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Discriminating Potential of Extraintestinal Systemic Manifestations and Colonoscopic Features in Chinese Patients with Intestinal Beh~：et＇s Disease and Crohn＇s Disease

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Chinese Medical Journal 2015年第2期128卷 233-238页

作者： Ji Li Pan Li Jing bai Hong Lyu Yue Li Hong Yang Bo Shen Jia-Ming Qian department of Gastroenterology Peking Union Medical College Hospital Beijing 100730 China department of Gastroenterolgy First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China department of Intensive Care Beijing Friendship Hospital Capital Medical University Beijing 100050 China department of Gastroenterology-A31 The Cleveland Clinic Foundation 9500 Euclid Ave Cleveland OH 44195 USA

Background：The distinction between intestinal Beh（c）et＆#39;s disease （BD） and Crohn＆#39;s disease （CD） is always challenging due to many overlapping clinical *** conducted a retrospective study to reveal valuable strategies for the differential diagnosis between intestinal BD and CD in Chinese patients based on their clinical and colonoscopic ***：Thirty-five intestinal BD patients and 106 CD patients hospitalized from January 1983 to January 2.10,who had ulcerative lesions in the terminal ileum or colon under colonoscopy and no history of gastrointestinal operation except appendectomy before admission,were *** and multivariate logistic regression analyses were conducted to find discriminating predictors among demographic data,clinical manifestations,and colonoscopic ***：Based on univariate analysis,massive gastrointestinal hemorrhage,fever,and extraintestinal systemic manifestations were more common in intestinal BD patients （P =0.02.,0.048 and 0.001,respectively）,while diarrhea,intestinal obstruction,and perianal lesions were more common in CD patients （P =0.002.0.010,and 0.02. respectively）.Based on colonoscopy,focal involvement,ileocecal valve deformity,solitary ulcers,large ulcers （ulcer size 〉 2.cm）,and circumferential ulcers were more common in intestinal BD patients （P =0.003,0.003,0.014,0,013,and 0.003,respectively）,while segmental involvement,longitudinal ulcers,a cobblestone or nodular appearance,and pseudo-polyps were more common in CD patients （P =0.003,0.008,0.02.,and 0.002.respectively）.Based on multivariate logistic regression analysis,diarrhea,extraintestinal manifestations,ulcer distribution,size,and type,and pseudo-polyps were independent discriminating predictors between the two groups （P =0.048,0.008,0.006,0.02.,0.002.and 0.041,respectively）.The discriminating algorithm composed of the above independent predictors had the highest area under the curve of 0.987 for distinguishing between the two dis

关键词： Behcet's Disease Colonoscopy Crohn's Disease Differential Diagnosis

安徽省维持性血液透析患者血清磷水平及其影响因素分析

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临床肾脏病杂志 2024年第6期24卷 446-451页

作者：钮铮石瑞汪炜李秀勇白友为刘智梁绍钦陈雷王德光安徽医科大学第二附属医院肾内科合肥230601 宣城市人民医院血液净化中心宣城242099 阜阳市第二人民医院血液净化中心阜阳236029 六安市人民医院肾内科六安237008 安徽理工大学第一附属医院肾脏内科淮南232007 亳州市人民医院血液净化中心亳州236804 金楠肾脏病专科医院血液净化中心合肥230071

目的分析维持性血液透析(maintenance hemodialysis,MHD)患者血清磷水平现状及其与临床指标的关系,探讨血清磷水平的相关影响因素。方法本研究为多中心横断面研究。纳入2.19~2.2.年安徽医科大学第二附属医院血液净化中心等2.家透析中心2...

目的分析维持性血液透析(maintenance hemodialysis,MHD)患者血清磷水平现状及其与临床指标的关系,探讨血清磷水平的相关影响因素。方法本研究为多中心横断面研究。纳入2.19~2.2.年安徽医科大学第二附属医院血液净化中心等2.家透析中心2.67例MHD患者,收集相关人口学特征、原发病、实验室检查等资料。按照血清磷水平分为低血磷组(磷1.78 mmol/L)。单因素方差分析3组间临床指标的差异,多元线性回归分析血清磷水平的相关影响因素。结果MHD患者中,低血磷组、正常血磷组、高血磷组分别占比7.6%、35.3%和57.1%。Spearman相关分析发现,年龄(r=-0.167,P2.3,P2.3,P2.9,P2.)、老年营养风险指数(r=0.162.P2.8,P2.P<0.001)、血镁(β=0.117,P<0.001)、甲状旁腺激素(β=0.196,P<0.001)独立相关。结论MHD患者高磷水平占比较高,血红蛋白、尿素氮、肌酐、血钙、血镁、甲状旁腺激素是影响MHD患者血磷水平下降的独立因素。

关键词：血清磷维持性血液透析甲状旁腺激素

Images for diagnosis Sarcomatoid carcinoma of the renal pelvis in duplex kidney

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Chinese Medical Journal 2011年第13期124卷 2074-2076页

作者： CHEN Ge-ming CHEN Shan-wen XIA Dan LI Jun YAN Sheng JIN bai-ye department of Urology First Affiliated Hospital Medical College of Zhejiang University Hangzhou Zheiiang 310031 China department of Pathology First Affiliated Hospital Medical College of Zhejiang University Hangzhou Zheiiang 310031 China department of Surgery First Affiliated Hospital Medical College of Zhejiang University Hangzhou Zheiiang 310031 China

Sarcomatoid transitional cell carcinoma of the renal pelvis is a rare neoplasm with only 14 well-illustrated examples reported previously. Duplex kidney is the most common congenital abnormality of the urinary tract, with an incidence of around 2.. Neoplasia of the renal pelvis in duplex kidney is rare. We reported a case whose sarcomatoid carcinoma originated from the upper portion of the duplicated renal pelvis with hydronephrosis, and total nephroureterectomy with bladder cuff excision surgery of both renal units was carried out. Because of the rare nature of renal pelvic sarcomatoid carcinoma and its apparent lack of response to adjuvant therapy, it is essential to do early diagnosis and early radical surgery to improve survival. It is important to stress the need for frequent and diligent monitoring or treating complex duplex kidney with hydronephrosis of either moiety in case of a risk of havina neoplasias.

关键词： duplicated renal pelvis sarcomatoid transitional cell carcinoma

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唐百戏赋简论

上海交通大学学报（哲学社会科学版） 2003年第1期11卷 72-76页

作者：赵俊波四川大学中文系四川成都610064

以唐代百戏赋为考察对象 ,分析了百戏赋的创作在唐代走向兴盛的原因 ,探讨了其在史料保存、题材开拓及创作手法诸方面的意义。

关键词：百戏赋题材史料保存创作手法唐代

Wearable sensors for activity monitoring and motion control:A review

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Biomimetic Intelligence & Robotics 2023年第1期3卷 1-10页

作者： Xiaoming Wang Hongliu Yu Soren Kold Ole Rahbek Shaoping bai department of Materials and Production Aalborg UniversityAalborg 9220Denmark Rehabilitation Engineering and Technology Institute University of Shanghai for Science and TechnologyShanghai 200093China department of Orthopedic Surgery Aalborg University HospitalAalborg 9220Denmark

Wearable sensors for activity monitoring currently are being designed and developed,driven by an increasing demand in health care for noninvasive patient monitoring and rehabilitation *** article reviews state-of-the-art wearable sensors for activity monitoring and motion *** technologies,including electromechanical,bioelectrical,and biomechanical sensors,are reviewed,along with their broad ***,an overview of existing commercial wearable products and the computation methods for motion analysis are *** research issues are identified and discussed.

关键词： Wearable sensor Activity monitoring and tracking Intelligent motion control Human–machine interface

Combination of medial patellofemoral ligament reconstruction with vastus medialis advancement for chronic patellar dislocation

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Chinese Medical Journal 2010年第21期123卷 3024-3029页

作者： WANG Fei KANG Hui-jun CHEN bai-cheng CHEN Wei SU Yah-ling ZHANG Ying-ze department of Joint Surgery Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Orthopedic Institute Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Center of Trauma Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China

Background The medial patellofemoral ligament （MPFL） reconstruction is popular in clinical practice for chronic patellar dislocation; however, the combination with vastus medialis advancement is rare. The aim of this study was to evaluate the clinical outcome of the combination of MPFL reconstruction with vastus medialis *** We retrospectively analyzed 69 patients with chronic patellar dislocation between July 2.04 and October 2.08： twenty eight cases with isolated MPFL reconstruction （group Ⅰ）, forty one cases with the combination of MPFL reconstruction with vastus medialis advancement （group C）. All patients had CT scans available for review with knee flexion at 30 degree, on which the congruence angle, patellar tilt angle and patellar lateral shift were measured. Physical apprehension tests were examined and the redislocation was recorded. In addition, knee function was evaluated using the Kujala score and subjective *** Patients were followed up for a mean of 42.months （12.65 months） without a recurrent dislocation ***, all indexes on CT scan were within the normal range without a statistical difference between the two groups. Results from the apprehension test showed eight patients in group Ⅰ and three in group Chad patellar lateral shift exceeding 1.5 cm with a hard end point （P 〈0.05）. The Kujala score improved significantly from 51.3±4.5 to 79.9±6.2.in group Ⅰ and from 53.7±5.2.to 83.9±6.5 in group C （P 〉0.05）. However, the subjective questionnaire revealed a significant difference （P 〈0.05）, including 12.excellent, seven good and nine fair in group Ⅰ and 30 excellent, six good and five fair in group *** The combination of MPFL reconstruction with vastus medialis advancement is better than isolated reconstruction to improve the subjective effects and decrease the patellar instability rate for chronic patellar dislocation.

关键词： patellar dislocation medial patellofemoral ligament isometric reconstruction combined reconstruction vastus medialis advancement

Antitumor activity of F90, an epidermal growth factor receptor tyrosine kinase inhibitor, on glioblastoma cell line SHG-44

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Chinese Medical Journal 2008年第17期121卷 1702-1706页

作者： LIU Fang-jun GUI Song-bai LI Chu-zhong SUN Ze-lin ZHANG Ya-zhuo Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background Over-expression of epidermal growth factor receptor （EGFR） is thought to be related to cell proliferation, invasion, metastasis, resistance to chemoradiotherapy and poor prognosis of various human cancers. Forty percent to fifty percent of glioblastoma multiforme （GBM） possess deregulated EGFR, which may contribute to the aggressive and refractory course of GBM. Therefore, blockade of EGFR signal transduction may be a promising treatment strategy for GBM. Methods MTT assay, cell growth curve assay and tumor xenograft model were used to evaluate the antitumor activity of F90 against SHG-44 in vitro and in vivo. Western blot assay was applied to evaluate the expression of p-EGFR, p-ERK1, p-JNK, p-P38, Bcl2.and P53 proteins. Results F90 inhibited the cell proliferation in a dose-dependent manner in vitro. The growth of SHG-44 tumor xenografts was suppressed by F90 at a high dose level （100 ***^-1·d^-1）. Phosphorylation of EGFR and activated downstream signaling proteins, such as ERK1, JNK and P38, were found to be depressed after incubation with F90 for 48 hours in vitro. Down-regulated Bcl2.protein and up-regulated P53 protein were also observed. Conclusions The results demonstrate that F90 is effective in inhibiting the proliferation of SHG-44 cells in vitro and tumor growth in vivo, suggesting that F90 may be a new therapeutic option for treatment of GBM.

关键词： glioblastoma epidermal growth factor receptor Iressa

Idiopathic pulmonary fibrosis in relation to gene polymorphisms of transforming growth factor-β1 and plasminogen activator inhibitor 1

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Chinese Medical Journal 2011年第13期000卷 1923-1927页

作者： LI Xin-xia LI Ning BAN Cheng-jun ZHU Min XIAO bai DAI Hua-ping Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory Medicine Department ofRespiratory and Critical Care Medicine Beijing Chao-YangHospital Capital Medical University Beijing 100020 China department of Respiratory Medicine Beijing Shijitan HospitalCapital Medical University Beijing 100038 China department of Respiratory Medicine Beijing Fu 'Xing I~IospitalCapital Medical University Beijing 100038 China

Background Idiopathic pulmonary fibrosis （IPF） is a progressive and lethal fibrotic lung disease of unknown etiology. Host susceptibility or genetic factors may be important for the predisposition to it. Transforming growth factor-β1 （TGF-β1 a potent profibrotic cytokine） and plasminogen activator inhibitor 1 （PAl-1） play important roles in the development of pulmonary fibrosis. The objective of the study was to investigate the association between the gene polymorphisms of TGF-β1 869 T〉C and PAl-1 4G/5G and the susceptibility to IPF in Han ethnicity. Methods Polymerase chain reaction （PCR） and restriction fragment length polymorphism were performed to analyse the gene polymorphisms of TGF-β1 in 869T〉C and PAl-1 4G/5G in 85 IPF patients and 85 healthy controls matched in age, gender, race and smoker status. Results There was a significant difference in 869T〉C genotype distribution of TGF-β1 between IPF cases and controls, a significant negative association between TC genotype and the development of IPF （OR=0.508, 95% CI： 0.2.5-0.941） and a positive association between CC genotype and the development of IPF （OR=1.967, 95% CI： 1.063-3.641）. There was a significant positive association between PAl-1 5G/5G genotype and the development of IPF （OR=0.418, 95% CI： 0.193-0.904）. Conclusions Gene polymorphisms of TGF-β1 in 869T〉Cand PAl-1 4G/5G may affect the susceptibility to IPF in Han ethnicity. Further investigations are needed to confirm these findings and assess their biological significance in the development of the disease in this ethnic population.

关键词： gene polymorphism genetic susceptibility idiopathic pulmonary fibrosis plasminogen activator inhibitor 1 transforming growth factor-beta 1

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疏血通注射液体外抗栓及抗凝作用研究

中国全科医学 2018年第36期21卷 4502-4505页

作者：陈艳明夏珂何杨赵赟霄张忠兵江淼郑顺亮王思瑶周剑波白芳牡丹江友搏药业有限责任公司黑龙江省牡丹江市157013 北京友博药业有限责任公司北京市101300 天津大学药物科学与技术学院天津市现代药物传递及功能高效化重点实验室天津市300072 苏州大学附属第一医院江苏省血液研究所卫生部血栓与止血重点实验室江苏省苏州市215006

目的探讨疏血通注射液(以下简称疏血通)体外抗凝、抗栓作用。方法 2.15年5—7月,收集来自江苏省血液研究所的6例健康献血者的外周血,采用同一健康献血者的血液或血浆,以疏血通1份+血液或血浆9份作为加药组,0.9%氯化钠溶液1份+血液或血浆... 详细信息

目的探讨疏血通注射液(以下简称疏血通)体外抗凝、抗栓作用。方法 2.15年5—7月,收集来自江苏省血液研究所的6例健康献血者的外周血,采用同一健康献血者的血液或血浆,以疏血通1份+血液或血浆9份作为加药组,0.9%氯化钠溶液1份+血液或血浆9份作为对照组。检测两组血常规指标、凝血指标、纤溶指标、血小板功能、体外血栓形成情况。结果对照组白细胞计数、血小板计数高于加药组(P0.05)。加药组活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)长于对照组(P0.05)。纠正试验的APTT、PT、TT长于对照组(P0.05);加药组P-选择素高于对照组(P<0.05)。加药组R值、K值长于对照组,α角、MA值小于对照组(P<0.05)。结论疏血通在体外实验中显示出一定的抗凝、促纤溶、抑制血小板聚集和抑制血栓形成的作用。

关键词：血栓形成抗凝药血液凝固疏血通注射液血小板聚集血小板黏附