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Assessment of single nucleotide polymorphisms associated with steroid-induced ocular hypertension

International Journal of Ophthalmology(English edition) 2020年第8期13卷 1294-1305页

作者： lakshmi Badrinarayanan Srujana Chitipothu Sharada Ramasubramanyan Sarangapani Sripriya Pukhraj Rishi Ekta Rishi Ronnie George baddireddi subhadra lakshmi Sailaja VElchuri Department of Nano-biotechnology KNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India Department of Biotechnology Anna UniversityChennaiTamilNadu 600025India Central Research Instrumentation Facility KNBIRVO blockVision Research FoundationTamilNadu 600006India RS.Mehta Jain Department of Biochemistry and Cell BiologyKNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India SNONGC Department of Genetics and Molecular Biology KNBIRVO blockVision Research FoundationChennaiTamilNadu 600006India Shri Bhagwan Mahavir Vitreo-Retinal Service Medical Research FoundationChennaiTamilNadu 600006India Smt.Jadhavbai Nathamal Singhree Glaucoma Service Medical Research FoundationChennaiTamilNadu 600006India

AIM:To access the association of forty-eight single nucleotide polymorphisms(SNPs)identified from Caucasian population with steroid-induced ocular hypertension(OHT)in India ***:Fifty-four triamcinolone-acetonide(TA)and for ty-seven dexamethasone(Dex)administered subjects were enrolled in the study after a written *** pressure(IOP)values were recorded for a period of 6-month post steroid injections and patients were grouped as steroid-responders(SR:IOP≥21 mm Hg)and non-responders(NR:IOP≤20 mm Hg).Genomic DNA was isolated from peripheral venous ***-eight SNPs identified in TA treated Caucasian patients by genome wide association study(GWAS)were genotyped using iPLEXTM MassA RRAY among TA as well as Dex administered Indian *** data of 48 general subjects from a previous study were considered as reference controls for statistical *** frequencies were calculated and P-value,Chi-square and odds ratio at 95%confidenceinterval of group A(steroid treated vs controls),group B(SR vs NR),group C(phenotype correlation:influence of time,severity and gender on IOP rise),were calculated.P30 mm Hg)and immediate(<1 wk)among TA-SR patients while it was noticed to be mild(<30 mm Hg)and between 1-2 mo among Dex-SR *** regression for risk factor correlation with OHT remained non-significant,hence these factors were not considered as confounding parameters for further ***133,rs34016742,rs274554,rs10936746,rs274547,rs804854,rs7751500,rs359498,and rs7547448 SNPs significantly varied even after Bonferroni corrections(P<0.0025;group A).rs1879370(TA)and rs6559662(Dex)were significantly(P<0.05)associated with OHT(group B).rs133(severe IOP rise),rs11047639 and rs1879370(male gender),and rs11171569(immediate IOP rise)significantly(P<0.05)infl

关键词： triamcinolone-acetonide dexamethasone ocular hypertension single nucleotide polymorphisms diabetes neurodegeneration myopia

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