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Prevalence and Factors Associated with Positivity of Antinuclear Antibodies (ANA) Patterns, Native Anti-DNA and Extractable Nuclear Antigens (ENA) Antibodies: Experience from a Laboratory in Dakar

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第1期14卷 26-36页

作者： Diop Abdou Diallo Thierno Abdoulaye ndiaye babacar Mahou Chantal Diop Marième Gaye Dubrous Phillippe Seck Abdoulaye Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal Cheikh Anta Diop University of Dakar Dakar Senegal

Background: Diagnosis of autoimmune diseases (AID) is challenging, due to overlapping features with other non-immune disorders. Anti-nuclear antibodies (ANA) are sensitive screening tests but anti-deoxyribonucleic acid-antibody (anti-DNA), and anti-extractable nuclear antigens (anti-ENA) are specific for AIDs. We aimed to look at ANA patterns in our patients and correlated them with anti-ENA for proper interpretation and better patient management cost-effectively. Methods: A retrospective study was conducted over 1 year from January to December 2022 who were tested for ANA at biology medical laboratory of Pasteur Institute of Dakar. Anti-ENA and anti-DNA results were also analyzed for ANA-positive patients. Statistical analysis was performed using STATA 14.0, p Results: 216 patients were analyzed. Women predominated at 79.2% and mean age was 48 years [CI 95%, 46 - 50], with extremes of 10 and 89. Most represented age group was [41 - 60] with 38%. ANA was positive in 27 (12.5%) of patients, 59.2% of whom were strongly positive (titer of 1/1000, 1/3200 or 1/6400). The most common pattern was nuclear speckled, which was found in 77.8% of samples. Anti-ENA and anti-DNA positivity in ANA-positive patients was found respectively in 63% (17/27) and 1.4% (3/27) of the samples analyzed. Most commonly identified anti-ENA was anti-Sm 29.6%, anti-SSA 29.6%, anti-Ro-52 25.9%, anti-RNP 18.5% and anti-SSB 14.8% which was associated with speckled pattern. Association results indicated a significant relationship between both tests and between ANA titer in the anti-ENA- and ANA-positive patients (p 0.001). Conclusions: ANA, Anti-ENA and anti-DNA antibodies are essential for AIDS diagnosis. However, the testing repertoire should follow an algorithm comprising of clinical features, followed by ANA results with nuclear, mitotic, and cytoplasmic patterns, anti-ENA, and anti-DNA for a more meaningful, and cost-effective diagnostic approach.

关键词： Antinuclear Antibodies Extractable Nuclear antigen Autoimmune Disease Indirect Immunofluorescence

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Phenotypic Detection of Enterobacterales Strains Susceptible of Producing OXA-48 Carbapenemase

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Advances in Microbiology 2024年第2期14卷 115-121页

作者： Abdoulaye Seck Abdou Diop babacar ndiaye Assane Dieng Awa Ba Amadou Diop Chantal Mahou Douala-Djemba Thierno Abdoulaye Diallo Cheikh Anta Diop University of Dakar Dakar Senegal Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal

Background: Nowadays, emergence of Carbapenemase-Producing Enterobacterales (CPE) throughout the world has become a public health problem, especially in countries with limited resources. In recent years, CPE of type OXA-48 (Ambler class D) have been identified in Dakar. The aim of this study was to evaluate the phenotypic detection of OXA-48 CPE using a temocillin disc (30 μg). Methodology: A retrospective study was carried out at Medical Biology Laboratory of Pasteur Institute in Dakar on Ertapenem-Resistant Enterobacterales (ERE) strains isolated from 2015 to 2017. These strains were then tested with a 30 μg temocillin disc. Any strain resistant to temocillin (inhibition diameter Results: Forty-one ERE isolated during the study period were tested, of which 34 (82.9%) were OXA-48 based on phenotypic detection using temocillin disc and confirmed by PCR (100%). OXA-48 CPE strains detected were composed of Klebsiella pneumoniae (n = 14;41.2%), Enterobacter cloacae (n = 8;23.5%), Escherichia coli (n = 7, 20.5%), Citrobacter freundii (n = 3;8.8%), Cronobacter sakazakii (n = 1;3%) and Morganella morganii (n = 1;3%). Conclusion: Temocillin resistance has a good positive predictive value for detecting OXA-48 CPE by phenotypic method, confirmed by PCR. Temocillin is therefore a good marker for detection of OXA-48 CPE except Hafnia alvei.

关键词： Ertapenem Temocillin Phenotypic Detection Carbapenemase-Producing Enterobacterales OXA-48

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Numerical Approach of Network Problems in Optimal Mass Transportation

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Applied Mathematics 2012年第5期3卷 457-466页

作者： Lamine ndiaye babacar Mbaye ndiaye Pierre Mendy Diaraf Seck Laboratory of Mathematics of Decision and Numerical Analysis (LMDAN) FASEG University of Cheikh Anta Diop Dakar Senegal Unité Mixte Internationale UMMISCO Institut de Recherche pour le Développement Bondy France

In this paper, we focus on the theoretical and numerical aspects of network problems. For an illustration, we consider the urban traffic problems. And our effort is concentrated on the numerical questions to locate the optimal network in a given domain (for example a town). Mainly, our aim is to find the network so as the distance between the population position and the network is minimized. Another problem that we are interested is to give an numerical approach of the Monge and Kantorovitch problems. In the literature, many formulations (see for example [1-4]) have not yet practical applications which deal with the permutation of points. Let us mention interesting numerical works due to E. Oudet begun since at least in 2002. He used genetic algorithms to identify optimal network (see [5]). In this paper we introduce a new reformulation of the problem by introducing permutations . And some examples, based on realistic scenarios, are solved.

关键词： Optimal Mass Transportation Network Urban Traffic Monge-Kantorovich Problem Global Optimization

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Hepatitis B Virus (HBV) Infection in Patients at Pasteur Institute of Dakar in Senegal from 2016 to 2020: Prevalence and Seroprotection Level

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Open Journal of Medical Microbiology 2023年第1期13卷 68-77页

作者： Diop Abdou ndiaye babacar Diallo Thierno Abdoulaye Mahou Chantal Guèye Omar Dubrous Philippe Dubrous Philippe Seck Abdoulaye Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal National Public Health Laboratory Thiès Senegal Cheikh Anta Diop University of Dakar Dakar Senegal

Hepatitis B virus (HBV) infection is highly endemic in Senegal. Vaccination of all children against HBV was introduced in 1999 and included in Expanded Programme on Immunisation in 2005. The aim of this study was to assess the prevalence and immune status against HBV in patients received at Pasteur Institut in Dakar, Senegal. Methods: Between January 2016 and December 2020, patients aged between 1 and 96 years received laboratory were included in the study. Serum samples were analysed for HBV serology (HBs antigen: HBsAg, HBs antibody: HBsAb and HBc antibody: HBcAb) using ARCHITECT? analyser. Patients with anti-HBs antibody levels (HBsAb ≥ 10 IU/l) were considered seroprotected against HBV. Results: A total of 5629 patients were analysed with a mean age of 39 years and extremes from 1 to 96 years. The most represented age group was 31 - 45 years with 38.4%. HBsAg was present in 520 patients (9.2%) and was signed by sex and age group. Anti-HBc antibodies were found in 52.7% of patients and 1603 (28.48%) had isolated anti-HBs antibodies reflecting proportion of people vaccinated at the time of the study. However, 2143 patients (41.9%) had no seroprotection (HBsAb 10 IU/L) and 640 (12.6%) had strong seroprotection defined as HBsAb > 1000 IU/L. Conclusion: Our results show a significant presence of virus in Senegalese population and low vaccination coverage, especially in adults. Evaluation of HBsAb levels and provision of HBV booster shots should be considered for children in Senegal.

关键词： HBsAb HBsAg HBV Seroprevalence Seroprotection Vaccination

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Prevalence and Resistance Profile of Muenchen Cefotaximase (CTX-M) Group 1 Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic Escherichia coli Strains in Dakar, Senegal

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Open Journal of Medical Microbiology 2023年第2期13卷 137-145页

作者： Abdoulaye Seck babacar ndiaye Abdou Diop Malick Ndao Cheikh Fall Assane Dieng Thierno Abdoulaye Diallo Chantal Mahou Philippe Dubrous Laboratoire de Biologie Médicale Institut Pasteurde Dakar Dakar Senegal Laboratoire de Bactériologie-Virologie Université Cheikh Anta Diop Dakar Senegal Laboratoire National de Santé Publique Thies Senegal Laboratoire de Bactériologie-Virologie H&#244pital Aristide Le Dantec Dakar Senegal

Background: Extended-spectrum beta-lactamase (ESBL) producing bacteria are a real public health problem, particularly in Africa. Among these ESBLs, there are the Muenchen Cefotaximase (CTX-M) described all over the world of which the most frequent is the CTX-M of group 1 particularly the CTX-M-15 variant. The objective of this study was to determine the prevalence of CTX-M group 1 ESBL-producing Escherichia coli strains and to test their antibiotics susceptibility profile. Methodology: A retrospective cross-sectional descriptive study was conducted to detect ESBL-secreting Escherichia coli strains by the synergy test. Identification of CTX-M type ESBL from group 1 was performed using the NG-Test CTX-M rapid diagnostic test (NG-Biotech®). Antibiotic susceptibility profile was determined using CA-SFM/EUCAST guidelines 2019. Data entry and statistical analysis were performed with Excel version 2010 and SPSS 20.0 respectively. Results: Eighty-two ESBL-producing Escherichia coli strains were tested. A group 1 CTX-M ESBL was detected in 75.6% of the strains (n = 62). These strains were highly resistant to cefotaxim (100%), aztreonam (100%), ceftazidim (85.4%) and cefepim (66.1%). They were also resistant to quinolones, gentamycin and sulfadoxine-trimethoprim combination. However, these strains showed sensitivity to ertapenem (100%), cefoxitin (69.3%), tigecyclin (66%), and amikacin (66.1%). The combination of piperacillin and tazobactam was active on 30.6% of the strains against 6.4% for the combination of amoxicillin and clavulanic acid. Conclusion: The CTX-M type ESBL of group 1 was present in the majority of ESBL-producing Escherichia colis trains. Despite the production of this enzyme conferring resistance to most beta-lactam antibiotics, some antibiotics remain active to treat infections caused by these germs.

关键词： Escherichia coli ESBL CTX-M Group Prevalence Antibiotic Resistance

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Application of the p-Median Problem in School Allocation

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American Journal of Operations Research 2012年第2期2卷 253-259页

作者： Fagueye ndiaye babacar Mbaye ndiaye Idrissa Ly Laboratory of Mathematics of Decision and Numerical Analysis Cheikh Anta Diop University Dakar Senegal

This paper focus on solving the problem of optimizing students’ orientation. After four years spent in secondary school, pupils take exams and are assigned to the high school. The main difficulty of Education Department Inspection (EDI) of Dakar lies in the allocation of pupils in the suburbs. In this paper we propose an allocation model using the p-median problem. The model takes into account the distance of the standards imposed by international organizations between pupil’s home and school. The p-median problem is a location-allocation problem that takes into account the average (total) distance between demand points (pupil’s home) and facility (pupil’s school). The p-median problem is used to determine the best location to place a limited number of schools. The model has been enhanced and applied to a wide range of school location problems in suburbs. After collecting necessary numerical data to each EDI, a formulation is presented and computational results are carried out.

关键词： Non-Convex Optimization Location Models School Allocation

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Vaginal Carriage of Group B Streptococcus in Pregnant Women in Rural Areas in Senegal

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Open Journal of Medical Microbiology 2023年第3期13卷 207-219页

作者： babacar ndiaye Fatoumata Diene Sarr Mam Coumba Diouf Rokhaya Diop Hamidou Thiam Mohamed Abass Yugo Rose Mbaye Amadou Alpha Sall Cheikh Loucoubar Abdoulaye Seck Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal Epidemiology Clinical Research and Data Science Unit Pasteur Institute of Dakar Dakar Senegal Virology Unit Pasteur Institute of Dakar Dakar Senegal

Vaginal carriage of Group B Streptococcus (GBS) is a maternal and child health issue. Our objective was to determine the prevalence of GBS carriage;identify the factors associated with this carriage and determine the antibiotic sensitivity of the isolated strains. We conducted a cross-sectional and prospective study in rural Senegal (in the health district of Sokone). Socio-demographic, clinical and gynaeco-obstetrical data were collected. Vaginal swabs were taken by the midwives on specific settings in order to test for GBS and other High Risk Vaginal Bacteria (HRVB). Antibiotic susceptibility testing was done according to the recommendations of the CA SFM/EUCAST 2020. In total, 100 pregnant women were targeted and 97 pregnant women were included. Their age ranged from 18 to 40 years with 64.9% (63/97) of participants belonging to the “20 - 30” age group. The overall prevalence of Group B Streptococcus carriage was 15.5% (15/97). However, the proportion of women with at least one high risk infectious bacteria was 29.89% (29/97). No statistically significant differences were found between GBS carriage and the potential factors studied. However, the study also looked for the presence of other high-risk bacteria and coinfections were indeed found between GBS and E. coli and Staphylococcus aureus. Antibiotic susceptibility testing shows that GBS strains were fully susceptible to penicillin G, erythromycin, clindamycin, chloramphenicol, rifampicin and vancomycin. Sensitivities to norfloxacin and gentamycin were 73.3% and 86.7% respectively. In contrast, high resistance to tetracycline (86.7%) was observed. GBS carriage remains a major public health issue because of its consequences for the mother and the newborn. Correct screening and proper monitoring of strain susceptibility remain one of the most effective means of patient management and care.

关键词： Group B Streptococcus (Streptococcus agalactiae) Vaginal Carriage Antibiotic Susceptibility Senegal

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Scheduling Aircraft Landings at LSS Airport

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American Journal of Operations Research 2012年第2期2卷 235-241页

作者： Coumba Diallo babacar Mbaye ndiaye Diaraf Seck Laboratory of Mathematics of Decision and Numerical Analysis Cheikh Anta Diop University Dakar Senegal Unité Mixte Internationale UMMISCO Institut de Recherche pour le Développement Bondy France

This paper presents a short contribution in air transportation, specifically in scheduling aircraft (plane) landings at Léopol Sédar Senghor (LSS) airport of Dakar. The safety of air navigation of LSS is managed by ASECNA: Agency for Air Navigation Safety in Africa and Madagascar. Scheduling aircraft landing is the problem of deciding a landing time on an appropriate runway for each aircraft in a given set of aircraft such that each aircraft lands within a predetermined time window. The separation criteria between the landing of an aircraft, and the landing of all successive aircraft, are respected. Our objective is to minimize the cost of deviation from the target times. We present a mixed-integer 0 - 1 formulation for the single runway case. Numerical experiments and comparisons based on real datasets of LSS airport are presented.

关键词： Air Traffic Control Runway Operations Scheduling Non Convex Optimization

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Intra-Dialytique Hypotension: Prevalence and Associated Factors in 2 Haemodialysis Centres in Senegal

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Open Journal of Nephrology 2022年第4期12卷 361-368页

作者： Ba A. Mamadou Yaya Kane Moustapha Faye Ameth Dieng Ba Bacary Niakhalen Keita babacar ndiaye Modou Ndongo Sy Abou Maria Faye Ahmed Tall Lemrabott Ka E. Fary Department of Nephrology Internal Medicine Faculty of Health Sciences Assane Seck University Ziguinchor Senegal Department of Nephrology ALDH Cheikh Anta Diop University Dakar Senegal

Introduction: This study aimed to assess the prevalence of Intra-dialytic hypotension (IDH) according to the European Best Practice Guidelines (EBPG) definition in relation to the number of haemodialysis sessions and the number of chronic haemodialysis patients and to identify its associated factors. Patients and Methods: We conducted an observational, multicentre and looking-forward study of descriptive and analytical purposes over a 4-week period. The study included all patients with regular chronic haemodialysis with at least two sessions per week and a duration of 180 minutes, who consented to participate in the study and were over 15 years of age. Data collection was done with pre-established forms. The following data were collected: blood pressure before each session, at 30, 60, 120, 180 and 240 minutes of each session;socio-demographic data;dialysis data;clinical, paraclinical, therapeutic data and nursing interventions. Results: The mean age of the patients was 43.84 ± 12.10 years. Among 568 haemodialysis sessions recorded in 50 patients, IDH was noted in 12 haemodialysis sessions, representing a prevalence of 2.11%. Fatigue was found in 5 sessions with IDH episodes (41.66%) followed by yawning (25%), nausea ± vomiting (16.66%) and cramps (16.66%). As nursing interventions, Trendelenburg position and normal saline administration were performed in all IDH episodes. High blood pressure, inter-dialytic weight gain greater than 3 kg, Uf/H > 10 ml/kg/H, anaemia and hypoalbuminaemia were associated with the occurrence of IDH. Conclusion: The prevalence of IDH according to the EBPG definition is low. However, it is an important cause of morbidity and mortality, especially cardiovascular involvement, and the factors associated with its presence have been clearly identified.

关键词： Intra-Dialytic Hypotension Chronic Hemodialysis Patients Dakar Ziguinchor

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Analysis of the Behavior of Local Cooking Utensils in Tap Water, Salt Tap Water and Vegetable Oil According to the Temperature

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Open Journal of Metal 2013年第4期3卷 80-85页

作者： Mamadou babacar ndiaye Sandrine Bec Bernard Coquillet Ibrahima Khalil Cissé Laboratory of Materials Mechanical and Hydraulic Polytechnic School of Thies Thies Senegal Laboratory of Tribology and Dynamics of Systems CNRS UMR 5513 Lyon France University Institute of Technology IUT/UT University of Thies Thies Senegal

In Senegal the aluminum scrap are mainly recycled kitchen utensils [1]. The craftsmanship poses the problem of the quality of finished products [1] especially when we know they are used for everyday cooking. Given that none of these alloys should not be used to make cooking utensils if we refer to the EN 601 standard in July 2004, which refers to this regard [1], this study aims at analyzing behavior of these alloys reconstructed in three settings (tap water, vegetable oil and salt water more than 3 grams per liter), chosen for their importance in Senegalese cuisine. Significant loss of mate- rial was observed mainly by intergranular corrosion. It would be interesting that additional studies be conducted to ex- amine the impact of the daily use of these alloys on the health of Senegalese.

关键词： Aluminum Alloys Recycling Cooking Utensils Chemical Analysis Salt Water Vegetable Oil

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