检索结果-南通市图书馆

Rosa moschata ameliorates haloperidol-induced Parkinson's disease via reduction of neurodegeneration and oxidative stress

引用

Asian Pacific Journal of Tropical Biomedicine 2025年第1期15卷 24-33,I0013-I0015页

作者： badriyah s.alotaibi Uzma saleem Maryam Farrukh Zunera Chaudhary Nabia Anwar Ifat Alsharif Abdullah R.Alanzi Tasahil s.Albishi Fatima A.Jaber Wedad saeed Al-Qahtani Muhammad Ajmal shah Department of Pharmaceutical sciences College of PharmacyPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Punjab University College of Pharmacy University of the PunjabLahore-54000Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesGovt.College UniversityFaisalabad-38000Pakistan Department of Biology Jamoum University CollegeUmm Al-Qura University-21955 MakkahSaudi Arabia Department of Pharmacognosy College of PharmacyKing Saud UniversityRiyadh-11451Saudi Arabia Department of Biology College of SciencesUmm Al-Qura UniversityMakkahSaudi Arabia Department of Biological sciences College of ScienceUniversity of JeddahJeddah 21589Saudi Arabia Department of Forensic sciences College of Criminal JusticeNaif Arab University for Security SciencesP.O.Box 6830Riyadh 11452Saudi Arabia Department of Pharmacy Hazara UniversityMansehra-21300Pakistan

Objective:To investigate the effect of Rosa moschata(***)extract on haloperidol-induced Parkinson’s disease(PD)in ***:Haloperidol(1 mg/kg)was given to rats intraperitoneally for 3 weeks for induction of *** extract(150,300 and 600 mg/kg)was administered orally for 21 *** neuroprotective role of *** leaf extract in PD was explored by performing neurobehavioral tests and RT-PCR analysis and measuring neurotransmitters and oxidative stress ***:An improvement in motor functions and muscle strength was observed in PD rats treated with *** *** levels of dopamine,serotonin,noradrenaline,superoxide dismutase,catalase,glutathione,and superoxide dismutase were significantly increased(Ps acetylcholinesterase and malondialdehyde levels were markedly decreased by treatment with *** extract(Pso markedly downregulated the mRNA expressions of IL-1β,α-synuclein,IL-1α,and TNF-αin brain ***,histopathological analysis indicated that neurofibrillary tangles and plaques were noticeably decreased in a dose-dependent manner in PD rats treated with *** ***:*** extract alleviates haloperidol-induced PD in rats by reducing oxidative stress and *** may be used for management and treatment of *** additional studies are required to confirm its efficacy and molecular mechanisms.

关键词： Parkinson’s disease Rosa moschata Neurotransmitter,α-synuclein Haloperidol Neurodegeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：