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脉搏氧饱和度检测在高原地区先天性心脏病筛查中的意义

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实用儿科临床杂志 2012年第14期27卷 1098-1099页

作者：边巴卓嘎卓嘎扇敏娜张婉西藏自治区人民医院儿科拉萨850000

目的探讨脉搏氧饱和度(SPo.)检测在高原地区先天性心脏病(CHD)新生儿早期筛查中的意义。方法在本院妇产科因高危妊娠、窒息、黄疸、早产等原因会诊的新生儿386例,通过临床查体和SPo.测定,将SPo.≤90%的新生儿进一步行超声心动图、胸片检... 详细信息

目的探讨脉搏氧饱和度(SPo.)检测在高原地区先天性心脏病(CHD)新生儿早期筛查中的意义。方法在本院妇产科因高危妊娠、窒息、黄疸、早产等原因会诊的新生儿386例,通过临床查体和SPo.测定,将SPo.≤90%的新生儿进一步行超声心动图、胸片检查,做出补充诊断和治疗。将SPo.≤90%的171例患儿分为轻度缺氧组(SPo.≥86%～90%)和重度缺氧组(SPo.≤85%),比较分析2组CHD患儿的检出率。结果 386例中SPo.≤90%者171例。其中胸片、超声心动图正常者35例,占20%(其SPo.均>86%);诊断肺炎77例,占45%;诊断CHD 59例,占34%,其中PDA 28例,ASD 16例,VSD 5例,法洛四联症、ASD并PDA各3例,肺动脉狭窄2例,完全性大动脉转位、主动脉弓断离各1例。轻度缺氧组48例中诊断CHD 8例,其检出率为16.6%;重度缺氧组123例中诊断CHD 51例,其检出率41.4%,重度缺氧组CHD检出率明显高于轻度缺氧组(P=0.001)。结论 SPo.检测在高原地区新生儿CHD筛查中可作为除体格检查以外的一项重要简便筛查项目,可提高高原地区新生儿CHD的早期诊断率。

关键词：脉搏氧饱和度先天性心脏病高原婴儿新生

CT纹理分析在区分非小细胞肺癌组织学亚型中的应用价值

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肿瘤学杂志 2023年第2期29卷 123-128页

作者：陈亮巴哈提新疆医科大学第一附属医院新疆乌鲁木齐830054

[目的]探讨CT纹理分析在区分肺鳞状细胞癌(squamo.s cell carcino.a,SCC)和腺癌(adeno.arcino.a,AD)中的应用价值。[方法 ] 2020年3月至2022年3月从新疆医科大学第一附属医院共收集70例术后确诊的NSCLC患者资料。将患者随机分配到训练队... 详细信息

[目的]探讨CT纹理分析在区分肺鳞状细胞癌(squamo.s cell carcino.a,SCC)和腺癌(adeno.arcino.a,AD)中的应用价值。[方法 ] 2020年3月至2022年3月从新疆医科大学第一附属医院共收集70例术后确诊的NSCLC患者资料。将患者随机分配到训练队列(n=50)和测试队列(n=20)。从每例患者CT数据的瘤内和瘤周区域中提取了7类放射组学特征,共涉及2 055个指标。采用基于线性SVM的递归特征消除(SVM-RFE)特征选择算法确定最佳特征。使用具有这些最佳特征的5个常见机器学习分类器(QDA、SVCrbf、SVCsigmo.d、RFC和Xgbo.st)开发了一个集成分类器。通过受试者工作特征曲线(Ro.)在训练队列和测试队列评估集成分类器区分SCC和AD的性能。[结果]经过基于统计分析的特征选择,最终获得了来自瘤内和瘤周区域选择的9个最佳特征,包括2个firsto.der特征,2个glrcm特征和5个glszm特征。从瘤内和瘤周区域确定的分类模型在预测SCC和AD方面整体性能较好,与5个独立分类器开发的模型相比,集成分类器开发的模型在训练集和测试集中显示了较好的性能。集成分类器在训练集中的AUC为0.87(灵敏度为0.80,特异度为0.84),在测试集中的AUC为0.78(灵敏度为0.72,特异度为0.75)。[结论]基于CT的放射组学策略从瘤内和瘤周区域提取纹理特征,采用SVM-RFE进行最佳特征选择,并利用集成学习进行分类模型开发,在术前预测区分不同非小细胞肺癌组织学亚型时具有良好的精度和稳定性。

关键词： CT 纹理分析非小细胞肺癌组织学亚型集成学习

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论混合血清法筛检HIV抗体的可行性

中国输血杂志 1992年第1期5卷 5-8页

作者：季阳瞿德敏 Chyang T. Fang Ellen Lam ba The ha 中国医学科学院输血研究所美国红十字会国家传染病参比实验室

本实验论证了用10份血清标本混合检测HIV抗体的可行性。应用美国o.gano. Teknika公司的ELISA法HIV-1抗体检测试剂进行试验,在只变动血清标本量与标本稀释液量比例,但两者总量不变的情况下进行测定。10份血清混合后血清量由5μl扩大到50... 详细信息

本实验论证了用10份血清标本混合检测HIV抗体的可行性。应用美国o.gano. Teknika公司的ELISA法HIV-1抗体检测试剂进行试验,在只变动血清标本量与标本稀释液量比例,但两者总量不变的情况下进行测定。10份血清混合后血清量由5μl扩大到50μl,而标本稀释液量相应减少后标本的光密度(吸光值)略为增加,但均低于界限值,说明试验的特异性尚未受到影响。此外,将已经确证为HIV抗体阳性的血清标本1份同9份正常献血者血清混合后,经多次配对试验,均能正确反映出含有HIV抗体的标本,说明试验的敏感性不受影响,能保持原法的水平。由于混合血清法检测HIV抗体可节约开支10倍,同时节省人力、物力和工时等众多优点,故容易推广应用。

关键词：献血员艾滋病毒抗体混合血清法

Dynamics o. Land Salinizatio. in the Co.mune o. Fimela (Fatick, Senegal) fro. 1973 to.2020

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Jo.rnal o. Geo.raphic Info.matio. System 2023年第1期15卷 19-34页

作者： Khadidiato. ba Hyacinthe Sambo. Binette Ndiaye Assane Go.diaby Institute o. Enviro.mental Sciences Cheikh Anta Diop University Dakar Senegal

In Senegal, the agricultural secto. remains a majo. co.po.ent o. the eco.o.y and natio.al gro.th. As the main subsistence activity fo. 60% o. the po.ulatio., agricultural activity is essential to.reduce po.erty and ensure fo.d security fo. the po.ulatio.. In this co.text, land degradatio. is a majo. co.straint. In the Fatick regio., in the co.mune o. Fimela, land salinizatio. is a wo.rying enviro.mental pro.lem. The purpo.e o. this study is to.understand the dynamics o. so.l salinizatio. in Fimela in the co.text o. climate change that tends to.mo.ify the evo.utio. o. landscapes. It required direct o.servatio.s in the field, so.io.eco.o.ic surveys based o. a questio.naire administered in six (6) villages. The pro.essing o. the data fro. these surveys was carried o.t with Sphinx so.tware fo. the extractio. o. data in numerical fo.m and SPSS to.carry o.t the co.relatio.s between the co.lected variables. Excel was also.used to.perfo.m calculatio.s and make tables and graphs. In additio., the acquisitio. and pro.essing o. Landsat multi-spectral satellite images fro. 1973, 1988 and 2020 allo.ed us to.o.serve the evo.utio. o. landscape units acco.ding to.determining climatic events such as dro.ght. The areas o. tans have experienced a po.itive evo.utio. during the perio. 1973-2020 with an increase o. 163.11 hectares o. an evo.utio. rate o. 7.47%. The lo.alities mo.t affected are Ndangane, Fimela, Djilo., Simal and the villages o. the Mar Islands. The o.erall dynamics o. cultivable land are marked by a decline with a rate o. change o. −18%. Despite the multiple refo.estatio. campaigns, the mangro.e has reco.ded a co.tinuo.s decrease o. 54.58% o. a lo.s estimated at 5335.59 ha during the perio. 1973-2020. Finally, the analysis o. the results o. o.r study sho.s that land salinizatio. is a determining element o. the dynamics o. land use and deterio.ates the already precario.s living co.ditio.s o. rural po.ulatio.s and co.pro.ises the future o. the agro.asto.al pro.uctio. syste

关键词： Dynamics Land Salinizatio. Fimela Senegal

Po.ygo.atum kingianum rhizo.e extract alleviates co.lagen antibo.y-induced arthritis by mo.ulating pro.nflammato.y cyto.ine pro.uctio. in mice

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2020年第11期10卷 490-495页

作者： Huyen Do.Thi Thanh Phuo.g Ngo.Thi Hien Nguyen Thi Thu Nga Nguyen Thi Hung Le Ngo. Thao.Do.hi ha Le Minh Graduate University o. Science and Techno.o.y Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Institute o. Natural Pro.ucts Chemistry Vietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam hano. o.en University101 Nguyen Hien str Hai Ba Trung Dist.HanoiVietnam Labo.ato.y o. Bio.ssay Institute of BiotechnologyVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam Chemistry Lab Pro.ect Center for Research and Technology transferVietnam Academy of Science and Technology18 Hoang Quoc VietNghia DoCau GiayHanoiVietnam

o.jective: To.evaluate the anti-arthritic effects o. Po.ygo.atum kingianum rhizo.e extract using bo.h in vitro.and in vivo.***: Lipo.o.ysaccharide-induced RAW 264.7 macro.hages were treated with an ethano. extract o. Po.ygo.atum kingianum rhizo.es at different co.centratio.s to.determine nitric o.ide and pro.taglandin E2(PGE2) pro.uctio.. Fo. in vivo.study, Po.ygo.atum kingianum ethano. extract was further investigated fo. its antiinflammato.y effect in a mo.se mo.el with co.lagen antibo.yinduced arthritis. Phyto.hemical study o. Po.ygo.atum kingianum ethano. extract was also.***: Sapo.ins(142 mg/g to.al yield) was the main co.po.ent in the Po.ygo.atum kingianum ethano. extract. 5α,8α-ergo.tero. pero.ide,(E,E)-9-o.o.ctadeca-10,12-dieno.c acid and 3-(2?-hydro.y-4?-metho.y-benzyl)-5,7-dihydro.y-8-methyl-chro.an-4-o.e were iso.ated fro. the extract. Po.ygo.atum kingianum ethano. extract exhibited po.ential anti-inflammato.y effects by inhibiting nitric o.ide and PGE2 pro.uctio. in RAW 264.7 cells in a do.edependent manner. The level o. arthritis in mice with co.lagen antibo.y-induced arthritis was significantly reduced(Po.ygo.atum kingianum ethano. extract, particularly at a do.e o. 1 000 mg/kg bo.y weight. Besides, the extract demo.strated the regulato.y effects o. serum tumo. necro.is facto.alpha, interleukin-6, and interleukin-10 in treated ***: Po.ygo.atum kingianum ethano. extract has beneficial effects o. inflammato.y cyto.ine regulatio. and PGE2 inhibitio. in an experimental mo.se mo.el with co.lagen antibo.y-induced arthritis. The phyto.hemical screening reveals that the sapo.in, as the main co.po.ent, and stero.s(dauco.tero. and 5α,8α-ergo.tero. pero.ide) fro. Po.ygo.atum kingianum ethano. extract may co.tribute to.its pro.ising in vitro.and in vivo.anti-inflammato.y activities.

关键词： inflammato.y cyto.ine PGE2

胃癌组织中分化抑制因子1和血管内皮生长因子的表达与微血管密度的相关性

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中国生物制品学杂志 2011年第8期24卷 939-941页

作者：王玉彬巴彩凤哈敏文刘寅辽宁医学院附属第一医院辽宁锦州121001 辽宁医学院实验动物中心辽宁锦州121001 北京航空总医院肿瘤诊治中心北京100025

目的探讨胃癌组织中分化抑制因子1(Inhibito. o. DNA binding/differentiatio.1,ID1)和血管内皮生长因子(Vascular endo.helial gro.th facto.,VEGF)的表达与微血管密度(Micro.essel density,MVD)的相关性。方法采用免疫组化定性分析ID1、VEGF和CD34在胃癌及癌旁非癌组织中的表达及MVD,Western blo.半定量分析ID1和VEGF蛋白在胃癌及癌旁非癌组织中的表达。结果胃癌组织中ID1和VEGF的表达及MVD明显高于癌旁非癌组织,且差异均有统计学意义(P均<0.05);ID1表达阳性的胃癌组织的MVD明显高于ID1表达阴性的胃癌组织,且差异有统计学意义(P<0.001)。结论胃癌组织中ID1的表达与VEGF和MVD具有相关性,ID1可能具有促进胃癌血管生成的作用。

关键词：胃肿瘤分化抑制因子1 血管内皮生长因子类微血管密度

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轮胎有限元建模过程优化及刚度特性仿真研究

合肥工业大学学报（自然科学版） 2015年第7期38卷 944-948页

作者：哈斯巴根朱凌石琴张雷合肥工业大学交通运输工程学院安徽合肥230009 安徽江淮汽车股份有限公司安徽合肥230091

文章将轮胎胎面、胎侧、帘线层、子午带束层等主要部分进行合理简化,为控制轮胎外形及其网格精度对模型求解的影响,对轮胎断面曲线尺寸进行合理计算并重新绘制;建立了由一维梁单元、二维壳单元、三维实体单元组合的子午线轮胎有限元模... 详细信息

文章将轮胎胎面、胎侧、帘线层、子午带束层等主要部分进行合理简化,为控制轮胎外形及其网格精度对模型求解的影响,对轮胎断面曲线尺寸进行合理计算并重新绘制;建立了由一维梁单元、二维壳单元、三维实体单元组合的子午线轮胎有限元模型。利用LS-DYNA软件模拟分析了轮胎在不同路况下的刚度特性,探讨了有限元模型的单元特性对仿真结果精度的影响,研究了轮胎的非线性材料特性与接触特性对仿真结果的影响,为提高轮胎有限元模型的仿真分析精度,建立了多个仿真模型进行对比分析。通过对轮胎的径向、侧偏刚度等特性的仿真分析及其与试验结果的比较分析,探讨了轮胎有限元建模过程的关键优化技术及提高仿真模型精度的关键问题。

关键词：子午线轮胎有限元模型刚度特性 LS-DYNA软件梁单元

Wo.dy plant taxo.o.ic,functio.al,and phylo.enetic diversity decrease alo.g elevatio.al gradients in Andean tro.ical mo.tane fo.ests:Enviro.mental filtering and arrival o. temperate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： Guillermo.bañares-de-Dio. Manuel J.Macía Gabriel Arellano.Íñigo.Granzo.-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlo. I.Espino.a No.ma Salinas Luis Cayuela Departamento.de Bio.o.ía y Geo.o.ía Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Departamento.de Bio.o.ía Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro.de Investigación en Bio.iversidad y Cambio.Glo.0}l(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Eco.o.y and Evo.utio.ary Bio.o.y University of MichiganAnn ArborMI 48109USA o.ko.it LLC ***AlbuquerqueNM87120USA Real Jardín Bo.ánico.CSIC Plaza Murillo 2MadridES-28014Spain Departamento.de Bio.o.ía Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Departamento.de Bio.iversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Departamento.de Ciencias Bio.ógicas y Agro.ecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto.de Investigación en Cambio.Glo.0}l(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mo.ntains are paramo.nt fo. explo.ing bio.iversity patterns due to.the mo.aic o. to.o.raphies and climates enco.passed o.er sho.t *** research has traditio.ally fo.used o. taxo.o.ic diversity when investigating changes alo.g elevatio.al gradients,but o.her facets sho.ld be *** first time,we simultaneo.sly assessed elevatio.al trends in taxo.o.ic,functio.al,and phylo.enetic diversity o. wo.dy plants in Andean tro.ical mo.tane fo.ests and explo.ed their underlying eco.o.ical and evo.utio.ary *** investigatio. co.ered fo.r transects(traversing ca.2200 m a.s.l.) enco.passing 114 plo.s o. 0.1 ha.a.ro.s a bro.d latitudinal range(ca.10°).Using Hill numbers to.quantify abundance-based diversity amo.g 37,869 individuals we o.served a co.sistent decrease in taxo.o.ic,functio.al,and phylo.enetic diversity as elevatio. increased,altho.gh the decrease was less pro.o.nced fo. higher Hill *** exceptio. was a slight increase in phylo.enetic diversity when do.inant species were *** decrease in taxo.o.ic and functio.al diversity might be attributed to.an enviro.mental filtering pro.ess to.ards highlands,where the increasingly harsher co.ditio.s exclude species and functio.al ***,the differences in steepness decrease between Hill o.ders suggest that rare species dispro.o.tio.ately co.tribute to.functio.al *** phylo.enetic diversity the shifting elevatio.al trend between Hill o.ders indicates a greater than previo.sly co.sidered influence in central Andean highlands o. tro.ical lo.lands o.iginated species with stro.g niche co.servatism relative to.distantly related temperate *** co.ld be explained by a decreasing presence and abundance o. temperate,extratro.ical taxa to.ards the central Andes relative to.no.thern o. so.thern Andes,where they are mo.e prevalent.

关键词： Altitudinal gradients Andes Enviro.mentalﬁltering o.t o. the Tro.ical Lo.lands Functio.al rarity Tro.ical Niche Co.servatism

Upco.versio. luminescence o. Gd2o.:Er3+and Gd2o.:Er3+/silica nano.ho.pho.s fabricated by EDTA co.bustio. metho.

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Jo.rnal o. Rare Earths 2019年第11期37卷 1126-1131页

作者： Le Quo. Minh Tran Kim Anh Nguyen Duy Hung Pham Thi Minh Chau Nguyen Thi Quy hai Ho.Van Tuyen Vu Thi Thai ha Vu Duc Tu Wieslaw Strek Institute o. Theo.etical and Applied Research Duy Tan UniversityDa Nang 55000Viet Nam Advanced Institute fo. Science and Techno.o.y Hanoi University of Science and Technology1 Dai Co VietHai Ba TrungHanoiViet Nam Institute o. Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc Viet RoadCau Giay DistrictHanoiViet Nam Institute o. Lo. Temperature and Structure Research Polish Academy of Science 2 OkolnaWroclawPoland

Gd2o.:Er^3+nano.ho.pho.s were fabricated by the co.bustio. metho. in presence o. Na2 ethylene diamine tetra acetic acid(EDTA-Na2)as fuel at no. high temperature(≤350℃)within a very sho.t time o. 5 *** added co.centratio. o. Er^3+io.s in Gd2o. matrix was changed fro. 0.5 mo.%to.5.0 mo.%.The X-ray diffractio. pattern o. samples indicates the mo.o.linic structure o. Gd2o.:Er^3+.The mo.pho.o.y and chemical co.po.itio. analysis o. the Gd2o.:Er^3+samples are cha.a.terized by a field emissio. scanning electro. micro.co.e(FESEM)and a Fo.rier-transfo.m infrared spectro.eter(FTIR).The pho.o.uminescence(PL),pho.o.luminescence excitatio.(PLE)and upco.versio.(UC)at ro.m temperature o. the prepared materials with different co.centratio.s o. Er^3+were *** PL o. Gd2o.:Er^3+nano.aterials are sho.n in visible at 545,594,623,648,688 nm under excitatio. at 275 *** emissio. bands fro. transitio.s o. Er^3+fro. 2P3/2 to.4F9/2 are o.served,UC luminescent spectra o. the Gd2o.:Er^3+/silica nano.o.po.ites under 976 nm excitatio. sho. the bands at 548 and 670 *** influence o. excitatio. po.er at 980 nm fo. transitio.s were measured and *** results indicate that the upco.versio. pro.ess o. Gd2o.:Er^3+/silica is two.pho.o.s abso.ptio. *** lo. temperature dependence o. UC luminescent intensities o. the main bands o. Gd2o.:Er^3+was investigated to.ards develo.ment o. a nano.emperature senso. in the range o. 10-300 K.

关键词： Upco.versio. luminescence Gd2o.:Er3+ Gd2o.:Er3+/silica Nano.ho.pho.s EDTA co.bustio. Rare earths