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World Journal of Psychiatry 2023年第4期13卷 171-181页

作者： MeltemŞirin Gök baharÇiftçi Department of Fundamental of Nursing Ataturk UniversityErzurum 25000Turkey HGF Agro Ata TeknokentErzurum 25240Turkey

BACKGROUND The coronavirus disease 2019(COViD-19)pandemic has affected mental health and physical health negatively in some *** perceived social support and post-traumatic growth(PTG)in COViD-19 patients could facilitate our understanding of how patients maintain their mental *** To examine the relationship between the level of perceived social support and PTG in COViD-19 patients discharged from the *** This descriptive study was carried out between August and September 2022 with patients who were hospitalized due to COViD-19 in a university hospital in Erzurum and who were discharged at least 3 mo prior to the beginning of the *** study was completed by 196 *** data were collected faceto-face using a personal information form,multidimensional scale of perceived social support and PTG *** The total mean score of the multidimensional scale of perceived social support was 63.82±*** PTG inventory total mean score was 47.77±*** addition,a direct significant correlation was found between perceived social support in COViD-19 patients and *** The study results showed that perceived social support variables affected PTG ***,it is recommended for healthcare professionals to implement interventions to promote social support from healthcare professionals and the patient’s family and *** the negative effects of the ongoing COViD-19 pandemic,it is very important and necessary to implement effective public health interventions to promote PTG to reduce mental health problems.

关键词： COViD-19 patients Perceived social support Post-traumatic growth COViD-19

Hospital-acquired insomnia scale:A validity and reliability study

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World Journal of Psychiatry 2023年第3期13卷 113-125页

作者： bahar çiftçi Güzel Nur Yıldız Özgür Yıldız Department of Fundamental of Nursing Atateknokent Atatürk UniversityErzurum 25000Turkey Department of Dialysis MuşAlparaslan UniversityMuş49000Turkey Department of Nursing MuşAlparslan UniversityMuş49000Turkey

BACKGROUND Sleep breathing,one of the basic human needs,is a physiological need that affects cardiac functions,body temperature,daily vitality,muscle tone,hormone secretion,blood pressure,and many *** the international literature,studies reported that patients have had sleep problems in the hospital since the 1990s,but no measurement tool has been developed to determine the causes of hospitalacquired insomnia in *** findings suggest that sleep remains in the background compared to activities such as nutrition and *** patients generally experience hospital-acquired sleep problems,there is no measurement tool to determine hospital-acquired sleep *** features show the originality of the *** To develop a measurement tool to determine the sleep problems experienced by patients in the *** A personal information form,hospital-acquired insomnia scale(HAiS),and insomnia severity index(iSi)were used to collect research *** study population consisted of patients hospitalized in the internal and surgical clinics of a research hospital in Turkey between December 2021 and March *** sample consisted of 64 patients in the pilot application stage and 223 patients in the main application *** factor analysis and confirmatory factor analysis(CFA)analyses were performed using the SPSS 20 package program and the analysis of moment structure(AMOS)package *** forms method *** The HAiS consisted of 18 items and 5 *** Cronbach alpha values of the subscales ranged between 0.672 and 0.842 and the Cronbach alpha value of the overall scale was *** scale explained 58.269%of the total *** items that constitute the factors were examined in terms of content integrity and named as physical environmental,psychological,safety,socioeconomic,and nutritional *** analysis of the 5-factor structure was performed in the AMOS package *** fit indices of the

关键词： insomnia Sleeplessness Sleep disorder Scale development Hospital Hospital housekeeping

Persistent currents of ultrarelativistic plasma-encased endofullerene molecules entrapping a H atom

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Communications in Theoretical Physics 2024年第6期76卷 148-164页

作者： Mustafa Kemal bahar Department of Physics Faculty of ScienceSivas Cumhuriyet University58140SivasTurkey

in this work,for the first time in the relevant literature,the persistent currents(PC)and induced magnetic fields(iMF)of an endofullerene molecule entrapping a hydrogen atom,under spherical confinement,are *** endofullerene molecule is enclosed within a spherical region and embedded in a plasma *** plasma environment is depicted with the more general exponential cosine screened Coulomb potential,and its relevant effects are analyzed by considering plasma screening *** relevant model for endohedral confinement is the Woods-Saxon confinement potential,which is compatible with experimental *** effects of various forms of Cn are thoroughly elucidated via the analysis of the confinement depth,spherical shell thickness,the inner radius,and the smoothing *** find the bound states in the spherically confined endofullerene,the decoupling of the second-order Dirac equation for the large and small components of the radial atomic wave functions is *** Dirac equation with the interaction potential is solved numerically by using the Runge-Kutta-Fehlberg method via the decoupling *** influence of spin orientations on the PC and iMF is also *** effects of spherical confinement,plasma shielding,and the structural properties of the fullerene on the PC and iMF are thoroughly ***,under given physical conditions,the optimal ranges of these effects are determined.

关键词： quantum plasma endohedral fullerene persistent current ultrarelativistic interaction induced magnetic field

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

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Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz bahar Hyun Joon Kim Deok Ryong Kim Department of Biochemistry and Convergence Medical Sciences and institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence Medical Sciences and institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

Allogeneic mesenchymal stem cells may be a viable treatment modality in cerebral palsy

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World Journal of Clinical Cases 2024年第9期12卷 1585-1596页

作者： Osman Boyalı Serdar Kabatas ErdinçCivelek Omer Ozdemir Yeliz bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34360Turkey Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Cerebral palsy(CP)describes a group of disorders affecting movement,balance,and *** in motor functions constitute the main body of CP *** symptoms surface in early childhood and patients are affected for the rest of their ***,treatment involves various pharmacotherapies for different types of CP,including antiepileptics for epilepsy and Botox A for focal ***,none of these methods can provide full symptom *** has prompted researchers to look for new treatment modalities,one of which is mesenchymal stem cell therapy(MSCT).Despite being a promising tool and offering a wide array of possibilities,mesenchymal stem cells(MSCs)still need to be investigated for their efficacy and *** To analyze the efficacy and safety of MSCT in CP *** Our sample consists of four CP patients who cannot stand or walk without external *** of these cases received allogeneic MSCT six times as 1×106/kg intrathecally,intravenously,and intramuscularly using umbilical cord-derived MSCs(UC-MSC).We monitored and assessed the patients pre-and post-treatment using the Wee Functional independence Measure(WeeFiM),Gross Motor Function Classification System(GMFCS),and Manual Ability Classification Scale(MACS)*** utilized the Modified Ashworth Scale(MAS)to measure *** We found significant improvements in MAS scores after the intervention on both *** months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;four months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=0.046;12 months:Rightχ^(2)=4000,P=0.046,leftχ^(2)=4000,P=***,there was no significant difference in motor functions based on WeeFiM results(P>0.05).GMFCS and MACS scores differed significantly at 12 months after the intervention(P=0.046,P=0.046).Finally,there was no significant change in cognitive functions(P>0.05).CONCLUSiON in light of our findings,we believe that UC-MSC therapy has a positive effect on spasticity

关键词： Cerebral palsy Mesenchymal stem cell Transplantation Wharton’s jelly Muscle spasticity

Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury:First results of a phase i study

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World Journal of Stem Cells 2024年第6期16卷 641-655页

作者： Serdar Kabatas ErdinçCivelek Osman Boyalı Gülseli Berivan Sezen Omer Ozdemir Yeliz bahar-Ozdemir Necati Kaplan Eyüp Can Savrunlu Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34360Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Physical Medicine and Rehabilitation Health Sciences University Sultan Abdulhamid Han Training and Research HospitalIstanbul 34668Türkiye Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Türkiye Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Traumatic brain injury(TBi)is characterized by a disruption in the normal function of the brain due to an injury following a trauma,which can potentially cause severe physical,cognitive,and emotional *** cell transplantation has evolved as a novel treatment modality in the management of TBi,as it has the potential to arrest the degeneration and promote regeneration of new cells in the ***’s Jelly-derived mesenchymal stem cells(WJ-MSCs)have recently shown beneficial effects in the functional recovery of neurological *** To evaluate the safety and efficiency of MSC therapy in *** We present 6 patients,4 male and 2 female aged between 21 and 27 years who suffered a *** 6 patients underwent 6 doses of intrathecal,intramuscular(i.m.)and intravenous transplantation of WJ-MSCs at a target dose of 1×106/kg for each application *** was assessed using the Modified Ashworth scale(MAS),motor function according to the Medical Research Council Muscle Strength Scale,quality of life was assessed by the Functional independence Measure(FiM)scale and Karnofsky Performance Status *** Our patients showed only early,transient complications,such as subfebrile fever,mild headache,and muscle pain due to ***,which resolved within 24 *** the one year follow-up,no other safety issues or adverse events were *** 6 patients showed improvements in their cognitive abilities,muscle spasticity,muscle strength,performance scores and fine motor skills when compared before and after the *** values,which we used to assess spasticity,were observed to statistically significantly decrease for both left and right sides(PiM scale includes both motor scores(Pitive scores(Pignificant increase in pretest posttest *** difference observed in the participants’Karnofsky Performance Scale values pre and post the intervention was statistically si

关键词： Traumatic brain injury Wharton Jelly Stem cell therapy Transplantation Mesenchymal stem cell

The impact of Black Sea Sand Treatment Effectively Reducing Different Type of Pain

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Open Journal of Therapy and Rehabilitation 2024年第1期12卷 18-27页

作者： Mahmut Tokaç Abdulbari Bener Fatma Nur Kesiktaş bahar Dernek Semra Alkal Akkaya Zeynep Esra Akgün Department of Medicine and Education Unit School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Biostatistics & Medical informatics School of Medicine Istanbul Medipol University Istanbul Türkiye Department of Evidence for Population Health Unit School of Epidemiology and Health Sciences The University of Manchester Manchester UK Faculty of Medicine Health Sciences University Istanbul Physiotherapy Rehabilitation Training and Research Hospital Istanbul Türkiye Faculty of Medicine Health Sciences University Department of Physical Medicine and Rehabilitation Umraniye Training and Research Hospital Istanbul Türkiye Physical Medicine and Rehabilitation Vatan Clinics School of Medicine Istanbul Medipol University Istanbul Türkiye

Purpose: Low back pain (LBP), Gonarthrosis, knee, and Carpal Tunnel Syndrome have been regarded as affecting more than three-quarters’ of individuals in their lifetime. The aim of this study was conducted to determine and compare the effects of topical patients with sand compared with control related to Gonarthrosis, LBP, knee, and Carpal Tunnel Syndrome pain. Methods: This is a prospective case and control designed study based on 101 pain case with Sand and 101 control subjects. The interventional groups in addition either topical sand or without sand 2 months after the intervention were assessed. We assessed tolerability of an established pain perception scale by the Numeric Rating Scale (NRS). Categorical variables were compared using the chi-square (χ2) test. The paired t-test was used to compare the two groups before and after the intervention. One-way analysis of variance (ANOVA) was employed for comparison of several group means. Results: The study was based on 202 patients, 41 males (20.3%) and 161 females (79.7%). There were statistically significant differences between subjects with and without Sand in term of Gonarthrosis, Rheumatoid Arthritis LBP, knee, and Carpal Tunnel Syndrome pain (p = 0.033). Majority of patients were over age 55 years old (55%) and females 78 (77.2%). The mean score of total pain experience before and after the intervention was 7.41 ± 1.1 for black sand, and 4.24 ± 2.38 for without sand as control group. The mean scores of these 5 groups were highly significant before and after the intervention (p There was statistically highly significant in regarding subjects with Sand as compared with those before Sand after treatment mean score specifically with gonarthrosis before pain 7.23 ± 1.86 vs after treatment 4.54 ± 2.18 p id arthritis before 8.28 ± 1.48 vs after treatment 4.80 ± 3.71 p in before 8.42 ± 1.83 vs after treatment 4.37 ± 1.52 p in before 8.93 ± 0.89 vs after treat

关键词： Therapies Sand LBP Musculoskeletal Rheumatoid Arthritis Carpal Tunnel Syndrome

Smart and collaborative industrial ioT: A federated learning and data space approach

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Digital Communications and Networks 2023年第2期9卷 436-447页

作者： bahar Farahani Amin Karimi Monsefi Cyberspace Research institute Shahid Beheshti UniversityTehran***Iran Department of Computer Science and Engineering Ohio State UniversityColumbusOH43210USA

industry 4.0 has become a reality by fusing the industrial internet of Things(iioT)and Artificial intelligence(Ai),providing huge opportunities in the way manufacturing companies ***,the adoption of this paradigm shift,particularly in the field of smart factories and production,is still in its infancy,suffering from various issues,such as the lack of high-quality data,data with high-class imbalance,or poor diversity leading to inaccurate Ai ***,data is severely fragmented across different silos owned by several parties for a range of reasons,such as compliance and legal concerns,preventing discovery and insight-driven iioT ***,valuable and even vital information often remains unutilized as the rise and adoption of Ai and ioT in parallel with the concerns and challenges associated with privacy and *** adversely influences interand intra-organization collaborative use of iioT *** tackle these challenges,this article leverages emerging multi-party technologies,privacy-enhancing techniques(e.g.,Federated Learning),and Ai approaches to present a holistic,decentralized architecture to form a foundation and cradle for a cross-company collaboration platform and a federated data space to tackle the creeping fragmented data ***,to evaluate the efficiency of the proposed reference model,a collaborative predictive diagnostics and maintenance case study is mapped to an edge-enabled iioT *** results show the potential advantages of using the proposed approach for multi-party applications accelerating sovereign data sharing through Findable,Accessible,interoperable,and Reusable(FAiR)principles.

关键词： industry 4.0 industrial internet of things(iioT) Artificial intelligence(Ai) Predictive maintenance(PdM) Condition monitoring(CM) Federated learning(FL) Privacy preservinig machine learning(PPML) Edge computing Fog computing Cloud computing

Optimization of hydrolysis conditions for the production of protein hydrolysates from fish wastes using response surface methodology

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Food Bioscience 2022年第1期45卷 332-339页

作者： Koray Korkmaz bahar Tokur Fatsa Faculty of Marine Science Ordu UniversityOrduTurkey

The recycling of waste from food processing is an important industrial procedure for obtaining protein sources with high added *** this study,trout(Onchorynchus mykiss),anchovy(Engraulis encrasicolus),and whiting(Merlangius merlangus)wastes were *** hydrolyzation procedure was investigated under the optimum predicted conditions defined by time,temperature,and enzyme ratio(E/S)using alkaline protease(pH 8),Protamex(pH 7),and Flavourzyme(pH 7).The hydrolysis conditions that showed the best degree of hydrolysis(DH%)were optimized using response surface methodology(RSM)with the central composite design(CCD)and Box-Behnken design(BBD)*** effects of three independent variables,temperature(40-60℃),time(1-8 h),and enzyme concentrations(1-2%),were examined for model *** was determined that the DH%varies between 50.92%and 74.30% according to the type of fish waste and *** highest degree of hydrolysis was observed from trout waste(74.30%)and the lowest degree from whiting waste(50.92%)with *** this study,it has been shown that different degrees of hydrolysis and protein recovery can be obtained,depending on fish species,waste composition,enzyme type,and hydrolysis method.

关键词： Fish protein hydrolysate Optimization Degree of hydrolysis Protein recovery

Barriers to big data analytics (BDA) implementation in manufacturing supply chains

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Journal of Management Analytics 2023年第1期10卷 191-222页

作者： Amirhossein Dehkhodaei bahar Amiri Hasan Farsijani Abbas Raad Department of Management and Accounting Shahid Beheshti UniversityTehranIran

Big data analysis(BDA)can increase the capability of supply chain analysis of manufacturing ***,many manufacturing companies want to use BDA,but it has been seen that BDA implementation is difficult,especially in developing countries due to the existence of various barriers related to finance,government regulations,*** paper aims to investigate the barriers to BDA implementation in iranian *** literature,limited work has been done on identifying barriers to implementing BDA in developing *** this regard,34 barriers were identified to BDA adoption in iran by employing a literature review and feedback received from ***,the most important barriers(14)were analyzed using integrated interpretive Structural Modeling and MiCMAC *** show that two barriers;namely,lack of sufficient knowledge of senior managers and weakness of governance policies,are the most ***,crucial policy measures and recommendations are proposed to assist managers and government bodies.

关键词： Barriers Big data analytics interpretive Structural Modeling(iSM) MiCMAC Analysis Modeling Supply Chain Management