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Leukemia Inhibitory Factor Enhanced the Developmental and Implantation Compatibility of Mouse Embryos in Co-culture with Human Endometrial Epithelial Cells

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Reproductive and Developmental Medicine 2021年第4期5卷 199-205页

作者： Ali Hosseini bahar movaghar Showra Amani Abkenari Hassan Nazari Mehrdad Bakhtiyari Department of Anatomy Faculty of MedicineIran University of Medical SciencesTehranIran Cellular and Molecular Research Center Iran University of Medical SciencesTehranIran Department of Embryology Reproductive Biomedicine Research CenterRoyan Institute for Reproductive BiomedicineACECRTehranIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Research Institute of Animal Embryo Technology Shahrekord UniversityShahrekordIran

Objective:Among the variousin vitro embryo culture systems,co-culture has demonstrated remarkable effects in pre-implantation embryo development owing to the production of embryo-nourishing ***,little is known about the secretion of these ***,in this study,the effect of leukemia inhibitory factor(LIF),one of the most important nourishing factors in the early development of mouse embryos,in human endometrial epithelial cells(hEECs)was ***:Two-cell stage embryos were collected from the oviducts of hyper-stimulated and mated mice and cultivated in a co-culture with an hEEC monolayer with or without *** quality and developmental and attachment potential rates of cultured embryos were evaluated by determining the levels of octamer-binding transcription factor 4(Oct4)and caudal type homeobox 2(Cdx2)***:LIF significantly increased the developmental rate(82.67%vs.61.04%,respectively)and attachment rate(64%vs.45.45%,respectively)of mouse embryos co-cultured with hEECs compared to those in untreated *** expression levels ofOct4 andCdx2 in blastocysts cultured in the presence of LIF were higher than those in blastocysts cultured without ***:Despite the secretion of LIF by hEECs during co-culture with embryos,the amount of this factor was insufficient,and its addition to the culture media could increase the developmental potential of embryos.

关键词： Caudal Type Homeobox 2 Embryo Development Leukemia Inhibitory Factor Octamer-Binding Transcription Factor 4

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