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Mechanism of acupuncture for limb spasm of post-stroke spasticity based on GABA and BDNF/Trkb-KCC2 signaling pathway

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Traditional Medicine Research 2024年第7期9卷 42-48页

作者： Qiong-Shuai Zhang Yi Li Yu Zhang Yu-Feng Wang bai-lin song Department of Rehabilitation The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China. Graduate School Changchun University of Chinese MedicineChangchun 130000China. College of Acupuncture-Moxibustion and Tuina Changchun University of Chinese MedicineChangchun 130117China.

Background:To investigate the effects of acupuncture on post-stroke limb spasm model rats and the underlying ***:A total of 50 Sprague-Dawley rats were randomly divided into three groups,Control group(10),Model group(20)and Zhishen Tiaoxing(ZSTX)acupuncture group(20).Middle cerebral artery occlusion was conducted in SD rats to establish post-stroke limb spasm rats,which were treated with ZSTX *** assays were determined by the Narrow ally test,the limb muscle tension was detected by the BL-420S test system,and infarct volume was assessed after the cerebral infarction by 2,3,5-triphenyltetrazolium chloride *** neurotransmitterγ-aminobutyric acid(GABA)and its receptors GABAA and GABAB in the cerebral cortex of the infarct area were determined by immunofluorescence *** release of Trkb and K-Cl cotransporter isoform 2 was detected by an immunofluorescence double labeling *** Blot was utilized to measure the expression of BDNF and ***:The results showed that the behavioral assays in post-stroke limb spasm rats were significantly improved by the treatment of ZSTX acupuncture.14 days of ZSTX acupuncture can effectively inhibit muscle tone and decrease Infarct volume,which was measured with BL-420S biological function experiment system and triphenyltetrazolium ***,the results of Double-Label Immunofluorescence Assays showed that ZSTX acupuncture improved the expression of GABA,GABAA,GABAB,BDNF,and K-Cl cotransporter isoform ***-Label Immunofluorescence Assays and WB results showed that 14 days ZSTX acupuncture declined the expression of ***:Our results suggest that 14 days of ZSTX acupuncture can significantly improve post-stroke limb ***,the pathogenesis of post-stroke limb spasm and the efficacy of ZSTX acupuncture involve metabolic pathways of neurotransmitters,and electro-acupuncture can treat post-stroke limb spasm by regulating BDNF/Trkb-KCC2 signal

关键词： acupuncture scalp acupuncture limb spasm of post-stroke

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HYDROSTATIC STRESS-DEPENDENT PERFECTLY-PLASTIC STRESS FIELDS AT A STATIONARY PLANE-STRESS CRACK-TIP

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Applied Mathematics and Mechanics(English Edition) 1992年第8期13卷 767-770页

作者： lin bai-song Central-South University of Technology Changsha

Under the condition that all the stress components at a crack-tip are the functions ofθonly,making use of equilibrium equations and hydrostatic stress-dependent yield condition,in this paper,we derive the generally analytical expressions of the hydrostatic stress-dependent perfectly-plastic stress fields at a stationary plane-stress *** these generally analytical expressions to the concrete cracks,the analytical expressions of hydrostatic stress-dependent perfectly-plastic stress fields at the tips of mode I and mode II cracks are obtained.

关键词： hydrostatic stress-dependent perfectly-plastic stress field plane-stress crack-tip

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In Vitro and In Vivo Effects and Safety Assessment of Corn Peptides on Alcohol Dehydrogenase Activities

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Chemical Research in Chinese Universities 2011年第5期27卷 820-826页

作者： LI Hong-mei WEN Lian-kui LI Shi-jun ZHANG Da-li lin bai-song College of Food Science and Engineering .lilin Agricultural University Changchun 130118 P. R. China Departement of Cardiac Surgery China-Japan Union Hospital of Jilin University Changchun 130033 R R. China School of Environmental and Biological Engineering Jilin Institute Chemical Technology Jilin 132022 R R. China

The in vitro and in vivo effects of corn peptides（CPs） prepared from corn gluten meal by proteolysis with an alkaline protease and fractions of CPs from Sephadex G-15 and G-10 columns on activities of alcohol dehydroge-nase（ADH） were studied. The results show that CPs and fraction 3 of CPs from Sephadex G-10 column enhance in vitro ADH activity. Furthermore, the in vitro accelerating effect of the fraction 3 of CPs on ADH activity was superior to that of glutathione, which was also found even in the presence of ADH inhibitor, such as pyrazole. In the in vivo experiments, the animals were fed with different dosages of CPs and with a dose of Chinese distilled spirit orally, and sacrificed for the measurement of ADH activity. In vivo experimental results indicate that CPS enhanced hepatic ADH activities. To test the safety of CPs as health food, 30 d feeding test was performed. No obvious toxic effects were detected in treated Wistar rats.

关键词： Corn peptide Activity of alcohol dehydrogenase Activation effect Safety

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Dopamine D2 receptors in the dorsomedial prefrontal cortex modulate social hierarchy in male mice

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Current Zoology 2023年第6期69卷 682-693页

作者： Lai-Fu Li Zi-lin Li bai-lin song Yi Jiang Yan Wang Hua-Wei Zou Lun-Guang Yao Ying-Juan Liu Henan Key Laboratory of Insect Biology in Funiu Mountain Henan International Joint Laboratory of Insect BiologyCollege of Life Science and Agricultural EngineeringNanyang Normal UniversityNanyang 473061HenanChina Research Center of Henan Provincial Agricultural Biomass Resource Engineering and Technology College of Life Science and AgricultureNanyang Normal UniversityNanyang 473061HenanChina

Social hierarchy greatly influences behavior and *** human and animal studies have signaled the medial prefrontal cortex(mPFC)as specifically related to social *** D1 receptors(D1Rs)and D2 receptors(D2Rs)are abundantly expressed in the mPFC,modulat-ing its ***,it is unclear how DR-expressing neurons in the mPFC regulate social ***,using a confrontation tube test,we found that most adult C57BL/6J male mice could establish a linear social rank after 1 week of *** rank individuals showed social anxiety together with decreased serum testosterone levels.D2R expression was significantly downregulated in the dorsal part of mPFC(dmPFC)in lower rank individuals,whereas D1R expression showed no significant difference among the rank groups in the whole *** knockdown of D2Rs in the dmPFC led to mice being particularly prone to lose the contests in the confrontation tube ***,simultaneous D2R activation in the subordinates and D2R inhibition in the dominants in a pair switched their dominant-subordinate *** above results indicate that D2Rs in the dmPFC play an important role in social *** findings provide novel insights into the divergent func-tions of prefrontal D1Rs and D2Rs in social dominance,which may contribute to ameliorating social dysfunctions along with abnormal social hierarchy.

关键词： dopamine receptors medial prefrontal cortex social dominance social hierarchy tube test

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春尺蠖保幼激素结合蛋白AcinJHBP基因的克隆、分子特征与表达分析

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西南农业学报 2024年第7期37卷 1538-1544页

作者：朱圣杰崔阔澍白松林张鹏飞郝水源郝雅娴陈龙河套学院农学系内蒙古巴彦淖尔015000 河套地区绿色农产品安全生产与预警控制实验室内蒙古巴彦淖尔015000 四川省农业技术推广总站成都610041 鄂尔多斯市造林总场内蒙古鄂尔多斯010700 二连浩特市疾病预防控制中心内蒙古二连浩特011100

[目的]探究AcinJHBP基因在春尺蠖生长发育与滞育中的作用。[方法]基于前期所测春尺蠖蛹转录组数据(非滞育蛹-滞育蛹与滞育蛹-滞育解除蛹),克隆获取JHBP基因,命名为AcinJHBP(GenBank登录号:OR860357);利用生物信息学软件分析AcinJHBP基... 详细信息

[目的]探究AcinJHBP基因在春尺蠖生长发育与滞育中的作用。[方法]基于前期所测春尺蠖蛹转录组数据(非滞育蛹-滞育蛹与滞育蛹-滞育解除蛹),克隆获取JHBP基因,命名为AcinJHBP(GenBank登录号:OR860357);利用生物信息学软件分析AcinJHBP基因的序列特征及理化性质;采用qPCR技术检测AcinJHBP的时空表达(不同发育阶段和组织)情况。[结果]春尺蠖AcinJHBP基因完整CDS序列全长726 bp,编码241个氨基酸,蛋白质预测分子量为26.97 kDa,预测等电点为5.13。春尺蠖AcinJHBP基因预测分子式为C_(1211)H_(1915)N_(313)O_(364)S_(9),负电荷残基(Asp+Glu)总电荷为34,正电荷残基(Arg+Lys)总电荷为26,半衰期和脂肪指数分别为30 h和97.51。该蛋白的平均亲水性为-0.098,预测不稳定系数为27.13,故该蛋白属于亲水稳定蛋白,N端氨基酸为蛋氨酸(Met,M)。AcinJHBP在N端含一个长为17个氨基酸残基的信号肽,但无跨膜区;磷酸位点检测分别发现丝氨酸、苏氨酸和酪氨酸磷酸位点分别为9、6和3个,未发现糖基化位点。亚细胞定位结果显示,其主要位于细胞外。系统进化结果表明,AcinJHBP与同为鳞翅目尺蛾科的冬尺蠖(Operophtera brumata)血淋巴保幼激素结合蛋白JHBP亲缘关系最近。基因表达结果显示,在不同发育阶段,AcinJHBP基因在春尺蠖卵至5龄幼虫期间表达均较低(3龄幼虫除外),且无显著差异(P>0.05),而在非滞育蛹-成虫期,AcinJHBP表达量呈逐渐下降趋势。在不同组织中,春尺蠖AcinJHBP基因在雄虫头部表达量最高。[结论]AcinJHBP基因与春尺蠖生长发育与滞育密切相关,该结果为进一步揭示该基因在春尺蠖蛹越夏、越冬滞育中的功能奠定一定理论基础。

关键词：春尺蠖保幼激素结合蛋白基因分子特征表达谱

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High-lattice-adapted surface modifying Na_(4)MnV(PO_(4))_(3) for better sodium storage

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Nano Research 2024年第4期17卷 2728-2735页

作者： Chongran song Shiyu Li Ying bai International Joint Research Laboratory of New Energy Materials and Devices of Henan Province School of Physics and ElectronicsAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng 475004China

Sodium-ion batteries(SIBs)are required to possess long cycle life when used for large-scale energy *** polyanionic Na_(4)MnV(PO_(4))_(3)(NMVP)reveals good cyclic stability due to its unique three-dimensional(3D)frame structure,but it still faces the challenge of interfacial degradation in practical *** this work,NASICON-type Na_(1.3)Al_(0.7)Ti_(1.3)(PO_(4))_(3)(NATP)was deposited on the surface of NMVP to promote interface stability by surface modification and gradient *** a result,the optimized NMVP@2%NATP released a capacity retention of 44.8%after 1000 cycles at 5 C,much higher than that of the initial NMVP(28.9%).The enhanced electrochemical performance was mainly attributed to NATP coating acting as a fast ion transport carrier and physical barrier,significantly facilitating the Na^(+)diffusion and isolating side reaction at the electrode/electrolyte *** the other hand,Ti_(4)^(+)and Al^(3+)cations from the NATP were partially doped inside the NMVP surface to boost the transport of Na^(+),and the perfect lattice matching of NVMP and NATP improved the interface and structural stability accompanying long *** work demonstrated the effectiveness of surface modification with high lattice match material and provided new perspectives for high energy density solid-state SIBs.

关键词： high-lattice-adapted cathode surface modification sodium-ion batteries

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Multicolor emission from lanthanide ions doped lead-free Cs_(3)Sb_(2)Cl_(9) perovskite nanocrystals

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Journal of Rare Earths 2024年第5期42卷 940-946,I0005页

作者： He Shao Lifang Li Xiufeng Wu lin Xu Biao Dong Donglei Zhou Xue bai Hongwei song State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials College of Materials Science and EngineeringNanjing University of Posts&TelecommunicationsNanjing210023China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and Engineering Jilin UniversityChangchun130012China

The toxicity of lead ions has become the severe challenge for the all-inorganic lead halide p erovskite materials,although some works have rep orted the lead-free perovskite nanocrystals(NCs),the photoluminescence quantum yield(PLQY)of these materials is still ***,because the halogen ions can be easily exchanged,the controllable multicolor emission in perovskite NCs is difficult to realize in current *** this work,we introduced lanthanide ions into lead-free Cs_(3)Sb_(2)Cl_(9) perovskite *** from the energy transfer between Cs_(3)Sb_(2)Cl_(9) perovskite NC host and lanthanide ions,the multicolor emission was *** on controlling the doping concentration of Tb^(3+)and Eu^(3+)ions,the white light emission under UV excitation would be turned easily in the Tb^(3+)/Eu^(3+)codoped *** addition,efficient energy transfer from perovskite NCs to Tb^(3+)or Eu^(3+)ions is beneficial to improving the optical properties of lead-free perovskite NCs,resulting in maximum PLQYs of red,green and white light emission of 22.6%,19.7%and 28.5%,***,a white light emitting device(WLED)was fabricated with a power efficiency of 18.5 lm/W,which presents the Commission Internationale de l'Eclairage(CIE)of(0.33,0.35).

关键词： Perovskite nanocrystals Lead free Lanthanide ions Energy transfer White light emitting device Rare earths

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Effect of operational and geometric parameters on the hydrodynamics of a Wurster coater:A CFD-DEM study

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Particuology 2024年第2期85卷 62-76页

作者： Yinqiang song Tuo Zhou Ruiqi bai Man Zhang Hairui Yang Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Tsinghua UniversityBeijing100084China State Key Laboratory of Power System and Generation Equipment Tsinghua UniversityBeijing100084China

A coupled CFD-DEM method was used to study the hydrodynamics of a Wurster ***,the CFD part of the model was validated by the accurate prediction of the pressure drops over a pseudo-2D fluidized bed under various gas *** effect of gas velocity,gap height,tube length and batch volume of the particles on the cycle time and the residence time of the particles was thoroughly *** central jet gas velocity ui was found to speed up the particle cycle but undermine the coating *** gas velocity at the horizontal transport zone u2 was able to promote the horizontal transport of the particles but should not be too high,otherwise,it would obstruct the normal falling back of the particles in the downward *** gap heights would decrease the coating efficiency but tube length had little impact on *** increment of batch volume would commonly abase the cycle time and the working efficiency under a given *** de-fluidization problem arose when the batch volume increased to 550 ***,this problem could be swept out by the optimization of u1 and *** a mixture of different sizes,the coarse particles enjoyed higher coating efficiency and could travel closer to the *** may shield the fine particles from getting enough coating liquids,and thus coarse particles and fine particles were not recommended to get coated in the same batch.

关键词： Numerical simulation CFD-DEM Wurster coater Hydrodynamics Cycle time Residence time

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A New Method for the Aging Evaluation of Oil-Paper Insulation Using η-Butanol and Methanol

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 717-726页

作者： Jianyi Wang Yuanxiang Zhou Jun Liu Zhaowei Wang song bai Jiayu Lu Department of High Voltage China Electric Power Research InstituteBeijing 100192China State Key Laboratory of Power Grid Environmental Protection Beijing 100192China Electrical Engineering Department Tsinghua UniversityBeijing 100084China Solar Storage Division of State Key Lab of Power System and Generation Equipment School of Electrical EngineeringXinjiang UniversityUrumqi 830047China State Grid Wuwei Electric Power Supply Company Wuwei 733000China

To improve the accuracy and efficiency of the aging life prediction and assessment of transformer oil-paper insulation,and to make up for the deficiencies of traditional characterizers,such as 2-furfural,carbon monoxide,and carbon dioxide,a method for the simultaneous determination of methanol,ethanol,n−propanol,and η-butanol in oil with a single injection is established by headspace-gas chromatography-mass *** measured results show that the determination limits of the four alcohol characterizers can be controlled to 10μg/kg *** on this method,the change patterns of the above four alcohols with thermal aging time and degree of polymerization are obtained through thermal aging experimental ***,η-propanol,and η-butanol in oil indicate nearly linear correlations with thermal aging time and degree of polymerization,similar to that of *** analyzing 52 sets of measured data of 500 kV EHV transformers in operation,η-butanol is found to have excellent performance,and a new method to evaluate the aging state of oil-paper insulation employing η-butanol and methanol is proposed along with the aging attention value *** measured data of 500 kV EHV transformers in operation indicate that the combination of η-butanol and methanol as the preferred characterizers can effectively compensate for the shortcoming of traditional characterizers in the early stages of aging,and the feasibility of the method is *** possible pathways for the generation of η-butanol by cellulose cleavage during the aging of oil-paper are proposed from the chemical structure of cellulose.

关键词： Aging characterization determination method methanol η-butanol oil-paper insulation 500 kV transformers

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Influences of oscillation on the physical stability and explosion characteristics of solid-liquid mixed fuel

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Defence Technology（防务技术） 2024年第10期40卷 191-198页

作者： Chi Zhang Ge song Hui Guo Jiafan Ren Chunhua bai Beijing Aerospace Propulsion Institute Beijing 100076China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The stratification phenomenon resulting from differences in the physical properties of solid-liquid components seriously affect the final combustion and explosion characteristics of mixed fuel under the action of *** effects of oscillation on the physical stability of mixed fuel with two solid-liquid ratios and three liquid component distribution ratios have been investigated using a self-designed experimental system at oscillation frequencies of 60-300 r/*** explosion characteristics of mixed fuel before and after oscillation are gained from a 20 L spherical explosion container *** the mass ratio of liquid components is controlled at 66.9%,64.7%,62.6%the final explosion characteristics are stable,with a maximum difference of only 0.71%.The volume of liquid fuel precipitation increases with increasing oscillation frequency when the mass ratio of liquid components reaches 71.7%,69.6%,67.7%.The fuel explosion overpressure after oscillation decreases with increasing liquid precipitation volume,and the repeatability is poor,with a maximum standard deviation of 82.736,which is much higher than the ratio without *** controlling the mass ratio of liquid components of the mixed fuel can effectively combat the impact of oscillation on the physical state and maintain the stability of the final explosion characteristics.

关键词： Solid-liquid mixed fuel Physical stability Explosion characteristics

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