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A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis

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Bone Research 2024年第1期12卷 227-239页

作者： Yong Li Zhengwen Cai Wenjuan Ma Long bai En Luo yunfeng Lin State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengduSichuan 610041PR China Department of Oral and Maxillofacial Surgery Affiliated Stomatological HospitalSouthwest Medical UniversityLuzhouSichuan 646000PR China Sichuan Provincial Engineering Research Center of Oral Biomaterials ChengduSichuan 610041China

Diabetic osteoporosis(DOP)is a significant complication that poses continuous threat to the bone health of patients with diabetes;however,currently,there are no effective treatment strategies.In patients with diabetes,the increased levels of ferroptosis affect the osteogenic commitment and differentiation of bone mesenchymal stem cells(BMSCs),leading to significant skeletal changes.To address this issue,we aimed to target ferroptosis and propose a novel therapeutic approach for the treatment of DOP.We synthesized ferroptosis-suppressing nanoparticles,which could deliver curcumin,a natural compound,to the bone marrow using tetrahedral framework nucleic acid(tFNA).This delivery system demonstrated excellent curcumin bioavailability and stability,as well as synergistic properties with tFNA.Both in vitro and in vivo experiments revealed that nanoparticles could enhance mitochondrial function by activating the nuclear factor E2-related factor 2(NRF2)/glutathione peroxidase 4(GPX4)pathway,inhibiting ferroptosis,promoting the osteogenic differentiation of BMSCs in the diabetic microenvironment,reducing trabecular loss,and increasing bone formation.These findings suggest that curcumin-containing DNA tetrahedron-based ferroptosissuppressing nanoparticles have a promising potential for the treatment of DOP and other ferroptosis-related diseases.

关键词： curcumin osteoporosis diabetic

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Strigolactones modulate cotton fiber elongation and secondary cell wall thickening

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Journal of Integrative Agriculture 2024年第6期23卷 1850-1863页

作者： Yunze Wen Peng He Xiaohan bai Huizhi Zhang yunfeng Zhang Jianing Yu College of Life Sciences Shaanxi Normal UniversityXi’an 710119China

Cotton is one of the most important economic crops in the world,and it is a major source of fiber in the textile industry.Strigolactones(SLs)are a class of carotenoid-derived plant hormones involved in many processes of plant growth and development,although the functions of SL in fiber development remain largely unknown.Here,we found that the endogenous SLs were significantly higher in fibers at 20 days post-anthesis(DPA).Exogenous SLs significantly increased fiber length and cell wall thickness.Furthermore,we cloned three key SL biosynthetic genes,namely GhD27,GhMAX3,and GhMAX4,which were highly expressed in fibers,and subcellular localization analyses revealed that GhD27,GhMAX3,and GhMAX4 were localized in the chloroplast.The exogenous expression of GhD27,GhMAX3,and GhMAX4 complemented the physiological phenotypes of d27,max3,and max4 mutations in Arabidopsis,respectively.Knockdown of GhD27,GhMAX3,and GhMAX4 in cotton resulted in increased numbers of axillary buds and leaves,reduced fiber length,and significantly reduced fiber thickness.These findings revealed that SLs participate in plant growth,fiber elongation,and secondary cell wall formation in cotton.These results provide new and effective genetic resources for improving cotton fiber yield and plant architecture.

关键词： strigolactones fiber elongation secondary cell wall thickening cotton

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个人政府信息更正请求权之建构

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上海交通大学学报（哲学社会科学版） 2024年第4期32卷 66-78页

作者：白云锋南京大学法学院南京210093

信息化时代,个人信息包含个人市场信息和个人政府信息双重意涵,个人信息权利具有私权利和公权利双重面向。就权利基础而言,个人对于政府的信息更正请求是一种基于消极地位的防御请求权。就权利构造而言,个人政府信息更正权利的提出主体... 详细信息

信息化时代,个人信息包含个人市场信息和个人政府信息双重意涵,个人信息权利具有私权利和公权利双重面向。就权利基础而言,个人对于政府的信息更正请求是一种基于消极地位的防御请求权。就权利构造而言,个人政府信息更正权利的提出主体、是否记录不准确的判断主体,原则上均为本人。个人政府信息更正的内容应该区分事实与评价。信息更正的方式包括追加、更正和删除,其中删除标准不同于被遗忘权基于个人评价的主观标准,是基于事实是否准确的客观标准。个人申请信息更正无须实行公开申请前置主义,应由行政机关在审查更正申请时进行信息公开性的审查。就权利救济而言,应坚持更正申请前置,区分信息记录行为审查与行政行为审查,并允许法院在个人政府信息记录明显不准确的情形下作出变更判决。

关键词：个人信息保护政府信息公开公权利日本行政机关个人信息保护法

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欠发达地区农产品产地冷链建设影响因素与对策研究

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中国农业资源与区划 2024年第3期45卷 88-96页

作者：洪岚刘媛白云凤北京物资学院经济学院北京101126

[目的]我国欠发达地区的农产品产地冷链物流起步晚、发展基础薄弱,补齐产地冷链短板对增强农产品产业链韧性、实现冷链产业安全稳定发展有重要意义。[方法]文章基于各地的冷链物流专题调研资料,结合前期研究基础,通过扎根理论对资料进... 详细信息

[目的]我国欠发达地区的农产品产地冷链物流起步晚、发展基础薄弱,补齐产地冷链短板对增强农产品产业链韧性、实现冷链产业安全稳定发展有重要意义。[方法]文章基于各地的冷链物流专题调研资料,结合前期研究基础,通过扎根理论对资料进行编码分析,实现对欠发达地区产地冷链物流制约因素的概念化和范畴化。在此基础上,运用解释结构模型(Interpretative Structural Modeling Method,ISM模型)理清各项制约因素间的内在关联,构建层级递阶结构。[结果]结果表明,产地冷链物流制约因素共14项,其结构体系可划分为3个层次,其中产地物流设施水平低和上下游主体缺乏协调是欠发达地区产地冷链物流发展滞后的直接制约因素,位于表象层;企业投资回报率低、公共信息平台建设滞后等7项因素位于中间层;农户生产规模小且加工粗放型、设备投资额大和回收期过长、资产专用性强、追溯技术水平不高以及人才供给数量质量不足是最根本制约因素,位于根源层。[结论]欠发达地区需进一步重视产地冷链物流发展,从鼓励新型农业主体发展、吸纳各类资本参与产地建设、降低专用性冷链设备投资风险等方面补齐产地冷链短板。

关键词：冷链物流欠发达地区 ISM模型扎根理论产地冷链

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Pulse waves in hydrogen peroxide-sulfite-thiosulfate-perchlorate acid system

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Chinese Science Bulletin 2005年第16期50卷 1688-1690页

作者： AN Yingli bai yunfeng GAO Qingyu College of Chemical Engineering China University of Mining andTechnology Xuzhou 221008 China

The spatiotemporal dynamics of the hydrogen peroxide-thiosulfate-sulfite-perchlorate acid system was in-vestigated in reaction-diffusion medium. In the Petri dish, pulse waves were discovered, which had the maximum life-time and the maximum traveling distance when the initial concentration of thiosulfate was increased. In addition, pulse waves contracted back before disappearing, and the pulse waves with red spot were observed when the initial concen- tration of hydrogen peroxide was higher. The experimental results were analyzed and explained according to the reac- tion mechanism of positive and negative feedback in this system.

关键词：脉冲波过氧化氢亚硫酸盐非线性化学特性自身催化作用

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A Novel Coumarin-based Fluorescence Chemosensor for Fe^3＋

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Chemical Research in Chinese Universities 2014年第4期30卷 560-565页

作者： WANG Ruiping WAN Qihua FENG Feng bai yunfeng Department of Chemistry College of Sciences Nanchang University Nanchang 330047 P. R. China Department of Chemistry Datong University Datong 037009 P. R. China

A novel coumarin derivative[7-diethylamino-2-oxo-2H-chromene-3-carboxylic acid（6-amino-pyridin2-yl）-amide,CFe1] has been synthesized and its potential application as a chemosensor for the detection of metal ions has been further investigated.The responses of CFe1 to Fe^3＋ were studied by fluorescence emission spectrometry in the presence of other metal ions such as Al^3＋,Ba^2＋,Ca^2＋,Co^3＋,Cr^3＋,Cu^2＋,Fe^2＋,Hg^2＋,Mg^2＋,Mn^2＋,Na^＋,Ni^＋,Pb^2＋,Zn^2＋,K^＋,and Ag^＋.CFe1 showed a good selectivity for Fe^3＋ with fast response,a wide pH span of 3.3-9.18,and a large Stocks shift.CFe1 in the presence of Fe^3＋ and ethylene diamine tetraacetic acid（EDTA） makes the blue solution fade to colorless,which is due to the formation of CFe1-Fe^3＋ complex instead of any catalytic action of Fe^3＋.Furthermore,the imaging of Fe^3＋ in cultured single mice microglia cells was realized with the aid of CFe1,indicating that CFe1 has a great potential to be used as promising models for the future design of novel and robust chemosensor for metal ion detection in the field of biomedical and environmental analyses.

关键词： Coumarin Fe3＋ Fluorescence Selectivity

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三塘湖-淖毛湖地区地下水水质评价及PMF溯源解析

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环境科学学报 2024年第6期44卷 185-192页

作者：白云峰曾妍妍周金龙新疆农业大学水利与土木工程学院乌鲁木齐830052 新疆水文水资源工程技术研究中心乌鲁木齐830052 新疆水利工程安全与水灾害防治重点实验室乌鲁木齐830052

基于三塘湖-淖毛湖地区2022年地下水水质数据,运用描述性统计分析和Durov图开展了地下水水化学特征分析,采用基于熵权的水质指数法分别对潜水、承压水进行水质评价,并结合正定矩阵因子分解模型、Gibbs图、离子比值等方法进行水质影响因... 详细信息

基于三塘湖-淖毛湖地区2022年地下水水质数据,运用描述性统计分析和Durov图开展了地下水水化学特征分析,采用基于熵权的水质指数法分别对潜水、承压水进行水质评价,并结合正定矩阵因子分解模型、Gibbs图、离子比值等方法进行水质影响因素的溯源分析.结果表明:研究区地下水整体为弱碱性淡水,地下水水化学类型主要为HCO_(3)·SO_(4)型.地下水EWQI(基于熵权的水质指数)值为22.57~115.59,潜水和承压水中水质优良的水样占比分别为70.6%和77.8%.研究区地下水化学组分的形成主要受到岩石溶滤-蒸发浓缩(47.2%)、弱碱性水环境(35.2%)和农业活动(17.6%)的影响,其中以蒸发盐岩和硅酸盐岩的溶解作用为主,弱碱性地下水环境促进了阳离子交替吸附作用,导致地下水中盐分不断富集,频繁的农业活动是研究区地下水中NO3-的主要来源.

关键词：地下水水质评价溯源解析三塘湖-淖毛湖地区

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基于ANSYS Workbench的无袖紧身传感服装设计

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Journal of Donghua University(English Edition) 2024年第1期41卷 8-14页

作者：白云峰郑丽丁浩朱世根东华大学机械工程学院上海201620 东华大学纺织装备教育部工程研究中心上海201620

为减小人体运动时搭载于紧身服装上的传感模块与人体皮肤间的滑移,采用数值模拟仿真的方法对服装进行了优化设计。首先,利用逆向工程软件Geomagic Studio,建立了人体上半身和无袖紧身服装实体模型;其次,根据紧身服装的款式及各区域皮肤... 详细信息

为减小人体运动时搭载于紧身服装上的传感模块与人体皮肤间的滑移,采用数值模拟仿真的方法对服装进行了优化设计。首先,利用逆向工程软件Geomagic Studio,建立了人体上半身和无袖紧身服装实体模型;其次,根据紧身服装的款式及各区域皮肤变形范围,对无袖紧身服装进行了裁剪分片设计;最后,以跑步时人体的运动状态为例,利用ANSYS Workbench有限元分析平台,研究了当不同弹性面料组合成服装时传感模块装配点相对皮肤的位置变化。结果显示,当前片和后片选择弹性较好的面料、肩膀和侧边片选择弹性较差的面料时,传感模块与人体皮肤之间的滑移量较小。

关键词： Workbench 传感模块无袖紧身服装滑移上半身

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Effectiveness and safety of Chinese herbal medicines for hepatitis B virus-related acute-on-chronic liver failure:study protocol for a multicenter randomized controlled trial

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Journal of Traditional Chinese Medicine 2020年第6期40卷 1052-1059页

作者： Zhang Ning Zhou Chao Wang Lifu He Tingting Wang Yao Wang Yan bai yunfeng Li Jun Xiao Xiaohe Gong Man Integrated Traditional Chinese Medicine&Western Medicine Department the Fifth Medical CenterGeneral Hospital of PLABeijing 100039China

OBJECTIVE:To conduct a multicenter randomized controlled trial of the efficacy of standardized Chinese herbal medicines(CHMs)against acuteon-chronic liver failure(ACLF)and provide reproducible and high-level evidence for clinical practice.METHODS:This is a prospective,multicenter,centrally randomized controlled trial.Patients diagnosed with hepatitis B virus-related ACLF(n=510)will be allocated to the standard medical therapy or CHM group at a 1∶1 ratio.Two CHMs will be used on the basis of the traditional Chinese medicine syndrome:Liangxue Jiedu granules for excess syndromes and Yiqi Jiedu granules for deficiency syndromes.The primary outcome is transplant-free survival at week 12.The secondary outcomes are(a)transplant-free survival at week 24,(b)liver function as assessed using the model for end-stage liver disease score at week 12,(c)liver function as assessed using the Child-Pugh score at week 12,and(d)the incidence of complications at week 12.DISCUSSION:The effectiveness and safety of CHM formulations will be assessed following treatment for ACLF.TRIAL REGISTRATION:The trial was registered at Clinical Trials.gov(NCT03577938)on June 24,2018.

关键词： Acute-on-chronic liver failure Hepatitis B chronic Drugs Chinese herbal Randomized controlled trial Clinical protocols

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Numerical analysis of electromagnetic force field through the use of two examples

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Baosteel Technical Research 2013年第3期7卷 50-56页

作者： bai yunfeng Special Steel R & D Center Research InstituteBaoshan Iron & Steel Co.Ltd

In modern processing of conducting materials, such as steel,the time-varying electromagnetic field plays a key role in obtaining the desired microstructure or eliminating solidification defects such as porosity and segregation in cast billets. Up to now,few studies on the induced electromagnetic force （also called the Lorentz force） field in liquid metal have been reported. Compared with the magnetic field, the induced force field is the real and only direct cause for flow control. The electromagnetic force is comprised of two components. One is time-independent and the other is time- dependent. The time-dependent component varies with time in both amplitude and direction. When it reaches the extreme value,it can be one dozen times larger than the time-independent component. In this paper, a new method to quantitatively describe the induced electromagnetic force in liquid metal under a harmonic electromagnetic field,including both its time- independent and dependent components, was proposed based on the formula derivation from the data of amplitude and phase angle. Through this method ,the features of the time-dependent component were discussed, including the directions of rotation and the long axis. As a result, the force pattern was described. With two example calculations, the method was explained in detail. The results of both examples show that the force field in liquid metal can be divided into several regions with different force features. Example 1 shows the effect of coil position on the evolution of the force field pattern in liquid metal. Example 2 is a kind of stirring by the travelling magnetic field ,whose results present the sub-structures in metal and show that most of them have almost the same rotating direction.

关键词： electromagnetic force field numerical analysis time-dependent component quantitative description sub-structure in force field

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