检索结果-南通市图书馆

中华高血压杂志 2015年第11期23卷 1099-1099页

作者： Zhong J Cayir A Trevisi L Sanchez-Guerra M Lin X Peng C Bind MA Prada D Laue H Brennan KJ Dereix A Sparrow D Vokonas P Schwartz J baccarelli aa 刘莉叶鹏

该文研究线粒体丰度（一种代偿细胞氧化还原失衡的自适应机制）在黑色碳（车辆交通污染的示踪剂）和血压关系中的作用。方法：纳入标准老龄化研究中的675名老年男性进行一次或多次随访，评估定点监视器中的每日环境黑色碳与血压水平。

关键词：血压水平交通污染线粒体空气污染丰度适应机制氧化还原老年男性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

引用

World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A baccarelli Rob McConnell David V Conti Lida Chatzi Department of Population and Public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Environmental Toxicology University of CaliforniaDavisCA 95616United States Department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States Department of Pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States Department of Pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States Department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in *** To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with *** This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key *** Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The epigenetics of autoimmunity

引用

Cellular & Molecular Immunology 2011年第3期8卷 226-236页

作者： Francesca Meda Marco Folci Andrea baccarelli Carlo Selmi Department of Medicine and Hepatobiliary Immunopathology Unit IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Department of Translational Medicine University of MilanRozzanoMilanItaly Harvard School of Public Health ExposureEpidemiology&Risk ProgramBostonMAUSA

The etiology of autoimmune diseases remains largely *** rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of *** lines of evidence strongly support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt *** in the post-translational modification of histones and DNA methylation are the two major epigenetic mechanisms that may potentially cause a breakdown of immune tolerance and the perpetuation of autoimmune *** recent years,several studies both in clinical settings and experimental models proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and *** specifically,data support the impact of epigenetic changes in systemic lupus erythematosus,rheumatoid arthritis,multiple sclerosis and other autoimmune diseases,in some cases based on mechanistical *** herein discuss what we currently know and what we expect will come in the next ***,epigenetic treatments already being used in oncology may soon prove beneficial also in autoimmune diseases.

关键词： DNA methylation histone modification microRNA tolerance breakdown

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

饮用水中砷减少与皮肤损害改善:孟加拉国的后续研究

引用

环境与职业医学 2013年第3期30卷 196-196页

作者： Wei Jie Seow Wen-Chi Pan Molly L.Kile Andrea A.baccarelli Quazi Quamruzzaman Mahmuder Rahman Golam Mahiuddin Golam Mostofa Xihong Lin David C.Christiani

摘要：[背景]慢性砷暴露与皮肤损害相关。然而，尚不知道减少砷暴露是否会改善皮肤损害。[目的]评估随时间的推移，砷暴露减少与皮肤损害恢复之间的关联。[方法]在2001-2003年间孟加拉国登记的基线皮肤损害病例（n=900）的基础上，于200... 详细信息

摘要：[背景]慢性砷暴露与皮肤损害相关。然而，尚不知道减少砷暴露是否会改善皮肤损害。[目的]评估随时间的推移，砷暴露减少与皮肤损害恢复之间的关联。[方法]在2001-2003年间孟加拉国登记的基线皮肤损害病例（n=900）的基础上，于2009-2011年随访研究550名患者。确定基线及随访时饮用水和脚趾甲中的砷与皮肤损伤的状态及严重程度。

关键词：皮肤损害孟加拉国砷暴露饮用水随访研究皮肤损伤基线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

表观遗传因素对空气污染物和老年男性肺功能之间关联的影响:标准老龄化研究

引用

环境与职业医学 2014年第9期31卷 684-684页

作者： Johanna Lepeule Marie-Abele Catherine Bind Andrea A. baccarelli Petros Koutrakis Letizia Tarantini Augusto Litonjua David Sparrow Pantel Vokonas Joel D. Schwartz

[背景]关于空气污染对中老年人——一个易感的、低储存量的人群——的肺功能影响的研究很少,其中的机制以及潜在效应的易感因素尚不清楚。[目的]在一个表征明确的老年男性队列中评估空气污染物与肺功能关联的滞后结构,以及9个候选基因... 详细信息

[背景]关于空气污染对中老年人——一个易感的、低储存量的人群——的肺功能影响的研究很少,其中的机制以及潜在效应的易感因素尚不清楚。[目的]在一个表征明确的老年男性队列中评估空气污染物与肺功能关联的滞后结构,以及9个候选基因的26个CpG位点上DNA甲基化（〈或≥中位数）的潜在效应修饰作用。[方法]1999至2009年间,对标准老龄化研究中的776名男性测量1至4次用力肺活量（FVC）、1秒用力呼气量（FEV1）和血液DNA甲基化。在肺功能测试前的4 h至28 d里,通过固定的监视仪测量空气污染。使用线性混合效应模型来估计空气污染物的主要影响以及DNA甲基化的效应修饰作用。[结果]黑炭、总的和非交通源颗粒物（空气动力学直径≤2.5μm,PM2.5）、一氧化碳和二氧化氮的亚慢性暴露（累计3~28 d）每增加一个四分位数间距（IQR）,与FVC和FEV1下降1%~5%有关联（P〈0.05）,但与急性暴露（前4 h内、当天或前一天）没有关联。FVC的斜率估计值比FEV1的大,并随累积暴露而增加。在TLR2位点2和位点5低甲基化（〈中位数）和GCR高甲基化（≥中位数）的参与者中,空气污染物（累计28 d）的斜率估计值都更高。[结论]亚慢性暴露于交通源污染物与老年人肺功能降低有显著的关联;非交通源污染物（颗粒物和臭氧）的关联性较弱。与炎症和免疫有关的表观遗传机制可能会影响这些关联。

关键词：空气污染物表观遗传亚慢性功能测试修饰作用用力呼气量估计值用力肺活量交通源候选基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

产前应激及炎症相关基因的甲基化水平对儿童早期肥胖指标影响的队...

引用

2017环境与公共健康学术会议暨中国环境科学学会环境医学与健康分会、中国毒理学会生化与分子毒理专业委员会2017年年会

作者： Shaowei Wu Chris Gennings Rosalind J.Wright ander Wilson Heather H.Burris Allan C.Just Joseph M.Braun Katherine Svensson Jia Zhong Kasey J.M.Brennan Alexandra Dereix Alejandra Cantoral Lourdes Schnaas Martha Maria Tellez-Rojo Robert O.Wright andrea A.baccarelli Department of Occupational and Environmental Health Sciences School of Public HealthPeking University Population Health and Science Policy Mount Sinai Hospital The Mindich Child Health & Development Institute Icahn School of Medicine at Mount Sinai Department of Statistics Colorado State University Department of Neonatology and Obstetrics Gynecology and Reproductive BiologyBeth Israel Deaconess Medical CenterHarvard Medical School Department of Preventive Medicine Icahn School of Medicine at Mount Sinai Department of Epidemiology School of Public HealthBrown University Department of Environmental Health Sciences Mailman School of Public HealthColumbia University

Background:Maternal stress during pregnancy may influence childhood growth and adiposity,possibly through immune/inflammatory *** investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in424 mother-child pairs in Mexico City,***:A stress index was created based on four

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：