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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing chen Shuyuan bai Qiong Wu Yushan chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： bai, Jie Jia, Jian hui Wang, Yu Yang, Chun cheng Jiang, Qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

辽宁朝阳凤凰山剖面古土壤序列土壤发育特征研究

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土壤通报 2010年第6期41卷 1281-1287页

作者：韩春兰王秋兵郭月白晨辉陈辉沈阳农业大学土地与环境学院辽宁沈阳110161

通过对形态特征、矿质元素含量变化及分布特征、元素的淋溶(或聚积)状况、土壤发育指标等进行分析,探讨了辽宁朝阳凤凰山剖面古土壤序列的土壤发育特征和发育程度。研究结果表明,在凤凰山古土壤剖面中,自地表向下至19.85 m范围内,除现... 详细信息

通过对形态特征、矿质元素含量变化及分布特征、元素的淋溶(或聚积)状况、土壤发育指标等进行分析,探讨了辽宁朝阳凤凰山剖面古土壤序列的土壤发育特征和发育程度。研究结果表明,在凤凰山古土壤剖面中,自地表向下至19.85 m范围内,除现代土壤层S0(0～108 cm)外,还可划分出9个土壤地层,包括5层黄土(L1～L5)和4层古红土(S1～S4)。所有这些土壤地层都是发育在风积粉尘母质上的古土壤,形成时间介于71～423 ka B.P.之间。古土壤的发生与成土母质(粉尘)的沉积同步进行,发育成红色还是黄色的古土壤决定于不同的成土环境条件和粉尘沉积速率的相对大小。在凤凰山古土壤序列中,各层古红土比各层黄土质古土壤经受了更强的风化和淋溶作用,古红土发育程度明显强于黄土质古土壤。5层黄土质古土壤比较,土壤发育程度最弱的是L1层,最强的是L5层;比较4层古红土的发育程度,最弱的是S2层。纵观凤凰山古土壤序列,各个发育不同程度的古土壤交错排列,说明当地成土环境(气候)在423～71 ka B.P.间经过多次波动变化。

关键词：古土壤古红土黄土质古土壤发育特征辽宁朝阳

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan bai hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

Long-term administration of scopolamine interferes with nerve cell proliferation, differentiation and migration in adult mouse hippocampal dentate gyrus, but it does not induce cell death

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Neural Regeneration Research 2014年第19期9卷 1731-1739页

作者： Bing Chun Yan Joon Ha Park bai hui chen Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Jae-Chul Lee In Koo Hwang Jun Hwi Cho Yun Lyul Lee Il-Jun Kang Moo-Ho Won Department of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Department of Anatomy and Cell Biology College of Veterinary MedicineSeoul National University Department of Emergency Medicine School of MedicineKangwon National University Department of Food Science and Nutrition Hallym University

Long-term administration of scopolamine, a muscarinic receptor antagonist, can inhibit the survival of newly generated cells, but its effect on the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus remain poorly understood. In this study, we used immunohistochemistry and western blot methods to weekly detect the biological behaviors of nerve cells in the hippocampal dentate gyrus of adult mice that received intraperito- neal administration of scopolamine for 4 weeks. Expression of neuronal nuclear antigen （NeuN; a neuronal marker） and Fluoro-]ade B （a marker for the localization of neuronal degeneration） was also detected. After scopolamine treatment, mouse hippocampal neurons did not die, and Ki-67 （a marker for proliferating cells）-immunoreactive cells were reduced in number and reac hed the lowest level at 4 weeks. Doublecortin （DCX; a marker for newly generated neurons）-im- munoreactive cells were gradually shortened in length and reduced in number with time. After scopolamine treatment for 4 weeks, nearly all of the 5-bromo-2＇-deoxyuridine （BrdU）-labeled newly generated cells were located in the subgranular zone of the dentate gyrus, but they did not migrate into the granule cell layer. Few mature BrdU/NeuN double-labeled cells were seen in the subgranular zone of the dentate gyrus. These findings suggest that long-term administration of scopolamine interferes with the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus, but it does not induce cell death.

关键词： nerve regeneration neurogenesis scopolamine dentate gyrus cell proliferation neuroblastdifferentiation neuroblast migration granule cell layer neural regeneration

Oenanthe Javanica Extract Protects Against Experimentally Induced Ischemic Neuronal Damage via its Antioxidant Effects

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Chinese Medical Journal 2015年第21期128卷 2932-2937页

作者： Joon Ha Park Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn Jae-Chul Lee bai hui chen Bich-Na Shin Hyun-Jin Tae Ki-Yeon Yoo SeongKweon Hong II Jun Kang Moo-Ho Won Jong-Dai Kim Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon 200-702 South Korea Department of Oral Anatomy College of Dentistry and Research Institute of Oral Science Gangneung-Wonju National University Gangneung 210-702 South Korea Department of Surgery School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Food Science and Nutrition Hallym University Chuncheon 200-702 South Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon 200-701 South Korea

Background： Water dropwort （Oenanthejavanica） as a popular traditional medicine in Asia shows various biological properties including antioxidant activity. In this study, we firstly examined the neuroprotective effect of Oenanthejavanica extract （OJE） in the hippocampal comus ammonis 1 region （CA 1 region） of the gerbil subjected to transient cerebral ischemia. Methods： Gerbils were established by the occlusion of common carotid arteries for 5 min. The neuroprotective effect of OJE was estimated by cresyl violet staining. In addition, 4 antioxidants （copper, zinc superoxide dismutase [SOD], manganese SOD, catalase, and glutathione peroxidase） immunoreactivities were investigated by immunohistochemistry. Results： Pyramidal neurons in the CA1 region showed neuronal death at 5 days postischemia; at this point in time, all antioxidants immunoreactivities disappeared in CA1 pyramidal neurons and showed 100 mg/kg, OJE protected CA 1 pyramidal neurons from ischemic damage in many nonpyramidal cells. Treatment with 200 mg/kg, not In addition, 200 mg/kg OJE treatment increased or maintained antioxidants immunoreactivities. Especially, among the antioxidants, glutathione peroxidase immunoreactivity was effectively increased in the CA 1 pyramidal neurons of the OJE-treated sham-operated and ischemia-operated groups. Conclusion： Our present results indicate that treatment with OJE can protect neurons from transient ischemic damage and that the neuroprotective effect may be closely associated with increased or maintained intracellular antioxidant enzymes by OJE.

关键词： Antioxidant Enzymes Hippocampal Comus Ammonis 1 Region: Neuroprotection, Oenanthe Javanica Extract: TransientCerebral Ischemia

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山西野生木本花卉植物名录

山西师大学报（自然科学版） 1994年第3期8卷 46-51页

作者：白新生陈惠山西师大生物系

本文记载了山西野生木本花卉植物28科、69属、190种、12变种.

关键词：花卉植物野生木本名录变种记载山西

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大鼠灌胃大豆肽后各组织ACE酶活性的研究

食品科学 2011年第3期32卷 216-218页

作者：韩飞于婷婷李军白慧称国家粮食局科学研究院北京100037 北京大学实验动物中心北京100871

利用体外ACE酶抑制实验筛选获得的自制大豆肽灌胃自发性高血压大鼠,经过8周灌胃后,测定大鼠的胸主动脉、肺、肾、心脏、大脑和血清各组织ACE酶活性的变化。结果表明:灌胃大豆肽的自发性高血压大鼠,其胸主动脉、肺、肾、大脑和血清的ACE... 详细信息

利用体外ACE酶抑制实验筛选获得的自制大豆肽灌胃自发性高血压大鼠,经过8周灌胃后,测定大鼠的胸主动脉、肺、肾、心脏、大脑和血清各组织ACE酶活性的变化。结果表明:灌胃大豆肽的自发性高血压大鼠,其胸主动脉、肺、肾、大脑和血清的ACE酶活性显著低于生理盐水对照组,且对肾脏组织的ACE酶活力呈剂量依赖性,大豆肽剂量越高,酶活力越低。但对心脏的ACE酶活力没有抑制作用。说明灌胃自制大豆肽对大鼠的肺、肾、大脑等组织中的ACE酶的表达或激活起到显著的抑制作用,但作用机制和途径尚需进一步研究。

关键词：大豆肽自发性高血压大鼠组织 ACE酶活性

Hippophae rhamnoides *** extract enhances cell proliferation and neuroblast differentiation through upregulation of intrinsic factors in the dentate gyrus of the aged gerbil

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Chinese Medical Journal 2014年第23期127卷 4006-4011页

作者： Ji Hyeon Ahn bai hui chen Joon Ha Park In Hye Kim Jeong-Hwi Cho Jae-Chul Lee Bing Chun Yan Jung Hoon Choi In Koo Hwang Ju-Hee Park Sang-No Han Yun Lyul Lee Myong Jo Kim Moo-Ho Won Department of Neurobiology School of Medicine Kangwon National University Chuncheon 200-701 South Korea Department of Physiology College of Medicine Hallym University Chuncheon 200-702 South Korea Institute of Integrative Traditional & Western Medicine Medical College Yangzhou University Yangzhou Jiangsu 225001 China Department of Anatomy College of Veterinary Medicine Kangwon NationaL University Chuncheon 200-701 South Korea Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul 151-742 South Korea Samsung Herb Medicine Company Limitedl 304 BIO-ldong ChunCheon Biotechnology Innovation Center Chuncheon 200-957 South Korea Oriental Bio-herb Research Institute Kangwon National University Chuncheon 200-701 South Korea

Background Hippophae rhamnoides L.（HL） exerts antioxidant activities against various oxidative stress *** this study,we investigated effects of extract from HL leaves （HLE） on cell proliferation and neuroblast differentiation in the subgranular zone （SGZ） of the dentate gyrus （DG） of aged *** Aged gerbils （24 months） were divided into vehicle （saline）-treated-and *** vehicle and HLE were orally administered with 200 mg/kg once a day for 20 days before *** proliferation and neurobiast differentiation were examined in the DG using Ki67 and doublecortin （DCX）,*** also observed changes in immunoreactivities of superoxide dismutase 1 （SOD1） and superoxide dismutase 2 （SOD2）,brain-derived neurotrophic factor （BDNF）,and phospho-glycogen synthase kinase-3-beta （p-GSK-3β） to examine their relation with neurogenesis using *** The administration of HLE significantly increased the number of Ki67-positive cells and DCX-positive neuroblasts with well-developed processes in the SGZ of the DG of the *** addition,immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in granule and polymorphic cells of the DG in the HLE-treated-group compared with those in the *** HLE treatment significantly increased cell proliferation and neuroblast differentiation,showing that immunoreactivities of SOD1,SOD2,BDNF,and p-GSK-3β were significantly increased in the *** indicate that increased neuroblast differentiation neurogenesis may be closely related to upregulation of SOD1,SOD2,BDNF,and p-GSK-3β in aged gerbils.

关键词： aging antioxidants dentate gyrus hippophae rhamnoides extract neurogenesis neurotrophic factors