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Comparative studies between humans and golden Syrian hamsters via thromboelastography

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Animal Models and Experimental Medicine 2024年第4期7卷 570-577页

作者： Ze Yang Lili Xie Jingjing ba Simin Zan Letong Zhang Xinyi Zhang Yang Yu School of Laboratory Animal&Shandong Laboratory Animal Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina the Second Affiliated Hospital of Shandong First Medical University TaianChina

background:thromboelastography(tEG)is a widely utilized clinical testing method for real-time monitoring of platelet function and the thrombosis *** metab-olism disorders are crucial risk factors for *** lipid metabolism charac-teristics of hamsters resemble those of humans more closely than mice and rats,and their relatively large blood volume makes them suitable for studying the mechanisms of thrombosis related to plasma lipid *** blood samples from golden Syrian hamsters and healthy humans were obtained following standard clinical *** was employed to evaluate coagulation factor function,fibrinogen(Fib)function,platelet function,and the fibrinolytic ***:the whole blood from hamster or healthy human was isolated following the clinical procedure,and tEG was employed to evaluate the coagulation factor func-tion,Fib function,platelet function,and fibrinolytic *** analysis used ACLtOP750 automatic coagulation analysis *** routine testing used XN-2000 automatic blood ***:tEG parameters revealed that hamsters exhibited stronger coagulation fac-tor function than humans(reaction time[R],p=0.0117),with stronger Fib function(alpha angle,ptime[K],ptelet function did not differ signifi-cantly(maximum amplitude[ma],p=0.077).Hamsters displayed higher coagulation status than humans(coagulation index[CI],p=0.0023),and the rate of blood clot dissolution in hamsters differed from that in humans(percentage lysis 30 min after ma,p=0.02).Coagulation analysis parameters indicated that prothrombin time(Pt)and activated partial thromboplastin time(APtt)were faster in hamsters than in hu-mans(Pt,p=0.0014;APtt,p=0.03),whereas the Fib content was significantly lower in hamsters than in humans(pt difference was observed in thrombin time(p=0.1949).Conclusions:In summary,tEG could be used to evaluate thrombosis and bleeding parameters in whole blood samples

关键词： platelet function Syrian hamster thromboelastography(tEG) thrombosis

Phase Ib study of anti-EGFR antibody(SCt200)in combination with anti-PD-1 antibody(SCt-I10A)for patients with RAS/BRAF wild-type metastatic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming bai Yao Lu Chunmei Shi Jianwei Yang Wei Li Xianli Yin Chenghui Huang Lin Shen Liangzhi Xie Yi ba Department of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical University Union Hospital Fuzhou 350001China Fujian Provincial Cancer Hospital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Medical Oncology Gastroenterology and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Department of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:this study evaluated the safety and efficacy of an anti-epidermal growth factor receptor(EGFR)antibody(SCt200)and an anti-programmed cell death 1(PD-1)antibody(SCt-I10A)as third-line or subsequent therapies in patients with rat sarcoma viral oncogene(RAS)/v-raf murine sarcoma viral oncogene homolog B(BRAF)wild-type(wt)metastatic colorectal cancer(mCRC).Methods:We conducted a multicenter,open-label,phase Ib clinical *** with histologically confirmed RAS/BRAF wt m CRC with more than two lines of treatment were enrolled and treated with SCt-I10A and *** primary endpoints were the objective response rate(ORR)and *** secondary endpoints included disease control rate(DCR),progression-free survival(PFS),and overall survival(OS).Results:twenty-one patients were enrolled in the study through January 28,*** ORR was 28.57%and the DCR was 85.71%(18/21).the median PFS and OS were 4.14 and 12.84 months,*** treatment-related adverse events(tRAEs)were ***,compared with the monotherapy cohort from our previous phase I study evaluating SCt200 for RAS/BRAF wt m CRC in a third-line setting,no significant improvements in PFS and OS were observed in the combination ***:SCt200 combined with SCt-I10A demonstrated promising efficacy in previously treated RAS/BRAF wt m CRC patients with an acceptable safety *** head-to-head studies with larger sample sizes are needed to validate whether the efficacy and safety of combined anti-EGFR and anti-PD-1 therapy are superior to anti-EGFR monotherapy in the third-line setting.(Registration ***04229537).

关键词： Colorectal cancer SCt-I10A SCt200 epidermal growth factor receptor programmed cell death 1

Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

baCKGROUND traditional treatments for pancreatic cancer(PC)are *** therapy(PDt)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** to investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CtX)]drugs in vitro,with or without verteporfin,as measured via Mtt,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and Mitotracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDt for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

Common-path illumination in ESPI: enhancing sensitivity for measuring specular deformation

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CHINESE OPtICS LEttERS 2024年第8期22卷 081201-081201页

作者： Yan, Peizheng Liu, Xiangwei Zhou, Xinda ba, Rongsheng Zhou, Hanxuan Wang, Yonghong Li, Jie Hefei Univ technol Sch Instrument Sci & Optoelect Engn Hefei 230009 Peoples R China Hefei Univ technol Anhui Prov Key Lab Measuring Theory & Precis Instr Hefei 230009 Peoples R China China Acad Engn Phys Laser Fus Res Ctr Mianyang 621900 Peoples R China

In this study, an innovative technique is introduced to significantly enhance the sensitivity of electronic speckle pattern interferometry (ESPI) for the dynamic assessment of specular (mirrorlike) object deformations. By utilizing a common-path illumination strategy, wherein illumination and observation beams are precisely aligned, this method effectively doubles the optical path difference, leading to a twofold increase in measurement sensitivity. In addition, this method mitigates the effects of speckle noise on the measurement of minor deformations, expanding the applications of ESPI. theoretical and experimental evaluations corroborate the efficacy of this approach.

关键词： ESPI common-path illumination measurement sensitivity specular deformation SPECKLE-PAttERN INtERFEROMEtRY SHEAROGRAPHY DSPI

the Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antiba.terial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu ba Xiao-Qing Liu School of Chemistry and materials Science Hebei UniversityBaoding 071000China Ningbo Institute of materials technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of marine materials and Related technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antiba.terial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antiba.terial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. the cured resins exhibited excellent allaround qualities, particularly in bonding and antiba.terial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antiba.terial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of ba.terial cell membranes. the architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings thermosets Catechol structure Antiba.terial High adhesion

circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKt-mtOR and maPK pathways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui ba Langda Suo Yuxuan Song Lei Zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

the development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKt-mtOR and maPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKt, mtOR, JNK, and P38 in the PI3K/AKt-mtOR and maPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

Alternative technology for the recovery of butyl acetate with low concentration:high capacity adsorbent and high efficiency adsorption

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Green Chemical Engineering 2024年第2期5卷 236-244页

作者： Chi ma Lihong Zhao Zhengxin mao Hao Su Qingfen Liu CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Industrial pharmaceutical wastewater usually contains butyl acetate(ba)with a concentration of 1 wt%-7 wt%,and the traditional method for ba recovery is distillation with high energy *** method is developed to recover ba with low concentration for the high efficiency and low energy *** polar polyacrylate resins with macroporous structure of 233.1 nm and average particle size of about 526.5μm are successfully synthesized by suspension polymerization and used for the ba adsorption and *** maximum adsorption capacity reaches 171.1 mg g^(-1)with relative standard deviation(RSD)value of 0.2%,which is more than twice the results in the *** ba desorption rate is 97.0%at 100℃with RSD value of 0.4%,and the resins are beneficial to the reuse in the adsorption-desorption *** adsorption thermodynamics and kinetics are investigated,and the ba adsorption is a spontaneous and endothermic process with the increase of disorder *** process is mainly contributed by physical absorption and agree well with Freundlich model and pseudo-first-order adsorption kinetic *** adsorption method avoids boiling a large amount of wastewater and hopefully provides a novel alternative technology for the ba recovery.

关键词： Butyl acetate recovery Resin adsorption Desorption thermodynamics Kinetics

Investigation of Fracture Strength of Current Post materials (Peek, Fiber, Cast Metal) in Different Ferrule Conditions

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Open Journal of Stomatology 2024年第3期14卷 153-172页

作者： başak topdaği Funda bayindir Department of Prosthetic Dentistry Atatürk University Erzurum Türkiye

Aim: the fracture resistance of the post materials used nowadays significantly impacts the fracture type of the post material. the current study aimed to examine the impact of the fracture resistance of PEEK posts, whose use as a post material has not yet become widespread, on the fracture pattern that will occur. materials and Methods: Sixty-six extracted upper central incisor human teeth were used in the study. Six groups of posts were produced from metal, fiber, and PEEK materials (n = 11). Afterward, the fracture resistance test was applied to the samples. Samples were classified according to fracture type as repairable or irreparable. the ANOVA and test were used in statistical analysis. Post-hoc tests were carried out using tukey’s and tamhane’s t2 tests. On the other hand, Pearson’s chi-square test and the Fisher-Freeman-Halton test were conducted for comparisons between categorical variables. the statistical significance level was accepted as p Results: According to the fracture resistance test results, the groups where metal personal posts were used displayed higher fracture resistance in comparison with all other groups. According to the results of the optical microscope examination, the incidence of repairable fractures was significantly higher in the PEEK post group with ferrule preparation (p 0.05). Conclusion: In the absence of the ferrule effect, fractures are catastrophic, regardless of the material used. the use of PEEK as a post material contributes to keeping fractures at a repairable level.

关键词： Component Formatting Style Styling Insert

基于动态知识流动特征的有向技术融合预测方法

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情报杂志 2024年第8期43卷 152-159,41页

作者：陈稳马亚雪巴志超李纲南京大学数据智能与交叉创新实验室南京210023 南京大学数据管理创新研究中心苏州215163 南京大学信息管理学院南京210023 武汉大学信息管理学院武汉430072

[研究目的]基于动态知识流动特征对有向的技术融合关系进行预测,有助于提高企业的研发效率及科技管理部门对科技资源的合理分配。[研究方法]首先,将IPC前4位代码作为技术单元,基于专利中主分类号与副分类号提取技术间的有向知识流动关系... 详细信息

[研究目的]基于动态知识流动特征对有向的技术融合关系进行预测,有助于提高企业的研发效率及科技管理部门对科技资源的合理分配。[研究方法]首先,将IPC前4位代码作为技术单元,基于专利中主分类号与副分类号提取技术间的有向知识流动关系;然后,借鉴关联规则挖掘算法从重要性、强度和依赖度3个维度对知识流动关系进行筛选,将满足指标阈值的知识流动关系作为有向技术融合关系;最后,将有向技术融合关系预测转化为有监督的二分类任务,以机器学习算法为模型基础,结合前两个时期的技术间知识流动特征及其时序变化特征,预测下一个时期内的技术间是否存在技术融合关系。[研究结论]增材制造领域的实证分析结果显示,以代价敏感机器学习算法为预测算法,基于前两个时期的技术间知识流动特征及其时序变化特征可以有效预测下一阶段中的技术融合。随着技术的发展,技术间的单向融合愈发频繁,并逐渐演变为技术双向融合,甚至呈现多技术融合的现象。

关键词：技术融合专利分类号知识流技术预测增材制造机器学习知识流动特征