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circRNA3669 promotes goat endometrial epithelial cells prolif.ration via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways

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Journal of.Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaof.i Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui ba Langda Suo Yuxuan Song Lei Zhang Division of.Laboratory Saf.ty and Services Northwest A&F UniversityYangling 712100China College of.Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of.Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of.receptive endometrium(RE) f.om pre-receptive endometrium(PE) f.r successf.l embryo implantation is a complex dynamic process in which the morphology and physiological states of.the endometrial epithelium undergo a series of.signif.cant changes, including cell prolif.ration and apoptosis. However, the molecular mechanisms are not yet f.lly understood. In this study, a higher circRNA3669 level was observed in PE than in RE of.goats. f.nctional assays revealed that this overexpression promoted the prolif.ration of.goat endometrial epithelial cells(GEECs) by activating the expression of.genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. f.rthermore, circRNA3669 f.nctioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of.goats, was f.und to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also af.ected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby f.cilitating GEECs prolif.ration and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which f.rther provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of.RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) prolif.ration

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Management of.Penetrating Cranioencephalic Trauma Caused by Sharp Metal Objects—Therapeutic and Evolutionary Aspects: 12 Cases at the Renaissance University Hospital in N’Djamena

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Open Journal of.Modern Neurosurgery 2024年第2期14卷 170-178页

作者： Goumantar f.licien Toudjingar Li-Iyane Olivier Ouambi Yannick Canton Kessely Donal Djasdé Mahouli f.ta Vounki Momar Codé ba Neurosurgery Unit of.Center Hospitalier Universitaire la Renaissance N&#8217Djamena Chad Neurosurgery Unit of.CHU la Ré f&#233rence Nationale N&#8217Djamena Chad Neurosurgery Department of.Centre Hospitalier National Universitaire de f.nn Dakar Senegal

Introduction: Cranioencephalic trauma caused by bladed weapons is rare, and that caused by sharp objects is exceptional. The aim of.our study was to describe the clinical, therapeutic and evolutionary aspects. Materials and method: This was a descriptive and analytical study over a 48-month period at CHU la Renaissance f.om January 1, 2018 to December 31, 2021, concerning patients admitted f.r penetrating cranioencephalic trauma by pointed object. Results: Twelve cases, all male, of.penetrating cranioencephalic sharp-f.rce trauma were identif.ed. The mean age was 34 ± 7 years, with extremes of.11 and 60 years. f.rmers and herders accounted f.r 31% and 25% of.cases respectively. The average admission time was 47 hours. Brawls were the circumstances of.occurrence in 81.2% of.cases. Knives (33%), arrows (25%) and iron bars (16.6%) were the objects used. Altered consciousness was present in 43.8% of.cases, and f.cal def.cit in 50%. Scannographic lesions were f.acture and/or embarrhment (12 cases), intra-parenchymal haematomas (6 cases) and presence of.object in place (4 cases). Surgery was perf.rmed in 11 patients. Postoperative outcome was f.vorable in 9 patients. Af.er 12 months, 2 patients were declared unf.t. Conclusion: Penetrating head injuries caused by sharp objects are common in Chad. Urgent surgery can prevent disabling af.er-ef.ects.

关键词： Penetrating Trauma Skull Encephalon Sharp Object Surgery Patient Outcome

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Estimation of.the Direct Cost of.Management of.Venous Thromboembolism in Three Ref.rence Hospitals in the City of.Yaoundé: A Retrospective Study over a Three-Year Period

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World Journal of.Cardiovascular Diseases 2024年第2期14卷 99-114页

作者： Hamadou ba Nganou-Ngnindjio Chris Nadège Tatchim Samuel Aimé Kamdem f.licité Tchoukoua Serge Honoré Ahmadou Jingi Danwe Dieudonne Kingue Samuel f.culty of.Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Department of.Internal Medicine Garoua General Hospital Garoua Cameroon Cardiology Department Yaoundé Central Hospital Yaoundé Cameroon Higher Institute of.Health Sciences University of the Mountains Bagangté Cameroon f.culty of.Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of.Internal Medicine Douala General Hospital Douala Cameroon f.culty of.Health Sciences University of Bamenda Bamenda Cameroon Cardiology Department Yaoundé General Hospital Yaoundé Cameroon

background: Venous thromboembolism (VTE) is a major public health problem due to its increasing f.equency, mortality and management cost. This cost may require major f.nancial ef.orts f.om patients, especially in developing countries like ours where less than 7% of.the population has health insurance. This study aimed to estimate the direct cost of.managing VTE in three ref.rence hospitals in Yaoundé. Methods: This was a cross-sectional retrospective study over a three-year period (f.om January 1st 2018 to December 31 2020) carried out in the Cardiology departments of.the Central and General Hospitals, and the Emergency Centre of.the city of.Yaoundé. All patients managed during the study period f.r deep vein thrombosis and pulmonary embolism conf.rmed by venous ultrasound coupled with Doppler and computed tomography pulmonary angiography respectively were included. f.r each patient, we collected sociodemographic and clinical data as well as data on the cost of.consultation, hospital stay, workups and medications. These data were analysed using SPSS version 23.0. Results: A total of.92 patient’s records were analysed. The median age was 60 years [48 - 68] with a sex ratio of.0.53. The median direct cost of.management of.venous thromboembolism was 766,375 Cf.f.[536,455 - 1,029,745] or $1415 USD. Management of.pulmonary embolism associated with deep vein thrombosis was more costly than isolated pulmonary embolism or deep vein thrombosis. f.ctors inf.uencing the direct cost of.management of.venous thromboembolism were: hospital structure (p = 0.015), health insurance (p 0.001), type of.pulmonary embolism (p = 0.021), and length of.hospital stay (p = 0.001). Conclusion: Management of.VTE is a major f.nancial burden f.r our patients and this burden is inf.uenced by the hospital structure, health insurance, type of.pulmonary embolism and length of.hospital stay.

关键词： Cost Management Venous Thromboembolism Yaoundé

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Woody plant taxonomic,f.nctional,and phylogenetic diversity decrease along elevational gradients in Andean tropical montane f.rests:Environmental f.ltering and arrival of.temperate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： Guillermo bañares-de-Dios Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlos I.Espinosa Norma Salinas Luis Cayuela Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Departamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain Departamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Departamento de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Departamento de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains are paramount f.r exploring biodiversity patterns due to the mosaic of.topographies and climates encompassed over short *** research has traditionally f.cused on taxonomic diversity when investigating changes along elevational gradients,but other f.cets should be *** f.rst time,we simultaneously assessed elevational trends in taxonomic,f.nctional,and phylogenetic diversity of.woody plants in Andean tropical montane f.rests and explored their underlying ecological and evolutionary *** investigation covered f.ur transects(traversing ca.2200 m a.s.l.) encompassing 114 plots of.0.1 ha across a broad latitudinal range(ca.10°).Using Hill numbers to quantif. abundance-based diversity among 37,869 individuals we observed a consistent decrease in taxonomic,f.nctional,and phylogenetic diversity as elevation increased,although the decrease was less pronounced f.r higher Hill *** exception was a slight increase in phylogenetic diversity when dominant species were *** decrease in taxonomic and f.nctional diversity might be attributed to an environmental f.ltering process towards highlands,where the increasingly harsher conditions exclude species and f.nctional ***,the dif.erences in steepness decrease between Hill orders suggest that rare species disproportionately contribute to f.nctional *** phylogenetic diversity the shif.ing elevational trend between Hill orders indicates a greater than previously considered inf.uence in central Andean highlands of.tropical lowlands originated species with strong niche conservatism relative to distantly related temperate *** could be explained by a decreasing presence and abundance of.temperate,extratropical taxa towards the central Andes relative to northern or southern Andes,where they are more prevalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of.the Tropical Lowlands f.nctional rarity Tropical Niche Conservatism

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Evaluation of.the Care of.Children Aged 0 to 10 Years Hospitalized f.r Severe Malaria at the Tambacounda Health Center, Senegal

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Advances in Inf.ctious Diseases 2024年第3期14卷 581-594页

作者： Tidiane Gadiaga Aminata f.ll Alioune badara Gueye Siré Sagna bayal Cissé Mouhamadou f.ly ba Médoune Ndiop babacar Gueye Samba Cor Sarr Sylla Thiam Elhadji ba Konko Ciré Jean Louis Abdou Ndiaye Issa Wone Directorate of.Research Planning and Statistics Ministry of Health and Social Action Dakar Senegal f.culty of.Medicine Assane Seck University of Ziguinchor Ziguinchor Senegal Presidents Malaria Initiative USAID Dakar Senegal Tambacounda Health District Ministry of Health and Social Action Tambacounda Senegal Institute of.Health and Development Faculty of Medicine Cheikh Anta Diop University Dakar Senegal National Malaria Control Program (NMCP) Dakar Senegal Uf. Sant Faculty of Medicine Iba Der Thiam University of This This Senegal

Introduction: Malaria remains a public health priority in Senegal, particularly in Tambacounda, where it is one of.the main causes of.child mortality. The objective of.this work was to evaluate the care of.children under 10 years of.age hospitalized at the Tambacounda Health Center and the f.ctors associated with recovery. Methods: An analytical, retrospective, and descriptive cross-sectional study with exhaustive recruitment of.children 0 to 120 months hospitalized at the Tambacounda ref.rence health center f.r severe malaria (according to WHO criteria) between 1 January 2018 and 31 December 2021 was perf.rmed. Data collection was done through a questionnaire. Records, hospitalization records, and treatment records were the sources of.collection. Data entry and analysis were perf.rmed on Epi Inf. 7.2 and R. Results: A total of.481 children hospitalized with severe malaria were recruited. The highest number of.cases was recorded in 2018 (33.05%). In the f.ur years of.the study, peaks were always observed between October and November and the highest peak in November 2020 with 95 cases. The mean age was 65.64 months with a standard deviation of.29.28 months and a predominance of.male (53.43%). The majority of.people were admitted f.om the outpatient clinic (57.79%) and the rest (42.21%) on the recommendation of.a peripheral health post. All hospitalized patients had a positive RDT and/or a positive thick drop. However, the sharp decline at admission or during hospitalization was positive in 93.80% of.patients in our series, negative in 5.20% and not achieved in 1.00%. Seizures and severe anemia topped the list of.signs of.severity with 45.94% and 8.11%, respectively. In terms of.evolution, f.r all hospitalized patients, there were 81.29% recovery, 10.19% ref.rral to the Tambacounda regional hospital center f.r hospitalization, 4.99% death, 0.83% discharge and 2.70% unknown evolution. There was a statistically signif.cant association between recovery without ref.rral f

关键词： Severe Malaria Children Tambacounda Senegal

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Results of.the f.rst 10 Cases of.Coronary Bypass Surgery in Senegal

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World Journal of.Cardiovascular Surgery 2024年第4期14卷 45-60页

作者： Papa Amath Diagne Jean Claude Ndiogou Dione Papa Ousmane ba Momar Sokhna Diop El Hadji Boubacar ba Momar Dioum Marième Soda Mbaye Moussa Seck Diop Mory Camara Abdou Lahad Mbengue Abdou Aziz Thiaw Abdoul Khoudoss Diallo Moussa Mareme Samba Dialtabé Ibrahima Guéssé ba Anta Mbaye Sall Papa Salmaneba Amadou Gabriel Ciss Department of.Cardiovascular and Thoracic Surgery FANN National University Hospital Dakar Senegal

This is a review of.the f.rst 10 coronary artery bypass surgeries perf.rmed by the local team. The mean age was 62 years old [45 - 74]. The patients were predominantly male, with a M/f.ratio of.4:1. Cardiovascular risk f.ctors were mainly myocardial inf.rction (MI) (60%), hypertension (50%), obesity (40%) and diabetes (30%), with at least two risk f.ctors per patient. Angina was the main symptom (80%). The average time f.om presentation to surgery was 8 months. The mean Euroscore 2 was 2.92 ± 1.65 [1.33 - 6.60]. Coronary angiography revealed an average of.2 lesions per patient, with 3-vessel involvement in 70% of.cases: the Interventricular artery (IVA) (100%), the right coronary artery (90%) and the circumf.ex artery (70%). On echocardiography, the mean Lef. ventricular ejection f.action (LVEf. was 59% [33% - 76%]. All patients underwent median sternotomy with bypass graf.ing. The average duration of.the cardiopulmonary bypass was 150 min [46 - 275 min];that of.aortic clamping, 120 min [43 - 232 min]. The graf.s used were internal thoracic artery (ITA) in 100% of.cases (80% on the lef. and 20% on the right), and the great saphenous vein (GSV) in 60% of.cases (50% on the lef. and 10 on the right). Double bypass was perf.rmed in 60% of.cases, single bypass in 30% and triple bypass in 10%. The bypasses were perf.rmed on the IVA (100%), the middle lateral of.the circumf.ex (30%) and the bisector (20%). The average time to extubation was 11 hours and the length of.stay in the intensive care unit was 7 days [03 - 17 days]. One patient had a reoperation on Day 0 post-op. The average hospital stay was 13 days [06 - 27 days]. Complications occurred in nine of.the patients (90%), with a predominance of.inf.ctious and neurological complications. Overall operative mortality was 3%, all in intensive care.

关键词： Coronary Bypass Surgery Coronary Lesions Cardiac Surgery Senegal

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Why Sustainable Porous Carbon Should be f.rther Explored as Radar-Absorbing Material? A Comparative Study with Dif.erent Nanostructured Carbons

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Journal of.Renewable Materials 2024年第10期12卷 1639-1659页

作者： Alan f.N.Boss Manuella G.C.Munhoz Gisele Amaral-Labat Rodrigo G.A.Lima Leonardo I.Medeiros Nila C.f.L.Medeiros Beatriz C.S.f.nseca f.avia L.Braghiroli Guilherme f.B.Lenz e Silva Department of.Metallurgical and Materials Engineering University of de São PauloAvenida Mello MoraesCidade UniversitáriaSão PauloSP 05508-030Brazil Coordination of.Applied Research and Technological Development National Institute for Space ResearchAvenida dos AstronautasJardim da GranjaSão Josédos CamposSP 12227-010Brazil Department of.Exact and Technological Sciences Santa Cruz State UniversityRodovia Jorge Amadokm16IlhéusBA 45662900Brazil Institut de recherche sur les f.rêts Universitédu Québec en Abitibi-TémiscamingueRouyn-Noranda445 Bd de l’UniversitéRouyn-NorandaQC J9X 5E4Canada

Radar Absorbing Materials(RAM)are a class of.composites that can attenuate incident electromagnetic waves to avoid radar *** carbon allotropes that have the potential to be used as RAM are either carbon nano-tubes(CNTs),graphene,carbon black(CB)and ultimately,sustainable porous carbon(SPC).Here,black wattle bark waste(f.llowing tannin extraction)was used as a sustainable source to produce SPC made f.om biomass *** was characterized and used as aﬁller f.r a silicone rubber matrix to produce aﬂexible *** elec-tromagnetic perf.rmance of.this composite was compared with composites made with commercial CB and CNT through reﬂection loss(RL),where-10 dB is equivalent to 90%of.*** composites were evaluated in single-layer,double-layer,and as radar absorbing structures(RAS)with the aim of.improving their ef.ective absorption bandwidth(EAB)perf.rmances and a reduction in *** CNT composite presented a RL of.26.85 dB at 10.89 GHz and an EAB of.2.6 GHz with a 1.9 mm thickness,while the double-layer structures using CNT and SPC provided a RL of.19.74 dB at 10.75 GHz and an EAB of.2.51 ***,the double-layer structures are~42%cheaper than the composite using only CNT since less material is ***,the largest EAB was achieved with a RAS using SPC,reaching~2.8 GHz and a RL of.49.09 dB at 10.4 ***,SPC made of.black wattle bark waste can be a competitive,alternative material f.r use as RAM and RAS since it is cheaper,sustainable,and suitable f.r daily lif. uses such as absorbers f.r anechoic chambers,sensors,and elec-tromagnetic interf.rence shields f.r electronics,wallets,vehicles,and others.

关键词： Microwave absorption material tannin waste dielectric constant carbon composite reﬂectivity

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西藏自治区科技创新工作指标体系和考核标准研究

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产业科技创新 2024年第3期6卷 22-25页

作者：拉巴西藏大学西藏拉萨850000

本文在对西藏科技创新工作指标体系构建理论认识的基础上,对比指标体系理论做出进一步分析,提出了在构建西藏科技创新工作指标体系时所应体现的价值标准以及构建西藏科技创新工作评价指标体系所要达到的目标,为进一步优化西藏科技管理... 详细信息

本文在对西藏科技创新工作指标体系构建理论认识的基础上,对比指标体系理论做出进一步分析,提出了在构建西藏科技创新工作指标体系时所应体现的价值标准以及构建西藏科技创新工作评价指标体系所要达到的目标,为进一步优化西藏科技管理体制、检验科技发展的问题和成就寻找完善路径。

关键词：科技发展科技创新考核标准

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Hyperprolactinemia in Hospitals in Lomé: Diagnostic and Therapeutic Aspects

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Open Journal of.Internal Medicine 2024年第1期14卷 43-52页

作者： Tchamdja Toyi Djalogue Lihanimpo Kodjo Kossi Ganu Koudjo Kaaga Laconi Yéba Mossi Komi Edem M’bortché B. Kodjo Djibril Mohaman Awalou balaka Abago Internal Medicine Departement University de Kara Kara Togo Internal Medicine Departement Université of Lomé Lomé Togo

Introduction. Hyperprolactinemia represents a supraphysiological secretion of.prolactin. In clinical practice, it is the most f.equently encountered anterior pituitary disorder. However, its real prevalence is little known in Af.ica. The purpose of.this study is to list all cases of.hyperprolactinemia over the past f.ur years and to make an inventory of.the various etiologies f.und and their management. Methodology. This is a cross-sectional descriptive study on the f.les of.patients who came f.r consultation in the internal medicine and endocrinology department with hyperprolactinemia retrospectively collected f.om January 2017 to December 2020. Included were patients f.llowed or whose the diagnosis of.hyperprolactinemia was established in endocrinological consultation during the study period. Results. This study recorded 26 cases of.hyperprolactinemia. The f.male sex represented 73.08% (sex ratio M/f.0.37) and the average age was 33.92 years. The 40 - 50 age group was the most represented with 30.77%. In women, galactorrhea accounted f.r 73.07%, amenorrhea 57.69% of.clinical pictures and inf.rtility 23.08%. In men, inf.rtility accounted f.r 7.69% of.presentations, gynecomastia 11.54% and erectile dysf.nction 15.38%. The duration of.evolution of.the signs was 4 months in 23.08% of.the patients. The mean prolactinemia was 702.58 ng/ml. CT was perf.rmed in 80.85% of.patients. The main etiologies were pituitary adenomas (77%). All our patients were treated with dopaminergic agonists. Cabergoline was prescribed in 77% of.patients. The evolution was f.vorable in 96.25% of.patients. Conclusion. Hyperprolactinemia is a pathology that exists in our regions. The main etiology remains pituitary adenomas and treatment with cabergoline.

关键词： Hyperprolactinemia Hospital Environment CHU SO Togo

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青少年广泛性焦虑障碍人群血清标志物表达变化

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中国学校卫生 2024年第3期45卷 398-401页

作者：都吉雅徐海霞巴特尔内蒙古医科大学附属医院蒙医科呼和浩特010050 内蒙古医科大学附属医院放疗科内蒙古医科大学公共卫生学院

目的探讨青少年广泛性焦虑障碍(GAD)人群血清神经元特异性烯醇化酶(NSE)、白细胞介素-1β(IL-1β)、脑源性神经营养因子(BDNf.的表达水平,为青少年GAD的早期诊断和病情评估提供参考依据。方法选取2020年3月—2023年2月在呼和浩特市3所... 详细信息

目的探讨青少年广泛性焦虑障碍(GAD)人群血清神经元特异性烯醇化酶(NSE)、白细胞介素-1β(IL-1β)、脑源性神经营养因子(BDNf.的表达水平,为青少年GAD的早期诊断和病情评估提供参考依据。方法选取2020年3月—2023年2月在呼和浩特市3所三甲医院就诊,年龄13~18岁的首发青少年GAD患者97例,根据入院时广泛性焦虑障碍问卷(GAD-7)评分将其分为轻中度GAD组(58例)和重度GAD组(39例),同时选取同期来自该3所医院参加常规体检的青少年健康人群为对照组(90名)。采用方差分析比较3组对象血清NSE、IL-1β及BDNf.平,进一步两两比较用LSD-t检验;采用Pearson相关性分析血清NSE、IL-1β及BDNf.间的关系。结果3组受试者血清NSE、IL-1β及BDNf.平的差异均有统计学意义(f.分别为10.73,12.80,20.67,P值均f.平为(27.16±4.42)ng/mL,为最高;重度GAD组为(10.46±3.27)ng/mL,为最低。双变量Pearson直线相关分析显示,GAD人群血清NSE、IL-1β水平与血清BDNf.平均呈负相关(r值分别为-0.49,-0.57),血清NSE与IL-1β水平呈正相关(r=0.40)(P值均f.平异常降低的表现。血清NSE、IL-1β及BDNf.平可作为青少年GAD的检测标志物,有助于其早期诊断和病情评估。

关键词：焦虑血清精神卫生方差分析青少年

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