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Epidemiology and Prognosis of Retroplacental Hematoma in a Maternity Ward at a Regional Hospital Center in Southern Senegal

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 149-157页

作者： babacar Biaye Omar Gassama Mame Diarra Ndiaye Gueye Moussa Diallo Aminata Niass Mor Cisse Alassane Diouf Jean Charles Moreau Gynecological and Obstetric Clinic University Hospital Aristide Le Dantec Dakar Senegal

Objectives: To study the epidemiological profile and the prognosis of the retro-placental hematoma (HRP) at the maternity ward at Kolda Regional Hospital Center. Materials and methods: This was a retrospective descriptive cross-sectional study conducted over a period of 11 years: from January 1st, 2006 to December 31st, 2016, at Kolda Regional Hospital Center. It included all patients admitted for HRP during this period. The studied parameters concerned sociodemographic characteristics, gynecological obstetrical history;clinical, therapeutic and prognostic data (non-inclusion or exclusion criteria). The data were collected from medical records, the delivery room and the surgery room registers using a collection sheet developed for this purpose. The statistical analysis of the variables studied was done with the software Epi-info 3.5. For the qualitative variables, we calculated the frequencies and for the quantitative variables, we studied the distributions. Results: During the study period, 15,343 were recorded deliveries and we carried out the diagnosis of HRP in 301 patients (1.97%). The average age of the patients was 24 years with an average parity of 4.8 deliveries. Almost all the patients (87.5%) were evacuated and half had delivered by caesarean section. Maternal and fetal deaths were 7% and 72.1%, respectively. Uterine atony accounted for 21.2% of complications. One third of the cases of uterine atony had resulted in a hysterectomy. The average duration of hospitalization was 6 days. Conclusion: The retro-placental hematoma is a serious medico-obstetric emergency. It is burdened with high maternal and fetal morbidity and mortality in developing countries.

关键词： Retro-Placental Hematoma Mortality Kolda

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Assessment of Poultry Feed Contamination Level by Aflatoxin B1: Quantification by Two Chromatographic Analysis Methods

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Food and Nutrition Sciences 2022年第11期13卷 950-961页

作者： Rokhaya Gueye Viviane Chatchueng Sandefo babacar Beye Elhadji Ousmane Faye Amadou Diop Serigne Omar Sarr Bara Ndiaye Yérim Mbagnick Diop Laboratoire de Chimie Analytique et Bromatologie Faculté de Médecine de Pharmacie et d’Odontologie-Stomatologie Université Cheikh Anta DIOP Dakar Sénégal Laboratoire de Mycotoxines Institut de Technologie Alimentaire Route des Pères Maristes Dakar Sénégal

Aflatoxin B1 is a mycotoxin that can contaminate a wide feedstuffs variety. Ingestion of contaminated feed by poultry can lead to impaired health and zootechnical performances but also a human diet safety problem related to residues presence in animal origin products. Aflatoxin B1 contamination of poultry feed samples marketed in Dakar city and in peri-urban areas (Gorom, Sangalkam) was studied. A total of 15 samples were collected from Dakar city markets as well as from poultry farms in Gorom and Sangalkam areas. Aflatoxin B1 quantification was performed by high performance liquid chromatography and thin-layer chromatography. HPLC results showed that all samples were contaminated with levels ranging from 0.15 to 22 ppb, 0.099 to 2.05 ppb and 0.099 to 4.95 ppb respectively for Gorom, Sangalkam and Dakar. Only the finishing feed from Gorom had an aflatoxin B1 level above the maximum limit set by regulations. TLC is a suitable method for aflatoxins detection. However, it was associated with overestimation for aflatoxin B1 quantification. Results suggest that poultry feed represents a real source of human diet contamination. In addition, HPLC remains the most reliable quantification technique for quality control.

关键词： Poultry Feed Aflatoxin High Performance Liquid Chromatography Thin-Layer Chromatography Dakar

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Ovarian Pregnancy: A Case Report

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1446-1451页

作者： Hadja Maïmouna Barro Daff Brahima Donigolo Aïssatou Mbodji Khalifa babacar Mansour Fall Youssoupha Touré Moussa Diallo Abdoul Aziz Diouf Alassane Diouf Cheikh Anta Diop University of Dakar Gynecological and Obstetrical Clinic Public Institution Aristide-Le Dantec Hospital Da-kar Senegal Department of Obstetrics and Gynecology University Hospital of Pikine Thiaroye Pikine Senegal

Background: Ovarian pregnancy is a rare entity of ectopic pregnancy, with a prevalence in the literature estimated between 1/2500 to 1/5000 births. The majority of ovarian pregnancies are diagnosed in the 1st trimester due to the noisy symptomatology. However, in small proportions, they may continue into the 2nd or 3rd trimester, making their diagnosis more difficult. Aim: We report a case of ovarian pregnancy in a 26-year-old patient, discovered intraoperatively as a large unruptured ovarian mass. Case report: A 26-year-old woman referred to the maternity ward for management of fetal death in utero at 31 weeks of amenorrhea associated with overlying placenta previa. Ultrasound performed in the department, was in favor of an abdominal pregnancy stopped at 31 SA with a placenta that seemed to adhere to the posterior wall of the uterus, which was empty. A Laparotomy was performed, on exploration, a large right ovarian mass was found, the site of the pregnancy. A right adnexectomy, after adhesiolysis, was performed. The incision of the operative part revealed a macerated female fetus. The clinical evolution was favorable. Conclusion: We report on a case of unruptured ovarian pregnancy, discovered in the 3rd trimester of pregnancy. The ultrasound diagnosis of an ovarian pregnancy beyond the 2nd trimester remains a challenge, the management remains surgical.

关键词： Ectopic Pregnancy Ovarian Pregnancy Adnexal Mass

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Diagnostic Rigid Urethrocystoscopy: Indications, Results and Pain Assessment

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Open Journal of Urology 2020年第8期10卷 239-244页

作者： Ousmane Sow Abdoulaye Ndiath Aboubacar Traore Alioune Sarr babacar Sine Modou Ndiaye Yassin Sayerh Cyrille Ze Ondo Amath Thiam Ndiaga Seck Ndour El Hadj Malick Daw Ndeye Aissatou Bagayogo Yaya Sow Boubacar Fall babacar Diao Papa Ahmed Fall Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal Urology-Andrology Department Dalal Jamm Hospital Dakar Senegal

Background: Over the last 50 years, endourology has revolutionized urological practices worldwide. This is not so in many urological centers in West Africa. Although, some centers have made progress in the level of urological services that they offer;many of such centers provide rigid urethrocystoscopy services. Rigid urethrocystoscopy is an endoscopic examination that explores the urethra, bladder and prostate in men. Aims: We report the indications, results and pain assessment of rigid urethrocystoscopy in our center. Patients and Methods: We carried out a retrospective, descriptive, monocentric study in our center between January 2016 and June 2018. The study included all patients who had a rigid urethrocystoscopy under local anaesthesia. We studied the following parameters: sex, age, indications for the examination, outcomes and the pain assessment. Results: Five hundred and forty-one patients were included. The sex-ratio was 1.49. The mean age was 49.47 ± 18.48 years (12 years and 91 years). Lower urinary tract symptoms (29%) and hematuria (28%) were the most common indications. The rigid urethrocystoscopy was normal in 26.8% of patients. Bladder tumors (21.2%) were the most frequent lesions. In men, prostate tumors were more common (21%) followed by bladder tumors (17.9%), while in women, bladder tumors (26.3%) were predominant followed by cystopathy lesions (12.4%).The mean Simple Verbal Scale (SVS) score was 1.25 in women and 2.1 in men. Conclusion: Rigid urethrocystoscopy was relatively well tolerated by our patients. Hematuria was the primary indication and the main etiologies were bladder and prostate tumors.

关键词： Rigid Urethrocystoscopy Bladder Tumors Hematuria

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A Shoulder Mass Revealing a Metastatic Prostate Cancer

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Case Reports in Clinical Medicine 2021年第4期10卷 133-139页

作者： Kanta Ka Mohamed Jalloh babacar Sine Oumar Gaye Awa Sadikh Badiane Ibrahima Thiam Mamadou Moustapha Dieng Papa Macoumba Gaye Radiotherapy Department Centre Hospitalier National Universitaire Dalal Jamm Guédiawaye Senegal Urology Department H&ocirc pital Général Idrissa Pouye Grand Yoff Senegal Cheikh Anta Diop University Dakar Senegal Urology Department Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal

Introduction: A shoulder mass revealing metastatic prostate cancer is very rare. We report a case of metastatic prostate cancer diagnosed on a shoulder mass and treated with analgesic radiotherapy and chemotherapy and androgen deprivation therapy (ADT). Observations: A 66 years old patient was referred for a painful right shoulder mass whose biopsy and pathological examination found a Gleason 8 (4 + 4) moderately differentiated adenocarcinoma. The PSA level was 508.52 ng/ml. The patient was treated with analgesic radiotherapy on the right shoulder and chemo-hormonal therapy. At 2 years follow-up, the disease was well controlled. Conclusion: A shoulder mass revealing metastatic prostate cancer is not common. Local treatment of the symptomatic metastasis while continuing chemotherapy and ADT improves the quality of life.

关键词： Shoulder Prostate Cancer Metastasis

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Prevalence and Resistance Profile of Muenchen Cefotaximase (CTX-M) Group 1 Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic Escherichia coli Strains in Dakar, Senegal

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Open Journal of Medical Microbiology 2023年第2期13卷 137-145页

作者： Abdoulaye Seck babacar Ndiaye Abdou Diop Malick Ndao Cheikh Fall Assane Dieng Thierno Abdoulaye Diallo Chantal Mahou Philippe Dubrous Laboratoire de Biologie Médicale Institut Pasteurde Dakar Dakar Senegal Laboratoire de Bactériologie-Virologie Université Cheikh Anta Diop Dakar Senegal Laboratoire National de Santé Publique Thies Senegal Laboratoire de Bactériologie-Virologie H&#244pital Aristide Le Dantec Dakar Senegal

Background: Extended-spectrum beta-lactamase (ESBL) producing bacteria are a real public health problem, particularly in Africa. Among these ESBLs, there are the Muenchen Cefotaximase (CTX-M) described all over the world of which the most frequent is the CTX-M of group 1 particularly the CTX-M-15 variant. The objective of this study was to determine the prevalence of CTX-M group 1 ESBL-producing Escherichia coli strains and to test their antibiotics susceptibility profile. Methodology: A retrospective cross-sectional descriptive study was conducted to detect ESBL-secreting Escherichia coli strains by the synergy test. Identification of CTX-M type ESBL from group 1 was performed using the NG-Test CTX-M rapid diagnostic test (NG-Biotech®). Antibiotic susceptibility profile was determined using CA-SFM/EUCAST guidelines 2019. Data entry and statistical analysis were performed with Excel version 2010 and SPSS 20.0 respectively. Results: Eighty-two ESBL-producing Escherichia coli strains were tested. A group 1 CTX-M ESBL was detected in 75.6% of the strains (n = 62). These strains were highly resistant to cefotaxim (100%), aztreonam (100%), ceftazidim (85.4%) and cefepim (66.1%). They were also resistant to quinolones, gentamycin and sulfadoxine-trimethoprim combination. However, these strains showed sensitivity to ertapenem (100%), cefoxitin (69.3%), tigecyclin (66%), and amikacin (66.1%). The combination of piperacillin and tazobactam was active on 30.6% of the strains against 6.4% for the combination of amoxicillin and clavulanic acid. Conclusion: The CTX-M type ESBL of group 1 was present in the majority of ESBL-producing Escherichia colis trains. Despite the production of this enzyme conferring resistance to most beta-lactam antibiotics, some antibiotics remain active to treat infections caused by these germs.

关键词： Escherichia coli ESBL CTX-M Group Prevalence Antibiotic Resistance

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Influence of Heat Exchange Coefficients on Both Optimized Thermal Contact (OTCR) and Critical (CTCR) Resistances at the Contact Interface of a Flat Concrete Slab and a Rice Straw Board

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Energy and Power Engineering 2021年第12期13卷 392-402页

作者： Alassane Diene Mamadou Lamine Lo Abdoulaye Sene Ablaye Fame Youssou Traore Seydou Faye Issa Diagne Mamadou babacar Ndiaye Gregoire Sissoko Polytechnic School of Thiès Thiès Senegal Laboratory of Semiconductors and Solar Energy Physics Department Faculty of Science and Technology University Cheikh Anta Diop Dakar Senegal University Institute of Technology University Iba Der THIAM of Thiès Thiès Sénégal Groupe International de Recherche en Energie Renouvelable Dakar Senegal

The study is carried out in imperfect contact with a concrete slab wall attached to a panel based on rice straw compressed in a dynamic frequency regime. We will propose the characterization of thermal insulation for thermal resistance of contact (x = 0.05 m). The impact of heat exchange coefficients on the front face (x = 0 m) and the rear face (x = 0.1 m) on these resistors is shown.

关键词： Concrete Slab Rice Straw Board Thermal Resistance of Contact Frequency Dynamic

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Relationship between Circulating Plasma Galectin-3 Levels and T-Cell Activation during Cervical Cancer Chemotherapy

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Open Journal of Immunology 2023年第1期13卷 14-31页

作者： Folly M. Gaba Maïmouna Diop Doudou G. M. Niang Sidy Ka Doudou Diouf Moussa Ndour Comlan J. G. Montcho Moustapha Mbow babacar Faye Rokhaya N. Diallo Maguette S. Niang Ahmadou Dem babacar mben.ue Alioune Dieye Immunology Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal Immunology Laboratory Aristide Ledantec Hospital (HALD) Dakar Senegal Oncology Department Juliot Curie Institute Aristide Ledantec Hospital (HALD) Dakar Senegal Human Genetic Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal

Objective: Despite the existence of several therapeutic strategies, the management of cervical cancer remains challenging. Our region has very little data on the interaction between the immune system and the clinical response to chemotherapy. This work examines plasma levels of galectin-3 (Gal-3) and percentages of activated T cells in patients with cervical cancer treated with chemotherapy and investigates if there is a relationship between the rates of these two elements. Methods: We compared data from 37 patients with cervical cancer undergoing chemotherapy and 42 controls with normal cervical cytology. Plasma Gal-3 concentrations were assessed by ELISA and expression of activation markers by T cells (CD69 and HLA-DR) was assessed by flow cytometry at three different time points during chemotherapy. Results: Our results showed that patients had a significantly higher concentration of Gal-3 compared to controls (4.025 vs. 1.340, p 0.001), similarly, they had a significantly high percentage of activated lymphocytes (2.610 vs. 0.731;p 0.0001). According to the response to treatment, patients with no response to treatment had a lower concentration of circulating Gal-3 but had approximately the same percentage of activated CD4 and CD8 lymphocytes as patients with a partial or total response. In addition, we found a positive correlation between the Gal-3 level and CD4 T cells expressing the activation marker CD69 (p 0.05;rho = 0.44). Conclusion: In conclusion, our results show that there would be a relationship between circulating galectin-3 and the percentage of peripheral CD4+CD69+ cells in cervical cancer.

关键词： Uterine Cervical Neoplasm Chemotherapy Galectin 3 T-Lymphocytes Activation

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Metastatic Prostate Cancer under Androgen Deprivation Therapy: Factors Influencing Castration Resistance

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Open Journal of Urology 2020年第7期10卷 225-232页

作者： Modou Ndiaye Ousmane Sow babacar Sine Omar Gaye Alioune Sarr Abdoulaye Ndiath Cyrille Ze Ondo Amath Thiam Ndeye Aissatou Bagayogo Samba Thiapato Faye Ndiaga Seck Ndour Aboubacar Traore Ngor Mack Thiam El Hadj Malick Diaw Yaya Sow Boubacar Fall babacar Diao Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal

Objective: To evaluate the factors predicting the time to progression to castration-resistant in metastatic prostate cancer under Androgen Deprivation Therapy (ADT) in our center. Patients and Methods: This is a retrospective, descriptive, analytical study in a single center over a period of 2 years. It has interest patients followed for metastasized prostate cancer under ADT. The parameters studied were: epidemiological, clinical, paraclinical, prostate specific antigen (PSA) nadir, time to nadir (TTN) and their link with the castration resistance. Results: The frequency of castration resistant prostate cancer was 28 patients per year. The mean age was 70.4 ± 7.9 years. An ECOG score ≥ 3 was more common as was the cT2c stage. The median of the initial total PSA was 489.6 ng/ml (203.3;1653.2). All patients had adenocarcinoma. The International Society of Urological Pathology (ISUP) 1 was more frequent. Bone metastases were more frequent. The medians of nadir, TTN and the castration resistance were 19.3 ng/ml (3.7;102.1), 5.5 months (3;9) and 11 months (6;15.3), respectively. The Eastern Cooperative Oncology Group (ECOG) score, clinical stage, metastatic site, the nadir and its TTN influenced the DSR. Age, lymph node involvement, initial total PSA and Gleason score did not influence the castration resistance. Conclusion: ADT should be initiated as soon as possible before an attack of general and/or clinical stage advanced to delay resistance. A drilling should be associated with this hormone therapy as much as possible because of its gain on resistance.

关键词： Cancer Prostate Androgen Deprivation Therapy Resistance Prognoses

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舟山群岛大鳞副泥鳅与台湾泥鳅的形态差异性分析

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水生态学杂志 2016年第2期37卷 83-87页

作者：黄涛赵波 babacar Diakhate 王小军高阳唐舟凯胡秀峰储张杰浙江海洋学院舟山台岛鳅业有限公司

台湾泥鳅(Misgurnus anguillicaudatus)是台湾地区选育的泥鳅新品种,虽具有明显优于大鳞副泥鳅(Paramisgurnus dabryanus)的养殖性状,但在实际生产过程中往往会将这2种泥鳅混淆,为了科学识别形态特征相似的台湾泥鳅和舟山群岛大鳞副泥鳅... 详细信息

台湾泥鳅(Misgurnus anguillicaudatus)是台湾地区选育的泥鳅新品种,虽具有明显优于大鳞副泥鳅(Paramisgurnus dabryanus)的养殖性状,但在实际生产过程中往往会将这2种泥鳅混淆,为了科学识别形态特征相似的台湾泥鳅和舟山群岛大鳞副泥鳅,采用单因素方差分析、主成分分析和判别分析等多元分析方法定量比较舟山群岛大鳞副泥鳅与台湾泥鳅人工养殖群体的形态特征差异。结果显示:(1)2种泥鳅在本研究所涉24项形态评价指标中存在显著差异的达8项,两者在形态特征上具较好的区分度;(2)经主成分分析,提取到5个特征值均大于1的主成分,累计贡献率达75.463%,其中第1主成分为以营养生理状况、体型匀称程度为主导的体质强壮因子,第2主成分为以头部大小和胸鳍长短为主导的觅食运动功能因子,后3个主成分是与眼睛发达程度为主导的视野功能因子;(3)采用逐步判别法,以判别贡献率较大的8项形态评价指标为自变量,建立分类函数方程组。大鳞副泥鳅:func=-681.190+4.992x1+498.305x2+1778.188x3;台湾泥鳅:func2=-860.382+5.373x1+650.034x2+1894.839x3;所建判别函数可清晰区分舟山群岛大鳞副泥鳅与台湾泥鳅人工养殖群体,且判别准确率为100%。研究表明,虽然台湾泥鳅和大鳞副泥鳅形态特征相似,但能利用形态指标建立判别函数对两者进行科学、快速的判别。

关键词：台湾泥鳅大鳞副泥鳅形态特征多元分析

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