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Impact of pediatric inflammatory bowel disease diagnosis on exercise and sports participation: Patient and parent perspectives

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World Journal of Gastroenterology 2019年第31期25卷 4493-4501页

作者： Renée M Marchioni Beery Enju Li Laurie n Fishman division of digestive diseases and nutrition University of South FloridaTampaFL 33612United States Institutional Center of Clinical and Translational Research Boston Children’s HospitalBostonMA 02115United States division of Gastroenterology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115United States

baCKGROUnd Inflammatory bowel disease(IBd)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise *** sought to evaluate the influence of IBd diagnosis on exercise and sports participation in a pediatric *** compared patient-reported and parent-reported *** To evaluate the influence of IBd diagnosis on exercise and sports participation in a pediatric *** Consecutive IBd outpatients(aged 10-18 years)and their parents completed parallel voluntary surveys.A validated,patient-reported functional activity scale,the Hospital for Special Surgery Pediatric Functional Activity Brief Scale(HSS Pedi-FABS)was used to assess children’s activity *** There were 149 completed surveys(75%response rate)with mean participant age of 16.5 years[standard deviation(Sd)=4.0]and mean age at IBd diagnosis of 11.8 years(Sd=3.4).Most patients(77%)were diagnosed within 12 mo of symptom *** athletic participation was reported in 65%across 65 *** was greatest before(40%)rather than after(32%)IBd diagnosis,with no reported change in 28%.IBd negatively impacted play/performance in 45%but did not change play/performance in 44%.IBd treatment improved patients’desire to exercise(70%)and subjective capacity for aerobic exercise(72%).Patients and parents agreed that IBd subjects demonstrate normal capacity for aerobic exercise(0.40,95%CI:0.22-0.58)and that treatment improved both participatory desire(0.33,95%CI:0.12-0.54)and capacity for aerobic exercise(0.52,95%CI:0.31-0.71).Almost all(99%)viewed exercise as healthy,and most encouraged its *** patients demonstrated normal mean HSS Pedi-FABS *** After pediatric IBd diagnosis,most patients continue exercise and sports,with mean activity levels comparable to American *** positively impacts participatory desire and aerobic *** favor the role of exercise in IBd.

关键词： Inflammatory bowel disease Physical activity Exercise Sports

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Risk of progression of barrett's esophagus in patients with cirrhosis

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World Journal of Gastroenterology 2017年第18期23卷 3287-3294页

作者： Tehilla Apfel Rocio Lopez Madhusudhan R Sanaka Prashanthi n Thota department of General Internal Medicine Cleveland Clinic Foundation department of Biostatistics Cleveland Clinic Foundation department of Gastroenterology and Hepatology Digestive Disease and Surgery InstituteCleveland Clinic Foundation

To study barrett’s esophagus (BE) in cirrhosis and assess progression to esophageal adenocarcinoma (EAC) compared to non-cirrhotic BE *** patients who were found to have endoscopic evidence of BE confirmed by the presence of intestinal metaplasia on histology from 1/1/2000 to 12/1/2015 at Cleveland Clinic were included. Cirrhotic patients were matched 1:4 to BE controls without cirrhosis. Age, gender, race, BE length, hiatal hernia size, Child-Pugh (CP) class and histological findings were recorded. Cases and controls without high-grade dysplasia (HGd)/EAC and who had follow-up endoscopies were studied for incidence of dysplasia/EAC and to assess progression rates. Univariable conditional logistic regression was done to assess differences in baseline characteristics between the two *** total of 57 patients with cirrhosis and BE were matched with 228 controls (BE without cirrhosis). The prevalence of dysplasia in cirrhosis and controls were similar with 8.8% vs 12% with low grade dysplasia (LGd) and 12.3 % vs 19.7% with HGd or EAC (P = 0.1). In the incidence cohort of 44 patients with median follow-up time of 2.7 years [interquartile range 1.0, 4.8], there were 7 cases of LGd, 2 cases of HGd, and 2 cases of EAC. There were no differences in incidence rates of HGd/EAC in nondysplastic BE between cirrhotic cases and noncirrhotic controls (1.4 vs 1.1 per 100 person- years, P = 0.8). In LGd, cirrhotic patients were found to have higher rates of progression to HGd/EAC compared to control group though this did not reach statistical significance (13.7 vs 8.1 per 100 person- years, P = 0.51). A significant association was found between a higher CP class and neoplastic progression of BE in cirrhotic patients (HR =7.9, 95%CI: 2.0-30.9, P = 0.003).COnCLUSIOnCirrhotics with worsening liver function are at increased risk of progression of BE. More frequent endoscopic surveillance might be warranted in such patients.

关键词： Liver cirrhosis barrett’s esophagus dysplasia Esophageal neoplasm Progression

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Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome

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World Journal of Stem Cells 2021年第8期13卷 1134-1150页

作者： María B Monzón-nomdedeu Karl J Morten Elisa Oltra School of Biotechnology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain nuffield department of Women's and Reproductive Health The Women CentreUniversity of OxfordOxford OX39DUUnited Kingdom department of Pathology Universidad Católica de Valencia San Vicente MártirValencia 46001Spain Centro de Investigación Traslacional San Alberto Magno Universidad Católica de Valencia San Vicente MártirValencia 46001Spain

baCKGROUnd Fibromyalgia(FM)and myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific *** patient heterogeneity linked to patient subgroups and variation in disease severity,anomalies are found in the blood and plasma of these patients when compared with healthy control *** seeming specificity of these“plasma factors”,as recently reported by Ron davis and his group at Stanford University,CA,United States,and observations by our group,have led to the proposal that induced pluripotent stem cells(iPSCs)may be used as metabolic sensors for FM and ME/CFS,a hypothesis that is the basis for this indepth *** To identify metabolic signatures in FM and/or ME/CFS supporting the existence of disease-associated plasma factors to be sensed by *** A PRISMA(Preferred Reported Items for Systematic Reviews and Meta-analysis)-based systematic review of the literature was used to select original studies evaluating the metabolite profiles of FM and ME/CFS body *** MeSH terms“metabolomic”or“metabolites”in combination with FM and ME/CFS disease terms were screened against the PubMed *** original studies applying omics technologies,published in English,were *** data obtained were tabulated according to the disease and type of body fluid *** across studies were searched and P-values reported by the original studies were gathered to document significant differences found in the disease *** Eighteen previous studies show that some metabolites are commonly altered in ME/CFS and FM body *** vitro cell-based assays have the potential to be developed as screening platforms,providing evidence for the existence of factors in patient body fluids capable of altering morphology,differentiation state and/or growth ***,they can be further develo

关键词： Myalgic encephalomyelitis/chronic fatigue syndrome Fibromyalgia Induced pluripotent stem cells Plasma factor Conditioned medium Sensor system

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Medium range Prediction of Summer Monsoon Activities over India vis-a-vis Their Correspondence with the Observational Features

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Advances in Atmospheric Sciences 1999年第1期16卷 135-148页

作者： Swati basu K. J. ramesh Z. n. Begum department of Science and Technology National Centre for Medium Range Weather Forecasting (NCMRWF) New Delhi India

A detailed examination on various aspects of the southwest monsoon over the Indian subcontinent using analyses and forecasts of the nCMRWF global data assimilation and forecast system for the years 1994 and 1996 is carried out in this study. Objective procedures developed by ramesh et al. (1996) based on the monsoon 1995 data are employed in the present work. It is found that all the deterministic features of the summer monsoon viz., the onset, its advancement, stagnation/revival and the withdrawal, can reasonably by prognosticated after employing the objective methodologies and monitoring daily variations of certain derived quantities from the large scale analyses and forecasts. Further, a good correspondence of the observed large scale/synoptic scale circulation features and the observed rainfall etc. with the deterministic characteristics of the summer monsoon show a good prospect for real time prognosis of the important summer monsoon activities over the Indian subcontinent.

关键词： Summer monsoon Objective procedure Onset Advancement Withdrawal

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Hydrogen Gas Sensor based on nanocrystalline SnO_2 Thin Film Grown on bare Si Substrates

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nano-Micro Letters 2016年第1期8卷 20-28页

作者： imad H.Kadhim H.Abu Hassan Q.n.Abdullah nano-Optoelectronics Research and Technology Laboratory School of Physics Universiti Sains Malaysia Ministry of Education Physics department College of Education Tikrit University

In this paper, high-quality nanocrystalline SnO_2 thin film was grown on bare Si(100) substrates by a sol–gel method. A metal–semiconductor–metal gas sensor was fabricated using nanocrystalline SnO_2 thin film and palladium(Pd)metal. The contact between Pd and nanocrystalline SnO_2 film is tunable. Ohmic barrier contact was formed without addition of glycerin, while Schottky contact formed by adding glycerin. Two kinds of sensor devices with Schottky contact were fabricated(device 1: 8 h, 500 °C; device 2: 10 h, 400 °C). The room temperature sensitivity for hydrogen(H_2) was120 and 95 % in 1000 ppm H_2, and the low power consumption was 65 and 86 l W for two devices, respectively. At higher temperature of 125 °C, the sensitivity was increased to 195 and 160 %, respectively. The sensing measurements were repeatable at various temperatures(room temperature, 75, 125 °C) for over 50 min. It was found that device 1 has better sensitivity than device 2 due to its better crystallinity. These findings indicate that the sensors fabricated on bare Si by adding glycerin to the sol solution have strong ability to detect H_2 gas under different concentrations and temperatures.

关键词： SnO2 Glycerin Sol–gel Schottky contact Hydrogen sensor

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Bone and brain metastases from ampullary adenocarcinoma

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World Journal of Gastroenterology 2009年第21期15卷 2665-2668页

作者： Ioannis A Voutsadakis Stergios doumas Konstantinos Tsapakidis Maria Papagianni Christos n Papandreou division of Medical Oncology University Hospital of Larissa

Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the ***-abdominal metastases are less *** this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain *** briefly discuss aspects of this comparatively rare gastrointestinal malignancy.

关键词： Adenocarcinoma Ampulla of Vater Peri-ampullary Metastases Prognosis

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Security-constrained model for integrated power and natural-gas system

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Journal of Modern Power Systems and Clean Energy 2017年第3期5卷 326-336页

作者： Carlos M.CORREA-POSAdA Pedro SánCHEZ-MARTín Sara LUMBREraS XM Compania de Expertos en MercadosMedellı´nColombia Technological Research Institute(IIT) ICAI School of EngineeringComillas Pontifical UniversityMadridSpain

One of the main factors impacting the reliability of energy systems nowadays is the growing interdependence between electricity and gas networks due to the increase in the installation of gas-fired units. Securityconstrained unit commitment(SCUC) models are used to economically schedule generating units without compromising the system reliability. This paper proposes a novel SCUC formulation that includes dynamic gas constraints,such as the line pack, and transmission contingencies in power and gas networks for studying the integrated system reliability. A Benders’ decomposition with linear programming techniques is developed to be able to study large systems. By including dynamic gas constraints into the SCUC, the proposed model accounts for the flexibility and reliability that power systems require from gas systems in the short term. Case studies of different size and complexity are employed to illustrate how the reliability of one system is affected by the reliability of the other. These experiments show how both systems operate in a secure way(by including contingencies) increases operating costs by approximately 9% and also show how these costs can vary by 24% depending on the line pack scheduling.

关键词： Benders’decomposition natural gas Reliability Security-constrained unit commitment

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Influence of Generalized （r, q） distribution Function on Electrostatic Waves

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Communications in Theoretical Physics 2006年第3期45卷 550-554页

作者： M.n.S. Qureshi SHI Jian-Kui MA Shi-Zhuang Key Laboratory of Space Weather the Chinese Academy of Sciences Beijing 100080 China department of Physics Government College University~ Lahore 54000~ Pakistan Graduate University of the Chinese Academy of Sciences Beijing 100049 China

non-Maxwellian particle distribution functions possessing high energy tail and shoulder in the profile of distribution function considerably change the damping characteristics of the waves. In the present paper Landau damping of electron plasma （Langmuir） waves and ion-acoustic waves in a hot, isotropic, unmagnetized plasma is studied with the generalized （r, q） distribution function. The results show that for the Langmuir oscillations Landau damping becomes severe as the spectral index r or q reduces. However, for the ion-acoustic waves Landau damping is more sensitive to the ion temperature than the spectral indices.

关键词： generalized (r q) distribution function electrostatic waves damping

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Extraction of the defect density of states in microcrystalline silicon from experimental results and simulation studies

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Journal of Semiconductors 2015年第9期36卷 15-19页

作者： T.Tibermacine A.Merazga M.Ledra n.Ouhabab Laboratory of Metallic and Semi-conducting Materials University of Biskra Physics department Faculty of ScienceTaif University

The constant photocurrent method in the ac-mode （ac-CPM） is used to determine the defect density of states （dOS） in hydrogenated microcrystalline silicon （μc-Si：H） prepared by very high frequency plasma-enhanced chemical vapor deposition （VHF-PECVd）. The absorption coefficient spectrum （ac-α （h v））, is measured under ac- CPM conditions at 60 Hz. The measured ac-α（hv） is converted by the CPM spectroscopy into a dOS distribution covering a portion in the lower energy range of occupied states. We have found that the density of valence band- tail states falls exponentially towards the gap with a typical band-tail width of 63 meV. Independently, computer simulations of the ac-CPM are developed using a dOS model that is consistent with the measured ac-α（hv） in the present work and a previously measured transient photocurrent （TPC） for the same material. The dOS distribution model suggested by the measurements in the lower and in the upper part of the energy-gap, as well as by the numerical modelling in the middle part of the energy-gap, coincide reasonably well with the real dOS distribution in hydrogenated microcrystalline silicon because the computed ac-α（h v） is found to agree satisfactorily with the measured ac-α （h v）.

关键词： constant photocurrent method optical absorption spectrum micro-crystalline silicon defect densityof states

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儿童紫癜性肾炎诊治现状多中心回顾性调查分析

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中华儿科杂志 2013年第12期51卷 881-887页

作者：全国儿童常见肾脏病诊治现状调研工作组全国儿童常见肾脏病诊治现状调研工作组

目的探讨我国住院儿童紫癜性肾炎的临床特点、病理表现及治疗现状.方法回顾性分析全国40所医院2008年7月1日至2011年6月30日收治的新发过敏性紫癜、经临床或病理确诊为紫癜性肾炎并在调查单位接受治疗的紫癜性肾炎患儿的病历资料,并... 详细信息

目的探讨我国住院儿童紫癜性肾炎的临床特点、病理表现及治疗现状.方法回顾性分析全国40所医院2008年7月1日至2011年6月30日收治的新发过敏性紫癜、经临床或病理确诊为紫癜性肾炎并在调查单位接受治疗的紫癜性肾炎患儿的病历资料,并填写统一的调查表,收集相关资料,病例登记表经参研单位初步汇总后,由中华医学会儿科学分会肾脏学组最终汇总,由专门数据录入人员录入和核对,并随机抽样进行数据核实,最后对儿童紫癜性肾炎的临床特点、病理表现及治疗现状进行统计分析.结果此次调研最终符合入选条件且病例完整可供分析者共4863例患儿,其中男2935例,女1928例,男女比例为1.52∶1,6～13岁为发病高峰.4702例（96.7％）患儿于过敏性紫癜起病6个月内确诊肾损害.临床分型最常见为血尿和蛋白尿型（2831例,58.2％）.其中1625例患儿行肾活检治疗,最常见肾活检指征为蛋白尿合并镜下血尿（1149例,70.7％）.1448例肾活检患儿提供病理分级,以Ⅲ级和Ⅱ级为多见.4863例患儿中接受激素及其他免疫抑制剂治疗者共3677例（75.6％）.最常见的治疗方案为单用激素1655例（34.0％）；单纯血尿型患儿（362例,56.2％）多未予特殊治疗,血尿和蛋白尿型患儿最常选择治疗方案仍为单用激素治疗.肾组织病理Ⅰ级和Ⅱ级以单用激素或联合雷公藤多甙治疗为主,病理Ⅲ级和Ⅳ级以激素＋环磷酰胺＋甲泼尼龙冲击治疗为主.结论本研究调查分析了我国住院紫癜性肾炎患儿的临床诊治现状,目前多根据临床分型及参照病理分级选择治疗方案,但免疫抑制剂及非特异性治疗的选择和使用方式多样,仍有待进一步临床多中心研究结果验证并加以规范.

关键词：紫癜,过敏性肾小球肾炎临床方案多中心研究儿童

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