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Body mass index and colon cancer screening:The road ahead

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World Journal of Gastroenterology 2015年第5期21卷 1372-1376页

作者： Kanwarpreet Tandon Mohamad Imam bahaa eldeen senousy Ismail Fernando Castro Department of Gastroenterology Cleveland Clinic FloridaWestonFL 33331United States Department of Internal Medicine University of North DakotaFargoND 58202United States

Screening for colorectal cancer(CRC) has been associated with a decreased incidence and mortality from ***,patient adherence to screening is less than desirable and resources are limited even indeveloped *** identification of individuals at a higher risk could result in improved screening *** the past few years,formulas have been developed to predict the likelihood of developing advanced colonic neoplasia in susceptible individuals but have yet to be utilized in mass screening *** models use a number of clinical factors that have been associated with colonic neoplasia including the body mass index(BMI).Advances in our understanding of the mechanisms by which obesity contributes to colonic neoplasia as well as clinical studies on this subject have proven the association between BMI and colonic ***,there are still controversies on this subject as some studies have arrived at different conclusions on the influence of BMI by *** studies should aim at resolving these discrepancies in order to improve the efficiency of screening strategies.

关键词： Body mass index Colorectal cancer Colon cancer scr

Spot urinary sodium for assessing dietary sodium restriction in cirrhotic ascites

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World Journal of Gastroenterology 2009年第29期15卷 3631-3635页

作者： Mohammed Abdelhamid El-Bokl bahaa eldeen senousy Khaled Zakaria El-Karmouty Inas El-Khedr Mohammed Sherif Monier Mohammed Sherif Sadek Shabana Hassan Shalaby Department of Gastroenterology and Hepatology Ain Shams University school of Medicine Abbassia 11566 Cairo Egypt

AIM： To evaluate the accuracy of spot urinary Na/K and Na/creatinine （Cr） ratios as an alternative to 24-h urinary sodium in monitoring dietary compliance in patients with liver cirrhosis and ascites treated with diuretics. METHODS： The study was carried on 40 patients with liver cirrhosis and ascites treated with diuretic therapy. Patients were divided into two groups according to 24-h urinary sodium. We measured spot urine Na/K ratio, Na/ Cr ratio and 24-h urinary sodium. Student＇s t test was used to compare the interval variables and x^2 test to compare the nominal variables between the two groups. Receiver operator characteristic curve was used to identify the best cutoff point for Na/K and Na/Cr ratio. RESULTS： The best cutoff point for Na/K ratio was 2.5 （P 〈 0.001） and area under the curve （AUC） was 0.9, and for Na/Cr ratio, the best cutoff point was 35 （P 〈 0.001） and AUC was 0.885. Na/K ratio showed higher sensitivity and accuracy compared to Na/Cr ratio （87.5% and 87% for Na/K ratio; 81% and 85% for Na/Cr ratio, respectively）. CONCLUSION： Spot urine Na/K ratio has adequate accuracy for assessment of dietary sodium restriction compared with 24-h urinary sodium in patients with liver cirrhosis and ascites.

关键词： Ascites Liver cirrhosis Portal hypertension Urinary sodium

Evaluation of children and adults with post-COVID-19 persistent smell,taste and trigeminal chemosensory disorders:A hospital based study

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World Journal of Clinical Pediatrics 2023年第3期12卷 133-150页

作者： Sherifa Ahmed Hamed Eman bahaa Kamal-eldeen Mohamed Azzam Abdel-Razek Ahmed Department of Neurology and Psychiatry Assiut UniversityFaculty of MedicineAssiut 71516Egypt Department of Pediatrics Assiut UniversityFaculty of MedicineAssiut 71516Egypt Department of ENT Assiut UniversityFaculty of MedicineAssiut 71516Egypt

BACKGROUND Smell disorders are the most frequent persistent coronavirus disease 2019(COVID-19)*** To describe the patterns and characteristics of persistent smell and taste disorders in Egyptian *** Assessment was done to 185 patients(adults=150,age:31.41±8.63 years;children=35;age:15.66±1.63 years).Otolaryngology and neuropsychiatric evaluations were *** included:A clinical questionnaire(for smell and taste);sniffin'odor,taste and flavor identification tests and the Questionnaire of Olfactory Disorders-Negative Statements(sQOD-NS).RESULTS Duration of disorders was 11.53±3.97 ms(6-24 ms).Parosmia(n=119;64.32%)was developed months after anosmia(3.05±1.87 ms).Objective testing showed anosmia in all,ageusia and flavor loss in 20%(n=37)and loss of nasal and oral trigeminal sensations in 18%(n=33)and 20%(n=37),*** had low scoring of sQOD-NS(11.41±3.66).There were no specific differences in other demographics and clinical variables which could distinguish post-COVID-19 smell and taste disorders in children from *** The course of small and taste disorders are supportive of the nasal and oral neuronal ***-COVID-19 taste and trigeminal disorders were less frequent compared to smell ***-COVID-19 flavor disorders were solely dependent on taste and not smell *** were no demographics,clinical variables at onset or specific profile of these disorders in children compared to adults.

关键词： Post-COVID-19 complications Anosmia Ageusia Trigeminal sensory loss Parosmia Quality of life

<i>In Vivo</i>and <i>In Vitro</i>Survival Rates of Protoscoleces Kept at Different Constant Temperature

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Open Journal of Epidemiology 2017年第2期7卷 124-130页

作者： Ekram Ismail Fagiree Ismail Mohammed bahaa eldeen Ahmed Saad Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan

An experiment was conducted on the survival rate of protoscoleces derived from hydatid cyst brought from infected camels in Tambool area (North Eastern Sudan). The survival rate was studied in vivo and in vitro through exposure to different constant temperatures to measure their viability. The results revealed that the protoscoleces remained viable in vitro for 20 days at 4°C, 7 and 5 days at 25°C and 37°C, respectively, while at 45°C the protoscoleces were immediately dead. This means that the infection rate of hydatid cyst becomes high in relatively cold seasons (winter and autumn). In the in vivo study, each mouse (five groups, four mice in each) was inoculated intraperitoneally with 2000 protoscoleces exposed to the same different constant temperature, as previously used. 6 months later, the mice in different groups were sacrificed and necropsied to study the development of hydatid cyst inside. The results showed that the rate of development inside the mice was clear in the first and the second groups (4°C and 25°C), however, in the other 2 groups (37°C and 45°C), no sign of development of the cyst was observed, with the presence of few number of hooks compared to the control group, which showed significant difference in the development of hydatid cyst.

关键词： Echinococcus granulosus Hydatid Cyst Protoscoleces Temprature Mice

Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice

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Open Journal of Epidemiology 2017年第4期7卷 307-316页

作者： Ekram Ismail Fagiree Ismail Mohammed bahaa eldeen Ahmed Saad Aisha Abass Elsadig Department of Biology Alzaem Alazhari University Khartoum Sudan Alahlia University Khartoum Sudan Department of Radioisotopes of the Veterinary Research Center Khartoum Sudan

In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p < 0.01). Inside the mice, small number of cysts was noticed in the group treated with albendazole and mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.

关键词： Hydatid Cyst Mebendazole Albendazole