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Chinese Journal of Integrative Medicine 2009年第2期15卷 95-100页

作者：杨燕汪受传白文静李瑞丽艾军 Nanjing University of Traditional Chinese Medicine China Academy of Chinese Medical Sciences

Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children s respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A single-blinded multi-center,blocked,randomized and parallel-controlled method was *** clinical study was carried out on 206 children with RSVP-PHBFS who were assigned to two groups,108 in the test group treated through intravenous dripping of Qingkailing Injection(清开灵注射液) in combination of or...

关键词： children respiratory syncytial viral pneumonia phlegm-heat blocking Fei syndrome therapeutic effect evaluation survival analysis

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Two Indium(III)-based Fluorescent Metal-Organic Frameworks for Highly Sensing Fe^(3+),2,4-DNP,and TNP

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Chemical Research in Chinese Universities 2024年第1期40卷 119-126页

作者： WANG Dan li wen li Guanghua HUA Jia liU Yunling State Key Laboratory of Inorganic Synthesis&Preparative Chemistry Jilin UniversityChangchun130012P.R.China

Two novel metal-organic frameworks(MOFs),JLU-MOF130([In(NH2−BDC)(Imi)(1H−Imi)]·DMF·H2O,NH2−H2BDC=2-aminobenzene-1,4-dicarboxylic acid,1H−Imi=1H-imidazole,DMF=N,N-dimethylformamide)and JLU-MOF131([In(1,4-NDC)(Imi)(1H−Imi)]·DMF0.5,1,4-H_(2)NDC=1,4-naphthalene-dicarboxylic acid),were ***-MOF130 features a three-dimensional(3D)architecture with a neb ***-MOF131 is characterized by a two-dimensional(2D)structure with an sql ***-MOF130 has excellent fluorescence detection performance towards Fe^(3+),2,4-dinitrophenol(2,4-DNP),and 2,4,6-trinitrophenol(TNP),but the fluorescence detection performance of JLU-MOF131 is further improved by converting NH2−H2BDC to more conjugated 1,4-H_(2)*** Stern-Volmer(SV)quenching constant(KSV)values of JLU-MOF130 sensing 2,4-DNP,TNP,and Fe^(3+)are 5.24×10^(4),4.44×10^(4),and 4.73×10^(3) L/mol,*** corresponding limit of detection(LOD)values are 1.17,1.36,and 14.59µmol/*** KSV values for JLU-MOF131 are 1.26×10^(5),9.02×10^(4),and 8.48×103 L/mol,and the corresponding LOD values are 0.35,0.42,and 3.60µmol/L,***,the emission wavelengths of the two MOFs obviously shift as the fluorescence emission intensities decrease upon the addition of 2,4-DNP and TNP,which can be applied in selective detection.

关键词： Metal-organic framework Fluorescence quenching Fe^(3+) 2 4-Dinitrophenol(2 4-DNP) 2 4 6-Trinitrophenol(TNP)

Constructing lithium-Free Anode/Separator Interface via 3D Carbon Fabric Scaffold for Ultrasafe lithium Metal Batteries

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Research 2024年第3期2023卷 359-368页

作者： Dongdong li Shengchen Yang Zijian Zheng wen-Yong Lai State Key Laboratory of Organic Electronics and Information Displays(SKLOEID) Institute of Advanced Materials(IAM)School of Chemistry and Life SciencesNanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210023China Department of Materials Chemistry Huzhou University1 Xueshi RoadHuzhou 313000China Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesDepartment of Applied Biology and Chemical TechnologyResearch Institute for Intelligent Wearable Systems(RI-IWEAR)Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityHong Kong SAR 999077China

Metallic lithium represents a promising anode candidate to be utilized in future high-energy lithium ***,the undesirable dendrite growth and fragile solid-electrolyte interphase(SEI)pose critical challenge for pursuing further practical *** contrast to traditional approaches of using inert/lithiophilicity coating,here,we demonstrate a reverse strategy of introducing a highly conductive and lithophobic carbon fabric(CF)scaffold on lithium foil to guide a favorable nucleation site of lithium far away from the anode/separator *** CF scaffold with high conductivity can couple with inner electric field for achieving a uniform distribution of the lithium-ion flux,while the lithophobic feature offers the condition to guide the preferred deposition of lithium onto the underlying lithium foil,which greatly reduces the risk of dendrite-induced short ***,the SEI immersed in the CF scaffold is well supported by CF fibers and therefore exhibits extremely high stability during charge–discharge *** a result,the lithium/CF anodes show>2,000-h stable cycling at 0.5 mA cm−*** metal batteries equipped with our lithium/CF anode deliver a high capacity retention of~99.99%per cycle,i.e.,retain~97.3%capacity after 200 *** unique interface-regulation strategy is versatile for various conductive scaffolds(e.g.,ultrathin and ultralight conductive fabrics),exhibiting high superiority for highly safe lithium metal batteries.

关键词： lithium equipped versatile

Analysis of Weakly Nonlinear Evolution Characteristics of Flow in the Constant Curvature Bend

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Advances in Applied Mathematics and Mechanics 2024年第1期16卷 101-121页

作者： Bin li Haijue Xu Yuchuan bai Ziqing Ji Skate Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Institute for Sedimentation on River and Coastal Engineering Tianjin 300072China

The meandering river is an unstable system with the characteristic of nonlinearity,which results from the instability of the flow and *** on the hydrodynamic nonlinearity of the bend,we use the weakly nonlinear theory and perturbation method to construct the nonlinear evolution equations of the disturbance amplitude and disturbance phase of two-dimensional flow in meandering *** influence of the curvature,Re and the disturbance wave number on the evolution of disturbance amplitude and disturbance phase are ***,the spatial and temporal evolution of the disturbance vorticity is *** research results show:that the curvature makes the flow more stable;that in the evolution of the disturbance amplitude effected by curvature,Re and the disturbance wave number,exist nonlinear attenuation with damping disturbances,and nonlinear explosive growth with positive disturbances;that the asymmetry distribution of the disturbance velocities increases with the curvature;that the location of the disturbance vorticity’s core area changes periodically with disturbance phase,and the disturbance vorticity gradually attenuates/increases with the decrease of the disturbance phase in the evolution process of damping/positive *** results shed light on the construction of the interaction model of hydrodynamic nonlinearity and geometric nonlinearity of bed.

关键词： Curvature bend hydrodynamics weakly nonlinearity disturbance vorticity

Distinct but correct: generating diversified and entity-revised medical response

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Science China(Information Sciences) 2024年第3期67卷 94-113页

作者： Bin li Bin SUN Shutao li Encheng CHEN Hongru liU Yixuan wenG Yongping bai Meiling HU College of Electrical and Information Engineering Hunan University School of Mathematics Sun Yat-sen University JD Technology National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of Sciences Xiangya Hospital of Central South University Teaching and Research Section of Clinical Nursing Xiangya Hospital of Central South University

Medical dialogue generation(MDG) is applied for building medical dialogue systems for intelligent consultation. Such systems can communicate with patients in real time, thereby improving the efficiency of clinical diagnosis. However, predicting correct entities and correctly generating distinct responses remain a great challenge. Inspired by actual doctors’ responses to patients, we consider MDG a two-stage task: entity prediction and dialogue generation. For entity prediction, we design an ent-mac post pre-training strategy by leveraging external medical entity knowledge to enhance the pre-trained model. For dialogue generation, we propose an entity-aware fusion MDG method in which predicted entities are integrated into the dialogue generation model through different encoding fusion mechanisms, using information from different sources. Because the diverse beam search algorithm can produce responses with entities that deviate from the predicted entities, an entity-revised diverse beam search is proposed to correct the entities entailed in the generated responses and make the generated responses more distinct. The experimental results on the China Conference on Knowledge Graph and Semantic Computing 2021(A/B tests) and the International Conference on Learning Representations 2021(online test) datasets show that the proposed method outperforms several state-of-the-art methods, which demonstrates its practicability and effectiveness.

关键词： medical entity prediction ent-mac post pre-training strategy entity-aware fusion medical dialogue generation encoding fusion mechanism entity-revised diverse beam search

Dietary fishmeal replacement by Clostridium autoethanogenum protein meal influences the nutritional and sensory quality of turbot(Scophthalmus maximus)via the TOR/AAR/AMPK pathways

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Animal Nutrition 2024年第3期18卷 84-95页

作者： Zezheng Qi Nan bai Qing li Shihui Pan Min Gu Marine College Shandong UniversityWeihaiShandongChina Key Laboratory of Modern Marine Ranching Technology of Weihai WeihaiShandongChina

Clostridium autoethanogenum protein(CAP)is a promising protein source for aquaculture;however,how CAP influences fish quality is worth extensive *** randomly allocated 630 turbot with initial body weights of about 180 g into 6 groups,with fishmeal-based control diet or diet with CAP replacing 15%(CAP15),30%(CAP30),45%(CAP45),60%(CAP60),or 75%(CAP75)of fishmeal *** a 70-d feeding trial,the fillet yield(P=0.015)and content of protein(P=0.017),collagen(P 0.05).By contrast,the muscle hardness increased linearly with increasing CAP(P=0.004),accompanied by linear reduction of muscle fiber area(P=0.003)and expression of myogenesis-related genes,including cathepsin D(ctsdPlinearly;however,phosphorylation of AMP-activated protein kinase(AMPK,Pling pathway was inhibited,and the amino acid response(AAR)and AMPK pathways were ***,expression of genes related to protein degradation,including myogenic factor 5(myf 5,Plinearly with increasing *** conclusion,CAP could be used to replace up to 15%of fishmeal without negatively impacting turbot ***,higher levels of CAP decreased fillet yield,muscle protein content,and muscle fiber diameter while increasing muscle hardness,which could be attributed to the inhibition of the TOR pathway and activation of the AAR and AMPK pathways.

关键词： Bacterial meal Clostridium autoethanogenum Turbot Fish quality Muscle growth

Distributed adaptive resilient formation control for nonlinear multi-agent systems under DoS attacks

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Science China(Information Sciences) 2024年第10期67卷 391-392页

作者： Hao wen Yongming li Shaocheng TONG College of Science Liaoning University of Technology

The cooperative control for multi-agent systems(MASs)with fixed topology [1–3] has been extensively studied recently. However, in practice, denial-of-service(DoS) attacks become an increasingly important issue due to... 详细信息

关键词： Directed graphs

Nanomaterial Assisted Exosome Analysis Using Mass Spectrometry

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Chemical Research in Chinese Universities 2024年第2期40卷 237-254页

作者： ZHANG Yi ZHOU Bokai li Qiuning JIN Mingshi bai Yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871P.R.China Department of Chemistry Yanbian UniversityYanji133002P.R.China

Exosomes,extracellular vesicles(EVs)that play crucial roles in biological processes,have emerged as attractive targets for noninvasive disease diagnosis and *** spectrometry(MS)offers high sensitivity,high throughput,and excellent qualification and quantification capacity,which is the ideal approach for exosome ***’unique physiochemical properties,controllable morphology,and large surface area make them promising in biological sample pretreatment and *** contributed diverse functions to the exosome MS analysis,encompassing substrates for exosome isolation and cargos enrichment,matrices for laser desorption/ionization(LDI),read-out signals and supporters for signal amplification strategies,*** this review,recent progress in the applications of nanomaterial in the exosome MS analysis was summarized and a comprehensive discussion on the challenges and perspectives was proposed for the development of an advancing analysis approach of exosomes for the accurate diagnosis and monitoring of diseases.

关键词： Exosome Nanomaterial Enrichment Matrix Mass spectrometry

Embedded Majorana islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 154-164页

作者： Jin-Xing Hou Alex Weststrom Rui Wang wen-li Yang Jian li Institute of Modern Physics Northwest UniversityXi’an 710127China Department of Physics School of ScienceWestlake UniversityHangzhou 310030China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi’an 710127China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center for Advanced Microstructures Nanjing 210093China Peng Huanwu Center for Fundamental Theory Xi’an 710127China

Mesoscopic superconducting islands hosting Majorana zero modes(MZMs),or Majorana islands in short,offer a prototype of topological *** this work we investigate theoretically the model of a generic Majorana island tunneling-coupled to a singlepiece metallic substrate,hence an embedded Majorana *** show the crucial consequences of an interplay between the topological ground states nonlocally addressed by the MZMs and the metallic bath with coherent electron propagation:on the one hand,the topological degeneracy on the Majorana island can be preserved,by virtue of the particle-hole symmetry,despite the apparent bath-induced coupling between MZMs;on the other hand,the electronic interference in the metallic bath may lead to profound alterations to the renormalization group behavior of the hybrid system towards low energy/temperature compared with conventional Kondo *** work serves to establish the model of embedded Majorana islands as an experimentally relevant and theoretically intriguing problem particularly in the direction of topological quantum computation.

关键词： topological quantum computation Majorana zero modes topological qubit mesoscopic superconductor topological Kondo effect

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Self-doping active sites in microbe-derived carbonaceous electrocatalysts for the oxygen reduction reaction performance

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Nano Research 2024年第8期17卷 6803-6819页

作者： Xiaofeng Xiao Xiaochun Tian Junpeng li Fan Yang Rui bai Feng Zhao Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Microorganisms are rich in heteroatoms,which can be self-doped to form active sites during pyrolysis and loaded on microbederived carbonaceous *** recent years,microbe-derived carbonaceous materials,characterized with abundant selfdoping sites,have been continuously developed as cost-effective electrocatalysts for oxygen reduction reaction(ORR).To fully unlock the catalytic potential of microbe-derived carbonaceous materials,a comprehensive analysis of catalytic sites and mechanisms for ORR is *** paper provides a summary of the ORR catalytic performance of microbe-derived carbonaceous materials reported to date,with a specific focus on the self-doping sites introduced during their pyrolytic *** highlights the mono-or co-doping sites involving nonmetallic elements such as oxygen(O),nitrogen(N),phosphorus(P),and sulfur(S)atoms,as well as covers the doping of metallic iron(Fe)atoms with various coordination configurations in microbe-derived carbonaceous *** the impact of these self-doping sites on ORR catalytic performance can guide the design of doping sites in microbe-derived carbonaceous *** approach has the potential to maximize electrocatalytic activity of microbe-derived carbonaceous materials and contributes to the development of more efficient and cost-effective carbonaceous electrocatalysts.

关键词： electrocatalysis heteroatoms self-doped single atom catalyst microbe-derived carbonaceous material