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Disposition and tissue distribution of imatinib in a liposome formulation after intravenous bolus dose to mice

药学学报 2010年第7期45卷 901-908页

作者： MOO Kai Shing RADHAKRISHNAN Shantini TEOH Magdalene NARAYANAN Prasad bukhari nadeem irfan SEGARRA Ignacio Department of Pharmaceutical Technology School of Pharmacy and Health SciencesInternational Medical University(Malaysia)

Imatinib is an efficacious anticancer drug with a spectrum of potential antitumour applications limited by poor biodistribution at therapeutic concentrations to the tissues of *** assess the pharma-cokinetic and tissue distribution profile of imatinib in a liposome *** single dose(6.25 mg·kg-1) in a liposome formulation was administered iv to male *** concentration was measured in plasma,spleen,liver,kidney and brain using a HPLC ***-compartmental pharmacokinetic approach was used to assess the disposition *** plasma disposition profile was biphasic with a plateau-like second *** AUC0→∞ was 11.24 μg·h·mL-1,the elimination rate constant(kel) was 0.348 h-1 and the elimination half life(t1/2) was 2.0 *** mean residence time(MRT) was 2.59 h,VSS was 1.44 L·kg-1 and clearance was 0.56 L·h·*** achieved the highest tissue exposure:CMAX = 18.72 μg·mL-1;AUC0→∞ = 58.18 μg·h·mL-1 and longest t1/2(4.29 h) and MRT(5.31 h).Kidney and spleen AUC0→∞ were 47.98 μg·h·mL-1 and 23.46 μg·h·mL-1,***-life was 1.83 h for the kidney and 3.37 h for the *** penetrated into the brain reaching ～1 μg·*** correction by organ blood flow the spleen showed the largest uptake *** imatinib presented extensive *** drug uptake kinetics showed mechanism differences amongst the *** findings encourage the development of novel imatinib formulations to treat other cancers.

关键词： imatinib pharmacokinetics liposome tissue distribution

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Unstable mode of ion-acoustic waves with two temperature q-nonextensive distributed electrons

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Chinese Physics B 2021年第9期30卷 313-319页

作者： S bukhari nadeem Hussain S Ali Department of Physics The University of Azad Jammu and KashmirMuzaffarabad 13100Azad KashmirPakistan National Center for Physics at QAU Campus Shahdra Valley RoadIslamabad 44000Pakistan

The linear characteristics of the unstable mode of ion-acoustic waves are examined in an electrostatic electron-ion plasma composed of streaming hot electrons,non-streaming cold electrons and dynamical positive *** plasma under consideration is modeled by using a non-gyrotropic nonextensive q-distribution function in which the free energy source for wave excitation is provided by the relative directed motion of streaming hot electrons with respect to the other plasma *** the frame work of kinetic model,a linearized set of Vlasov-Poisson's equations are solved to obtain the analytical expressions for dispersion relation and Landau damping *** threshold condition for the unstable ion-acoustic wave is derived to assess the stability of the wave in the presence of nonextensive *** in the wave spectrum and nontrivial effects of q-nonextensive parameter on the ion-acoustic waves can be of interest for the readers in the regions of Saturns's magnetosphere.

关键词： non-gyrotropic nonextensivity Saturns's magnetosphere

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