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Effect of switching from treatment with nucleos(t)ide analogs to pegylated interferon α-2a on virological and serological responses in chronic hepatitis B patients

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World Journal of Gastroenterology 2016年第46期22卷 10210-10218页

作者： Li-Ting He Xiao-Guang Ye Xiao-Yuan zho Department of Infectious Diseases The Second Affiliated Hospital of Guangzhou Medical University

AIM To investigate the efficacy of switching to pegylated interferon-α-2a(Peg IFNα-2a) treatment in nucleos(t)ide analog(NA)-treated chronic hepatitis B(CHB) responder patients. METHODS A 48-wk prospective and retrospective treatment trial of NA-treated CHB patients who had received entecavir(ETV) for at least 48 wk and had serum hepatitis B virus(HBV)-DNA < 500 IU/m L, serum hepatitis B envelope antigen(HBe Ag) < 100 S/CO, serum alanine aminotransferase, and aspartate aminotransferase levels < 2 × the upper limit of normal of 40 IU/L was performed. The effects on virological and serological responses and adverse reactions to 0.5 mg daily ETV for 48 wk vs switching to Peg IFNα-2a were compared. Forty-four patients were randomized to be switched from NA treatment to the Peg IFNα-2a group, and 44 patients were simultaneously randomized to the ETV group. RESULTS After 48 wk of therapy, the decrease in hepatitis B surface antigen(HBs Ag) levels was greater in the Peg IFNα-2a group than in the ETV group(3.1340 log10 IU/m L vs 3.6950 log10 IU/m L, P = 0.00). Seven patients who were anti-HBs-positive at baseline achieved HBs Ag loss when switched to Peg IFNα-2a(15.91% vs 0%,P = 0.018). The HBe Ag serological conversion rate was higher in the Peg IFNα-2a group than in the ETV group; however, the difference was not significant because of the small sample sizes(34.38% vs 21.88%, P = 0.232). In the Peg IFNα-2a group, patients with HBs Ag levels < 1500 IU/m L at baseline had higher HBe Ag seroconversion and HBs Ag loss rates at week 48 than those with HBs Ag levels ≥ 1500 IU/m L(HBe Ag seroconversion: 17.86% vs 62.5%, P = 0.007; HBs Ag loss: 41.67% vs 6.25%, P = 0.016). Moreover, patients with HBs Ag levels < 1500 IU/m L at week 24 had higher HBs Ag loss rates after therapy than those with HBs Ag levels ≥ 1500 IU/m L(36.84% vs 0%, P = 0.004). However, there were no statistically significant differences in HBe Ag seroconversion rates(47.06% vs 25.93%, P = 0.266). CONCLUSION NA-t

关键词： Chronic hepatitis B Entecavir pegylated interferon-α-2a Sequential therapy Effect

A Facile Strategy to Fabricate Polysaccharide-Based Magnetic Hydrogel Based on Enamine Bond

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Chinese Journal of Chemistry 2020年第11期38卷 1263-1268页

作者： Hongchen Liu Jingru Yang yunlei Yin Haisong Qi College of Textiles Zhongyuan University of TechnologyZhengzhouHenan 450007China State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhouGuangdong 510640China

of main observation and conclusion Magnetic hydrogels have found extensive applications in fields such as soft robotics,drug delivery and shape *** a facile method was fabricated to prepare polysaccharide-based magnetic *** chitosan-Fe3O4 ferrofluid was obtained by dispersing carboxyl groups modified Fe3O4 nanoparticles uniformly in chitosan ***,the magnetic polysaccharide hydrogel was obtained by simply mixing cellulose acetoacetate solution with chitosan-Fe3O4 *** structures and properties of the magnetic hydrogel were analyzed using Fourier-transform infrared spectroscopy,rheological recovery,responsiveness,and stability *** results indicated that magnetic polysaccharide hydrogel showed pH responsiveness and excellent self-healing properties,and the hydrogel manifested outstanding stability under physiological conditions(37℃)for 72 *** addition,the injectable polysaccharide-based hydrogel exhibited sensitive magnetic responsive and shape-shifting ability under an external magnetic ***,the strategy for the facile preparation of the magnetic polysaccharide-based hydrogel in this work could provide a benign and versatile method for achieving self-healing,responsive,injectable properties for the application in biomedical fields.

关键词： field. facile stability

NIR photothermal enhancement to achieve high-efficiency nitrogen reduction to ammonia by polyoxometalates@Fe-polydopamine

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Nano Research 2025年第1期18卷 118-128页

作者： Xiaofei Chen Lixin Wu Feng bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The development of atmospheric pressure N_(2)reduction to NH_(3)is attracting much attention in green chemistry,yet it is still a challenge to obtain satisfactory activity under mild ***,an efficient near-infrared(NIR)photothermal catalysis reduction of N_(2)constitutes an occurrence is *** or without V-substitute polyoxometalates(POMs)loaded on the surface of Fechelated polydopamine(Fe-PDA)photothermal support through the electrostatic interactions,NIR photothermal catalysts POMs@Fe-PDA are *** induction of“FeV”cofactor facilitates electron transfer between V(V)/V(IV)&Fe(III)/Fe(II)and N_(2),thereby activating N_(2)*** synergy between the catalytic activity of V-POMs and the local NIR photothermal effect of Fe-PDA dramatically enhances N_(2)***,PMo_(10)V_(2)@Fe-PDA exhibits a significantly enhanced NH_(3)production rate of 181.1μmol·LN^(-1)with a turnover frequency of 1006.1 mmol·MN^(-1)·hN^(-1)under 808 nm NIR laser radiation,being the highest values reported at atmospheric *** expect that this work could provide an alternative approach for photothermal catalysis N_(2)reduction under mild conditions.

关键词： polyoxometalate near-infrared photothermal catalysis N_(2)reduction mild condition

A Printable and Conductive Yield-Stress Fluid as an Ultrastretchable Transparent Conductor

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Research 2021年第1期2021卷 1554-1564页

作者： Qianying Lu yunlei zhou Xiangfei Yin Shitai Cao Xiaoliang Wang Desheng Kong College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life Scienceand Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210046China Key Laboratory of High Performance Polymer Materials and Technology of Ministry of Education Department of Polymer Science and EngineeringSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210046China

In contrast to ionically conductive liquids and gels,a new type of yield-stress fluid featuring reversible transitions between solid and liquid states is introduced in this study as a printable,ultrastretchable,and transparent *** fluid is formulated by dispersing silica nanoparticles into the concentrated aqueous *** as-printed features show solid-state appearances to allow facile encapsulation with *** transition into liquid-like behavior upon tensile deformations is the enabler for ultrahigh stretchability up to the fracture strain of the *** integrations of yield-stress fluid electrodes in highly stretchable strain sensors and light-emitting devices illustrate the practical *** yield-stress fluid represents an attractive building block for stretchable electronic devices and systems in terms of giant deformability,high ionic conductivity,excellent optical transmittance,and compatibility with various elastomers.

关键词： attractive electrolyte reversible

Ocean surface currents estimated from satellite remote sensing data based on a global hexagonal grid

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International Journal of Digital Earth 2023年第1期16卷 1073-1093页

作者： Wenbo Wang Huijun zho Senyuan Zheng Guonian Lu Liangchen zhou Key Laboratory of Virtual Geographic Environment Ministry of EducationNanjing Normal UniversityNanjing.People's Republic of China Jiangsu Centre for Collaborative Innovation in Geographical Information Resource Development and Application NanjingPeople's Republic of China

Global ocean surface currents estimated from satellite derived data based on a regular global grid are affected by the grid’s shape and *** to different neighbourhood relationships,the rectangular lat/lon grids lose accuracy when interpolating andfitting elevation *** grids have shown to be advantageous due to their isotropic,uniform *** these merits,this paper aims to estimate global ocean surface current using a global isotropic hexagonal grid from satellite remote sensing ***,gridded satellite altimeter data and wind data with different resolutions are interpolated into the centre of the global isotropic hexagonal ***,geostrophic and Ekman currents components are estimated according to the Lagerlof Ocean currents ***,the inversion results are *** analyzing the results,we conclude that the ocean surface currents estimated based on the global isotropic hexagonal grid have considerable accuracy,with improvement over rectangular lat/lon grids.

关键词： Isotropic hexagonal grid satellite remote sensing data geostrophic currents Ekman currents

基于贝叶斯图注意力Transformer的航空发动机剩余使用寿命概率预测

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工程科学学报 2025年第2期47卷 374-388页

作者：胡艳艳白雅婷北京科技大学智能科学与技术学院北京100083

航空发动机作为飞机的心脏,其健康状态对飞机的安全飞行至关重要.深度学习强大的数据挖掘能力,为通过海量历史数据预测航空发动机的剩余使用寿命提供了新方法.然而,传统基于深度学习的方法大都关注于挖掘数据在时间上的关联,而忽略了多... 详细信息

航空发动机作为飞机的心脏,其健康状态对飞机的安全飞行至关重要.深度学习强大的数据挖掘能力,为通过海量历史数据预测航空发动机的剩余使用寿命提供了新方法.然而,传统基于深度学习的方法大都关注于挖掘数据在时间上的关联,而忽略了多个传感器监测数据之间复杂的非欧氏空间关系.此外,少有研究考虑数据或者预测过程本身具有的不确定性,缺乏对预测结果可靠性的评估.为解决上述问题,本文提出了一种基于贝叶斯网络和图注意力Transformer的航空发动机剩余使用寿命概率预测方法.将图注意力机制融入Transformer的时间多头注意力模块,结合图注意力网络在空间特征提取上的优势和Transformer模型在时间特征提取的优势,实现数据特征时空关系的联合提取.同时,利用改进的贝叶斯网络度量预测不确定性,在得到剩余使用寿命预测点值的同时给出相应的置信区间.最后,通过在公开航空发动机数据集上的实验,证明了所提模型的有效性和先进性.

关键词：航空发动机剩余使用寿命图注意力Transformer 贝叶斯网络概率预测

Thermal decomposition mechanism of ammonium sulfate catalyzed by ferric oxide

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Frontiers of Chemical Science and Engineering 2013年第2期7卷 210-217页

作者： Xingfu SONG Jingcai ZHAO yunzhao LI Ze SUN Jianguo YU National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and Technology Shanghai 200237 China

The decomposition mechanism of ammonium sulfate catalyzed by ferric oxide was investigated in this paper. The decomposition kinetics parameters were determined via a global optimization of the Kissinger iterative method using the non-isothermal thermogravi- metric analysis data. The products and intermediates were synchronously characterized by X-ray diffraction and mass spectrometry. The obtained results indicate that the decomposition process of ammonium sulfate catalyzed by ferric oxide can be divided into four stages of which the activation energies are 123.64, 126.58, 178.77 and 216.99 kJ. mol^-1 respectively. The decomposition mechanisms at the first and the fourth stage both belong to Mample power theorem, the second stage belongs to Avrami-Erofeev equation and the third belongs to contracting sphere （volume） equation. The corresponding pre-exponential factors （A） are calculated simultaneously.

关键词： ammonium sulfate decomposition kinetics,ferric oxide thermogravimetric analysis

Analysis of the Microstructure and Mechanical Properties during Inertia Friction Welding of the Near-α TA19 Titanium Alloy

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Chinese Journal of Mechanical Engineering 2020年第6期33卷 205-217页

作者： Yanquan Wu Chunbo Zhang Jun zhou Wu Liang yunlei Li Research and Development Center Harbin Welding Institute Limited CompanyHarbin150028China China Academy of Machinery Science and Technology Group Co. LtdBeijing100044China

The current research of titanium alloy on friction welding process in the field of aero-engines mainly focuses on the linear friction *** to the linear friction welding,inertial friction welding of titanium alloy still has important application position in the welding of aero-engine rotating ***,up to now,few reports on inertial friction welding of titanium alloy are *** this paper,the near-alpha TA19 titanium alloy welded joint was successfully obtained by inertial friction welding(IFW)*** microstructures and mechanical properties were investigated *** showed that the refined grains within 15‒20μm and weak texture were found in the weld zone due to dynamic recrystallization caused by high temperature and plastic *** weld zone consisted of acicularα′martensite phase,αp phase and metastableβ*** lath-shapedαs andβphase in base metal were transformed into acicular martensiteα′phase and metastableβphase in thermo-mechanically affected zone and heat affected *** a result,the microhardness of welded joint gradually decreased from the weld zone to the base *** specimens in room temperature and high temperature of 480℃ were all fractured in base metal illustrating that the inertia friction welded TA19 titanium alloy joint owned higher tensile strength compared to the base metal.

关键词： Inertia friction welding TA19 Micostructure Mechanical property Texture

Forecasting time series with optimal neural networks using multi-objective optimization algorithm based on AICc

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Frontiers of Computer Science 2018年第6期12卷 1261-1263页

作者： Muzhou HOU yunlei YANG Taohua LIU Wenping PENG School of Mathematics and Statistics Central South UniversityChangsha 410083China School of Civil Engineering Changsha University of Science &TechnologyChangsha 410114China

In this letter, time series forecasting using optimal neural networks with optimal performance of generalization and stability is studied. After analyzing the reasons for overfitting and instability of neural networks, in order to find the optimal NNs (neural networks) architecture, we consider minimizing three objective index: average training AICc (ATRAICc), average testing AICc (ATEAICc) and testing error variance AICc (VAAICc) based on Akaike information criterion theory. Then we built a multi-objective optimization model and proved the existence and uniqueness theorem of optimal solution. After determining the searching interval, a multi-objective optimization algorithm for optimal neural network architecture based on AICc (ONNAICc) with optimal generalization and stability is constructed to solve above model. Some experiments with simple sample datasets A and B from simple function, complicated stock market time series datasets C and highly nonlinear tungsten price datasets D are taken to verify the validity of the model. And some performances of the presented ONNAICc algorithm are compared with the traditional prediction algorithms, such as AR, ARMA, ordinary BP, SVM, verified the superiority and accuracy of the proposed ONNAICc algorithm.

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