAN mi LEE Kok-Meng State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and Technology Woodruff School of Mechanical Engineering Georgia Institute of Technology

A variable magnetization(VM) motor by incorporating magnets that can be flexibly configured with variable magnetization process is proposed to meet the emerging requirements on motor efficiency and actuator compliance in robotic applications. A generalized spin torque model is established which provides a relationship between the motor torque and two different types of motor inputs, the current inputs and the magnet magnetizations. Avariable magnetization process is proposed based on the study of the hysteresis properties of the magnetic materials and the design criteria for implementing the variable magnetization process with current pulses are established. The feasibility of the variable magnetization is validated with experimental data and the motor functions and performances are numerically demonstrated and evaluated. The results show that the VM motor can maintain high efficiency by switching between two actuation modes. Controllable stiffness at different equilibria can be also achieved with the VM motor with instantaneous magnetizing current pulses.

关键词： compliant actuators direct-drive motors variable stiffness motors variable magnetization motors

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye mintsa mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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中华文化生命体的特征探析

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 122-127页

作者：秘天一新疆大学马克思主义学院新疆乌鲁木齐830046

中华文化生命体呈现对环境刺激的反应、生长发育、新陈代谢、自我调节和超脱自然选择等特征,具有整体性、连贯性、创新性、开放性与和平性特质。整体性和连贯性确保中华文化在数千年发展中的赓承延续与稳定,通过“天人合一”“和而不同... 详细信息

中华文化生命体呈现对环境刺激的反应、生长发育、新陈代谢、自我调节和超脱自然选择等特征,具有整体性、连贯性、创新性、开放性与和平性特质。整体性和连贯性确保中华文化在数千年发展中的赓承延续与稳定,通过“天人合一”“和而不同”实现内在和谐统一;创新性使中华文化在历史长河中保持强大的生长力,推动中华优秀传统文化现代转型,实现马克思主义中国化的新飞跃;开放性增强了中华文化的适应性和生命力,通过吸收和融合外来优秀文化元素,使中华文化在全球化进程中保持独特性和竞争力,并以开放姿态积极借鉴吸收人类文明一切优秀成果,推动文化守正创新;和平性源于对和谐、和合文化的深刻理解,强调和谐共生、和合共在、和平发展,通过对话与合作解决争端。中华文化生命体在全球化背景下展现出独特的现代价值和全球视野,彰显了中华文化的强大生命力和国际影响力。

关键词：习近平文化思想中华文化生命体两个结合文化新使命中华优秀传统文化

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基于电子商务环境的农机管理系统设计

农机化研究 2025年第2期47卷 96-100页

作者：王弥河南工业职业技术学院河南南阳473000

介绍了电子商务环境的背景和现状,详细描述了农机管理系统的实际需求和业务流程,并根据系统设计原则设计了系统总体架构,最后从人机管理、作业管理及综合信息等3个方面实现了农机管理系统。系统在测试过程中取得了较好的应用效果,是一... 详细信息

介绍了电子商务环境的背景和现状,详细描述了农机管理系统的实际需求和业务流程,并根据系统设计原则设计了系统总体架构,最后从人机管理、作业管理及综合信息等3个方面实现了农机管理系统。系统在测试过程中取得了较好的应用效果,是一种具有广泛应用前景的高效农机管理系统。

关键词：农机管理系统电子商务环境人机管理作业管理综合信息