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Sickle Cell Disease in the Zinder Region in 2023: Prevalence and Sociodemographic Factors

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Open Journal of Blood Diseases 2024年第1期14卷 1-7页

作者： Brah Moustapha Maman Amadou Djibrilla-Almoustapha Moustapha Elhadji-Chefou Illa Hamidine Moussa Diongolé Hassane badé malam-abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: In view of the number of sickle cell patients and due to a low production of descriptive studies, we decided to determine the prevalence of genes S and C of the disease in the Zinder region. The objective was to contribute to improving the management of sickle cell disease in Zinder. Methodology: This was a systematic screening by the “Sickle Scan” test of any blood donor admitted to the Zinder Regional Blood Transfusion Center during the 6-month study period, from January to June 2023. The Sickle Scan is a qualitative lateral flow chromatography immunoassay using whole blood samples that aid in the rapid diagnosis of sickle cell disease. Results: The study was carried out on 613 samples during the period concerned. The frequency of sickle cell genes was 26.9% (n = 165) in all samples collected, with 23.1% (n = 142) and 3.8% (n = 23) for the S gene and the C gene, respectively. The 18 - 30 age group was the most represented with 64.4% (n = 395) cases. The median age of blood donors was 26 years ± 10 years (min = 18 years/max = 60 years). The sex ratio was 2.5. Donors of Nigerien nationality accounted for 84.1% (n = 516). There is a predominance of blood donors with an average monthly income between 34,000 and 70,000 CFA francs in 44.3% (n = 272), lived in permanent housing with drinking water supply. Sickle cell trait (SMA) was found in 22.5% (n = 138). Conclusion: The analysis of these results highlights a high frequency of the S gene for sickle cell disease. The population with an average monthly income is the most affected, with a male predominance.

关键词： Sickle Cell Anemia Blood Donors Sickle Scan

Chronic Lymphocytic Leukemia of del 17p in a Young Subject: About a Case and Reviewed a Literature

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Open Journal of Blood Diseases 2022年第4期12卷 103-109页

作者： Amadou Djibrilla-Almoustapha Moustapha Mamane-Brah Moustapha Elhadj-Chefou Maman Rabiou badé Faiza Abba-Ousmane Fanta Ousseini Oumoulkairou abdoulaye-Soumana badé malam-abdou Departement of Onco-Hematology of the National Hospital of Niamey Niamey Niger Faculty of Health Science Abdou Moumouni University of Niamey Niamey Niger Faculty of Health Science André Salifou University of Zinder Zinder Niger Faculty of Health Science of Maradi Maradi Niger

Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation;the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.

关键词： Chronic Lymphocytic Leukemia Young Subject del 17 p HNN Niger

Profile of Anemia in Cirrhotic Patients at the National Hospital of Niamey

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Open Journal of Gastroenterology 2024年第10期14卷 340-347页

作者： Fanta Ousseini badé malam abdou Amadou Djibrilla Almoustapha Rekiatou Ali Cheik Illa Hamidine Lawagoulé Joseph Emile Ky Ben Moctar abdou Djibo Nafissatou abdou Boubé abdou Gloria Vidinhessi-Tona Faculty of Health Sciences Abdou Moumouni University Niamey Niger Department of Hepato-Gastroenterology National Hospital Niamey Niger Department of Hematology National Hospital Niamey Niger Regional Hospital of Niamey Niamey Niger Faculty of Health Sciences Andr Salifou University of Zinder/Clinical and Health System Research Laboratory Niamey Niger Department of Hepato-Gastroenterology Yalgado-Ouedraogo University Hospital Ouagadougou Burkina-Faso Department of Hepato-Gastroenterology The General Reference Hospital Niamey Niger

Objective: To study the profile of anemia in cirrhotic patients diagnosed in the Hepato-Gastroenterology (HGE) department of the National Hospital of Niamey. Patients and Method: This was a prospective and descriptive study carried out from August 1, 2023 to February 29, 2024, including cirrhotic patients, with anemia on the blood count, outside of any recent blood transfusion and/or treatment. History of anemia. Results: The diagnosis of anemia was made in 91 patients out of the 100 cirrhotics recorded, 91%. Men were more common, with a sex ratio of 2.79. The average age was 50 ± 14.22 years old. Anemia was moderate in 52.75% of cases (n = 48). It was non-microcytic in 50.55% (n = 46) and iron deficient in 55.56% of cases (n = 20). There was a statistically significant correlation between the severity of anemia and upper gastrointestinal bleeding with a p-value = 0.000. Conclusion: Cirrhotic anemia is multifactorial, which makes its etiological diagnosis complex.

关键词： Anemia Cirrhosis National Hospital of Niamey Niger

Primary Non-Hodgkin’s Malignant Lymphoma of the Uterus at the Reference Hospital of Maradi/Niger: A Case Report

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Open Journal of Blood Diseases 2024年第2期14卷 43-46页

作者： Moustapha Elhadji-Chefou badé malam-abdou Amadou Djibrilla-Almoustapha Maman Brah Moustapha Oumou Kimso Ibrahim Timi Liman Elhadji Ali Issa abdou Amadou Borges Moreno Yuribet Facult des Sciences de la Sant Universit Dan Dicko Dankoulodo de Maradi Maradi Niger Hopital de Reference de Maradi Maradi Niger Facult des Sciences de la Sant Universit Abdou Moumouni de Niamey Niamey Niger Facult des Sciences de la Sant Universit Andr Salifou de Zinder Zinder Niger

Malignant non-Hodgkins lymphoma (MHNL) of the uterus is uncommon. We report a case diagnosed on the basis of histologic and immunohistochemical studies of a hysterectomy specimen induced by a very painful pelvic mass in a 50-year-old patient with no previous history of the disease. It was classified as Ann Arbor IV Bb after imaging, given the medullary infiltration and signs of clinical and biological evolutivity: the patient had received two courses of chemotherapy, CHOP protocol. She died 23 days after the second treatment due to a hypertensive crisis.

关键词： Malignant Non-Hodgkin’s Lymphoma Uterus Referral Hospital Maradi/Niger

Acute Leukemia in Niger: Epidemiological, Diagnostic and Therapeutic Aspects

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Open Journal of Blood Diseases 2024年第3期14卷 81-90页

作者： Amadou Djibrilla-Almoustapha badé malam-abdou abdourahamane Yacouba Moussa Souley Moustapha Maman Brah Moustapha Elhadji-Chefou Boubacar Marou-Soumana Samaila Aboubacar Ousseini Fanta Maman Rabiou badé Oumarou Adamou-Chaibou Department of Hematology-Oncology National Hospital of Niamey Niamey Niger Faculty of Health Sciences University of Abdou Moumouni Niamey Niger Department of Medicine Zinder Hospital Regional Niger Departtment of Biology Amirou Boubacar Diallo National Hospital Niamey Niger Faculty of Health Sciences University of Dan Dicko Dankouloudo of Maradi Maradi Niger Laboratory of Biology National Hospital of Niamey Niamey Niger

Objective: Improve the care of patients followed for acute leukemia in the Oncohematology department of the National Hospital of Niamey. Methods: This was a prospective study, over a period of 2 years from January 1, 2018 to December 31, 2019, in patients with acute leukemia in the Oncohematology department of the National Hospital of Niamey (HNN), whose diagnosis was made on a blood smear associated with a myelogram and immunophenotyping and who were consenting. Results: We collected 25 cases of acute leukemia confirmed by myelogram and immunophenotyping. The mean age of the patients was 31.32 years, with a predominance of women, a sex ratio of 0.92. Pupils and students were in the majority with 40% and most came from the Niamey region, i.e. 68%. Anemic syndrome was the most common clinical sign in 96%. ALL predominated in 64% of cases. On the blood count, the hyperleukocytosis was more marked in AML (mean white count: 197256.6 elts/mm3) than in ALL (137891.6 elts/mm3), it was the same for thrombocytopenia which is more marked in AML (75588.89/mm3) than in ALL (52156.25/mm3). Therapeutically, 52% of patients received chemotherapy. The mean overall survival was 16.223 ± 3.191 months, including a mean survival for AML of 6.853 ± 1200 months compared to 21.720 ± 5.920 months for ALL. Conclusion: Acute leukemia still remains a major problem in our context, due to the precariousness of limited financial, diagnostic and therapeutic resources. Thus reflecting in our results, the increasing number of cases, the diagnostic delay and the guarded prognosis. This is the reality in several other countries in the sub-region and even in certain developed countries.

关键词： Acute Leukemia ALL AML Hematology-Niamey National Hospital (HNN) Niger

Pulmonary and Orbital Bifocal IgG4 Disease: Case Report and Literature Review

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Open Journal of Blood Diseases 2024年第2期14卷 59-64页

作者： Abasse Moussa Ounteini Mamane Daou badé malam-abdou Brah Souleymane Amadou Djibrilla Almoustapha Yerima Salifou Seraphin Adjoh Komi Etienne Devin Habeeb Mahmoud Anas Mehdaoui Department of Pneumology and Thoracic Cancerology Eure-Seine Hospital vreux France Pulmonology Department Niamey National Hospital Niamey Niger Department of Internal Medicine General Reference Hospital FSS-UAM of Niamey Niamey Niger Department of Hematology National Hospital of Niamey FSS-UAM of Niamey Niamey Niger Pneumology Department Sylvanus Olympio University Hospital of Lom Lom Togo

Introduction: IgG4 disease is an orphan, fibro-inflammatory autoimmune disease of recent discovery whose thoracic involvement is rarer. We report a case of Pulmonary and orbital bifocal IgG4 disease with a review of the literature. Observation: This is a 71-year-old patient with a history of hypertension, dyslipidemia, smoking cessation at 15 PA, with progressive dyspnoea, weight loss of 4 kg with PS = 0 for 2 months. The thoracic CT scan revealed 3 pseudotumoral lung lesions of the LIG, LID and LM. The histology of the two CT-guided lung biopsies and the LIG wedge had objectified inflammatory lesions without signs of malignancy. The evolution was marked by the occurrence of a right orbital edema. The cerebral scanner found a voluminous right orbital inflammatory pseudotumor. Biopsy with histology found fibroinflammatory lesions with lymphoplasmacytic infiltrates and positive immunolabeling with anti-IgG4 antibodies. The PET scanner had objectified pulmonary and pleural parenchymal consolidations and moderately hypermetabolic mediastinal ADP with max SUV between 3 and 6. The patient was put on corticosteroid therapy with a favorable outcome. Conclusion: IgG4 disease is rare and difficult to diagnose despite well-defined and consensual diagnostic criteria and classification. The discovery of new biomarkers facilitates the diagnosis and monitoring of patients. Well-codified corticosteroid therapy is effective but possibility of recurrence. The current challenge remains the lack of data on the follow-up of these patients to assess the risk of neoplasia (lymphoma).

关键词： Orphan Disease Thoracic IgG4 Disease Autoimmunity

First Case of Von Willebrand Disease in Niger

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Open Journal of Blood Diseases 2021年第1期11卷 1-5页

作者： Amadou Djibrilla-Almoustapha Moustapha Maman-Brah Moustapha Elhadji-Chefou Maman Rabiou badé Amal Al-Azhari Youssoufa Seydou-Moussa Maman Aminou Mahamane Sani Mamane Daou Souleymane Brah badé malam-abdou Hematology Department of the Niamey National Hospital Niamey Niger Department of Internal Medicine of the National Hospital of Niamey Niamey Niger Endocrinology Department of the Niamey General Reference Hospital Niamey Niger Department of Internal Medicine of the General Reference Hospital of Niamey Niamey Niger

Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of Niamey’s National Hospital.

关键词： Willebrand Disease Onco Hematology Niamey Niger

An analytical method for space-time fractional nonlinear differential equations arising in plasma physics

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Journal of Ocean Engineering and Science 2017年第4期2卷 288-292页

作者： Mohamed Aly abdou Physics Department College of Science and Home DomesticsUniversity of BishaBishaSaudi Arabia

Here,a new fractional sub-equation method with a fractional complex transform is proposed for constructing exact solutions of fractional partial differential equations arising in plasma physics in the sense of modified Riemann-Liouville derivative,which is the fractional version of the known D_(ξ)^(α)G(ξ)/G(ξ)*** illustrate the validity of this method,we apply it to the space-time fractional KdV equation on the dust ion acoustic waves in dusty plasma and space-time Boussinesq fractional *** proposed approach is efficient and powerful for solving wide classes of nonlinear evolution fractional order *** solutions obtained here are new and have not been reported in former literature.

关键词： New frcational subequation method Fractional complex transformation Riemann-Liouville derivative Exact solutions

Specific wave profiles and closed-form soliton solutions for generalized nonlinear wave equation in(3+1)-dimensions with gas bubbles in hydrodynamics and fluids

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Journal of Ocean Engineering and Science 2023年第1期8卷 91-102页

作者： Sachin Kumar Ihsanullah Hamid M.A.abdou Department of Mathematics Faculty of Mathematical SciencesUniversity of DelhiDelhi 110007India Department of Mathematics College of SciencesUniversity of BishaP.O.Box 344Bisha 61922Saudi Arabia Physics Department Faculty of ScienceMansoura UniversityMansoura 35516Egypt

Nonlinear evolution equations(NLEEs)are frequently employed to determine the fundamental principles of natural *** equations are studied extensively in nonlinear sciences,ocean physics,fluid dynamics,plasma physics,scientific applications,and marine *** generalized exponen-tial rational function(GERF)technique is used in this article to seek several closed-form wave solutions and the evolving dynamics of different wave profiles to the generalized nonlinear wave equation in(3+1)dimensions,which explains several more nonlinear phenomena in liquids,including gas bubbles.A large number of closed-form wave solutions are generated,including trigonometric function solutions,hyper-bolic trigonometric function solutions,and exponential rational functional *** the dynamics of distinct solitary waves,a variety of soliton solutions are obtained,including single soliton,multi-wave structure soliton,kink-type soliton,combo singular soliton,and singularity-form wave *** de-termined solutions have never previously been *** dynamical wave structures of some analyt-ical solutions are graphically demonstrated using three-dimensional graphics by providing suitable values to free *** technique can also be used to obtain the soliton solutions of other well-known equations in engineering physics,fluid dynamics,and other fields of nonlinear sciences.

关键词： Closed-form solutions Dynamical wave patterns Analytic solutions Nonlinear wave equation GERF Method Solitary waves Solitons