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Expected outcomes and patients’selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict”scores may help clinicians:Real-life French cohorts results

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World Journal of Clinical Cases 2021年第18期9卷 4559-4572页

作者： Xavier Adhoute Edouard Larrey Rodolphe Anty Patrick Chevallier Guillaume Penaranda Albert tran Jean-Pierre Bronowicki Jean-Luc Raoul Paul Castellani hervéPerrier Olivier Bayle Olivier Monnet Bernard Pol Marc Bourliere Department of Gastroenterology and hepatology Hôpital Saint-JosephMarseille 13008France Department of Gastroenterology and hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Radiology Hôpital Universitaire de l’ArchetNice 06000France Statistics Department AlphaBio LaboratoryMarseille 13003France Department of Gastroenterology and hepatology Centre Hospitalo-Universitaire de NancyVandoeuvre les Nancy 54511France Department of Medical Oncology Institut de Cancérologie de l’OuestSite de NantesNantes 44805France Department of Radiology Hôpital Saint-JosephMarseille 13008France Department of hepatobiliary Surgery Hôpital Saint-JosephMarseille 13008France

BACKGROUND Careful selection of hepatocellular carcinoma(hCC)patients prior to chemoembolization treatment is a daily reality,and is even more necessary with new available therapeutic options in *** propose two new models to better stratify patients and maximize clinical benefit:“6 and 12”and“pre/post-TACE-predict”(TACE,transarterial chemoembolization).METhODS We evaluated and compared their performance in predicting overall survival with other systems{Barcelona Clinic Liver Cancer(BCLC),Albumin-Bilirubin(ALBI)and NIACE[Number of tumor(s),Infiltrative hCC,alpha-fetoprotein,Child-Pugh(CP),and performance status]}in two hCC French cohorts of different stages enrolled between 2010 and *** The cohorts included 324 patients classified as BCLC stages A/B(cohort 1)and 137 patients classified as BCLC stages B/C(cohort 2).The majority of the patients had cirrhosis with preserved liver function.“Pre-TACE-predict”and“6 and 12”models identified three distinct categories of patients exhibiting different prognosis in cohort ***,their prognostic value was no better than the BCLC system or NIACE *** function based on CP and ALBI grades significantly impacted patient ***,the“post-TACE-predict”model had a higher predictive value than other *** stratification ability as well as predictive performance of these new models in an intermediate/advanced stage population was less efficient(cohort 2).CONCLUSION The newly proposed“Pre-TACE-predict”and“6 and 12”models offer an interesting stratification into three categories in a recommended TACE population,as they identify poor candidates,those with partial control and durable *** models'contribution was reduced in a population with advanced stage hCCs.

关键词： hepatocellular carcinoma transarterial chemoembolization Pre-TACEpredict Six-and-twelve Barcelona Clinic Liver Cancer Prognosis

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大肠埃希菌临床分离株对喹诺酮类抗菌药的质粒介导耐药

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中国感染与化疗杂志 2006年第4期6卷 217-221页

作者：王明贵 Johnh.tran GeorgeA.Jacoby 张婴元汪复 DavidC.hooper 复旦大学附属华山医院抗生素研究所上海200040 美国哈佛医学院麻省总医院感染科美国Lahey医学中心感染科

目的了解近年来发现的质粒介导耐药机制在大肠埃希菌临床株对喹诺酮类耐药中所起的作用。方法78株环丙沙星耐药菌株分离自上海5所教学医院。以克隆斑点杂交及Southern杂交方法筛选质粒介导耐药基因qnr；以接合试验了解喹诺酮耐药的可转... 详细信息

目的了解近年来发现的质粒介导耐药机制在大肠埃希菌临床株对喹诺酮类耐药中所起的作用。方法78株环丙沙星耐药菌株分离自上海5所教学医院。以克隆斑点杂交及Southern杂交方法筛选质粒介导耐药基因qnr；以接合试验了解喹诺酮耐药的可转移性；对qnr基因进行序列分析,以引物步移法对qnr周边质粒DNA进行测序、分析。结果78株大肠埃希菌中,6株(7．7%)qnr检测阳性。在6株阳性菌中,喹诺酮耐药性均可通过质粒转移,接合子对环丙沙星的MIC较受体菌上升16～250倍。qnr基因与最早报道的序列一致,qnr位于In4族的Ⅰ类整合子上,本研究中的2个新整合子命名为In36及In37。结论与qnr相关的质粒介导喹诺酮类耐药性在大肠埃希菌临床分离株中有一定程度流行,这可能是我国细菌对喹诺酮类耐药性上升迅速的原因之一。

关键词：大肠埃希菌质粒介导耐药喹诺酮类 qnr

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A study implementing real-time PCR to identify Strongyloides species of third-stage larvae in human stool samples from Southern Vietnam

Infectious Medicine

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Infectious Medicine 2023年第3期2卷 229-236页

作者： Le Duc Vinh Nguyen Kim Thach huynh hong Quang Do Nhu Binh tran Thi Duc hanh Nguyen Minh Toàn Nguyen Trung Tuyen Nguyen Thu huong Department of Medical Parasitology Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Department of Fundamental Chemistry-Biochemistry Pham Ngoc Thach University of MedicineHo Chi Minh City 700000Vietnam Clinical Epidemiology Research Unit Institute of MalariologyParasitologyand Entomology Quy NhonBinh Dinh 55000Vietnam Department of Infectious Disease Military Hospital 103Hanoi 100000Vietnam Department of Epidemiology Hanoi University of Public HealthHanoi 100000Vietnam Department of Microbiology-Parasitology Hanoi University of Public HealthHanoi 100000Vietnam Department of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi100000 Vietnam

Background:Strongyloidiasis,a neglected disease caused by intestinal nematodes of the genus,is endemic to tropical and subtropical areas such as *** methods only identify the genus,while DNA-molecular techniques are susceptible in Strongyloides *** study aims to determine the prevalence of dominant Strongyloides species among the population in Duc hoa district,Long An,***:A cross-sectional study used 1190 stool specimens collected from July 2017 to November *** samples were transported within 2 h,stored at 2-8℃,and processed within 48 h for microscopy smear and culture at the Laboratory of Medical Parasitology,Pham Ngoc Thach University of Medicine(PNT).Then all positive samples with the above 2 methods were verified by real-time PCR ***-time PCR amplification was conducted at the Laboratory of Molecular Biology,***:Direct microscopy and modified harada-Mori culture detected Strongyloides *** in 79/1190 sam-ples(6.6%).About 94.2%of the DNA samples were Strongyloides stercoralis,2.9%were co-infections with Strongy-loides ratti and ***,and 2.9%were patients with *** identity of 12/14 sequences was confirmed as *** with a high level of similarity(91.3%-100%)and over 98%for ***:DNA-molecular techniques and sequence analysis are highly suitable for identifying Strongyloides species isolated from stool *** is remarkable evidence of the presence of zoonosis *** disease in human,not just the known *** is likely to result in a certain proportion of people being infected by this animal-borne infectious pathogen.

关键词： Strongyloidiasis Strongyloides stercoralis Strongyloides ratti DNA-molecular techniques

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Investigation of negative-parity states in ^(16)C via deuteron inelastic scattering

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Chinese Physics C 2022年第5期46卷 70-76页

作者： Z.W.Tan J.L.Lou Y.L.Ye Y.Liu D.Y.Pang C.X.Yuan J.G.Li W.Liu Y.Jiang B.Yang L.C.Tao K.Ma Z.h.Li Q.T.Li X.F.Yang J.Y.Xu h.Z.Yu J.X.han S.W.Bai S.W.huang G.Li h.Y.Wu h.L.Zang J.Feng J.S.Wang Y.Y.Yang P.Ma Q.hu Z.Bai Z.h.Gao F.F.Duan L.Y.hu J.h.Tan S.Q.Sun Y.S.Song h.J.Ong D.T.tran h.Y.Zhu B.L.Xia School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China School of Physics Beijing Key Laboratory of Advanced Nuclear Materials and PhysicsBeihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin Engineering UniversityHarbin 150001China Research Center for Nuclear Physics Osaka universityOsaka 567-0047Japan Institute of Physics Vietnam Academy of Science and TechnologyHanoi 10000Vietnam Institute of Materials China Academy of Engineering PhysicsMianyang 621907China

Two low-lying unbound states in ^(16)C are investigated by deuteron inelastic scattering in inverse *** the 2^(-) state at 5.45 MeV previously measured in a 1n knockout reaction,a new resonant state at 6.89 MeV is observed for the first *** inelastic scattering angular distributions of these two states are well reproduced by the distorted-wave Born approximation(DWBA)calculation with an l=1 *** addition,the spinparities of the unbound states are discussed and tentatively assigned based on shell model calculations using the modified YSOX interaction.

关键词： negative-parity states inelastic scattering ^(16)C

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满足多款小型化汽油机应用的电动机械增压器性能参数研究

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汽车与新动力 2017年第3期49卷 43-49页

作者： h.h.tran B.Richard K.Gray M.Bassett 陈佳

发动机极度小型化是现代内燃机满足新排放法规的1种措施。发动机小型化程度越高,产生的CO2也越少。如此,发动机就需要更高的增压水平来达到更高的扭矩性能。对于目前的传统增压系统来说,低转速下实现瞬时负荷下的高增压是1个值得关注的... 详细信息

发动机极度小型化是现代内燃机满足新排放法规的1种措施。发动机小型化程度越高,产生的CO2也越少。如此,发动机就需要更高的增压水平来达到更高的扭矩性能。对于目前的传统增压系统来说,低转速下实现瞬时负荷下的高增压是1个值得关注的问题。Aeristech公司已经开发出1款电动机械增压器,与传统涡轮增压器匹配后组成1种新型的两级增压系统,这使得相对简单的小型化汽油发动机可以应用到主流汽车上。鉴于大多数电动增压装置是提供瞬时输出以减轻涡轮迟滞,电动机械增压器更能在稳态下提供空气。因此,电动机械增压器具有双重功能:减轻涡轮迟滞和弥补涡轮增压器或主要增压装置的压气机性能。电动机械增压器既有传统机械增压器的功能,同时又有传统电动增压装置的功能。同时,电动机械增压器可以替代多级涡轮增压器布置中的第一级涡轮增压器。对1款高级的2.0L增压汽油机应用此电动机械增压器进行了仿真,对1款1.2L极度小型化发动机应用此电动机械增压器进行了试验。目前,主要有2种电动机械增压器设计方案:一种使用单独的电动机和控制器(功率电子元件),另一种是将控制器(功率电子元件)和电动机集成为一体。压气机单独作用时有宽广的性能区间和80%的峰值效率,与电动机和控制器(功率电子元件)结合后可以在0.5s以内达到全负荷运行。方案设计时进行了优化使其单位体积最小化和提高其在汽车机舱内布置的灵活性。另外,电动机械增压器已经在MAhLE 3缸直接喷射发动机上进行试验。这款发动机的升功率高达161kW,同时在整个发动机转速区间内扭矩曲线大体上都是平坦的。

关键词：电动机械增压器小型化性能直接喷射

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Surveillance of adverse events following h1N1/09 influenza immunisation in Victoria, Australia

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Natural Science 2012年第12期4卷 1065-1073页

作者： David tran hazel Clothier Jim P. Buttery Nigel W. Crawford Department of General Medicine Royal Children’s Hospital (RCH) Melbourne Australia Department of Paediatrics The University of Melbourne Australia SAEFVIC Murdoch Childrens Research Institute (MCRI) Melbourne Australia

BACKGROUND: The h1N1 pandemic in 2009 required a systematic coordinated response, which in Australia included a monovalent (h1N1/09) vaccine (Panvax?). SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community) is the Victorian, Australia state-based vaccine safety unit. The aim of the study was to review SAEFVIC reports of adverse events following immunisations (AEFI) temporally associated with h1N1/09 vaccines [monovalent and Trivalent Influenza Vaccines (TIV)]. METhODS: 1) Analysis of AEFI related to h1N1/09 vaccines reported to SAEFVIC from September 2009 to December 2010;2) Review of febrile convulsions (ICD-10 code R56.0), in children under 5 years of age presenting to the Royal Children’s hospital (RCh) Melbourne, Emergency Department between 1 March-30 April 2010. The presentation details and immunisation history were clarified by a telephone interview. RESULTS: 1) There were 659 reports of 749 adverse events following h1N1 vaccines. Among the TIV group, Fluvax had the most AEFI reported, with 77 per 100,000 doses distributed. Serious AEFI temporally associated with h1N1/09 vaccines included: 3 deaths, 2 anaphylactic reactions, and 3 GuillainBarre Syndrome. There were 7 reports of drug administration error;2) There were 179 presentations with fever and 67 reported febrile convulsions out of 11025 presentations (0.61%), 11 following h1N1 vaccines. Fluvax? was associated with 55% (6/11) reports. The mean onset time of AEFI was 13.2 hours post vaccination, and there was complete resolution of symptoms in allcases with no significant morbidity. CONCLUSION: Consistent with other Australian states in 2010, there was a TIV brand specific [Fluvax?] increase in febrile convulsions post vaccination. As a result this vaccine is no longer licensed for children hensive passive and active surveillance for AEFI needs to be incorporated into future pandemic planning.

关键词： h1N1 Influenza Vaccine Adverse Events SAEFVIC

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次优日粮下家禽饲料转化率的遗传变异与选择

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中国家禽 2012年第24期34卷 37-39页

作者： S.Mignon-Grasteau A.Narcy S.T.tran h.de Verdal D.Bastianelli h.Juin B.Carre 孙晓先法国农业科学研究所法国国际农业研究中心

饲料成本是肉鸡生产成本中比重最大的部分，依据产品类型的不同，可占到总成本的55％~60％。因此，饲料效率是决定肉鸡饲养效益的关键因素。对速生型肉鸡30多年的选择导致了其饲料转化率的不断降低。由标准的肉用公鸡和慢生型母鸡杂交... 详细信息

饲料成本是肉鸡生产成本中比重最大的部分，依据产品类型的不同，可占到总成本的55％~60％。因此，饲料效率是决定肉鸡饲养效益的关键因素。对速生型肉鸡30多年的选择导致了其饲料转化率的不断降低。由标准的肉用公鸡和慢生型母鸡杂交的“认证鸡”也表现这样的趋势，然而，慢生型“标签鸡”的饲料转化率没有变化。

关键词：饲料转化率遗传变异家禽日粮生产成本饲料成本产品类型饲养效益

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transcriptional landscapes of de novo root regeneration from detached Arabidopsis leaves revealed by time-lapse and single-cell RNA sequencing analyses

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Plant Communications 2022年第4期3卷 83-104页

作者： Wu Liu Yuyun Zhang Xing Fang Sorrel tran Ning Zhai Zhengfei Yang Fu Guo Lyuqin Chen Jie Yu Madalene SIson Teng Zhang Lijun Sun hongwu Bian Yijing Zhang Li Yang Lin Xu National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of Sciences300 Fenglin RoadShanghai 200032China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing100049China Department of Plant Pathology University of GeorgiaAthensGA 30602USA College of Life Sciences Shanghai Normal UniversityShanghai 200234China hainan Institute of Zhejiang University Yazhou Bay Science and Technology CitySanya 572025China School of Life Sciences Nantong UniversityNantongChina Institute of Genetic and Regenerative Biology Key Laboratory for Cell and Gene Engineering of Zhejiang ProvinceCollege of Life SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentDepartment of BiochemistryInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China These authors contributed equally to this article Department of Pharmacology and Chemical Biology UPMC Hillman Cancer CenterMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA

Detached Arabidopsis thaliana leaves can regenerate adventitious roots,providing a platformfor studying de novo root regeneration(DNRR).however,the comprehensive transcriptional framework of DNRR remains ***,we provide a high-resolution landscape of transcriptome reprogramming from wound response to root organogenesis in DNRR and show key factors involved in ***-lapse RNA sequencing(RNA-seq)of the entire leaf within 12 h of leaf detachment revealed rapid activation of jasmonate,ethylene,and reactive oxygen species(ROS)pathways in response *** analyses confirmed that ethylene andROSmay serve as wound signals to ***,time-lapse RNA-seq within 5 d of leaf detachment revealed the activation of genes involved in organogenesis,wound-induced regeneration,and resource allocation in the wounded region of detached leaves during adventitious *** studies showed that BLADE-ON-PETIOLE1/2,which control aboveground organs,PLEThORA3/5/7,which control root organogenesis,and EThYLENE RESPONSE FACTOR115,which controlswound-induced regeneration,are involved in ***,single-cell RNA-seq data revealed gene expression patterns in thewounded region of detached leaves during adventitious ***,our study not only provides transcriptome tools but also reveals key factors involved in DNRR from detached Arabidopsis leaves.

关键词： single-cell RNA-seq time-lapse RNA-seq de novo root regeneration plant regeneration wounding Arabidopsis thaliana

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是否可利用1h-MRS匀场值获得31P-MRS频谱

是否可利用1H-MRS匀场值获得31P-MRS频谱

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第十四届全国波谱学学术会议

作者：吴仁华郭岗 tran h terBrugge KG Mikulis DJ 广东省汕头大学医学院第二附属医院多伦多大学西部医院

目的：P 磁共振频谱(MRS)在活体中应用时,理想的匀场非常困难。本研究的目的是应用相同的扫描序列,验证h MRS 的匀场值运用于p 频谱的可行性。材料和方法：本研究采用模型及4名健康志愿者。模型为充满脑代谢物的圆玻璃球。采用3-T GE ...

目的：P 磁共振频谱(MRS)在活体中应用时,理想的匀场非常困难。本研究的目的是应用相同的扫描序列,验证h MRS 的匀场值运用于p 频谱的可行性。材料和方法：本研究采用模型及4名健康志愿者。模型为充满脑代谢物的圆玻璃球。采用3-T GE 磁共振扫描仪。h和 P MRS 均采用同样的定位及同样大小的扫描野,应用 SE MRS 序

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Second-line therapy for advanced hepatocellular carcinoma with regorafenib or cabozantinib:Multicenter French clinical experience in real-life after matching

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1510-1527页

作者： Xavier Adhoute Marie De Matharel Laurent Mineur Guillaume Pénaranda Dann Ouizeman Clemence Toullec Albert tran Paul Castellani Armelle Rollet Valérie Oules hervéPerrier Si Nafa Si Ahmed Marc Bourliere Rodolphe Anty Department of Gastroenterology and hepatology Hôpital Saint-JosephMarseille 13000France Department of Gastroenterology and hepatology Hôpital Universitaire de l’ArchetNice 06000France Department of Oncology Institut Sainte-CatherineAvignon 84000France Department of Biostatistics AlphaBio LaboratoryMarseille 13000France

BACKGROUND Starting a second-line systemic treatment for hepatocellular carcinoma(hCC)is a common *** only therapeutic options in France are two broadspectrum tyrosine kinase inhibitors(TKIs),regorafenib(REG)and cabozantinib(CBZ),but no comparative real-life studies are *** To evaluate the progression-free survival(PFS)of patients treated with REG or CBZ,we investigated the disease control rate(DCR),overall survival(OS),and safety of both *** identify the variables associated with disease progression over *** A retrospective multicenter study was performed on the clinical data of patients attending one of three referral centers(Avignon,Marseille,and Nice)between January 2017 and March 2021 using propensity score *** and OS were assessed using the Kaplan-Meier *** analysis(MA)of progression risk factors over time was performed in matched-pair *** Fifty-eight patients 68(62-74)years old with hCC,Barcelona clinic liver cancer(BCLC)B/C(86%),Child-Pugh(CP)-A/B(24%)received REG for 3.4(1.4-10.5)mo as second-line *** patients 68(60-73)years,BCLC B/C(75%),CP-A/B(25%)received CBZ for 3.7(1.8-4.9)mo after first-line treatment with sorafenib[3(2-4)(CBZ)vs 4(2.9-11.8)mo(REG),P=0.0226].Twenty percent of patients received third-line *** matching,PFS and DCR were not significantly different after a median follow-up of 6.2(2.7-11.7)mo(REG)vs 5.2(4-7.2)mo(CBZ),P=*** was no difference in grade 3/4 toxicities,dose reductions,or *** OS of CP-A patients was 8.3(5.2-24.8)vs 4.9(1.6-11.7)mo(CP-B),P=*** MA of risk factors for progression over time identified C-reactive protein(CRP)>10 mg/L,neutrophil-to-lymphocyte ratio(NLR)>3,and aspartate aminotransferase(AST)>45 IU as predictive *** This multicenter indirect comparative study found no significant difference in PFS between REG and CBZ as second-line therapy for advanced *** levels of inflam

关键词： hepatocellular carcinoma Regorafenib Cabozantinib C-reactive protein Neutrophillymphocyte ratio

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