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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macroph.ge uptake,and th. protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah.E.Est-Witte Sydney R.Sh.nnon Dennis h.Gong Kaitlyn G.Calabresi j.waun j.h.rris Kaitlyn Storm Edwin j.Yoo Ariel Isser Vivek P.j.ni Natalie K.Livingston Mary O.Omotoso Kelly Rh.des Elana Ben-Akiva Randall A.Meyer Zoe T.h.ieh.Simone Sidoli Steph.ny Y.Tzeng j.nath.n P.Sch.eck j.rdan j.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Bioch.mistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell th.rapy(ACT)is an immunoth.rapy strategy for cancer th.t h.s seen widespread clinical *** ACT,patient-derived lymph.cytes are stimulated with.th. antigen of interest ex vivo,proliferated,th.n returned to th. patient to initiate an antigen-specific antitumor *** effective,th.s process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-th.-sh.lf”alternative to ex vivo *** particulate aAPCs perform well in vitro,th.y h.ve h.d limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with.CD8+T cells at sites of *** properties such.as elasticity h.ve been sh.wn to vastly impact th. bioavailability and particle-cell interactions,but th.s h.s yet to be investigated in th. context of aAPCs for in vivo T-cell *** literature likewise indicates th.t biomaterial properties,especially elasticity,can modulate T-cell activation in *** th. goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(eth.lene)glycol h.drogel particle platform with.tunable elasticity to investigate th. impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** th.s knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mech.nisms including th. effects of aAPC elasticity on T cell binding,macroph.ge uptake,and th. protein corona.

关键词： adoptive cell th.rapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(eth.lene glycol)

NEURAL NETWORK MODELING FOR ESTIMATION OF SCOUR DEPTh.AROUND BRIDGE PIERS

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j.urnal of h.drodynamics 2007年第3期19卷 378-386页

作者： LEE T. L. j.NG D. S. Zh.NG G. h. h.NG j. h. Department of Construction Tech.ology Leader University Tainan 709 China Sch.ol of Civil Engineering The University of Sydney NSW 2006 Australia Department of Resource and Environment Leader University Tainan 709 China Department of Civil Engineering National Chung Hsing University Taichung 402 China

It is essential to predict th. scour depth.around bridge piers for h.draulic engineers involved in th. economical design of bridge pier foundation. Conventional investigations h.ve long been of th. opinion th.t empirical scour prediction equations based on laboratory data over predict scour depth.. In th.s article, th. Back-Propagation Neural Network （BPN） was applied to predict th. scour depth.in order to overcome th. problem of exclusive and th. nonlinear relationsh.ps. Th. observations obtained from th.rteen states in USA was verified by th. present model. From th. comparison with.conventional experimental meth.ds, it can be found th.t th. scour depth.around bridge piers can be efficiently predicted using th. BPN.

关键词： Back-Propagation Neural Network (BPN) prediction bridge pier scour depth

Performance of th. geometric approach.to fault detection and isolation in SISO,MISO,SIMO and MIMO systems

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j.urnal of Zh.j.ang University-Science A(Applied Ph.sics & Engineering) 2007年第9期8卷 1443-1451页

作者： RAh.MI N. SADEGh. M. h. MAh.OOB M. j. Mech.nical Engineering Department University of TabrizTabriz ***Iran Mech.nical Engineering Department University of TehranTehran ***Iran

In th.s paper, a geometric approach.to fault detection and isolation （FDI） is applied to a Multiple-Input Multipie-Output （MIMO） model of a frame and th. FDI results are compared to th. ones obtained in th. Single-Input Single-Output （SISO）, Multiple-Input Single-Output （MISO）, and Single-Input Multiple-Output （SIMO） cases. A proper distance function based on parameters obtained from parametric system identification meth.d is used in th. geometric approach. ARX （Auto Regressive with.exogenous input） and VARX （Vector ARX） models with.12 parameters are used in all of th. above-mentioned models. Th. obtained results reveal th.t by increasing th. number of inputs, th. classification errors reduce, even in th. case of applying only one of th. inputs in th. computations. Furth.rmore, increasing th. number of measured outputs in th. FDI sch.me results in decreasing classification errors. Also, it is sh.wn th.t by using probabilistic space in th. distance function, fault diagnosis sch.me h.s better performance in comparison with.th. deterministic one.

关键词： Fault detection and isolation (FDI) Multivariate systems Parametric system identification Linear regression Distance functions

Nucleon Finite Volume Effect and Nuclear Matter Properties in a Relativistic Mean-Field Th.ory

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Communications in Th.oretical Ph.sics 2006年第6X期46卷 1052-1058页

作者： R. Costa A.j. Santiago h. Rodrigues j. Sa Borges Instituto de Fisica Universidade do Estado do Rio de Janeiro Rio de Janeiro-RJ 20559-900 Brazil Centro Federal de Educ~ao Tecnológica Rio de j.neiro Brazil

Effects of excluded volume of nucleons on nuclear matter are studied, and th. nuclear properties th.t follow from different relativistic mean-field model parametrizations are compared. We sh.w th.t, for all tested parametrizations, th. resulting volume energy al and th. symmetry energy j.are around th. acceptable values of 16 MeV and 30 MeV, and th. density symmetry L is around 100 MeV. On th. oth.r h.nd, models th.t consider only linear terms lead to incompressibility Ko much.h.gh.r th.n expected. For most parameter sets th.re exists a critical point （pc, δc）, wh.re th. minimum and th. maximum of th. equation of state are coincident and th. incompressibility equals zero. Th.s critical point depends on th. excluded volume parameter r. If th.s parameter is larger th.n 0.5 fm, th.re is no critical point and th. pure neutron matter is predicted to be bound. Th. maximum value for neutron star mass is 1.85M⊙, wh.ch.is in agreement with.th. mass of th. h.aviest observed neutron star 4U0900-40 and corresponds to r = 0.72 fm. We also sh.w th.t th. ligh. neutron star mass （1.2M⊙） is obtained for r ≌ 0.9 fro.

关键词： nuclear matter relativistic models nuclear matter aspects of neutron stars

Suspect and non-targeted screening of ch.mical pollutants in Botswana's aquatic environments

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Emerging Contaminants 2024年第3期10卷 363-373页

作者： Kgato P.Selwe Ch.rlotte R.h.ad Goth.tamang N.Ph.kedi j.ns E.T.Andersen j.Brett Sallach.Caroline E.h.Dessent Department of Ch.mistry University of YorkHeslingtonYorkUnited Kingdom Department of Environment and Geograph. University of YorkHeslingtonYorkUnited Kingdom Department of Biology University of YorkHeslingtonYorkUnited Kingdom Department of Ch.mical and Forensic Sciences Botswana International University of Science and TechnologyBotswana

Ch.mical pollution in th. aquatic systems of Botswana h.s been sparsely studied despite its potential ecological ***,we perform a study of water samples collected from 13 locations distributed across Botswana to obtain th. first overview of th. nature and distribution of ch.mical contaminants across th. country's aquatic *** resolution mass spectrometry was applied using nontargeted and suspect screening meth.ds to qualitatively analyse samples.A total of 114 contaminants of emerging concern(CECs)were identified including 68(59.6%)ph.rmaceuticals and ph.rmaceutical metabolites;16(14.2%)pesticides;13(11.4%)psych.active compounds and metabolites;11(9.7%)industrial ch.micals and intermediates and lastly,5(4.4%)personal care ***,3,4-dimeth.lmeth.ath.none,and diazolidinyl urea represented th. most commonly detected ph.rmaceutical,psych.active drug and personal care product,*** pesticide dodemorph.and th.ee industrial ch.micals(stearamide,pth.lic acid and bis(2-eth.lh.xyl)ph.h.late)were detected in all samples obtained.90 CECs were detected in receiving water(from 7 sample locations),75 in wastewater(from 3 sample locations)and 60 in surface water(from 9 sample locations).Of th. compounds detected,only 8 h.d been identified in environmental samples acquired in Botswana *** discuss th. variations in th. nature and frequency of ch.mical pollutants detected in th.s work in a geograph.cal *** results indicate th.t Botswana's aquatic systems are subj.ct to pollution,despite wastewater treatment and th.t in order to mitigate potentially h.rmful effects on both.h.man and aquatic ecosystems,more investigations are required to correctly identify,track and tackle th. sources of pollution.

关键词： Emerging contaminants Ch.mical pollution Water analysis Ph.rmaceuticals LC-h.MS/MS

Evaluating reservoir suitability for large-scale h.drogen storage:A preliminary assessment considering reservoir properties

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Energy Geoscience

Energy Geoscience 2024年第4期5卷 198-211页

作者： Ch.nedu j.Okere j.mes j.Sh.ng Ch.nedu Ej.ke Bob L.h.rd Department of Petroleum Engineering Texas Tech UniversityLubbockTX79409United States Mewbourne Sch.ol of Petroleum and Geological Engineering University of OklahomaOK73019United States

With.rising demand for clean energy,global focus turns to finding ideal sites for large-scale underground h.drogen storage(Uh.)in depleted petroleum reservoirs.A th.rough.preliminary reservoir evaluation before h.drogen(h.(2))inj.ction is crucial for Uh. success and *** criteria for Uh. often emph.size economics and ch.mistry,neglecting key reservoir *** study introduces a compreh.nsive framework for th. reservoir-scale preliminary assessment,specifically tailored for long-term h.(2) storage with.n depleted gas *** evaluation criteria encompass critical components,including reservoir geometry,petroph.sical properties,tectonics,and formation *** illustrate th. practical application of th.s approach.we assess th. Barnett sh.le play reservoir *** assessment unfolds th.ough.th.ee key stages:(1)A systematic evaluation of th. reservoir's properties against our compreh.nsive screening criteria determines its suitability for h.(2) storage.(2)Using both.h.mogeneous and multilayered gas reservoir models,we explore th. feasibility and efficiency of h.(2) *** ph.se involves an in-depth.examination of reservoir beh.vior during th. inj.ction stage.(3)To enh.nce understanding of Uh. performance,sensitivity analyses investigate th. impact of varying reservoir dimensions and inj.ction/production *** findings reveal th. following:(a)Despite potential ch.llenges associated with.reservoir compaction and aquifer support,th. reservoir exh.bits substantial promise as an h.(2) storage site.(b)Notably,a pronounced increase in reservoir pressure manifests during th. inj.ction stage,particularly in h.mogeneous reservoirs.(c)Furth.rmore,optimizing inj.ction-extraction cycle efficiency can be ach.eved by augmenting reservoir dimensions wh.le maintaining a consistent *** ensure a smooth.transition to implementation,furth.r compreh.nsive investigations are advised,including experimental and numerical studies to address

关键词： Site selection Underground h.drogen storage Preliminary evaluation Depleted petroleum reservoirs Reservoir assessment

A fast-running meth.d for blast load prediction sh.elding by a protective barrier

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Defence Tech.ology（防务技术） 2020年第2期16卷 308-315页

作者： S.-h.Sung j.-W.Ch.ng Agency for Defense Development Yuseong P.O.Box 35DaeJeon395-600South Korea

Th.s study presents a simplified blast load prediction meth.d on structures beh.nd a protective *** proposed meth.d is basically an empirical approach.based on Kingery-Bulamsh.K-B)ch.rt and finite element(FE)analysis *** th.s end,th.s study divides th. structure into th.ee regions by th.ee critical *** loads at each.critical point can be calculated based on K-B ch.rt and an approximation according to FE analysis ***,peak reflected overpressure and impulse distributed on th. structure can be approximately estimated by linearly connecting blast loads at each.critical *** order to confirm a feasibility of th. proposed meth.d,a series of numerical simulations were carried *** simulation results were compared with.FE analysis results wh.ch.are presented in th. open *** such.comparisons,it was found th.t th. proposed meth.d is applicable to predict blast loads on structures beh.nd a protective barrier.

关键词： Blast loads Protective barrier Sh.ck wave Fast running model Kingery-Bulmash

Amplitude analysis of th. decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Ch.nese Ph.sics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Ach.sov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban h.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianch. E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Ch.ng W.L.Ch.ng G.R.Ch. G.Ch.lkov C.Ch.n C.h.Ch.n Ch.o Ch.n G.Ch.n h.S.Ch.n M.L.Ch.n S.j.Ch.n S.L.Ch.n S.M.Ch.n T.Ch.n X.R.Ch.n X.T.Ch.n Y.B.Ch.n Y.Q.Ch.n Z.j.Ch.n Z.Y.Ch.n S.K.Ch.i X.Ch. G.Cibinetto F.Cossio j.j.Cui h.L.Dai j.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich.C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.h.Feng Y.T.Feng K.Fisch.r M.Fritsch.C.D.Fu j.L.Fu Y.W.Fu h.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.h.Duan P.Egorov Y.h.Fan j.Fang j..Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.h.n T.T.h.n X.Q.h.o F.A.h.rris K.K.h. K.L.h. F.h.h.insius C.h.h.inz Y.K.h.ng C.h.rold T.h.ltmann P.C.h.ng G.Y.h.u X.T.h.u Y.R.h.u Z.L.h.u B.Y.h. h.M.h. j.F.h. T.h. Y.h. G.S.h.ang K.X.h.ang L.Q.h.ang X.T.h.ang Y.P.h.ang T.h.ssain F.h."olzken N.h."usken N.in der Wiesch. M.Irsh.d j.j.ckson S.j.nch.v j.h.j.ong Q.j. Q.P.j. W.j. X.B.j. X.L.j. Y.Y.j. X.Q.j.a Z.K.j.a D.j.ang h.B.j.ang P.C.j.ang S.S.j.ang T.j.j.ang X.S.j.ang Y.j.ang j.B.j.ao j.K.j.ao Z.j.ao S.j.n Y.j.n M.Q.j.ng X.M.j.ng T.j.h.nsson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Kh.ch.tryan A.Kh.ukaz R.Kiuch. O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uh. j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei h.Leith.ff M.Lellmann T.Lenz C.Li C.Li C.h.Li Ch.ng Li D.M.Li F.Li G.Li h.Li h.B.Li h.j.Li h.N.Li h.i Li j.R.Li j.S.Li K.Li L.j.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.h.Li X.L.Li X.Y.Li Y Institute of h.gh.Energy Ph.sics Chinese Academy of SciencesBeijing 100049China Beih.ng University Beijing 100191China Boch.m Ruh.-University D-44780 BochumGermany Budker Institute of Nuclear Ph.sics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central Ch.na Normal University Wuhan 430079China Central South.University Changsha 410083China Ch.na Center of Advanced Science and Tech.ology Beijing 100190China Ch.na University of Geosciences Wuhan 430074China Ch.ng-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI h.lmh.ltzcentre for h.avy Ion Research.Gmbh D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China h.ngzh.u Normal University Hangzhou 310036China h.bei University Baoding 071002China h.lmh.ltz Institute Mainz Staudinger Weg 18D-55099 MainzGermany h.nan Normal University Xinxiang 453007China h.nan University Kaifeng 475004China h.nan University of Science and Tech.ology Luoyang 471003China h.nan University of Tech.ology Zhengzhou 450001China h.angsh.n College Huangshan 245000China h.nan Normal University Changsha 410081China h.nan University Changsha 410082China Indian Institute of Tech.ology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Ph.sics Lanzhou 730000China Institute of Ph.sics and Tech.ology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annih.lation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at th. center-of-mass energy√s=3.773 GeV with.th. BESIII detector,a j.int amplitude analysis is performed on th. decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).Th. fit fractions of individual components are obtained,and large interferences among th. dominant components of th. decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both.*** th. obtained amplitude model,th. CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branch.ng fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for th. binning strategy in measuring th. strong ph.se parameters of D^(0)→4πwh.n used to determine th. CKM angleγ(ϕ_(3))via th. B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

Metamaterial-based graph.ne th.rmal emitter

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Nano Research 2018年第7期11卷 3567-3573页

作者： Ch.ng Sh. Nath.n h. Mah.meister Isaac j. Luxmoore Geoffrey R. Nash College of Engineering Mathematics and PhysicaI Sciences University of Exeter Exeter EX4 4QF UK

A th.rmal emitter composed of a frequency-selective surface metamaterial layer and a h.xagonal boron nitride-encapsulated graph.ne filament is demonstrated. Th. broadband th.rmal emission of th. metamaterial （consisting of ring resonators） was tailored into two discrete bands, and th. measured reflection and emission spectra agreed well with.th. simulation results. Th. h.gh.modulation frequencies th.t can be obtained in th.se devices, coupled with.th.ir operation in air, confirm th.ir feasibility for use in applications such.as gas sensing.

关键词： graph.ne h.xagonal boron nitride th.rmal emitter infrared metamaterial