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Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2296-2307页

作者： shan-shan Xie Yong Zhi Chang-Ming Shao Bin-Fang Zeng Department of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017Xinjiang Uygur Autonomous RegionChina

BACKGROUND The Chinese medicine Yangyin Huowei mixture(YYHWM)exhibits good clinical efficacy in the treatment of chronic atrophic gastritis(CAG),but the mechanisms underlying its activity remain *** To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat *** Sprague-Dawley rats were allocated into control,model,vitacoenzyme,and low,medium,and high-dose YYHWM *** was induced in rats using Nmethyl-N′-nitro-N-nitrosoguanidine,ranitidine hydrochloride,hunger and satiety perturbation,and ethanol *** an 8-wk intervention period,stomach samples were taken,stained,and examined for histopathological *** was utilized to quantify serum levels of PG-I,PG-II,G-17,IL-1β,IL-6,and TNF-α.Western blot analysis was performed to evaluate protein expression of IL-10,JAK1,and *** The model group showed gastric mucosal layer disruption and inflammatory cell *** with the blank control group,serum levels of PGI,PGII,and G-17 in the model group were significantly reduced(82.41±3.53 vs 38.52±1.71,23.06±0.96 vs 11.06±0.70,and 493.09±12.17 vs 225.52±17.44,P<0.01 for all),whereas those of IL-1β,IL-6,and TNF-αwere significantly increased(30.15±3.07 vs 80.98±4.47,69.05±12.72 vs 110.85±6.68,and 209.24±11.62 vs 313.37±36.77,P<0.01 for all),and the protein levels of IL-10,JAK1,and STAT3 were higher in gastric mucosal tissues(0.47±0.10 vs 1.11±0.09,0.49±0.05 vs 0.99±0.07,and 0.24±0.05 vs 1.04±0.14,P<0.01 for all).Compared with the model group,high-dose YYHWM treatment significantly improved the gastric mucosal tissue damage,increased the levels of PGI,PGII,and G-17(38.52±1.71 vs 50.41±3.53,11.06±0.70 vs 15.33±1.24,and 225.52±17.44 vs 329.22±29.11,P<0.01 for all),decreased the levels of IL-1β,IL-6,and TNF-α(80.98±4.47 vs 61.56±4.02,110.85±6.68 vs 89.20±8.48,and 313.37±36.77 vs 267.30±9.31,P<0.01 for all),and evidently decreased the protein levels of IL-10 and STAT3 in gastric mucosal tissues(1

关键词： Yangyin Huowei mixture IL-10/JAK1/STAT3 pathway Chronic atrophic gastritis Inflammatory factor Gastric secretory function

Theoretical Analysis on Deflection and Bearing Capacity of Prestressed Bamboo-Steel Composite Beams

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Journal of Renewable Materials 2024年第1期12卷 149-166页

作者： Qifeng shan Ming Mao Yushun Li School of Civil Engineering Zhejiang Industry Polytechnic CollegeShaoxing312000China School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China College of Civil Engineering and Architecture Qingdao Agricultural UniversityQingdao266109China

A theoretical analysis of upward deflection and midspan deflection of prestressed bamboo-steel composite beams is presented in this *** deflection analysis considers the influences of interface slippage and shear ***,the calculation model for flexural capacity is proposed considering the two stages of *** theoretical results are verified with 8 specimens considering different prestressed load levels,load schemes,and prestress *** results indicate that the proposed theoretical analysis provides a feasible prediction of the deflection and bearing capacity of bamboo-steel composite *** deflection analysis,the method considering the slippage and shear deformation provides better *** theoretical method for bearing capacity matches well with the test results,and the relative errors in the serviceability limit state and ultimate limit state are 4.95%and 5.85%,respectively,which meet the accuracy requirements of the engineered application.

关键词： Bamboo scrimber composite beam prestress deflection bearing capacity

同步放化疗前食管鳞癌患者血清Galectin-3的表达及预后价值

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中国肿瘤 2018年第5期27卷 376-381页

作者：卜珊珊丁丹红王修身徐靖郑州大学附属肿瘤医院

[目的]检测健康人及食管鳞癌（ESCC）患者治疗前血清Galectin-3表达水平,分析Galectin-3表达水平与ESCC患者临床特征及同步放化疗后预后之间的关系。[方法 ]采用酶联免疫吸附试验检测ESCC患者及健康人血清Galectin-3的表达水平,分析二... 详细信息

[目的]检测健康人及食管鳞癌（ESCC）患者治疗前血清Galectin-3表达水平,分析Galectin-3表达水平与ESCC患者临床特征及同步放化疗后预后之间的关系。[方法 ]采用酶联免疫吸附试验检测ESCC患者及健康人血清Galectin-3的表达水平,分析二者的表达差异;分析ESCC患者血清中Galectin-3表达水平与临床分期、肿瘤部位、肿瘤长度、有无淋巴结转移和远处转移的关系;采用Kaplan-Meier法探讨ESCC患者血清Galectin-3表达水平对同步放化疗治疗后总生存率及无进展生存率的影响。[结果]ESCC患者组血清Galectin-3的表达水平明显高于健康人对照组,分别为（9.703±1.310）ng/ml和（7.858±1.017）ng/ml,差异有统计学意义（P=0.000）。根据ROC曲线,确定Galectin-3对ESCC诊断的界值为9.0ng/ml,Galectin-3诊断ESCC的敏感性、特异性和准确性分别为69.0%、87.2%和86.0%。血清Galectin-3表达水平受肿瘤长度的影响（P=0.003）。血清Galectin-3表达水平≥9.0ng/ml和〈9.0ng/ml的1年无进展生存率分别为47.4%和75.0%（P=0.037）。[结论]ESCC患者血清中Galectin-3的表达水平受病变长度的影响。除临床分期外,ESCC患者治疗前血清Galectin-3的表达水平有可能作为一个独立的预后指标。

关键词：食管鳞癌(ESCC) 血清半乳糖凝集素-3(Galectin-3) 同步放化疗预后

n-octyl acrylate is a candidate sex pheromone component involved in courtship in parasitoid wasp Microplitis mediator

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Insect Science 2024年第4期31卷 1200-1210页

作者： Yu-Xiao Tao Shuang shan Youssef Dewer shan-Ning Wang Adel Khashaveh Rui-Jun Li Yong-Jun Zhang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina College of Plant Protection Agricultural University of HebeiBaodingHebei ProvinceChina Bioassay Research Department Central Agricultural Pesticide LaboratorySabahia Plant Protection Research StationAgricultural Research CenterAlexandriaEgypt Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijingChina

Sex pheromones are considered to play critical roles in partner communication of most parasitic ***,the identification of sex pheromone components remains limited to a few families of parasitoid *** this study,we functionally characterized a candidate sex pheromone component in Microplitis mediator(Hymenoptera:Braconidae),a solitary parasitoid of Noctuidae *** found that the body surface extract from female wasps could significantly stimulate courtship behavior of *** chromatography-electroantennographic detection(GC-EAD)analysis revealed that a candidate semiochemical from extract triggered significant electrophysiological response of antennae of *** performing gas chromatography-mass spectrometer(GC-MS)measurement,GC-EAD active compound was identified as n-octyl acrylate,a candidate sex pheromone component in female *** electroantennogram(EAG)tests,antennae of male wasps showed significantly higher electrophysiological responses to n-octyl acrylate than those of females.Y-tube olfactometer assays indicated that male wasps significantly chose n-octyl acrylate compared with the ***,male wasps showed a remarkable preference for n-octyl acrylate in a simulated field condition behavioral trial;simultaneously,n-octyl acrylate standard could also trigger significant courtship behavior in *** propose that n-octyl acrylate,as a candidate vital sex pheromone component,could be utilized to design behavioral regulators of *** to implement the protection and utilization of natural enemies.

关键词： behavioral assay courtship behavior GC-EAD analysis Microplitis mediator sex pheromone

Fake News Detection Based on Cross-Modal Message Aggregation and Gated Fusion Network

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Computers, Materials & Continua 2024年第7期80卷 1521-1542页

作者： Fangfang shan Mengyao Liu Menghan Zhang Zhenyu Wang College of Computer Zhongyuan University of TechnologyZhengzhou450007China Henan Key Laboratory of Cyberspace Situation Awareness Zhengzhou450001China

Social media has become increasingly significant in modern society,but it has also turned into a breeding ground for the propagation of misleading information,potentially causing a detrimental impact on public opinion and daily *** to pure text content,multmodal content significantly increases the visibility and share ability of *** has made the search for efficient modality representations and cross-modal information interaction methods a key focus in the field of multimodal fake news *** effectively address the critical challenge of accurately detecting fake news on social media,this paper proposes a fake news detection model based on crossmodal message aggregation and a gated fusion network(MAGF).MAGF first uses BERT to extract cumulative textual feature representations and word-level features,applies Faster Region-based ConvolutionalNeuralNetwork(Faster R-CNN)to obtain image objects,and leverages ResNet-50 and Visual Geometry Group-19(VGG-19)to obtain image region features and global *** image region features and word-level text features are then projected into a low-dimensional space to calculate a text-image affinity matrix for cross-modal message *** gated fusion network combines text and image region features to obtain adaptively aggregated *** interaction matrix is derived through an attention mechanism and further integrated with global image features using a co-attention mechanism to producemultimodal ***,these fused features are fed into a classifier for news *** were conducted on two public datasets,Twitter and *** show that the proposed model achieves accuracy rates of 91.8%and 88.7%on the two datasets,respectively,significantly outperforming traditional unimodal and existing multimodal models.

关键词： Fake news detection cross-modalmessage aggregation gate fusion network co-attention mechanism multi-modal representation

IHVFL: a privacy-enhanced intention-hiding vertical federated learning framework for medical data

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Cybersecurity 2024年第2期7卷 96-112页

作者： Fei Tang Shikai Liang Guowei Ling Jinyong shan College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsNo.2Chongwen RoadNan'an DistrictChongqing 400065China School of Cyber Security and Information Law Chongqing University of Posts and TelecommunicationsChongqing 400065China sudo Technology Co. LTD.Beijing 100083China

Vertical Federated Learning(VFL)has many applications in the field of smart healthcare with excellent ***,current VFL systems usually primarily focus on the privacy protection during model training,while the preparation of training data receives little *** real-world applications,like smart healthcare,the process of the training data preparation may involve some participant's intention which could be privacy information for this *** protect the privacy of the model training intention,we describe the idea of Intention-Hiding Vertical Feder-ated Learning(IHVFL)and illustrate a framework to achieve this privacy-preserving ***,we construct two secure screening protocols to enhance the privacy protection in feature ***,we implement the work of sample alignment bases on a novel private set intersection ***,we use the logistic regression algorithm to demonstrate the process of *** show that our model can perform better efficiency(less than 5min)and accuracy(97%)on Breast Cancer medical dataset while maintaining the intention-hiding goal.

关键词： Medical data Vertical federated learning Privacy-presserving Intention-hiding Logistic regression

Location of Asymmetric Ground Fault Using Virtual Injected Current Ratio and Two-stage Recovery Strategy in Distribution Networks

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 151-161页

作者： Haiting shan Luliang Zhang Q.H.Wu Mengshi Li School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

Sparse measurements challenge fault location in distribution *** paper proposes a method for asymmetric ground fault location in distribution networks with limited measurements.A virtual injected current vector is formulated to estimate the fault line,which can be reconstructed from voltage sags measured at a few buses using compressive sensing(CS).The relationship between the virtual injected current ratio(VICR)and fault position is deduced from circuit analysis to pinpoint the ***,a two-stage recovery strategy is proposed for improving reconstruction accuracy of the current vector,where two different sensing matrixes are utilized to improve the *** proposed method is validated in IEEE 34 node test *** results show asymmetric ground fault type,resistance,fault position and access of distributed generators(DGs)do not significantly influence performance of our *** addition,it works effectively under various scenarios of noisy measurement and line parameter *** on 134 node test feeders prove the proposed method is also suitable for systems with more complex structure.

关键词： Distribution networks fault location reconstruction accuracy two-stage recovery virtual injected current ratio

HCRVD: A Vulnerability Detection System Based on CST-PDG Hierarchical Code Representation Learning

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Computers, Materials & Continua 2024年第6期79卷 4573-4601页

作者： Zhihui Song Jinchen Xu Kewei Li Zheng shan School of Cyberspace Security Information Engineering UniversityZhengzhou450001China

Prior studies have demonstrated that deep learning-based approaches can enhance the performance of source code vulnerability detection by training neural networks to learn vulnerability patterns in code ***,due to limitations in code representation and neural network design,the validity and practicality of the model still need to be ***,due to differences in programming languages,most methods lack cross-language detection *** address these issues,in this paper,we analyze the shortcomings of previous code representations and neural *** propose a novel hierarchical code representation that combines Concrete Syntax Trees(CST)with Program Dependence Graphs(PDG).Furthermore,we introduce a Tree-Graph-Gated-Attention(TGGA)network based on gated recurrent units and attention mechanisms to build a Hierarchical Code Representation learning-based Vulnerability Detection(HCRVD)*** system enables cross-language vulnerability detection at the *** experiments show that HCRVD surpasses many competitors in vulnerability detection *** benefits from the hierarchical code representation learning method,and outperforms baseline in cross-language vulnerability detection by 9.772%and 11.819%in the C/C++and Java datasets,***,HCRVD has certain ability to detect vulnerabilities in unknown programming languages and is useful in real open-source *** shows good validity,generality and practicality.

关键词： Vulnerability detection deep learning CST-PDG code representation tree-graph-gated-attention network cross-language

DYRK1B基因对食管鳞癌细胞放射敏感性影响的研究

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中国肿瘤 2020年第8期29卷 629-633页

作者：王修身许刚丁丹红周莎卜珊珊郑州大学附属肿瘤医院河南郑州450052 中山大学肿瘤防治中心广东广州510060

[目的]探讨DYRK1B对食管鳞癌放射敏感性的影响及潜在机制,为提高食管鳞癌患者放射敏感性提供理论依据。[方法]用脂质体Lipofectamine 3000分别包裹siNC、siDYRK1B转染食管鳞癌细胞ECA109,48小时后收集细胞RT-PCR和蛋白印迹实验检测ECA10... 详细信息

[目的]探讨DYRK1B对食管鳞癌放射敏感性的影响及潜在机制,为提高食管鳞癌患者放射敏感性提供理论依据。[方法]用脂质体Lipofectamine 3000分别包裹siNC、siDYRK1B转染食管鳞癌细胞ECA109,48小时后收集细胞RT-PCR和蛋白印迹实验检测ECA109细胞中DYRK1B表达水平。同时取转染siNC、siDYRK1B的ECA109细胞给予放射处理,用克隆形成实验检测经不同剂量放射处理后的细胞存活情况并计算放射增敏比;用流式细胞术检测4Gy照射后细胞凋亡率;用蛋白印迹实验检测凋亡相关蛋白cleaved PARP-1、cleaved caspase-3及DNA损伤相关蛋白γ-H2AX表达水平。[结果]转染siDYRK1B的ECA109细胞中DYRK1B mRNA和蛋白水平明显下降(P<0.05)。与对照组相比,转染siDYRK1B的ECA109细胞放射处理后细胞存活减少,细胞凋亡率增加(P<0.05),细胞中cleaved PARP-1、cleaved caspase-3、γ-H2AX蛋白表达水平升高(P<0.05)。siDYRK1B转染的ECA109细胞放射增敏比为1.711。[结论]下调DYRK1B明显增强食管鳞癌细胞的放射敏感性,其机制可能与促进细胞凋亡、抑制DNA损伤修复有关。

关键词： DYRK1B 食管鳞癌放射敏感性凋亡 DNA损伤修复