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Mesenchymal stem cell as a novelapproach to systemic sclerosis;currentstatus and future perspectives

Cell Regeneration 2020年第1期9卷 207-225页

作者： Mina Abedi Sepideh Alavi-Moghadam Moloud Payab Parisa Goodarzi Fereshteh Mohamadi-jahani Forough Azam Sayahpour Bagher Larijani babak arjmand Cell Therapy and Regenerative Medicine Research Center Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran Metabolomics and Genomics Research Center Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran Brain and Spinal Cord Injury Research Center Neuroscience InstituteTehran University of Medical SciencesTehranIran Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehranIran Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical sciencesTehranIran

Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelialcells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal *** to epidemiological data, women’s populations are more susceptible to systemic sclerosis than men. Untilnow, various therapeutic options are employed to manage the symptoms of the disease. Since stem cell-basedtreatments have developed as a novel approach to rescue from several autoimmune diseases, it seems that stemcells, especially mesenchymal stem cells as a powerful regenerative tool can also be advantageous for systemicsclerosis treatment via their remarkable properties including immunomodulatory and anti-fibrotic ***, we discuss the contemporary status and future perspectives of mesenchymal stem cell transplantationfor systemic sclerosis.

关键词： Anti-fibrotic effect Autoimmune disease Cell therapy Immunomodulation Mesenchymal stem cells Regenerative medicine Systemic sclerosis

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Regulations and ethical codes for clinical cell therapy trials in Iran

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Translational Neuroscience and Clinics 2015年第2期1卷 110-113页

作者： Hooshang Saberi Nazi Derakhshanrad babak arjmand Jafar Ai Masoud Soleymani Amir Ali Hamidieh Mohammad Taghi Joghataei Zahid Hussain Khan Seyed Hassan Emami Razavi Department of Neurosurgery Imam Khomeini HospitalTehran University of Medical Sciences Brain and Spinal cord Injuries Repair Research Center Tehran University of Medical Sciences cG MP‐Compliant Stem Cell Facility Brain and Spinal Cord Injury Research Center Tehran University of Medical Sciences Department of Hematology Tarbiat Modarres University Department of Hematology-Oncology Shariati Hospital Tehran University of Medical Sciences Department of Anatomy Cellular and Molecular Research Center Iran University of Medical Sciences Department of Neurosurgery Imam Khomeini HospitalTehran University of Medical Sciences

Objective: The local regulations for conducting experimental and clinical cell therapy studies are dependent on the national and cultural approach to the issue, and may have many common aspects as well as differences with the regulations in other *** study reflects the latest national aspects of cell therapy in Iran and relevant regulations. Methods: The following topics are discussed in the article including sources of cell harvest, regulations for cell disposal, stem cell manufacturing, and economic aspects of stem cell, based on current practice in Iran. Results: All cell therapy trials in Iran are required to strictly abide with the ethical codes, national and local regulations, and safety requirements, as well as considering human rights and respect. Adherence to these standards has facilitated the conduct of human cell therapy trials for research, academic advancement, and therapy. Conclusions: The cell therapy trials based on the aforementioned regulations may be assumed to be ethical and they are candidates for clinical translations based on safety and efficacy issues.

关键词： stem cell research ethical codes animal models cell therapy embryonic

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