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Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

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World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan Liu bai-jin-tao sun Chuan Zhang Bing Li Xiao-Xuan Yu Yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

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Online control for pressure regulation of oxygen mask based on neural network

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Control Theory and Technology 2024年第3期22卷 487-501页

作者： Ligan Zhao Qinglin sun Hao sun jin tao Zengqiang Chen College of Artificial Intelligence Nankai UniversityTianjin 300350China Silo Al Helsinki 00100Finland

The aviation oxygen mask,which has a small volume of less than 1L and strong air tightness,imposes extremely high requirements on control performance of the oxygen *** on analyses of the operation principle of oxygen supply system,the dynamic model is established through the combination of mechanism analysis and experimental *** that the traditional fixed-parameter controllers are difficult to meet the control requirements with changes in pulmonary ventilation,this paper presents an online feedback controller based on neural network compensation(NNC),with connection weights that can be updated without *** mathematical simulations at different respiratory parameters,such as respiratory rate,are performed to verify the superior lower inspiratory resistance of controller with *** terms of hardware,an embedded AI control platform is to complete the experimental ***,the work may have downward compatibility to achieve stable oxygen supply in civil fields,such as medical ventilators,high-altitude expeditions.

关键词： Neural network Online control Pressure regulation AI platform

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Adjusting oxygen vacancy of VO_(2)·xH_(2)O nanoarray architectures for efficient NH_(4)^(+) storage

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Nano Research 2024年第4期17卷 2646-2654页

作者： Jia’ni Gong Pengfei bai jingjing sun Yanyan Liu Xueying Dong tao Hu Changgong Meng Yifu Zhang School of Chemistry Dalian University of TechnologyDalian 116024China School of Chemistry and Materials Sciences CAS Key Laboratory of Materials for Energy ConversionCAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China College of Environmental and Chemical Engineering Dalian UniversityDalian 116622China

Aqueous rechargeable batteries are the promising energy storge technology due to their safety,low cost,and environmental *** ion(NH_(4)^(+))is an ideal charge carrier for such batteries because of its small hydration radius and low molar *** this study,VO_(2)·xH_(2)O with rich oxygen defects(d-HVO)is designed and synthesized,and it exhibits unique nanoarray structure and good electrochemical performances for NH_(4)^(+)*** and calculation results indicate that oxygen defects in d-HVO can enhance the conductivity and diffusion rate of NH_(4)^(+),leading to improved electrochemical *** most significant improvement is observed in d-HVO with 2 mmol thiourea(d-HVO-2)(220 mAh·g^(-1) at 0.1 A·g^(-1)),which has a moderate defect content.A full cell is assembled using d-HVO-2 as the anode and polyaniline(PANI)as the cathode,which shows excellent cycling stability with a capacity retention rate of 80%after 1000 cycles and outstanding power density up to 4540 W·kg^(-1).Moreover,the flexible d-HVO-2||PANI battery,based on quasi-solid electrolyte,shows excellent flexibility under different bending *** study provides a new approach for designing and developing high-performance NH_(4)^(+)storage electrode materials.

关键词： hydrate vanadium dioxide oxygen defects ammonium-ion battery anode material

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Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1542-1559页

作者： Xiaolan Xu Jiaming Zhang tao Wang jing Li Yukang Rong Yanfang Wang Chenxia bai Qing Yan Xiaohua Ran Yingli Wang Tianhong Zhang jin sun Qikun Jiang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Education University of NottinghamNottingham NG72RDUK Department of Pharmacy Linyi People's HospitalShandong UniversityLinyi 276000China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100871China

The non-selective cytotoxicity of toxins limits the clinical relevance of the *** recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity against various cancer *** ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ***,non-ADC delivery strategies for toxins have been extensively *** further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery *** addition,toxins and their combination strategies with other therapies were ***,the prospect and challenge of toxins in cancertreatmentwerealso summarized.

关键词： Toxins Non-antibody-drug conjugates Delivery strategies Prodrugs Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment

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ONE-PARAMETER FINITE DIFFERENCE METHODS AND THEIR ACCELERATED SCHEMES FOR SPACE-FRACTIONAL SINE-GORDON EQUATIONS WITH DISTRIBUTED DELAY

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Journal of Computational Mathematics 2024年第3期42卷 705-734页

作者： tao sun Chengjian Zhang Haiwei sun School of Mathematics and Statistics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Modeling and Scientific Computing Huazhong University of Science and TechnologyWuhan 430074China Department of Mathematics University of MacaoMacaoChina

This paper deals with numerical methods for solving one-dimensional(1D)and twodimensional(2D)initial-boundary value problems(IBVPs)of space-fractional sine-Gordon equations(SGEs)with distributed *** 1D problems,we construct a kind of oneparameter finite difference(OPFD)*** is shown that,under a suitable condition,the proposed method is convergent with second order accuracy both in time and *** implementation,the preconditioned conjugate gradient(PCG)method with the Strang circulant preconditioner is carried out to improve the computational efficiency of the OPFD *** 2D problems,we develop another kind of OPFD *** such a method,two classes of accelerated schemes are suggested,one is alternative direction implicit(ADI)scheme and the other is ADI-PCG *** particular,we prove that ADI scheme can arrive at second-order accuracy in time and *** some numerical experiments,the computational effectiveness and accuracy of the methods are further ***,for the suggested methods,a numerical comparison in computational efficiency is presented.

关键词： Fractional sine-Gordon equation with distributed delay One-parameter finite difference methods Convergence analysis ADI scheme PCG method

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Analysis of the Influence of Geometrical Parameters on the Performance of a Proton Exchange Membrane Fuel Cell

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Fluid Dynamics & Materials Processing 2024年第1期20卷 219-237页

作者： Guodong Zhang Huifang tao Da Li Kewei Chen Guoxiang Li Shuzhan bai Ke sun School of Energy and Power Engineering Shandong UniversityJinan250061China Sinotruk jinan Special Purpose Vehicle Co. Ltd.Jinan250117China

A suitable channel structure can lead to efficient gas distribution and significantly improve the power density of fuel *** this study,the influence of two channel design parameters is investigated,namely,the ratio of the channel width to the bipolar plate ridge width(i.e.,the channel ridge ratio)and the channel *** impact of these parameters is evaluated with respect to the flow pattern,the gas composition distribution,the temperature field and the fuel cell output *** results show that a decrease in the channel ridge ratio and an increase in the channel depth can effectively make the distributions of velocity,temperature and concentration more uniform in each channel and improve the output capability of the fuel *** increase in the channel ridge ratio and depth obviously reduces the flow resistance and improves the flow characteristics.

关键词： Hydrogen fuel cell bipolar plate flow channel multiphysics coupling

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Improved Weighted Local Contrast Method for Infrared Small Target Detection

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Journal of Beijing Institute of Technology 2024年第1期33卷 19-27页

作者： Pengge Ma Jiangnan Wang Dongdong Pang tao Shan Junling sun Qiuchun jin School of Intelligent Engineering Zhengzhou University of AeronauticsZhengzhou 450000China Beijing Key Laboratory of Fractional Signals and Systems School of Information and ElectronicsBeijing Institute of TechnologyBeijing 100081China

In order to address the problem of high false alarm rate and low probabilities of infrared small target detection in complex low-altitude background,an infrared small target detection method based on improved weighted local contrast is proposed in this ***,the ratio information between the target and local background is utilized as an enhancement *** local contrast is calculated by incorporating the heterogeneity between the target and local ***,a local product weighted method is designed based on the spatial dissimilarity between target and background to further enhance target while suppressing ***,the location of target is obtained by adaptive threshold *** experimental results demonstrate,the method shows superior performance in several evaluation metrics compared with six existing algorithms on different datasets containing targets such as unmanned aerial vehicles(UAV).

关键词： infrared small target unmanned aerial vehicles(UAV) local contrast target detection

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Highly Efficient Broadband Achromatic Microlens Design Based on Low-Dispersion Materials

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Engineering 2024年第7期38卷 194-200页

作者： Xueqian Wang Chuanbao Liu Feilou Wang Weijia Luo Chengdong tao Yuxuan Hou Lijie Qiao Ji Zhou jingbo sun Yang bai Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Materials and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Metalenses with achromatic performance offer a new opportunity for high-quality imaging with an ultracompact configuration;however,they suffer from complex fabrication processes and low focusing *** this study,we propose an efficient design method for achromatic microlenses on a wavelength scale using materials with low dispersion,an adequately designed convex surface,and a thickness profile *** taking into account the absolute chromatic aberration,relative focal length shift(FLS),and numerical aperture(NA),microlens with a certain focal length can be realized through our realized map of geometric ***,the designed achromatic microlenses with low-dispersion fused silica were fabricated using a focused ion beam,and precise surface profiles were *** fabricated microlenses exhibited a high average focusing efficiency of 65%at visible wavelengths of 410-680 nm and excellent achromatic capability via white light ***,the design exhibited the advantages of being polarization-insensitive and *** results demonstrate the effectiveness of our proposed achromatic microlens design approach,which expands the prospects of miniaturized optics such as virtual and augmented reality,ultracompact microscopes,and biological endoscopy.

关键词： Broadband achromatic focusing Metamaterials Low dispersion materials Visible wavelength Microlenses

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Intramolecular Hydrogen Bond Improved Durability and Kinetics for Zinc‑Organic Batteries

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Nano-Micro Letters 2024年第3期16卷 138-148页

作者： Tianjiang sun Jun Pan Weijia Zhang Xiaodi Jiang Min Cheng Zhengtai Zha Hong jin Fan Zhanliang tao Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityHaihe Laboratory of Sustainable Chemical TransformationsTianjin 300071People’s Republic of China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092People’s Republic of China

Organic compounds have the advantages of green sustainability and high designability,but their high solubility leads to poor durability of zinc-organic ***,a high-performance quinone-based polymer(H-PNADBQ)material is designed by introducing an intramolecular hydrogen bonding(HB)*** intramolecular HB(C=O⋯N-H)is formed in the reaction of 1,4-benzoquinone and 1,5-naphthalene diamine,which efficiently reduces the H-PNADBQ solubility and enhances its charge transfer in *** situ ultraviolet-visible analysis further reveals the insolubility of H-PNADBQ during the electrochemical cycles,enabling high durability at different current ***,the H-PNADBQ electrode with high loading(10 mg cm^(-2))performs a long cycling life at 125 mA g^(-1)(>290 cycles).The H-PNADBQ also shows high rate capability(137.1 mAh g^(−1)at 25 A g^(−1))due to significantly improved kinetics inducted by intramolecular *** work provides an efficient approach toward insoluble organic electrode materials.

关键词： Zn-organic batteries H-PNADBQ polymer Intramolecular hydrogen bond Reduced solubility Improvedπ-conjugated level

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The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Biomedical and Environmental Sciences 2024年第1期37卷 31-41页

作者： HONG tao sun Wei DENG Yuan LYU Jian Da jin Cui Hong bai Ying Long NA Jun ZHANG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun Research Center for Universal Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Pain Management Shengjing Hospital of China Medical UniversityShenyang 110004LiaoningChina Department of Toxicology School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Department of Maternal and Child Health School of Public HealthChina Medical UniversityShenyang 110122LiaoningChina Institute of Preventive Medicine China Medical UniversityShenyang 110122LiaoningChina Institute of Chronic Diseases Liaoning Provincial Center for Disease Control and PreventionShenyang 110000LiaoningChina

Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in *** Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after *** was performed to corroborate these *** In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by *** peak time of nanoplastic absorption in blood was *** Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs.

关键词： Microplastics Nanoplastics IVIS Spectrum small-animal imaging system Tissue distribution Blood

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