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World Journal of Clinical Cases 2021年第8期9卷 1835-1843页

作者： Pei Zheng Zhen-Yu Shen bai-ping fu The Affiliated Stomatology Hospital Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND The success rate of conservative endodontic management for root fracture varies greatly based on different methods *** has been rarely reported that calcium silicate-based materials are applied in root fracture *** SUMMARY A 38-year-old male patient presented with spontaneous pain from the upper left anterior teeth for 1 *** spontaneous pain was subsequently relieved,but pain on mastication persisted for 3 *** patient had a dental trauma from a boxing match 15 years *** beam computed tomography showed that the maxillary left central incisor had oblique fracture lines and a radiolucent lesion around the fracture *** tooth was diagnosed with an oblique root fracture with no healing and symptomatic apical *** the following conservative endodontic management,the coronal and apical fragments of the canal both were chemo-mechanically prepared and obturated using a single cone gutta-percha with iRoot SP(Innovative BioCreamix Inc,Vancouver,Canada),a new calcium silicate-based bioceramic root canal *** follow-ups at 1,6,12,and 24 mo,the patient was asymptomatic and the radiolucency around the fracture line was healing *** Conservative root canal treatment is an alternative treatment in some cases of oblique root fracture with no *** application of bioceramic sealers and single core obturation techniques may also be essential to obtain an excellent outcome.

关键词： Oblique root fracture Endodontic treatments Single core obturation iRoot SP Calcium silicate-based sealer Case report

Improvement of enamel bond strengths for conventional and resin-modified glass ionomers: acid-etching vs. conditioning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1013-1024页

作者： Ling ZHANG Tian TANG Zhen-liang ZHANG Bing LIANG Xiao-miao WANG bai-ping fu Hospital of Stomatology Affiliated to Zhejiang University School of Medicine

Objective:This study deals with the effect of phosphoric acid etching and conditioning on enamel micro-tensile bond strengths(μTBSs)of conventional and resin-modified glass ionomer cements(GICs/RMGICs).Methods:Forty-eight bovine incisors were prepared into rectangular ***-polished labial enamel surfaces were either acid-etched,conditioned with liquids of cements,or not further treated(control).Subsequently,two matching pre-treated enamel surfaces were cemented together with one of four cements[two GICs:fuji I(GC),Ketac Cem Easymix(3M ESPE);two RMGICs:fuji Plus(GC),RelyX Luting(3M ESPE)]in preparation forμTBS ***-treated enamel surfaces and cement-enamel interfaces were analyzed by scanning electron microscopy(SEM).Results:Phosphoric acid etching significantly increased the enamelμTBS of GICs/*** with the liquids of the cements produced significantly weaker or equivalent enamelμTBS compared to the *** of etching,RMGICs yielded stronger enamelμTBS than GICs.A visible hybrid layer was found at certain enamelcement interfaces of the etched ***:Phosphoric acid etching significantly increased the enamelμTBSs of GICs/*** acid etching should be recommended to etch the enamel margins before the cementation of the prostheses such as inlays and onlays,using GICs/RMGICs to improve the bond *** provided stronger enamel bond strength than GICs and conditioning did not increase enamel bond strength.

关键词： Glass ionomer cements Surface treatments Bovine enamels Scanning electron microscopy(SEM) Micro-tensile bond strengths

Adhesion of bone marrow mesenchymal stem cells on porous titanium surfaces with strontium-doped hydroxyapatite coating

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第9期18卷 778-788页

作者： Dan-li fu Qiao-hong JIANG fu-ming HE bai-ping fu Department of General Dentistry West Branch of Stomatology Hospital School of Medicine Zhejiang University Department of Oral Implantology Stomatology Hospital School of Medicine Zhejiang University Department of Prosthodontics Stomatology Hospital School of Medicine Zhejiang University

Objective: To determine the adhesion behavior of bone marrow mesenchymal stem cells(MSCs) on a titanium surface with a nanostructured strontium-doped hydroxyapatite(Sr-HA) coating. Methods: Sr-HA coatings were applied on roughened titanium surfaces using an electrochemical deposition method. Primary cultured rat MSCs were seeded onto Sr-HA-, HA-coated titanium, and roughened titanium surfaces, and they were then cultured for 1,6, and 24 h.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to determine the metabolic condition of the cells. Scanning electron microscopy(SEM) was used to observe the cell morphology. The cytoskeletal structure was analyzed using fluorescence actin staining to characterize cell adherence. Quantitative real-time reverse transcription polymerase chain reaction(RT-q PCR) was used to analyze the gene expression levels of FAK(focal adhesion kinase), vinculin, integrin β1, and integrin β3 after culturing for 24,48, and 72 h. Results: MSCs cultured on the Sr-HA surface showed better cell proliferation and viability. Improvement of cell adhesion and structural rearrangement of the cytoskeleton were observed on the Sr-HA surface. The gene expression of FAK, vinculin, integrin β1, and integrin β3 was also elevated on the Sr-HA surface. Conclusions: Cell viability, adhesion, cell morphology, and the cytoskeletal structure were all upregulated considerably by the titanium surface modified with a Sr-HA coating.

关键词： Cell adhesion Bone marrow mesenchymal stem cell Strontium-doped hydroxyapatite Titanium

我国体外诊断试剂参考区间监管现状分析和思考

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中国食品药品监管 2024年第7期 68-75页

作者：胡琳琳杜昕昱李蓓白馥萍李楚桐刘玉北京协和医学院卫生健康管理政策学院

参考区间是定量体外诊断试剂性能的关键参数,也是体外诊断试剂注册审评的重要关注点。2022年9月,国家药品监督管理局医疗器械技术审评中心发布《体外诊断试剂参考区间确定注册审查指导原则》,作为专门针对体外诊断试剂参考区间监管的指... 详细信息

参考区间是定量体外诊断试剂性能的关键参数,也是体外诊断试剂注册审评的重要关注点。2022年9月,国家药品监督管理局医疗器械技术审评中心发布《体外诊断试剂参考区间确定注册审查指导原则》,作为专门针对体外诊断试剂参考区间监管的指导文件,其为提升体外诊断试剂的准确性和可靠性提供了保障,也对行业产生了积极影响。本文通过对监管部门、相关企业及医学实验室进行访谈,并结合相关文献和数据,对我国体外诊断试剂参考区间的监管现状和问题进行分析。在借鉴国际经验的基础上,提出优化体外诊断试剂参考区间监管的几点思考,包括实施分类管理、允许特殊产品上市后补充数据、允许部分产品同步开展参考区间研究和临床评价、推动参考区间行业标准建立及建立多元合作机制等,以期为完善体外诊断试剂的监管体系提供参考。

关键词：体外诊断试剂参考区间注册审查行业标准监管建议

Separated root tip formation associated with a fractured tubercle of dens evaginatus: A case report

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World Journal of Clinical Cases 2021年第12期9卷 2944-2950页

作者： Zhi-Fang Wu Ling-Jiao Lu Hai-Yan Zheng Yan Tu Ying Shi Zi-Huai Zhou Lin-Xian Fang bai-ping fu Department of Pediatric Dentistry The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina Department of Prosthodontics The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina Department of Endodontics The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Several previous studies have reported an unusual root formation in which a fractured apical fragment of an immature root continued to develop independent of the main root after trauma to an immature *** date,there have been only rare reports of the continuing apical formation of the fractured root associated with dens evaginatus(DE).This paper presents a case of a separated root tip formation associated with a fractured tubercle of *** SUMMARY An 11-year-old boy was referred for gingival sinus on the buccal side of the right mandibular second premolar(tooth#45).Clinically,tooth#45 was free of caries,but there was a sign of a fractured tubercle of DE on the occlusal *** showed that the root canal of tooth#45 was widely radiolucent.A separated root apex was found apically under the main root and was nearly completely formed with an apical orifice at the apical ***#45 was diagnosed as tubular fracture of DE with chronic apical periodontitis.A revascularization technique was recommended to treat the *** 3-mo and 1-yr follow-up,the patient remained *** radiography revealed that the separated root tip distally drifted with closure of the ***,the root length and thickness of the main root did not *** Clinicians should be aware that even if tubercle of DE is fractured in an immature tooth,the root tip may be separated from the main root and completely formed.

关键词： Separated root tip Dens evaginatus Tubercle fracture Young permanent tooth Revascularization Case report

Temperature influence on minimum fluidization velocity:Complexity,mechanism,and solutions

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Particuology 2024年第5期88卷 344-349页

作者： Qingjin Zhang Liangliang fu Guangwen Xu Dingrong bai Key Laboratory on Resources Chemicals and Material of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110142China School of Chemical Engineering University of Science and Technology LiaoningAnshan 114051China

Fluidized-bed reactors are widely employed in various high-temperature industrial ***,it is crucial to understand the temperature effect on various fluidization phenomena,specifically the minimum fluidization velocity(U_(mf))that governs various aspects of fluidized bed *** this study,we comprehensively analyze U_(mf) data from the literature to unravel the complexity and underlying mechanisms of temperature influence on this critical *** research examines experimental data encompassing a wide range of temperatures,pressures,and solid *** analysis reveals that the influence of temperature on U_(mf) is fundamentally determined by the relative importance of hydrodynamic forces and interparticle forces within fluidized beds and is realized by three distinctive temperature-induced changes:gas properties,bed voidage,and physiochemical characteristics of *** this basis,an equation is derived to enable predictions of temperature influences on the minimum fluidization velocity under broad temperature conditions.

关键词： High-temperature gas-solids fluidized beds Minimum fluidization velocity Hydrodynamic forces Interparticle forces Bed voidage

The transition to turbulent fluidization in a gas-solid fluidized bed operating from ambient temperature to 1600 °C

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PARTICUOLOGY 2024年第10期93卷 111-124页

作者： Zhang, Qingjin fu, Liangliang Xu, Guangwen bai, Dingrong Shenyang Univ Chem Technol Key Lab Resources Chem & Mat Minist Educ Shenyang 110142 Peoples R China Shenyang Univ Technol Sch Mat Sci & Engn Shenyang 110142 Peoples R China Ordos Lab Ordos 017010 Peoples R China

Turbulent fluidized bed proves effective in industrial processes due to superior heat and mass transfer and chemical reaction performance. However, understanding the transition to turbulent fluidization remains limited, especially at temperatures exceeding 1000 degrees C, making it challenging to develop hightemperature fluidized bed applications. This paper presents an experimental investigation on the turbulent fluidization onset velocity (Uc), measured in a 30 mm diameter bed using corundum particles with average diameters from 0.68 mm to 1.58 mm in temperatures from ambient to 1600 degrees C. Experimental results reveal that Uc increases with temperature up to 600 degrees C, stabilizes within the 600-1200 degrees C range, and then decreases above 1200 degrees C, demonstrating the varying relative significance of hydrodynamic and interparticle forces at different temperatures. To help design and operate high-temperature applications of turbulent fluidization, we developed Uc correlations based on experimental data from both literature sources and this study, covering temperatures of up to 1600 degrees C and particles of Groups A to D.

关键词： High-temperature fluidized beds Turbulent fluidization Transition velocity Pressure fluctuations Hydrodynamic forces Interparticle forces REGIME TRANSITION HYDRODYNAMICS PRESSURE VELOCITIES SIZE

A fuzzy Trust Management Mechanism with Dynamic Behavior Monitoring for Wireless Sensor Networks

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China Communications 2024年第5期21卷 177-189页

作者： fu Shiming Zhang ping Shi Xuehong School of Artificial Intelligence Chongqing University of EducationChongqing 400065China School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information *** wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various *** encryption and authentication mechanisms cannot prevent attacks launched by internal malicious *** trust-based security mechanism is usually adopted to solve this problem in ***,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor ***,how to efficiently collect behavioral evidences are rarely *** address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud ***,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate ***,the cloud model is introduced to estimate the trust values for sensor ***,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety *** results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.

关键词： behavior monitoring cloud fuzzy trust wireless sensor networks

Efficient synthesis of forsterite via high-temperature thermochemical reactions from boron mud waste without briquetting

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Particuology 2024年第4期87卷 124-132页

作者： Fangling Hu Liangliang fu Qingjin Zhang Guangwen Xu Dingrong bai Key Laboratory on Resources Chermticals and Material of Ministry of Education Sheryang Unfversity of Chemical Technology.Shenyang110142China School of Chemical Engineering University of Science and Technology Liaoning.Anshan 114051China School of Materials Science and Engineering Shenyang University of Technology.Shenyang110142China

Forsterite is a highly demanded material in high-temperature industries due to its superior performance in elevated *** study proposes synthesizing high-quality forsterite via high-temperature thermochemical reactions using abundant boron mud *** new synthesis method capitalizes on the high reactivity of fine raw powder materials,enabling the reaction to reach completion at low temperatures *** chemical characteristics,microscopic morphology,and structure of synthe-sized samples are systematically studied using XRD and *** results confirm that boron mud can be efficiently transformed into forsterite after 10 min of reactions at 1500℃.The synthesized products attain over 98.7%densification and contain more than 85.0%forsterite with well-developed *** activation energy of forsterite grain growth in the 1100-1500℃temperature range is 165.5 kJ/*** study provides a low-cost method for producing forsterite and an efficient and environmentally friendly solution for treating solid waste.

关键词： Fluidized bed Boron mud Forsterite Solid state reaction Activation energy Grain growth

Off-farm employment,agriculture production activities,and household dietary diversity in environmentally and economically vulnerable areas of Asia

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Journal of Integrative Agriculture 2024年第2期23卷 359-373页

作者： Yunli bai Xuanye Zeng Chao fu Linxiu Zhang Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China United Nations Environment Programme-International Ecosystem Management Partnership(UNEP-IEMP) Beijing 100101China University of Chinese Academy of Sciences Beijing 100101China

Access to off-farm employment has been expected to be a critical approach to ending hunger and all forms of malnutrition,two important targets of achieving Zero *** study aims to investigate the role of off-farm employment in improving dietary diversity through substitution effect and complementary effect with agricultural production activities and income *** study adopts Poisson/Tobit/Probit/OLS regressions and the instrument variable method based on the primary survey data collected among 1,282 households at 12 sites in environmentally and economically vulnerable areas of China,Nepal,Cambodia,Thailand,and Myanmar in *** results show that off-farm employment is positively associated with household dietary diversity and the consumption of flesh meat,fish and other aquatic animals,fruits,and milk and dairy products,which are rich in protein and *** results of mechanism analysis show that off-farm employment contributes to household dietary diversity by improving crop diversity,especially for poor households,boosting the probability of livestock raising for households with the middle one-third disposal income,and increasing household *** positive association between off-farm employment and household dietary diversity is much higher for households with the bottom one-third disposal income,low illiteracy,and from upper-middle income *** findings imply that off-farm employment does play a vital role in achieving multiple benefits of poverty alleviation,malnutrition reduction,and agrobiodiversity conservation in environmentally and economically vulnerable ***,it may enlarge the gaps in dietary diversity between households with low human capital and from low and lower-middle income countries and those with high human capital and from middle-high countries.

关键词： off-farm employment dietary diversity income effect substitution effect complementary effect