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Phase Ib study of anti-EGFR antibody(SCT200)in combination with anti-PD-1 antibody(SCT-I10A)for patients with RAS/BRAF wild-type metastatic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming bai Yao Lu Chunmei Shi Jianwei Yang Wei Li Xianli Yin Chenghui Huang Lin Shen Liangzhi Xie Yi ba Department of GI Medical Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin Key Laboratory of Digestive CancerTianjin 300060China Fujian Medical University Union Hospital Fuzhou 350001China Fujian Provincial Cancer Hospital Fuzhou 350014China Cancer Center The First Hospital of Jilin UniversityChangchun 130021China Department of Medical Oncology Gastroenterology and Urology Hunan Cancer HospitalAffiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Department of Oncology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing)Peking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Bejing 100176China Department of Cancer Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100010China

Objective:This study evaluated the safety and efficacy of an anti-epidermal growth factor receptor(EGFR)antibody(SCT200)and an anti-programmed cell death 1(PD-1)antibody(SCT-I10A)as third-line or subsequent therapies in patients with rat sarcoma viral oncogene(RAS)/v-raf murine sarcoma viral oncogene homolog B(BRAF)wild-type(wt)metastatic colorectal cancer(mCRC).Methods:We conducted a multicenter,open-label,phase Ib clinical *** with histologically confirmed RAS/BRAF wt m CRC with more than two lines of treatment were enrolled and treated with SCT-I10A and *** primary endpoints were the objective response rate(ORR)and *** secondary endpoints included disease control rate(DCR),progression-free survival(PFS),and overall survival(OS).Results:Twenty-one patients were enrolled in the study through January 28,*** ORR was 28.57%and the DCR was 85.71%(18/21).The median PFS and OS were 4.14 and 12.84 months,*** treatment-related adverse events(TRAEs)were ***,compared with the monotherapy cohort from our previous phase I study evaluating SCT200 for RAS/BRAF wt m CRC in a third-line setting,no significant improvements in PFS and OS were observed in the combination ***:SCT200 combined with SCT-I10A demonstrated promising efficacy in previously treated RAS/BRAF wt m CRC patients with an acceptable safety *** head-to-head studies with larger sample sizes are needed to validate whether the efficacy and safety of combined anti-EGFR and anti-PD-1 therapy are superior to anti-EGFR monotherapy in the third-line setting.(Registration ***04229537).

关键词： Colorectal cancer SCT-I10A SCT200 epidermal growth factor receptor programmed cell death 1

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Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： Ying-Qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

baCKGROUND Traditional treatments for pancreatic cancer(PC)are *** therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including ***,the mitochondrial concentration of the photosensitizer,such as verteporfin,is *** To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,*** Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal *** cell proliferation was associated with GEM that was more enduring compared with *** laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,*** Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or *** cell lines responded similarly to *** intensity of fluorescence was associated with the concentration of *** experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil *** and dead stained cells treated with GEM were *** GEM treatment,verteporfin was observed primarily in the *** Verteporfin was observed in living *** GEM-treated human PC cells,verteporfin was particularly prevalent in the *** study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

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Common-path illumination in ESPI:enhancing sensitivity for measuring specular deformation

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Chinese Optics Letters 2024年第8期22卷 47-51页

作者： Peizheng Yan Xiangwei Liu Xinda Zhou Rongsheng ba Hanxuan Zhou Yonghong Wang Jie Li School of Instrument Science and Optoelectronics Engineering Hefei University of TechnologyHefei 230009China Anhui Province Key Laboratory of Measuring Theory and Precision Instrument Hefei University of TechnologyHefei 230009China Laser Fusion Research Center China Academy of Engineering PhysicsMianyang 621900China

In this study,an innovative technique is introduced to significantly enhance the sensitivity of electronic speckle pattern interferometry(ESPI)for the dynamic assessment of specular(mirrorlike)object *** utilizing a common-path illumination strategy,wherein illumination and observation beams are precisely aligned,this method effectively doubles the optical path difference,leading to a twofold increase in measurement *** addition,this method mitigates the effects of speckle noise on the measurement of minor deformations,expanding the applications of *** and experimental evaluations corroborate the efficacy of this approach.

关键词： ESPI common-path illumination measurement sensitivity specular deformation

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The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue Dai Li-Yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang Wu Xin-Wu ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： Xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui ba Langda Suo Yuxuan Song Lei Zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

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Discovering genetic biomarkers for targeted cancer therapeutics with eXplainable Artificial Intelligence

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Cancer Communications 2024年第5期44卷 584-588页

作者： Debaditya Chakraborty Elizabeth Gutierrez-Chakraborty Cristian Rodriguez-Aguayo Hakan başağaoğlu Gabriel Lopez-Berestein Paola Amero School of Civil and Environmental Engineering and Construction Management The University of Texas at San AntonioSan AntonioTexasUSA Department of Cell Systems and Anatomy University of Texas Health Science CenterSan AntonioTexasUSA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Edwards Aquifer Authority San AntonioTexasUSA

High-Grade Serous Ovarian Cancer(HGSC)is the most prevalent and lethal form of gynecologic malignancies[1],accounting for 70%-80%of ovarian cancer *** decades of research,the overall survival rate for HGSC has remained largely unchanged[2],and patients with advanced stages of the disease have only a 41%chance of surviving beyond five years[3].

关键词： cancer Cancer targeted

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Investigation of Fracture Strength of Current Post Materials (Peek, Fiber, Cast Metal) in Different Ferrule Conditions

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Open Journal of Stomatology 2024年第3期14卷 153-172页

作者： başak Topdaği Funda bayindir Department of Prosthetic Dentistry Atatürk University Erzurum Türkiye

Aim: The fracture resistance of the post materials used nowadays significantly impacts the fracture type of the post material. The current study aimed to examine the impact of the fracture resistance of PEEK posts, whose use as a post material has not yet become widespread, on the fracture pattern that will occur. Materials and Methods: Sixty-six extracted upper central incisor human teeth were used in the study. Six groups of posts were produced from metal, fiber, and PEEK materials (n = 11). Afterward, the fracture resistance test was applied to the samples. Samples were classified according to fracture type as repairable or irreparable. The ANOVA and test were used in statistical analysis. Post-hoc tests were carried out using Tukey’s and Tamhane’s T2 tests. On the other hand, Pearson’s chi-square test and the Fisher-Freeman-Halton test were conducted for comparisons between categorical variables. The statistical significance level was accepted as p Results: According to the fracture resistance test results, the groups where metal personal posts were used displayed higher fracture resistance in comparison with all other groups. According to the results of the optical microscope examination, the incidence of repairable fractures was significantly higher in the PEEK post group with ferrule preparation (p 0.05). Conclusion: In the absence of the ferrule effect, fractures are catastrophic, regardless of the material used. The use of PEEK as a post material contributes to keeping fractures at a repairable level.

关键词： Component Formatting Style Styling Insert

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Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 331-344页

作者： Miran Bezjak Ivan Stresec Branislav Kocman Stipislav Jadrijević Tajana Filipec Kanizaj Miro Antonijević Bojana Dalbelo bašić Danko Mikulić Department of Surgery University Hospital MerkurZagreb 10000Croatia Department of Electronics MicroelectronicsComputer and Intelligent SystemsFaculty of Electrical Engineering and ComputingZagreb 10000Croatia Department of Gastroenterology University Hospital MerkurZagreb 10000Croatia Development of Software Nanobit Ltd.Zagreb 10000Croatia

baCKGROUND The growing disparity between the rising demand for liver transplantation(LT)and the limited availability of donor organs has prompted a greater reliance on older liver ***,utilizing livers from elderly donors has been associated with outcomes inferior to those achieved with grafts from younger *** accounting for additional risk factors,we hypothesize that the utili-zation of older liver grafts has a relatively minor impact on both patient survival and graft *** To evaluate the impact of donor age on LT outcomes using multivariate analysis and comparing young and elderly donor *** In the period from April 2013 to December 2018,656 adult liver transplants were performed at the University Hospital *** multivariate Cox propor-tional hazards models were developed to independently assess the significance of donor *** age was treated as a continuous *** approach involved univariate and multivariate analysis,including variable selection and assessment of interactions and ***,to exemplify the similarity of using young and old donor liver grafts,the group of 87 recipients of elderly donor liver grafts(≥75 years)was compared to a group of 124 recipients of young liver grafts(≤45 years)from the *** rates of the two groups were estimated using the Kaplan-Meier method and the log-rank test was used to test the differences between *** Using multivariate Cox analysis,we found no statistical significance in the role of donor age within the constructed *** when retained during the entire model development,the donor age's impact on survival remained insignificant and transformations and interactions yielded no substantial effects on *** insigni-ficance and low coefficient values suggest that donor age does not impact patient survival in our ***,there was no statistical evidence that the five developed models did not adhe

关键词： Liver transplantation Elderly donors Survival analysis Postoperative complications Cox proportional hazard models

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舞蹈高等教育面向未来发展的八个引擎

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北京舞蹈学院学报 2024年第1期 1-7页

作者：巴图北京舞蹈学院北京100081

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育... 详细信息

在北京舞蹈学院建校70周年之际,文章提出舞蹈高等教育面向未来发展的八个引擎,即先进舞蹈文化之光的映照、优质舞蹈教育供给的扩容、贤哲云集的变量效应、自觉的舞蹈学术驱动、学院风格的艺术创作、更有效能的舞蹈教育国际化、舞蹈教育的数字化赋能、舞蹈课堂中的革命风暴。

关键词：舞蹈高等教育未来发展引擎

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新文科建设背景下中国教育人类学学科建设研究

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西北民族研究 2024年第1期 75-88页

作者：巴战龙北京师范大学社会学院北京100875

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会... 详细信息

中国教育人类学在百余年发展历程中取得长足进步和显著成就,但也面临如何提高研究质量和提升创新能力的尖锐挑战。当前中国教育人类学的繁荣发展,需要紧紧抓住新文科建设提供的难得契机,在厘清和重构学科定位和愿景的基础上,构建以学会组织为核心的学科创新生态系统。为实现“世界水平、中国特色”的学科建设目标和任务,中国教育人类学界需要齐心协力,从开发和健全学会组织功能、激励和加强高等学校教学、构建和密织学术合作网络、加强和提升学术创新能力、普及和传播学科视角方法等五个方面着手构建学科创新生态系统。通过不懈努力将教育人类学打造成文科教育中国范式的典型案例和示范学科,真正开创出国际学界公认和国内学界自豪的“教育人类学的中国时代”。

关键词：创新生态系统新文科建设学科建设教育人类学

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