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Predicting morbidity and mortality in acute pancreatitis in an Indian population:a comparative study of the BISAP score,Ranson’s score and CT severity index

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Gastroenterology Report 2016年第3期4卷 216-220,I0002页

作者： Jitin Yadav Sanjay Kumar Yadav Satish Kumar Ranjan George Baxla Dipendra Kumar Sinha Pankaj Bodra Ram Chandra Besra babu mani baski Om Prakash Abhinav Anand Department of General Surgery Rajendra Institute of Medical SciencesRanchiJharkhandIndia

Objective:Our aim was to prospectively evaluate the accuracy of the bedside index for severity in acute pancreatitis(BISAP)score in predicting mortality,as well as intermediate markers of severity,in a tertiary care centre in east central India,which caters mostly for an economically underprivileged ***:A total of 119 consecutive cases with acute pancreatitis were admitted to our institution between November 2012 and October *** scores were calculated for all cases,within 24 hours of ***’s score and computed tomography severity index(CTSI)were also *** respective abilities of the three scoring systems to predict mortality was evaluated using trend and discrimination *** optimal cut-off score for mortality from the receiver operating characteristics(ROC)curve was used to evaluate the development of persistent organ failure and pancreatic necrosis(PNec).Results:Of the 119 cases,42(35.2%)developed organ failure and were classified as severe acute pancreatitis(SAP),47(39.5%)developed PNec,and 12(10.1%)*** area under the curve(AUC)results for BISAP score in predicting SAP,PNec,and mortality were 0.962,0.934 and 0.846,***’s score showed a slightly lower accuracy for predicting SAP(AUC 0.956)and mortality(AUC 0.841).CTSI was the most accurate in predicting PNec,with an AUC of *** sensitivity and specificity of BISAP score,with a cut-off of≥3 in predicting mortality,were 100%and 69.2%,***:The BISAP score represents a simple way of identifying,within 24 hours of presentation,patients at greater risk of dying and the development of intermediate markers of *** risk stratification method can be utilized to improve clinical care and facilitate enrolment in clinical trials.

关键词： acute pancreatitis mortality bedside index for severity in acute pancreatitis(BISAP) Ranson’s score computed tomography severity index(CTSI)

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Distribution,Use Pattern and Prospects for Conservation of Medicinal Shrubs in Uttaranchal State,India

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Journal of Mountain Science 2007年第2期4卷 155-180页

作者： Bhupendra S. Adhikari mani M. babu Prem L. Saklani Gopal S. Rawat Herbarium Section Department of Habitat Ecology Wildlife Institute of India P.O. Box # 18 Chandrabani Dehra Dun 248 001 Uttaranchal

The present paper gives an insight into the distribution and use pattern of medicinal shrubs in Uttaranchal State. A total of 222 medicinal and aromatic shrub species have been appended based on secondary information. Euphorbiaceae, Rosaceae, Verbenaceae, and Fabaceae have the highest repre- sentatives of medicinal shrubs. Twenty one families had one species each in medicinal use. Verbenaceae and Euphorbiaceae in the sub-tropical region, Rosaceae in the temperate region, and Ericaceae and Rosaceae in the sub-alpine and alpine regions, respectively, had the highest representatives of medicinal shrubs. The distribution of medicinal shrubs was 42 % in sub-tropical, 29 % in warm temperate, 13 % in cool temperate, 9 % in sub-alpine and 7 % in the alpine region. Of the total species, 70 medicinal shrubs were native to the Himalayas and 22 native to Himalayan region including other Hima- layan countries. The most frequently used plant parts for various ailments were leaves (31 %) and roots (23 %). Most shrubs are being used for the diseases, viz. skin diseases, dysentery, cough, fever, wounds, and rheumatism. The present paper will help in the execution of strategies for promotion and cultivation of medicinal shrubs in Uttaranchal State.

关键词： Medicinal shrub distribution use pattern eco-region Uttaranchal Himalayan region India

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Optimizing Plant Geometry and Nutrient Management for Grain Yield and Economics in Irrigated Greengram

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American Journal of Plant Sciences 2015年第8期6卷 1144-1150页

作者： Murugesan Mohana Keerthi Rajagopalan babu mani Joseph Rajiah Amutha Department of Agronomy Agricultural College and Research Institute Tamil Nadu Agricultural University Killikulam Tuticorin Tamil Nadu India

Greengram (Vigna radiata L.) is important pulse crop in India. The yield and economics were in-creased by optimization of plant geometry and nutrient management under irrigated condition. The field experiment was conducted during Rabi season of November 2013 to January 2014 at Tamil Nadu Agricultural University, Agricultural College and Research Institute, Killikulam. An experiment was laid out in randomised block design and replicated thrice and the test variety of the crop greengram (CO 6) was used. The plant geometry of 30 × 30 cm, 25 × 25 cm and 30 × 10 cm was adopted. The Soil Test Crop Response (STCR) based fertilizer application, RDF, FYM and ZnSO4 was applied in soil as basal. The foliar spray of Pulse Wonder and Pink-pigmented facultative methylotrophs (PPFM) spray was done at one week after flowering and 1% KNO3 at 50 per cent flowering. Adoption of planting geometry of 30 × 30 cm, application of RDF, 12.5 t of FYM and 25 kg ZnSO4 as basal and foliar spraying of 1% KNO3 at 50 per cent flowering recorded higher dry matter production of 2865 kg·ha-1 and yield attributes viz., number of pod clusters plant-1 (10.34), number of pods plant-1 (53.40), number of seeds pod-1 (13.23), pod length (8.77 cm) and seed test weight (3.42 g). Higher grain yield of 1775 kg·ha-1, haulm yield (2920 kg·ha-1), harvest index (0.38), net return (57,806 Rs·ha-1) and B:C ratio (2.43) were associated with the treatment comprising of 30 × 30 cm spacing, application of RDF, 12.5 t of FYM and 25 kg ZnSO4 as basal and foliar spraying of 1% KNO3 at 50 per cent flowering.

关键词： Greengram Plant Geometry Nutrients Yield

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Interaction study between Ocimum sanctum and Glimepiride(sulfonylurea derivative) in diabetic rats

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Journal of Chinese Pharmaceutical Sciences 2015年第3期24卷 156-163页

作者： Mohd Fasih Ahmad Raj K.Keservani D J mani babu Department of Pharmacology V. L. College of Pharmacy School of Pharmaceutical Sciences Rajiv Gandhi Proudyogiki Vishwavidyalaya

The present study was intended to discover the interaction between Ocimum sanctum(O. sanctum) and Glimepiride, a sulfonylurea derivative used in the treatment of type-2 diabetes, in diabetic rats to suggest an alteration in the dose of Glimepiride in case of hypoglycaemia. LD50 studies for the aqueous extract of O. sanctum leaf were carried out in albino mice up to the dose level of 2000 mg/kg. O. sanctum at low, medium and high doses(100, 200 and 400 mg/kg, per oral), respectively and Glimepiride ?(half) therapeutic dose, therapeutic dose and 2 time therapeutic dose(0.036, 0.072 and 0.144 mg/200 g, per oral) were selected. After the treatment with O. sanctum and Glimepiride as single doses and in various combinations of these two drugs in streptozotocin-induced diabetic rats serum glucose levels in all the groups were analysed by the glucose oxidase-peroxidase method. When administered alone as single doses both aqueous extract of O. sanctum leaf and Glimepiride produced a significant anti-diabetic effect in diabetic rats. The anti-diabetic effect observed with combination of aqueous extract of O. sanctum leaf and Glimepiride was significant and more when compared to either of the drugs given alone. There was a definite interaction that necessitates dose readjustment of Glimepiride and further glucose levels are to be frequently monitored to avoid complication of hypoglycemic condition with aqueous extract of O. sanctum leaf and Glimepiride combination.

关键词： Herb-drug interaction Ocimum sanctum Glimepiride Type-2 diabetes

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Comparative study between intramedullary interlocking nailing and minimally invasive percutaneous plate osteosynthesis for distal tibia extra-articular fractures

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Chinese Journal of Traumatology 2022年第2期25卷 90-94页

作者： Kapil mani KC Bandhu Ram Pangeni Suman babu Marahatta Arun Sigdel Amuda KC Civil Service Hospital KathmanduNepal Nepalese Army Institute of Health Sciences KathmanduNepal

Purpose:Treatment of distal tibia fractures poses significant challenge to orthopedic surgeon because of poor blood supply and paucity of soft tissue *** is considerable controversy regarding the superior option of treatment for distal tibia fracture between the minimally invasive percutaneous plate osteosynthesis(MIPPO)technique and intramedullary interlocking(IMIL)nailing for extra-articular distal tibia *** aim of our study is to compare the functional outcome between the two treatment ***:This was the prospective comparative study of 100 patients with distal third tibia fractures divided into two *** first group of patients were treated with MIPPO technique while the second group of patients were managed by IMIL *** were followed up in outpatient department to assess the functional outcomes,malunion,delayed union,nonunion,superficial and deep infection between the two *** analyses were performed using the SPSS software(version 16.0).Results:Average malunion(degrees)in the MIPPO group was 5(3—7)±1.41 vs.10.22(8—14)±2.04 in the IMIL group(p=0.001).Similarly postoperative knee pain in the IMIL group was 10%vs.2%in the MIPPO group(p=0.001).In terms of superficial infection and nonunion,the results were 8%vs.4%and 2%vs.6%for the MIPPO and IMIL group,respectively(p=0.001).Conclusion:Both procedures have shown the reliable method of fixation for distal extra-articular tibia fractures preserving the soft tissue,bony vascularity and fracture hematoma that provide a favourable biological environment for fracture *** the results of the study,we have slightly more preference for the MIPPO technique.

关键词： Distal tibia fractures IMIL nailing Maiunion MIPPO technique

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Bio-potency of Dictyota ciliata ***

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Journal of Coastal Life Medicine 2014年第9期 684-688页

作者： Kalaiarasi Velayutham Johnson Marimuthu Alias Antonysamy Narayani mani Sivaraman Arumugam Janakiraman Narayanan babu Anantham Centre for Plant Biotechnology Department of BotanySt.Xavier’s College(Autonomous)Palayamkottai-627002Tamil NaduIndia

Objective:To reveal the antibacterial,cytotoxicity,larvicidal potentials of Dictyota ciliata ***(***).Methods:Phytochemical,antibacterial screening,cytotoxicity and larvicidal properties of the *** extracts were carried out according to standard *** and larvicidal potentials were analyzed by means of computerized probit analysis ***:The phytochemical screening showed the presence of steroids,alkaloids,phenolic groups,cardiac glycosides,flavonoids and tannins in the crude extracts of *** methanolic extracts of *** showed the highest metabolites presence compared to other tested *** antibacterial activity illustrated that the acetone extracts of *** exhibited the highest zone of inhibition[(10±0.2)mm]against Morganella *** larval mortality(50%)was observed in the crude methanolic extracts of *** against Culex quinquefasciatus(LC_(50)=202.82 mg/L and LC_(90) value is 488.52 mg/L).The result of brine shrimp lethality bioassay showed highest cytotoxicity in methanolic extracts of *** with LC_(50) and LC_(90) values at 340.14 mg/L and 555.58 mg/L ***:The results of the present phytochemical analysis and biological assays will help the manufacturers for identification and selection of raw materials for drug production.

关键词： Dictyota ciliata Larval mortality Morengilla morrgani Culex quinquefasciatus Brine shrimp

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