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Labetalol versus Hydralazine in the Management of Severe Pre-Eclampsia at Tertiary Hospitals in a Low-Resource Setting: A Randomised Controlled Trial

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Open Journal of Obstetrics and Gynecology 2023年第6期13卷 1058-1067页

作者： Uzoma Otutoaja Adeyemo Olabisi Timothy Emmanuel Olumide Adewara Olufunmilayo Victoria Adebara Augustine Adebayo Adeniyi babatunde sunday Awoyinka Raymond Akujuobi Okere Idowu Oluseyi Adebara Adewumi Bakare Mojisola Olumide Ayankunle Department of Obstetrics and Gynaecology Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria Department of Paediatrics Ado-Ekiti/Federal Teaching Hospital Afe Babalola University Ido-Ekiti Nigeria

Objective: Intravenous labetalol and hydralazine are both considered first-line medications for the management of acute-onset, severe hypertension in pregnant and postpartum women. The study compared the efficacy and safety profile of intravenous labetalol and hydralazine in the control hypertension in severe pre-eclampsia. Materials and Methods: One hundred patients who presented with severe pre-eclampsia were randomized into two study groups. The fifty patients in each arm of the study received either intravenous labetalol or intravenous hydralazine for the control of blood pressure. Results: The mean age of the labetalol subjects was 28.6 ± 5.47 years while that of their hydralazine counterparts was 29.12 ± 5.77 years. The majority of respondents in both groups were primigravidae (76% vs. 78%) (P = 0.813). The number of doses of drug needed to significantly lower the mean systolic blood pressure was slightly lower in the labetalol group (2 doses) compared to the hydralazine group (5 doses) (t = 0.803Y, P = 0.977). The incidence of headaches which were the commonest complaints was comparable in both groups 8% and 10% of respondents respectively (P > 0.05). Conclusion: Although both intravenous labetalol and hydralazine are useful in patients with severe pre-eclampsia, the response to labetalol was better with comparable side effects.

关键词： Blood Pressure Hydralazine Labetalol Low-Resource Setting Severe Pre-Eclampsia Side Effects

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Maternal Serum Lipids in Pre-Eclamptic and Normotensive Pregnant Women: A Case-Control Study

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1619-1628页

作者： Olumide Emmanuel Adewara Adeleye Niyi Ogundolire Adebayo Augustine Adeniyi Segun Murtala Ghazali sunday babatunde Awoyinka Idowu Adebara Olumide Mojisola Ayankunle Ayokunle Moses Olumodeji Olabisi Timothy Adeyemo Adewumi Bakare Department of Obstetrics and Gynaecology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Federal Teaching Hospital Ido-Ekiti Ekiti State Nigeria Department of Chemical Pathology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Lagos State University Teaching Hospital Ikeja Lagos State Nigeria

Background: Preeclampsia-eclampsia is a major contributor to maternal and fetal, morbidity and mortality especially in low to middle income countries. This hypertensive disorder of pregnancy remains a disease of theories due to its unclear etiology. We evaluated for possible associations between maternal serum lipids and preeclampsia. Methods: This was a prospective case-control study that recruited 60 consenting women diagnosed with preeclampsia (cases) and 60 normotensive healthy pregnant women (controls), matched for maternal age and gestational age over an 8-month period (18th June, 2014 to 18th February, 2015) at the Federal Teaching Hospital Ido-Ekiti, Nigeria. Cases and controls were recruited using the non-probability convenience sampling. Fasting venous blood samples were collected in both cases and controls and analyzed for serum total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL) using Randox standard enzymatic methods. Data obtained were analyzed using SPSS version 18 to compare and test for significance using Student t-test, Chi-square, and Pearson’s correlation as the appropriate. Tests of association were determined using logistic regression models. The difference was considered significant at P Findings: The mean serum levels of TC, HDL and LDL were significantly (p < 0.001) higher in the pre-eclamptics (6.6 ± 2.9 mmol/L, 2.1 ± 1.0 mmol/L and 3.6 ± 2.6 mmol/L) th

关键词： Pregnancy and Serum Lipids Serum Lipids and Preeclampsia Preeclampsia

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Malaria Retinopathy among Under-Five Children with Severe and Uncomplicated Malaria in a Tertiary Health Institution in Southwest Nigeria: A Comparative Study

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Advances in Infectious Diseases 2023年第3期13卷 355-374页

作者： Olusoji Omotayo Olayinka Philip Olayele Abiodun Tolulope Opeoluwa Jegede Ifedayo Olabisi Fasoranti Qasim Olakunle Salau Abiodun John Kareem Juliet Nnenda Olayinka Evbenaye Stanley Obasohan babatunde David Babalola Adeoye Adeleke Ademuyiwa Foluwakemi Tope Ekogiawe Ikechukwu sunday Abazu Emmanuel Olasunkanmi Babalola Department of Paediatrics Federal Medical Centre Owo Nigeria Department of Pharmacology Afe Babalola University Ado-Ekiti Nigeria

Introduction: Malaria retinopathy refers to retinal abnormalities unique to malaria resulting from prolonged parasitization by Plasmodium falciparum. Identifying these features and treating them promptly could prevent lethal complications of malaria. Therefore, this study was conducted to identify and compare retinal findings in severe and uncomplicated malaria. Methods: A cross-sectional study of 260 subjects was equally divided into two groups of severe and uncomplicated malaria. Direct ophthalmoscopy was done at recruitment for all subjects. Information on sociodemographics, physical examination, nutritional status, and retinal abnormalities were recorded. A p-value Results: There were 141 (54.2%) males and 70 (26.9%) aged between 13 - 24 months. Severe anaemia, multiple convulsions, prostration, and cerebral malaria were the predominant forms of severe malaria. Twenty-three (17.7%) subjects with severe malaria and none with uncomplicated malaria had retinopathy. Retinal whitening (17.7%), vessel changes (16.2%), and retinal haemorrhages (5.4%) were the major forms of retinopathy. Retinopathy occurred in 43.8% of those with cerebral malaria. Retinal whitening and vessel changes were significantly associated with multiple convulsions, cerebral malaria, and metabolic acidosis;retinal haemorrhage was associated with cerebral malaria and haemoglobinuria (p = 0.022) and vessel changes with hypoglycaemia (p = 0.037). Cerebral malaria was an independent predictor of retinal whitening (p = 0.004) and vessel changes (p = 0.008) while haemoglobinuria was an independent predictor of retinal haemorrhages (p = 0.007). Conclusion: Ophthalmoscopy is an important examination in children with severe malaria which could assist in early detection and with prompt treatment, reduce morbidities and mortalities.

关键词： Children Malaria Nigeria Ophthalmoscopy Retinopathy

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Morbidity and mortality outcomes of COVID-19 patients with and without hypertension in Lagos,Nigeria:a retrospective cohort study

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Global Health Research and Policy 2021年第1期6卷 227-234页

作者： Akin Abayomi Akin Osibogun Oluchi Kanma-Okafor Jide Idris Abimbola Bowale Ololade Wright Bisola Adebayo Mobolanle Balogun Segun Ogboye Remi Adeseun Ismael Abdus-Salam Bamidele Mutiu babatunde Saka Dayo Lajide Sam Yenyi Rotimi Agbolagorite Oluwatosin Onasanya Eniola Erinosho Joshua Obasanya Olu Adejumo sunday Adesola Yewande Oshodi Iorhen E Akase Shina Ogunbiyi Adenike Omosun Femi Erinoso Hussein Abdur-Razzaq Nike Osa Kingsley Akinroye Lagos State Ministry of Health/Lagos Incident Management Command System LagosNigeria College of Medicine University of Lagos Idi-ArabaLagosNigeria Lagos State Primary Health Care Board LagosNigeria Mainland Hospital YabaLagosNigeria Lagos State University College of Medicine LagosNigeria Lagos State Biobank LagosNigeria World Health Organization Nigeria OfficeAbujaNigeria Nigeria Centre for Disease Control AbujaNigeria Lagos University Teaching Hospital LagosNigeria Lagos State University Teaching Hospital LagosNigeria Nigerian Heart Foundation LagosNigeria

Background:The current pandemic of coronavirus disease(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has shown epidemiological and clinical characteristics that appear worsened in hypertensive *** morbidity and mortality of the disease among hypertensive patients in Africa have yet to be well ***:In this retrospective cohort study all confirmed COVID-19 adult patients(≥18 years of age)in Lagos between February 27 to July 62,020 were ***,clinical and outcome data were extracted from electronic medical records of patients admitted at the COVID-19 isolation centers in *** included dying,being discharged after recovery or being evacuated/*** statistics considered proportions,means and *** Chi-square and Fisher’s exact tests were used in determining associations between ***–Meier survival analysis and Cox regression were performed to quantify the risk of worse outcomes among hypertensives with COVID-19 and adjust for confounders.P-value≤0.05 was considered statistically ***:A total of 2075 adults with COVID-19 were included in this *** prevalence of hypertension,the most common comorbidity,was 17.8%followed by diabetes(7.2%)and asthma(2.0%).Overall mortality was 4.2%while mortality among the hypertensives was 13.7%.Severe symptoms and mortality were significantly higher among the hypertensives and survival rates were significantly lowered by the presence of additional comorbidity to 50%from 91%for those with hypertension alone and from 98%for all other patients(P<0.001).After adjustment for confounders(age and sex),severe COVID-19and death were higher for hypertensives{severe/critical illness:HR=2.41,P=0.001,95%CI=1.4–4.0,death:HR=2.30,P=0.001,95%CI=1.2–4.6,for those with hypertension only}{severe/critical illness:HR=3.76,P=0.001,95%CI=2.1–6.4,death:crude HR=6.63,P=0.001,95%CI=3.4–1.6,for those with additional comorbidities

关键词： COVID-19 Nigeria Hypertension Comorbidities Coronavirus SARS-CoV-2 virus Pandemic

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Correction to:Morbidity and mortality outcomes of COVID-19 patients with and without hypertension in Lagos,Nigeria:a retrospective cohort study

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Global Health Research and Policy 2021年第1期6卷 213-214页

作者： Akin Abayomi Akin Osibogun Oluchi Kanma-Okafor Jide Idris Abimbola Bowale Ololade Wright Bisola Adebayo Mobolanle Balogun Segun Ogboye Remi Adeseun Ismael Abdus-Salam Bamidele Mutiu babatunde Saka Dayo Lajide Sam Yenyi Rotimi Agbolagorite Oluwatosin Onasanya Eniola Erinosho Joshua Obasanya Olu Adejumo sunday Adesola Yewande Oshodi Iorhen EAkase Shina Ogunbiyi Adenike Omosun Femi Erinoso Hussein Abdur-Razzaq Nike Osa Kingsley Akinroye Lagos State Ministry of Health/Lagos Incident Management Command Sys-tem LagosNigeria College of Medicine University of LagosIdi-ArabaLagosNigeria Lagos State Primary Health Care Board LagosNigeria Mainland Hospital YabaLagosNigeria Lagos State University College of Medicine LagosNigeria Lagos State Biobank LagosNigeria World Health Organiza-tion Nigeria OfficeAbujaNigeria Nigeria Centre for Disease Control AbujaNigeria Lagos University Teaching Hospital LagosNigeria Lagos State University Teaching Hospital LagosNigeria Nigerian Heart Foundation LagosNigeria

Correction to:Global Health Research and Policy(2021)6:26 https://***/10.1186/s41256-021-00210-6 Following publication of the original article[1],it is reported the second paragraph of the introduction includes some e... 详细信息

关键词： hypertension patients mortality

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