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Lesions requiring wound management in a central tertiary neonatal intensive care unit

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World Journal of Pediatrics 2017年第2期13卷 165-172页

作者： Angéla meszes Gyula Tálosi Krisztina máder Hajnalka Orvos Lajos Kemény Zsanett Renáta Csoma Department of dermatology and Allergology University of SzegedSzegedHungary Department of Pediatrics University of SzegedSzegedHungary Department of Obstetrics and Gynecology University of SzegedSzegedHungary Department of dermatology and Allergology University of SzegedSzegedHungary mta-SZTE dermatological Research Group SzegedHungary

background:most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal *** iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic *** study was to review the neonates admitted to our neonatal intensive care unit who needed wound management,and to assess the most common skin injuries and wounds,and their ***:Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31,2012 and January 31,*** about gestational age,sex,birth weight,area of involvement,wound aetiology,and therapy were ***:Among the 211 neonates observed,wound management was required in 10 cases of diaper dermatitis,7 epidermal stripping,6 extravasation injuries,5 pressure ulcers,1 surgical wound and infection,1 thermal burn,and 5 other ***:International guidelines in neonatal wound care practice are not available,and further research concerns are clearly *** and antiseptic agents should be chosen with great care for application to neonates,with particular attention to the prevention of adverse events in this sensitive *** work among dermatologists,neonatologists and nurses is crucial for the successful treatment of neonates.

关键词： epidermal stripping extravasation injury neonatal intensive care unit surgical wound wound care in neonates

凹坑织构化81107轴承变载摩擦磨损性能研究

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机械设计与制造 2024年第3期 305-309页

作者：金志浩韩辉龙日升张义民沈阳化工大学装备可靠性研究所辽宁沈阳110142

为了探究变载条件下凹坑织构化轴承的摩擦磨损性能,以81107TN推力圆柱滚子轴承为研究对象,通过在轴圈表面制备不同直径和不同深度的凹坑型织构,利用mmW-1A型万能摩擦磨损试验机,在阶梯渐进增长式载荷和贫油条件下进行试验。通过分析和... 详细信息

为了探究变载条件下凹坑织构化轴承的摩擦磨损性能,以81107TN推力圆柱滚子轴承为研究对象,通过在轴圈表面制备不同直径和不同深度的凹坑型织构,利用mmW-1A型万能摩擦磨损试验机,在阶梯渐进增长式载荷和贫油条件下进行试验。通过分析和对比试验后的摩擦系数、磨损量以及表面形貌,发现:直径250μm、深度20μm的凹坑织构化轴承表现出良好的摩擦磨损性能,其平均摩擦系数上升时间点比光滑无织构轴承滞后6000s,磨损量相比光滑无织构轴承降低7%;这里的条件下,变载荷条件下轴承的平均摩擦系数比恒定载荷低,最大差值为0.031,且后期变载荷轴承平均摩擦系数更稳定,变载荷轴承磨损量相比恒定载荷轴承也减少了7.3%。

关键词：凹坑织构滚动轴承摩擦磨损贫油润滑

Protective effect and mechanisms of action of mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats

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World Journal of Gastroenterology 2021年第16期27卷 1770-1784页

作者： Shan Tong Huan Wang Li-Sha A ta-Na bai Ju-Hua Gong Wen-Jie Jin Li-Li Dai Gen-Na ba Sung-Bo Cho ming-Hai Fu School of mongolian medicine Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina mongolian medicine Surgery Department Affiliated Hospital of Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina Traditional mongolian medicine Research Institute Inner Mongolia University for NationalitiesTongliao 028000Inner Mongolia Autonomous RegionChina

baCKGROUND Sulongga-4(SL-4)is a herbal formula used in traditional mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis,even though its pharmacological mechanism has not been well *** To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation(PL)in *** PL was performed to induce gastric and duodenal ulcers in rats,which were then treated with oral SL-4(1.3,2.6,or 3.9 g/kg per day)for 15 ***-induced gastroduodenal *** effects were characterized by pathological and histological evaluations and inflammatory indicators were analyzed by enzyme-linked immunosorbent *** analyses were conducted to identify gene expression profiles of gastroduodenal tissue in PL rats with or without SL-4 *** candidate target genes were selected and verified by quantitative reverse transcription polymerase chain reaction(qRT-PCR).RESULTS SL-4 decreased histopathological features in the PL-induced ulcerated ***-4 significantly (P mor necrosis factor-α,interleukin (IL)-1β, IL-6, endotoxin, platelet-activating factor, and increasedprostaglandin E2 and epidermal growth factor in ulcer tissue. microarray analysiswas used to identify a panel of candidate target genes for SL-4 acting on PLinducedulceration. Genes included some complement and coagulation cascadeand retinol metabolism pathways that are closely associated with inflammatoryresponses and gastric mucosal protective mechanisms. qRT-PCR showed thataltered expression of the selected genes, such as CYP2b2, UGT2b1, A2m, andmASP1 was consistent with the microarray ***-4 exerts protective effects against PL-induced gastroduodenal ulcers viareducing inflammatory cytokines and elevating expression of gastric acidinhibitory factors. Downregulation of CYP2b2 and UGT2b1 genes in retinolmetabolism and upregulation of A2m and mASP1 ge

关键词： Sulongga-4 Peptic ulcer Pyloric ligation microarray analysis Inflammatory reaction Retinol metabolism

microstructure and properties of as-cast Zr-2.5Nb-1X(X=Ru,mo,ta and Si) alloys for biomedical application

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Rare metals 2023年第10期42卷 3497-3509页

作者： Xi-Nu tan Fei-tao Li Yu-Shun Liu ri-Sheng Qiu Qing Liu Electron microscopy Center College of Materials Science and EngineeringChongqing UniversityChongqing400044China International Joint Laboratory for Light Alloys(mOE) College of Materials Science and EngineeringChongqing UniversityChongqing400044China TU Ilmenau Chair Materials for Electrical Engineering and ElectronicsInstitute of Materials Science and Engineering and Institute of Micro-and Nanotechnologies MacroNanoIlmenau98693Germany Department of mechanical Engineering University of ManitobaWinnipegMBR3T 5V6Canada Key Laboratory for Light-Weight materials Nanjing Tech UniversityNanjing210009China

The micro structure and properties of as-cast Zr-2.5Nb-1X(X=Ru,mo,ta and Si) alloy are screened to explore novel biomedical zirconium alloys for magnetic resonance *** micro structure and phase transformation were characterized using X-ray diffraction(XRD),scanning electron microscope(SEm)and transmission electron microscope(TEm).Hardness test,magnetic detection and electrochemical corrosion measurements are taken to present *** results show that all alloys consist of α-Zr,β-Zr and ω-Zr.α-Zr and β-Zr mainly exist in the form of parallel and intersecting plates,and nanoscale ω-Zr is dispersed in β-Zr ***,blocky ω-Zr with needle-like α-Zr is only found in plate-free blocks of Zr-2.5Nb-1mo/Ru *** orientation relationship(OR) between α-Zr and ω-Zr follows [1120]_α//[1101]_ω and(0001)_α//([1011]_ω 011)_ω.Combining this OR with the OR between β-Zr and ω-Zr,the transformation relationship between β-Zr/ω-Zr and α-Zr is also ***-2.5Nb-1Ru alloy with high corrosion potential(-0.500 V),low corrosion rate(0.949 μm·year^(-1)) and low magnetic susceptibility(92×10^(-6)) shows great potential to be a novel biomedical implant with magnetic resonance imaging *** on the experimental results,the possible relationship among alloying elements,micro structure and properties has been established in these Zr-2.5Nb-1X alloys.

关键词： Zirconium alloy microstructure Phase transformation Electrochemical corrosion magnetic susceptibility

Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin bartyik Krisztina míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss miklós Garami István Peták Oncompass medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(m,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(mTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

Quercetin Attenuates Benzo(α)pyrene-induced CYP1A Expression

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Biomedical and Environmental Sciences 2017年第4期30卷 308-313页

作者： Perepechaeva mL Seredina ta Sidorova YA Pivovarova EN markel AL Lyakhovich VV Grishanova AY Institute of molecular Biologv and Biophysics Novosibirsk 630117Russia Federal research center Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences(SB RAS)Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia

We studied effects of nutrient quercetin on cytochromes＇ Р450 1А （CYP1A） activities （measured spectrofluorimetrically using 7-ethoxy-resorufin for CYP1A1 and 7-methoxy-resorufin for CYP1A2 as substrates）, on m RNA levels （measured by RT-PCR）, and on DNA-binding activities （evaluated by an electrophoretic mobility shift assay） of proteins regulating CYP1A expression in untreated and benzo（α）pyrene （ba P）-treated rats. Wistar rats received quercetin, ba P, or both once daily for 1-3 days. Quercetin did not influence CYP1A1 in untreated rats but inhibited ba P-mediated CYP1A induction on the transcriptional level decreasing positive input （Ah R functional activity） and increasing negative input （Ah RR/ARNT expression and Oct-1 and C/EBP functional activities）.

关键词： CYP pyrene-induced CYP1A Expression Quercetin Attenuates Benzo

Epidemiological and Clinical Aspects of Chronic Renal Failure in the medical Department at the Hospital of Sikasso

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Open Journal of Nephrology 2023年第1期13卷 57-66页

作者： Djénéba maïga Drissa Goïta magara Samaké Aboudou messoum Dolo Yohanna Koné Aboubacar Sidiki Fofana Seydou Sy moctar Coulibaly Atabième Kodio Sahdit baba Coulibaly Saharé Fongoro Nephrology Unit of Sikasso Hospital Sikasso Mali National Center for Scientific and Technological Research (CNRST) Bamako Mali Service de médecine CHU Mère-Enfant le Luxembourg Bamako Mali Nephrology Unit of the Fousseyni DAOU Hospital Kayes Mali Nephrology and Hemodialysis Service CHU du Point-G Bamako Mali Faculty of medicine of bamako Bamako Mali Nephrology Unit of mali GAVARDO Hospital of Sebenicoro Bamako Mali

Introduction: Chronic renal failure is a real public health problem because of its prevalence, the cost of its management and the high morbidity and mortality rate associated with it. The objective of this study was to determine the frequency, causes and main aggravating factors of chronic renal failure in the medical department of the hospital of Sikasso. materials and methods: This was a cross-sectional, retrospective, descriptive study conducted in the medical department of the Sikasso hospital from January 1, 2021 to November 30, 2022. It covered all the records of patients with chronic renal failure hospitalized in the department during this period. The mDRD formula was used to estimate the glomerular filtration rate. The KDIGO 2012 classification was used to stage CKD. Results: Of 820 patient records reviewed, we retained 197 records. The mean age of our patients was 42.25 ± 10 years. The male sex represented 114 (57.9%). The socio-economic level was considered low and precarious in 79.8% of cases. The frequency of chronic renal failure was 24%. The reason for hospitalization was mostly hyper creatinine > 185 μmol/l (92.4%). Herbal medicine was reported in 103 cases (52.3%). medical history was hypertension 101 cases (51.3%), undocumented gastro duodenal ulcer (UGD) 14 cases (7.6%), hypertension and diabetes 11 cases (5.1%), diabetes 8 cases (4%), lower limb edema 9 cases (4.6%). Hypocalcemia was 147 cases (75.6%) with hyper phosphoremia was 153 cases (77.7%). Hemoglobin level was: m 8 - 10 g/dl, 54 cases (27.4%). The etiologies of CKD were vascular nephropathy 106 cases (53.8%), interstitial nephropathy, 44 cases (22.3%), glomerular nephropathy, 33 cases (16.8%), diabetic nephropathy, 12 cases (6.1%) and polycystic kidney disease 2 (1%). CKD was classified as stage 5, 171 cases (86.8%), stage 4, 11 cases (5.6%), stage 3, 13 cases (6.6%) and stage 2, 2 cases (1%.) Dialysis was performed in 1095

关键词： Epidemiology Clinical Chronic Renal Failure Sikasso mali

Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi balázs rdg Zoltán Rakonczai Jr tamás takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró mária K Kovács mike A Gray barry E Argent Zsolt Boldogki First Department of medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and molecular Biosciences

AIm： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PRV） on pancreatic ductal secretion. mETHODS： The virulent ba-DupGreen （BDG） and non- virulent Ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3-buffered ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. CONCLUSION： Incubation with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

德都红花-7味散原药方与优化方对肝纤维化大鼠Ⅰ,Ⅲ型胶原mRNA表达的影响

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中国实验方剂学杂志 2016年第7期22卷 134-138页

作者：巴图德力根徐艳华韩志强山丹塔娜安达娜日苏内蒙古民族大学附属医院内蒙古通辽028007 内蒙古民族大学蒙医药学院内蒙古通辽028000

目的:探讨德都红花-7味散原药方及优化方对肝纤维化大鼠Ⅰ,Ⅲ型胶原mRNA表达的影响。方法:40只Wistar大鼠分为正常组、模型组、阳性药组、原药组、优化组。大鼠ip 30%CCl4橄榄油溶液建立肝纤维化模型。同时1次/日ig给药,阳性药组给予秋... 详细信息

目的:探讨德都红花-7味散原药方及优化方对肝纤维化大鼠Ⅰ,Ⅲ型胶原mRNA表达的影响。方法:40只Wistar大鼠分为正常组、模型组、阳性药组、原药组、优化组。大鼠ip 30%CCl4橄榄油溶液建立肝纤维化模型。同时1次/日ig给药,阳性药组给予秋水仙碱片0.4 mg·kg-1;原药组给予德都红花-7味散0.6 g·kg-1;优化组给予德都红花-7味散优化方0.6 g·kg-1。连续40 d后处死大鼠。取肝脏天狼星红染色,观察肝组织纤维化程度和Ⅰ,Ⅲ型胶原分型。酶联免疫吸附法(ELISA)检测肝组织匀浆Ⅲ型前胶原和Ⅳ型胶原,层粘连蛋白(LN),透明质酸(HA)含量。实时荧光定量PCR法检测Ⅰ型胶原,Ⅲ型胶原mRNA表达变化。结果:天狼星红染色模型组Ⅰ,Ⅲ型胶原纤维较正常组增多,阳性药组、原药组、优化组Ⅰ,Ⅲ型胶原纤维较模型组减少。与正常组比较,酶联免疫法检测模型组Ⅳ型胶原,HA含量升高(PmRNA和Ⅲ型胶原mRNA表达较正常组上调(PmRNA和Ⅲ型胶原mRNA表达较模型组下调(PmRNA表达较阳性药组下调(PmRNA表达较原药组下调(PmRNA和Ⅲ型胶原mRNA的转录,达到阻断或延缓肝纤维化的发生发展,德都红花-7味散优化方优于原药方。

关键词：德都红花-7味散肝纤维化,Ⅰ型胶原mRNA Ⅲ型胶原mRNA