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Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients

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World Journal of Gastroenterology 2016年第34期22卷 7767-7777页

作者： Noha G bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mosta.a.M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mosta.a.K El a.a.y Department of Microbial Biotechnology National Research Centre Department of Biochemistry Faculty of ScienceAin Shams University Endemic Medicine Department Faculty of MedicineCairo University

AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype *** This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism a.a.ysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically a.a.yzed. The OR and 95%CI were calculated to assess the relative risk *** Current da.a.showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and a.a.lele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression a.a.ysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the a.a.lele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected

关键词： Hepatitis C virus immune response Tumor necrosis factor alpha Single nucleotide polymorphisms Cytokine expression Liver disease progression

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Health care reform in the USA: Recommendations from USa.a.d non-USA radiologists

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World Journal of Radiology 2012年第2期4卷 44-47页

作者： Lauren MB Burke Diego R Martin Till bader Richard C Semelka Department of Radiology University of North Carolina Chapel Hill NC 27599-7510 United States Department of Radiology Emory University School of Medicine Atlanta GA 30322 United States Department of Radiology Medical University of Vienna Waehringer Guertel 18-20 1090 Vienna Austria

AIM: To compare the opinions and recommendations of imaging specialists from United States (USA) and non-USA developed nations for USA health care reform. METHODS: A survey was emailed out to 18 imaging specialists from 17 non-USA developed nation countries and 14 radiologists within the USA regarding health care reform. The questionnaire contained the following ques tions: what are the strengths of your health care system, what problems are present in your nation's health care system, and what recommendations do you have for health care reform in the USA. USa.a.d non-USA radiologists received the same questionnaire. RESULTS: Strengths of the USA health care system include high quality care, autonomy, and access to timely care. Twelve of 14 (86%) USA radiologists identified medicolegal action as a major problem in their health care system and felt that medicolegal reform was a critical aspect of health care reform. None of the non-USA radiologists identified medicolegal aspects as a problem in their own country nor identified it as a subject for USA health care reform. Eleven of 14 (79%) USA radiologists and 16/18 (89%) non-USA radiologists identified universal health care coverage as an important recommendation for reform. CONCLUSION: Without full universal coverage, meaningful health care reform will likely require medicolegal reform as an early and important aspect of improved and efficient health care.

关键词： Health care reform Health care policy

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HIV重叠肝炎病毒感染者血清IL-18和IL-10水平分析

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浙江大学学报（医学版） 2003年第2期32卷 94-96页

作者：吴南屏李丹 Armin bader Hoxtermann Stefan Norbert Brockmeyer 浙江大学医学院附属第一医院传染病研究所浙江杭州310003 德国鲁尔大学约瑟夫艾滋病研究中心

目的 :探讨细胞因子在 HIV- HBV/ HCV重叠感染中的意义。方法 :采用 ELISA法检测血清 IL- 18和 IL- 10的水平 ,荧光定量 PCR计数测定 HIV- RNA滴度 ,流式细胞仪检测 CD4 + T细胞。结果 :HIV感染后 ,血清 IL- 18显著高于正常对照 (P<0 .0... 详细信息

目的 :探讨细胞因子在 HIV- HBV/ HCV重叠感染中的意义。方法 :采用 ELISA法检测血清 IL- 18和 IL- 10的水平 ,荧光定量 PCR计数测定 HIV- RNA滴度 ,流式细胞仪检测 CD4 + T细胞。结果 :HIV感染后 ,血清 IL- 18显著高于正常对照 (P<0 .0 5 )。随着疾病的进展 ,IL- 18逐渐上升而 IL - 10逐渐下降。重叠感染组血清 IL - 18和 IL- 10显著高于单纯 HIV感染组。结论 :肝炎病毒感染是影响 HIV感染者血清细胞因子水平的一个协变量 ,上调 IL- 18和下调 IL - 10可能起到改善重叠感染的预后的作用。

关键词： HIV感染重叠感染肝炎病毒感染血清 IL-18 IL-10

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HIV感染对记忆型和处女型CD4^+T细胞上CD95的影响

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浙江大学学报（医学版） 2003年第2期32卷 90-93页

作者：吴南屏李丹 Armin bader Hoxtermann Stefan Norbert Brockmeyer 浙江大学医学院附属第一医院传染病研究所浙江杭州310003 德国鲁尔大学约瑟夫艾滋病研究中心

目的 :了解 CD95在 HIV感染者记忆型和处女型 CD4 + T细胞表面的表达情况 ,探讨 Fas/ CD95在 HIV感染中的作用。方法 :采用流式细胞检测仪 (FACS)对 HIV感染者外周血 CD4 + T细胞表面 CD95、CD4 5 RA、CD4 5 RO的表达进行分析 ,用 EL IS... 详细信息

目的 :了解 CD95在 HIV感染者记忆型和处女型 CD4 + T细胞表面的表达情况 ,探讨 Fas/ CD95在 HIV感染中的作用。方法 :采用流式细胞检测仪 (FACS)对 HIV感染者外周血 CD4 + T细胞表面 CD95、CD4 5 RA、CD4 5 RO的表达进行分析 ,用 EL ISA检测血清中 Fas水平。结果 :HIV感染后 ,血清 Fas水平随疾病的进展而逐渐升高 ,同时伴有处女型 T细胞表面 CD95表达增高以及记忆型 T细胞 CD95表达逐渐下降。结论 :Fas参与了 HIV的感染过程。研究 Fas和 CD95、CD4 5 RA、CD4 5 RO之间的关系 ,可以加深对 HIV致病机制的认识 ,并可了解疾病的进展情况和指导治疗。

关键词： HIV感染记忆型处女型 CD4^-T细胞 CD95 艾滋病流式细胞检测

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Association of Human Herpesvirus 6 and 8 in Relapsing Remitting Multiple Sclerosis Type during Exacerbation

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Neuroscience & Medicine 2010年第1期1卷 33-37页

作者： Hassan Sa.a.a Mohamed El-Khateeb Rawya bader Mohamed Saleh Enas Ha.a. 不详

Multiple Sclerosis (MS) is a chronic demyelinating disease of the CNS with assumed autoimmune etiology. Human herpes viruses have probable effects on relapsing-remitting MS pathogenesis presumably through molecular mimicry and/or bystander mechanisms. In this study we probed the possible contribution of the two herpes viruses, human herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8), in clinically definite multiple sclerosis (CDMS) pa-tients-relapsing remitting type (RRMS) during clinical exacerbations. All patients had no history of immune modulating or suppressing drugs intake in the last 6 months. The peripheral blood samples, from CDMS patients (n = 20) (13F/7M, age (y) = 30.3 ± 3.21) and other immune mediated neurological disorders (OIND) (11F/9M, age = 25.2 ± 12.1), (My-asthenia Gravis, Guillain Barré Syndrome, ischemic stroke in adolescent and young adult with no clear risk factors), as a control group, had been enrolled within 15 months (January-2007-- March -2008). We investigated the existence of specific deoxyribonucleic acid (DNA) sequences belonging to HHV-6 and HHV-8, using polymerase chain reaction (PCR) in the isolated peripheral blood mononuclear cells (PBMCs) and in plasma. PCR demonstrated HHV-6 DNA in 7 cases (35%), HHV-8 sequences in only one cases (5%) in PBMCs from 20 relapsed CDMS patients;all HHV-6 posi-tive cases showed positive plasma results, while the blood samples from 20 OIND patients showed negative results ex-cept one case (5%) out of 9 cases of GBS was positive for HHV-8 in PBMCs. We consequently concluded that there is considerable evidence in this study that proposed the roles of HHV-6 and HHV-8 in MS pathogenesis and clinical ex-acerbation.

关键词： Multiple Sclerosis HHV6 HHV8 Antiviral Drugs

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高效抗逆转录病毒治疗对T细胞亚群上第二受体影响的研究

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浙江大学学报（医学版） 2003年第2期32卷 97-100页

作者：李丹吴南屏 Armin bader Hoxtermann Stefan Norbert Brockmeyer 浙江大学医学院附属第一医院传染病研究所浙江杭州310003 德国鲁尔大学约瑟夫艾滋病研究中心

目的 :研究高效抗逆转录病毒治疗 (HAART)后 T细胞亚群上第二受体的变化及其意义。方法 :采用流式细胞仪检测 CD4 + 、CD8+ 、CD4 + CD4 5 RA+ 以及 CD4 + CD4 5 RO+ 细胞表面 CCR5及 CXCR4的表达水平。结果 :HIV感染后 ,第二受体在 CD4... 详细信息

目的 :研究高效抗逆转录病毒治疗 (HAART)后 T细胞亚群上第二受体的变化及其意义。方法 :采用流式细胞仪检测 CD4 + 、CD8+ 、CD4 + CD4 5 RA+ 以及 CD4 + CD4 5 RO+ 细胞表面 CCR5及 CXCR4的表达水平。结果 :HIV感染后 ,第二受体在 CD4和 CD8以及记忆型和处女型 CD4 T细胞亚群上的表达水平 ,与正常对照没有显著性差异。 HAART治疗仅能在一定程度上改变细胞表面的第二受体水平。结论 :第二受体参与了 HIV的致病过程 ,B期之前开始抗病毒治疗将有较好的疗效。

关键词：高效抗逆转录病毒治疗 T细胞亚群第二受体 HIV 艾滋病

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Calcitriol induced hypercalcemia.a.rare phenomenon in lung cancer:A case report

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World Journal of Clinical Oncology 2023年第11期14卷 544-548页

作者： Amulya Pra.a.h Farhan Khalid Ahmad a.a.wan Husam bader Doantrang Du Trisha.a.Meghal Department of Internal Medicine Haywood Regional Medical CenterClydeNC 28721United States Department of Internal Medicine Monmouth Medical CenterLong BranchNJ 07740United States Department of Hematology-Oncology Monmouth Medical CenterLong BranchNJ 07740United States

BACKGROUND Calcitriol-induced hypercalcemia has been rarely reported in cases of lung cancer;however,it is frequently reported in cases of lymphoid malignancy and granulomatous *** present a rare case of hypercalcemia.a.sociated with squamous cell cancer of the lung with elevated calcitriol *** SUMMARY A 61-year-old Caucasian female with severe hypercalcemia of 15 mg/dL,which led to a new diagnosis of metastatic lung *** the pa.a.hyroid hormonerelated peptide(PTHrP)level was minimally elevated at 2.1 pmol/L,we believe excessive calcitriol production by tumor cells was the underlying mechanism for *** was significantly elevated at 130 pg/mL with a low 25-hydroxyvitamin D level of 25.9 ng/mL and suppressed PTH level of 8 pg/*** are generally used to treat calcitriol-induced hypercalcemia,but we successfully treated our patient with bisphosphonate,highlighting the further utility of bisphosphonates in hypercalcemia *** We believe that the underlying cause of hypercalcemia,in this case of metastatic squamous cell lung carcinoma,was elevated calcitriol,which was likely produced by the tumor *** addition to PTHrP,calcitriol levels should be included in the workup for hypercalcemia in cases of lung ***,the pathophysiology and prognostic significance of dysregulated calcitriol production in solid tumors remain unclear and warrant further *** may be used as a steroid-sparing therapy even in cases of calcitriol-induced hypercalcemia.a.d warrants further investigation.

关键词： Hypercalcemia.a.sociated malignancy Lung cancer Denosumab Calcitriol Vitamin D Case report

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艾滋病相关的卡波西肉瘤免疫激活状态研究

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浙江大学学报（医学版） 2003年第2期32卷 101-103页

作者：朱彪吴南屏 Hoxtermann Stefan Armin bader Norbert Brockmeyer 浙江大学医学院附属第一医院传染病研究所浙江杭州310003 德国鲁尔大学约瑟夫艾滋病研究中心

目的 :进一步探讨免疫功能改变在艾滋病相关的卡波西肉瘤 (AIDS- KS)发病中的作用。方法 :对 12例AIDS- KS,32例无卡波西肉瘤的 HIV感染者 (HIV- NKS)和 16例正常对照进行了研究 ,用 EL ISA对 8例 AIDS- KS,2 8例 HIV- NKS和 16例正常... 详细信息

目的 :进一步探讨免疫功能改变在艾滋病相关的卡波西肉瘤 (AIDS- KS)发病中的作用。方法 :对 12例AIDS- KS,32例无卡波西肉瘤的 HIV感染者 (HIV- NKS)和 16例正常对照进行了研究 ,用 EL ISA对 8例 AIDS- KS,2 8例 HIV- NKS和 16例正常对照血清 (或血浆 )进行了 s Fas,β 2 -微球蛋白 (β 2 - MG) ,IL - 10 ,IL- 16 ,IL- 18,IL- 6和可溶性 IL - 4受体 (s IL- 4R)测定 ,对 12例 AIDS- KS,32例 HIV- NKS外周血淋巴细胞、淋巴细胞亚群及 CD38+CD8,HLA- DR+ CD8进行了分析。结果 :β 2 - MG,s IL- 4R水平在 HIV- NKS组明显高于正常对照组 ,IL- 16水平在HIV- NKS组明显低于正常对照组 ,IL - 18水平在 HIV- NKS组和 AIDS- KS组均明显高于正常对照组 ;CD3、CD4、CD8、NK、HLA- DR+ CD8在 AIDS- KS均低于 HIV- NKS,而 AIDS- KS组 CD19、CD38+ CD8高于 HIV- NKS组 ,但各组间差异无显著性。结论 :AIDS- KS和 HIV- NKS一样存在一定程度的免疫激活 ,但 AIDS- KS和 HIV- NKS间免疫状态无明显差异 ,提示免疫状态的差异可能不是艾滋病患者并发卡波西肉瘤的主要原因。

关键词：艾滋病卡波西肉瘤免疫激活状态研究免疫功能淋巴细胞亚群 β2-微球蛋白

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Expla.a.ion of the Da.a.e to the Royal Family’s Cemetery in Historic Cairo and Examination of the Building Materials

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Open Journal of Civil Engineering 2021年第1期11卷 28-59页

作者： Ahmed Elya.a.i Nabil A. Abd El-Ta.a. bader Mahmoud Algohary Ra.a. Abou El Hassan Department of Archaeological Conservation Faculty of Archaeology Cairo University Cairo Egypt Treatment and Conservation Department Faculty of Archaeology Zagazig University Zagazig Egypt Restoration and Conservation of Antiquities Department Faculty of Archaeology and Tourism Guidance Misr University for Science and Technology 6th October City Egypt

The cemetery of the royal family, who ruled Egypt from 1805 to 1952, is one of the masterpieces of the UNESCO World Heritage Site of Historic Cairo. It is a complex building from massive stone masonry walls supporting hemispherical domes and is very rich with the marble decorative elements. Unfortunately, it suffers nowadays from serious cracking due to on-going structural damage. Almost all the structural elements are cracked. Besides, thea.a."> continuous rise in the groundwater table affects both its structural stability and aesthetics. A detailed inspection was carried out to identify and explain all the manifested da.a.e by the structural elements of the cemetery. The differential settlement da.a.e was found to be very noticeable in the form of many diagonal cracks that are active and threaten the overall stability of the cemetery. The construction history was investigated and found to have a clear effect on the noticed da.a.e. Examination of the construction materials and deterioration products was carried out by inspecting representative samples of the stone, the marble, the mortar, the plaster and the salt. They were examined using different a.a.ysis techniques including the Polarized Microscope, the Stereo Microscope, the X-Ray Diffraction (XRD), and the Scanning Electron Microscope (SEM) provided with Energy-Dispersive X-ray spectroscopy (EDX) unit. This examination helped in identifying the type of the used stone, the mortar components, the types of salts affecting the structure, and the deterioration manifested by the marble. It seems that the cemetery needs an urgent conservation project to stop the deterioration and keep it safe for the next generations.

关键词： Historic Cairo Cemetery Differential Settlement Groundwater Da.a.e XRD SEM-EDX Examination

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Titanium allergy or not? “Impurity” of titanium implant materials

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Health 2010年第4期2卷 306-310页

作者： Thomas Harloff Wolfgang Honle Ulrich Holzwarth Rainer bader Peter Thomas Alexander Schuh Research Unit Neumarkt Clinical CenterNeumarktGermany Orthopedic Clinic Neumarkt NeumarktGermany MedTitan ErlangenGermany Orthopedic Clinic and Polyclinic University of RostockRostockGermany Clinic and Polyclinic for Dermatology and Allergology of the Ludwig-Maximilians-University of Munich MunichGermany

For patients suffering from allergies to nickel, chrome and cobalt, titanium implants are the implants of choice. Nevertheless, titanium implant sensitivity has been reported in the form of “allergies” and an increasing number of patients are confused. This paper aims to use spectral a.a.ysis as a diagnostic tool for a.a.yzing different titanium implant alloys in order to determine the percentage of the alloy components and additions that are known to cause allergies. Different materials, such as sponge titanium, TiAl6Nb7, Ti21SRx, TiAl6V4 [forged alloy], TiAl6V4 [cast alloy], TMZF, pure titanium [c. p. 1] and iodide titanium were a.a.yzed for the presence of the elements that have been associated with allergic reactions using spectral a.a.ysis. All the implant material samples contained traceable amounts of Be, Cd, Co, up to a maximum of 0.001 percent by weight [wt.%], Cr up to 0.033 wt.%, Cu up to 0.007 wt.%, Hf up to 0.035 wt.%, Mn up to 0.007 wt.%, Ni up to 0.031 wt.%, and Pd up to 0.001 wt.%. This paper demonstrates that all the investigated implant material samples contained a low but consistent percentage of components that have been associated with allergies. For example, low nickel contents are related to the manufacturing pro- cess and are completely dissolved in the titanium grid. Therefore, they can virtually be classified as “impurities”. Under certain circumstances, these small amounts may be sufficient to trigger allergic reactions in patients suffering from the corresponding allergies, such as a nickel, palladium or chrome allergy.

关键词： Allergy Implant Nickel Spectral a.a.ysis Titanium

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