检索结果-南通市图书馆

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

引用

Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan Guo Di Gu Jing Liu Piao Luo Yunmeng bai Jiayun Chen Xinzhou Zhang sheng nie Chunbo Chen Yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

引用

Chinese Medical Journal 2024年第11期137卷 1351-1359页

作者： Jiacheng Li Ruopu Li Xue bai Wenlong Zhang Yu nie shengshou Hu State Key Laboratory of Cardiovascular Disease Fuwai Hospital and Cardiovascular InstituteNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Obstetrics and Gynecology Beijing Advanced Innovation Center for GenomicsThird HospitalSchool of Life SciencesPeking UniversityBeijing 100871China

Background:The ability to generate functional hepatocytes without relying on donor liver organs holds significant therapeutic promise in the fields of regenerative medicine and potential liver disease *** regularly interspaced short palindromic repeats(CRISPR)activator(CRISPRa)is a powerful tool that can conveniently and efficiently activate the expression of multiple endogenous genes simultaneously,providing a new strategy for cell fate *** main purpose of this study is to explore the feasibility of applying CRISPRa for hepatocyte reprogramming and its application in the treatment of mouse liver ***:The differentiation of mouse embryonic fibroblasts(MEFs)into functional induced hepatocyte-like cells(iHeps)was achieved by utilizing the CRISPRa synergistic activation mediator(SAM)system,which drove the combined expression of three endogenous transcription factors-Gata4,Foxa3,and Hnf1a-or alternatively,the expression of two transcription factors,Gata4 and *** vivo,we injected adeno-associated virus serotype 6(AAV6)carrying the CRISPRa SAM system into liver fibrotic Col1a1-Cre^(ER);Cas9^(fl/fl)mice,effectively activating the expression of endogenous Gata4 and Foxa3 in *** endogenous transcriptional activation of genes was confirmed using real-time quantitative polymerase chain reaction(RT-qPCR)and RNA-seq,and the morphology and characteristics of the induced hepatocytes were observed through *** level of hepatocyte reprogramming in vivo is detected by immunofluorescence staining,while the improvement of liver fibrosis is evaluated through Sirius red staining,alpha-smooth muscle actin(α-SMA)immunofluorescence staining,and blood alanine aminotransferase(ALT)***:Activation of only two factors,Gata4 and Foxa3,via CRISPRa was sufficient to successfully induce the transformation of MEFs into *** iHeps could be expanded in vitro and displayed functional characteristics similar to th

关键词： Liver fibrosis CRISPRa Cell reprogramming Transcriptional activation Hepatocytes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism investigation on coal and gas outburst: An overview

引用

International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 872-887页

作者： Yan-kun Ma bai-sheng nie Xue-qiu He Xiang-chun Li Jun-qing Meng Da-zhao Song State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology(Beijing)Beijing 100083China Beijing Key Laboratory for Precise Mining of Intergrown Energy and Resources China University of Mining and Technology(Beijing)Beijing 100083China Xinjiang Institute of Engineering Urumqi 830023China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 10083China

Coal and gas outburst is a frequent dynamic disaster during underground coal mining *** about 150 years of exploration,the mechanisms of outbursts remain unclear to *** on outburst mechanisms worldwide focused on the physicochemical and mechanical properties of outburst-prone coal,laboratory-scale outburst experiments and numerical modeling,mine-site investigations,and doctrines of outburst *** mechanisms are divided into two categories:single-factor and multi-factor *** multi-factor mechanism is widely accepted,but all statistical phenomena during a single outburst cannot be explained using present *** topics about outburst mechanisms are proposed by summarizing the phenomena that need precise *** most appealing research is the microscopic process of the interaction between coal and *** physical-chemical methods can help characterize the natural properties of outburst-prone *** experiments can compensate for the deficiency of first-hand observation at the *** the original outburst scene by constructing a geomechanical model or numerical model and reproducing the entire outburst process based on mining environment conditions,including stratigraphic distribution,gas occurrence,and geological structure,are *** studies can explore outburst mechanisms at the microscale.

关键词： coal and gas outburst outburst mechanism outburst model outburst simulation microscopic pore structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atomically Precise Design of PtSn Catalyst for the Understanding of the Role of Sn in Propane Dehydrogenation

引用

Precision Chemistry 2024年第6期2卷 245-255页

作者： Hui Ye Lina Cao Minghui Gu Han nie Qingqing Gu Bing Yang Yunxing bai Qinxue nie Weixin Huang Junling Lu Institute of Advanced Technology Key Laboratory of Precision and Intelligent ChemistryDepartment of Chemical PhysicsHefei National Research Center for Physical Sciences at the MicroscaleKey Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education InstitutesUniversity of Science and Technology of ChinaHefei 230026P.R.China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsThe Chinese Academy of SciencesDalian 116023P.R.China

Propane dehydrogenation(PDH),an atom-economic reaction to produce high-value-added propylene and hydrogen with high efficiency,has recently attracted extensive *** severe deactivation of Pt-based catalysts through sintering and coking remains a major challenge in this high-temperature *** introduction of Sn as a promoter has been widely applied to improve the stability and selectivity of the ***,the selectivity and stability of PtSn catalysts have been found to vary considerably with synthesis methods,and the role of Sn is still far from fully *** gain in-depth insights into this issue,we synthesized a series of PtSn/SiO_(2)and SnPt/SiO_(2)catalysts by varying the deposition sequence and Pt:Sn ratios using atomic layer deposition with precise *** found that PtSn/SiO_(2)catalysts fabricated by the deposition of SnO_(x)first and then Pt,exhibited much better propylene selectivity and stability than the SnPt/SiO_(2)catalysts synthesized the other way *** demonstrate that the presence of Sn species at the Pt-SiO_(2)interface is of essential importance for not only the stabilization of PtSn clusters against sintering under reaction conditions but also the promotion of charge transfers to Pt for high *** the above,the precise regulation of the Sn content is also pivotal for high performance,and the excess amount of Sn might generate additional acidic sites,which could decrease the propylene selectivity and lead to heavy coke *** findings provide deep insight into the design of highly selective and stable PDH catalysts.

关键词： Propane dehydrogenation PtSn catalysts sintering coke formation acidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人工耳蜗儿童音乐感知评价方法概述

引用

中华耳科学杂志 2024年第2期22卷 279-282页

作者：聂嘉城白艳茹倪广健天津大学医学工程与转化医学研究院天津300072 天津大学国际工程师学院脑机交互与人机共融海河实验室天津大学先进医用材料与医疗器械全国重点实验室

人工耳蜗可以有效帮助重度和极重度听力损失群体重建听觉,但人工耳蜗听力无法实现自然听力情况下的复杂声音感知,音乐感知困难,并且个体差异大。音乐在儿童发展发育、接受教育阶段十分重要,因此需要有效评估人工耳蜗儿童音乐感知能力。... 详细信息

人工耳蜗可以有效帮助重度和极重度听力损失群体重建听觉,但人工耳蜗听力无法实现自然听力情况下的复杂声音感知,音乐感知困难,并且个体差异大。音乐在儿童发展发育、接受教育阶段十分重要,因此需要有效评估人工耳蜗儿童音乐感知能力。我们综述了评价人工耳蜗儿童音乐感知的主客观方法及相关研究工作,讨论了各方法的适用性和局限性。基于脑机接口的客观评价方法在人工耳蜗儿童群体适用性强、效果良好,具有较高的推广潜力和价值。

关键词：人工耳蜗儿童音乐感知评价方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

铁路大范围复杂地质区域环境三维建模方法研究

引用

铁道学报 2024年第2期46卷 105-113页

作者：吕希奎白娇娇庄建杰聂良涛高崇文石家庄铁道大学交通运输学院河北石家庄050043 河北雄安轨道快线有限责任公司河北保定071700 中国铁路设计集团有限公司天津300308

科学合理的规划铁路线位,使铁路地质灾害问题解决在成灾之前,一直是复杂山区铁路选线的难题。基于空间数据三维可视化建模技术,提出一种铁路大范围复杂地质区域环境整体三维建模方法。通过对遥感地质解译图的矢量化信息提取与处理,采用... 详细信息

科学合理的规划铁路线位,使铁路地质灾害问题解决在成灾之前,一直是复杂山区铁路选线的难题。基于空间数据三维可视化建模技术,提出一种铁路大范围复杂地质区域环境整体三维建模方法。通过对遥感地质解译图的矢量化信息提取与处理,采用拉格朗日插值和三次Hermite曲线插值算法,实现由数据驱动的矢量化不同类型地质对象三维模型创建。根据地质对象空间边界数据和区域边界,构建填充封闭区域和填充色系,实现颜色填充模式的三维地质建模。以DEM模型与DOM影像为数据源,在Infraworks BIM平台中实现大范围三维地形场景建模。基于七参数的坐标系转换方法,以面积比值、空间距离误差和灰度状态均值为标准,建立基于灰度直方图的图像匹配度分析方法和最优控制点选取策略,解决选线完整区域大范围矢量化地质模型在三维地形场景中的精确定位和集成难题,建立铁路工程完整区域的三维工程地质模型,实现大范围复杂地质区域的三维可视化。采用设计方案和铁路线路BIM设计结果在BIM平台定位和集成,实现在三维地质区域环境中无缝展示线路方案BIM模型设计效果。结果表明,构建的大范围的三维地质区域环境模型具有很好的地质信息完整性和可视性,直观展示了整个选线区域的三维地质区域环境,能够较好地满足预可研和可研阶段复杂山区铁路规划线位要求。

关键词：铁路选线设计大范围区域复杂地质区域环境三维建模 BIM技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

环金属配体Ir(Ⅲ)配合物结构、光谱和量子效率的理论研究

引用

高等学校化学学报 2024年第4期45卷 78-86页

作者：聂建航王天奇金丽张建坡张红星白福全吉林化工学院化学与制药工程学院吉林132022 吉林大学化学学院理论化学研究所纳米微结构化学国际联合研究实验室长春130023

对一类环金属Ir(Ⅲ)[(C^N)_(2)Ir(A^A)]配合物[C^N=ptaz(1,2,4),mhtz(3),ptaz=3,4,5-三苯基-4H-1,2,4-三唑,mhtz=1,3-双甲基-5-苯基-1H-1,2,4-三唑;A^A=pzpy(1),npzpy(2,3),bicb(4),pzpy=2-(1H-吡唑-1-基)吡啶,npzpy=4-二甲基氨基-2-(1H-吡唑-1-基)吡啶,bicb=3,3′-亚甲基双(1-甲基-1H-咪唑-2-亚基)]的结构、光谱特征和磷光量子效率进行了理论研究.计算方法探究表明,基于B3LYP泛函优化的基态结构和单激发组态相互作用(CIS)方法得到的激发态结构计算的吸收和发射光谱更准确.配合物1~4的最低吸收峰和发射峰分别位于408,376,382,365 nm和503,506,468,511 nm处,其HOMOs主要由金属和C^N配体占据,而配合物1~3的LUMOs由A^A配体的π反键轨道组成,配合物4的LUMO存在于C^N配体上.因此,配合物4的最低吸收峰和发射峰具有与配合物1~3不同的金属到配体和配体内部(MLCT/ILCT)的混合跃迁性质,非共轭N^N配体的引入显著消弱了其在跃迁过程中的贡献程度.配合物1~4的量子效率取决于非辐射跃迁速率常数k_(nr),这与它们重组能的贡献[4569 cm^(-1)(3)>2583 cm^(-1)(1)>1232 cm^(-1)(2)>975 cm^(-1)(4)]相一致,表明主配体的体积和辅助配体的共轭能力都能影响配合物的磷光量子效率.

关键词：环金属铱(Ⅲ)配合物电子结构光谱特征量子效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超超临界转子用Inconel 617合金的热塑性

引用

金属热处理 2024年第1期49卷 103-107页

作者：李红梅白亚冠郭伟聂义宏天津重型装备工程研究有限公司天津300457 中国第一重型机械股份公司黑龙江齐齐哈尔161042

研究了不同温度对Inconel 617合金铸锭高温拉伸热塑性的影响。结果表明,Inconel 617合金在900℃以上有良好的热塑性,拉伸断口有明显的颈缩,断面收缩率均在90%以上。随拉伸温度的升高,颈缩越来越明显,断口韧窝变深,热塑性越来越好。拉伸... 详细信息

研究了不同温度对Inconel 617合金铸锭高温拉伸热塑性的影响。结果表明,Inconel 617合金在900℃以上有良好的热塑性,拉伸断口有明显的颈缩,断面收缩率均在90%以上。随拉伸温度的升高,颈缩越来越明显,断口韧窝变深,热塑性越来越好。拉伸时发生了局部动态再结晶,随温度升高,再结晶变得充分,高于1200℃拉伸时晶粒快速长大,且断口出现熔融现象。

关键词： IN617合金热塑性动态再结晶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多准则决策模型对隐形和固定矫治器治疗儿童错[牙合]畸形的效益-风险分析

引用

郑州大学学报（医学版） 2024年第3期59卷 415-419页

作者：张力山白晓滟聂汶涵成都中医药大学附属医院口腔科成都610072

目的:基于多准则决策模型对隐形和固定矫治器治疗儿童错[牙合]畸形进行效益-风险分析。方法:选择2022年1月至10月进行正畸治疗的110例错[牙合]畸形患儿,采用无托槽隐形矫正器治疗(隐形组)55例,采用多托槽固定矫治器治疗(固定组)55例。... 详细信息

目的:基于多准则决策模型对隐形和固定矫治器治疗儿童错[牙合]畸形进行效益-风险分析。方法:选择2022年1月至10月进行正畸治疗的110例错[牙合]畸形患儿,采用无托槽隐形矫正器治疗(隐形组)55例,采用多托槽固定矫治器治疗(固定组)55例。比较两组患儿治疗前后牙龈指数(GI)、菌斑指数(PLI)、龈沟出血指数(SBI)和龈沟探诊深度(SPD)、咀嚼功能、口腔健康影响程度量表(OHIP)得分、龈沟液中TNF-α和IL-1β含量、牙槽骨密度、牙槽骨高度的差值,以及治疗费用和并发症发生状况。建立多准则决策模型,比较两组的效益值和风险值。结果:两组治疗前后SBI、PLI、咀嚼功能、OHIP得分,IL-1β和TNF-α含量、不适感差值比较,差异有统计学意义(P<0.05),隐形组治疗费用高于固定组(P<0.05)。多准则决策决策模型显示效益指标中对治疗影响最大的是PLI,风险指标是牙周脓肿;隐形组和固定组的效益值分别为78和63,风险值分别为74和57,隐形组效益-风险总值比固定组高出16;在0%~100%相对风险权重范围内,隐形组的效益-风险总值总是高于固定组。结论:隐形矫治器治疗儿童错[牙合]畸形有助于保持牙周健康,具有更高的安全性。

关键词：错[牙合]畸形牙周健康隐形矫治器固定矫治器正畸治疗

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SiO_(2)/KH560改性玄武岩纤维混凝土力学性能研究

引用

硅酸盐通报 2024年第1期43卷 102-112页

作者：杨鑫于奎吉冯春聂堂哲李科白天黑龙江大学水利电力学院哈尔滨150800 国防科技大学空天科学学院新型陶瓷纤维及其复合材料重点实验室长沙410073 南阳师范学院土木工程学院冲击与结构安全重点实验室南阳473061

为了研究硅烷偶联剂(KH560)和纳米SiO_(2)协同KH560改性玄武岩纤维(BF)对混凝土力学性能的影响,本文采用KH560对BF进行表面改性,制得KH560-BF,并采用纳米SiO_(2)和KH560改性BF制得SiO_(2)-KH560-BF。通过正交试验筛选出高强度改性纤维,... 详细信息

为了研究硅烷偶联剂(KH560)和纳米SiO_(2)协同KH560改性玄武岩纤维(BF)对混凝土力学性能的影响,本文采用KH560对BF进行表面改性,制得KH560-BF,并采用纳米SiO_(2)和KH560改性BF制得SiO_(2)-KH560-BF。通过正交试验筛选出高强度改性纤维,研究了纳米SiO_(2)分散液、润滑剂和KH560三者的质量分数对SiO_(2)-KH560-BF的丝束强度影响。采用SEM和EDS对改性混凝土的7和28 d的力学性能进行评估,并对混凝土的微观结构进行表征。结果表明,SiO_(2)-KH560-BF的最佳上浆剂成分为纳米SiO_(2)分散液1.6%、润滑剂0.4%和KH5600.5%,且三个因素的影响程度从大到小依次为纳米二氧化硅分散液、KH560、润滑剂。与KH560-BF相比,SiO_(2)-KH560-BF纤维丝束强度提高了8.62%,拉伸强度提高了4.41%,Si含量提升了24.9%,并且从SEM照片中可以看出SiO_(2)-KH560-BF团状堆积比KH560-BF少。掺入适量SiO_(2)-KH560-BF的混凝土7和28 d抗压、劈裂抗拉和轴心抗压强度提升效果均高于掺入KH560-BF的混凝土。

关键词：纳米二氧化硅玄武岩纤维纤维混凝土硅烷偶联剂正交试验力学性能

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：