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‘All-in-one’ strategy for metalla[3]catenanes and ring-in-ring complex

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National Science Review 2021年第5期8卷 14-15页

作者： Xian-He bu School of Materials Science and Engineering National Institute for Advanced MaterialsNankai University

Research into mechanically interlocked molecules, such as catenanes, rotaxanes and molecular knots, has been gaining momentum in recent decades, not only because of their intriguing structures and topological importance, but also because of their important applications as molecular machines and nanoscale devices [1,2]. In addition to traditional organic macrocycles based on covalent bonds,

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Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials

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Neural Regeneration Research 2018年第6期13卷 1087-1095页

作者： Ming Zhao Jia-yi Chen Yu-Dong Chu Ya-Bin Zhu Lin Luo Shi-Zhong bu Runliang Diabetes Laboratory Diabetes Research Center Ningbo University Department of Public Health Longsai Hospital Department of Nephrology Ningbo Medical Center Lihuili Eastern Hospital Medical School Ningbo University

OBJECTIVE： To evaluate the efficacy of α-lipoic acid（ALA） plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy（DPN）. DATA SOURCES： The electronic databases of Pub Med, Medline, Embase, the Cochrane Library, the Chinese National Knowledge Infrastructure, the Wanfang Database and the Chinese Biomedical Database were used to retrieve relevant studies without language restrictions. The search was conducted from the inception of each database to 7 October 2016. The key terms were（diabetic peripheral neuropathy or diabetic neuropathy or DPN） AND（α-lipoic acid or lipoic acid or thioctic acid） AND epalrestat. DATA SELECTION： All of the eligible studies met the following inclusion criteria：（1） Randomized controlled trials that compared efficacy and safety of epalrestat plus ALA combination therapy versus epalrestat or ALA monotherapy in patients with DPN.（2） The minimum duration of treatment was 2 weeks.（3） The DPN patients were diagnosed using the World Health Organization standardized type 2 diabetes mellitus and DPN criteria.（4） Studies contained at least one measure that could reflect the efficacy of the drug and nerve conduction velocities. Studies in which the control group used epalrestat or ALA combined with other drugs were excluded. Statistical analyses were performed using STATA software for meta-analysis. OUTCOME MEASURES： The primary outcomes were the therapeutic efficacy, median motor nerve conduction velocity（MNCV）, median sensory nerve conduction velocity（SNCV）, peroneal MNCV and peroneal ***： Twenty studies with 1894 DPN patients were included, including 864 patients in the ALA plus epalrestat group, 473 in the ALA group and 557 in the epalrestat group. The efficacy of ALA plus epalrestat combination therapy was superior to ALA and epalrestat monotherapies（RR = 1.29, 95% CI： 1.21–1.38; RR = 1.43, 95% CI： 1.34–1.54, respectively）. ALA plus epalrestat combination therapy also significantly improved median MNCV（WMD = 5

关键词： nerve regeneration antioxidant aldose reductase inhibitor diabetic complication diabetes combination therapy nerve conduction velocity nerve electrophysiology peripheral nerve injury neural regeneration

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Dermatosis as the initial presentation of gastric cancer: two cases

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Chinese Journal of Cancer Research 2014年第5期26卷 632-638页

作者： Wei Ge bu-Wei Teng De-Cai Yu Gang Chen Li-Ming Zheng yi-Tao Ding Department of General Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School

Paraneoplastic dermatoses are known to be certain dermatosis related with tumor. The common paraneoplastic dermatoses are acanthosis nigricans, acquired ichthyosis, dermatomyositis, erythroderma, and so on. Here we report two cases of paraneoplastic dermatoses associated with gastric cancer. One case was a 57-year-old man with dermatomyositis and proved to be associated with gastric cancer through stomachoscopy. The other was a 66-year-old man with erythroderma and proved to be associated with gastric cancer through stomachoscopy. Both cases were treated with radical total gastrectomy with lymphadenectomy（D2） and esophagojejunostomy of Roux-en-Y. The skin symptom of both cases had improved a lot but still existed after operation. Paraneoplastic dermatoses can be seen as the early manifestation of visceral carcinomas. As a result, gastric cancers should be excluded in the patients with paraneoplastic dermatoses.

关键词： Paraneoplastic dermatoses erythroderma dermatomyositis malignancy gastric cancer

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Operational Optimization for a Regional Multi-energy System Considering Thermal Quasi-dynamic Characteristics

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CSEE Journal of Power and Energy Systems 2024年第6期10卷 2551-2563页

作者： Xingying Chen Le bu Cheng Chen Lei Gan kun Yu College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China Jiangsu Engineering Research Center for Distribution&Utilization and Energy Efficiency Nanjing 210098China

With the development of energy internet technology,the operational optimization of regional electricity-heating-gas systems is becoming a key research *** that the thermal system’s quasi-dynamic characteristics will make the dispatching of regional multi-energy systems more accurate,the flexibility and energy efficiency of electricity-heating-gas system’s operations can be *** quasi-dynamic characteristics of regional thermal networks are analyzed here,as well as the demand side of the heating *** on thermal inertia characteristics,the virtual thermal energy storage models of both thermal networks and buildings,considering the thermal comfort index,are formulated synthetically for a central heating *** comparing the operating results of different adjustment methods,a quality adjustment method is found to have the most flexibility for regional heating system *** the hot water supply network and heating load modeling considering virtual storage,an operational optimization model for a regional electricity-heating-gas system is presented with the purpose of reducing the total operating *** results show the effectiveness of the proposed *** a case study,it is found that when considering the virtual energy storage specialty for both the heating supply and demand side,the heating load can be shifted across the time periods under a time-of-use(TOU)price,leading to the obvious economic improvement of multienergy system operation.

关键词： Electricity-heating-gas system operational optimization thermal quasi-dynamic time-of-use electricity price virtual energy storage

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基于改进DGCNN的树木点云分割方法

南京农业大学学报 2025年第1期48卷 240-248页

作者：刘超卜鑫荣刘慧杨官学沈跃徐婕江苏大学电气信息工程学院江苏镇江212000

[目的]通过目标分割为果园喷雾机提供树木的表征信息,使喷雾机能够实现精准喷雾。在分割过程中,对苗圃中的树冠、树干等不同部位进行分割,可以帮助喷雾机对喷雾部分对靶,在果园或苗圃景观中实现自动导航以及精准喷药等操作。与图片相比... 详细信息

[目的]通过目标分割为果园喷雾机提供树木的表征信息,使喷雾机能够实现精准喷雾。在分割过程中,对苗圃中的树冠、树干等不同部位进行分割,可以帮助喷雾机对喷雾部分对靶,在果园或苗圃景观中实现自动导航以及精准喷药等操作。与图片相比,点云能够更好地表征树木的三维结构并且受照明条件影响小,因此针对点云树木设计分割算法更适合应用在果园、苗圃等室外环境作业的农业机械。[方法]本文基于DGCNN提出了一种分割精度准确、参数量小的树木点云分割网络——TSNet,它可以很容易被部署在果园喷雾机上。该网络主要具有以下特点:1)该网络是基于DGCNN改进的,可以更好实现点云分割任务;2)网络引入了连续递归门控卷积模块(gnConv),可以提高树木分割的准确率;3)为避免全局信息损失并增加信息传递效率,我们设计了权重通道用于特征传递。[结果]TSNet分割树木的mIoU达到90.08%,模型大小为0.72 M,优于PointNet、PointNet++、DGCNN、CurveNet、PointMLP和D-PointNet++等常用的点云分割算法。[结论]TSNet能够为苗圃树木检测识别和农业机器人作业提供更准确的感知信息。

关键词：点云树木分割深度学习精准喷雾果园喷雾机

Highly Stretchable and Transparent Ionic Conductor with Novel Hydrophobicity and Extreme-Temperature Tolerance

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Research 2020年第1期2020卷 363-372页

作者： Lei Shi kun Jia yiyang Gao Hua Yang Yaming Ma Shiyao Lu Guoxin Gao Huaitian bu Tongqing Lu Shujiang Ding Department of Applied Chemistry School of ScienceXi’an Key Laboratory of Sustainable Energy Materials ChemistryMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterState Key Laboratory of Electrical Insulation and Power EquipmentXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Strength and Vibration of Mechanical Structure School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China SINTEF Industry Forskningsvei 10373 OsloNorway

Highly stretchable and transparent ionic conducting materials have enabled new concepts of electronic devices denoted as iontronics,with a distinguishable working mechanism and performances from the conventional ***,the existing ionic conducting materials can hardly bear the humidity and temperature change of our daily life,which has greatly hindered the development and real-world application of ***,we design an ion gel possessing unique traits of hydrophobicity,humidity insensitivity,wide working temperature range(exceeding 100℃,and the range covered our daily life temperature),high conductivity(10^(-3)~10^(-5) S/cm),extensive stretchability,and high transparency,which is among the bestperforming ionic conductors ever developed for flexible *** ion gel-based iontronics have been demonstrated,including large-deformation sensors,electroluminescent devices,and ionic cables,which can serve for a long time under harsh *** designed material opens new potential for the real-world application progress of iontronics.

关键词： Highly humidity exceeding

Testosterone and its metabolites： differential associations with cardiovascular and cerebrovascular events in men

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Asian Journal of Andrology 2018年第2期20卷 109-114页

作者： bu B Yeap School of Medicine University of Western Australia Perth Western Australia 6009 Australia Deportment of Endocrinology and Diabetes Fiona Stanley Hospital Perth Western Australia 6150 Australia

As men grow older, circulating testosterone declines while the incidence of cardiovascular disease increases. Thus, the role of sex hormones as biomarkers, and possibly contributing factors to clinical manifestations of cardiovascular disease in the increasing demographic of aging men, has attracted considerable interest. This review focuses on observational studies of endogenous androgens, namely circulating testosterone and dihydrotestosterone, which have examined their associations with cardiovascular events such as myocardial infarction and stroke. Studies which have examined the associations of endogenous estrogens, namely circulating estradiol, with these outcomes are also discussed. In large prospective cohort studies of predominantly middle-aged and older men, lower circulating testosterone consistently predicts higher incidence of cardiovascular events. Of note, both lower circulating testosterone and lower dihydrotestosterone are associated with higher incidence of stroke. These associations are less apparent when myocardial infarction is considered as the outcome. Results for estradiol are inconsistent. Lower circulating testosterone has been shown to predict higher cardiovascular disease-related mortality, as has lower circulating dihydrotestosterone. It is possible that the relationship of circulating androgens to cardiovascular events or mortality outcomes may be U-shaped rather than linear, with an optimal range defining men at lowest risk. Epidemiological studies are observational in nature and do not prove causality. Associations observed in studies of endogenous androgens need not necessarily translate into similar effects of exogenous androgens. Rigorous randomized controlled trials are needed to clarify the effects of testosterone treatment on cardiovascular risk in men.

关键词： cardiovascular disease cardiovascular-related mortality dihydrotestosterone estradiol male aging myocardial infarction stroke testosterone

Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells

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Genes & Diseases 2018年第2期5卷 158-166页

作者： Lian Zhang Yunlong Lei ying Zhang yi Li Youquan bu Fangzhou Song Chundong Zhang Department of Biochemistry and Molecular Biology Chongqing Medical University1 Yixueyuan RoadYuzhong DistrictChongqing400016China Molecular Medicine and Cancer Research Center Chongqing Medical University1 Yixueyuan RoadYuzhong DistrictChongqing400016China

Our previous studies have demonstrated that proline-rich protein 11(PRR11)is a novel tumor-related gene and implicates in regulating the proliferation in lung ***,its precise role in cell cycle progression remains *** recent evidences show that PRR11 silencing has an effect on autophagy in non-small-cell lung cancer(NSCLC)*** human NSCLC cell lines,H1299 and A549 were transiently transfected with against PRR11 *** Cell Counting Kit-8 and plate clone formation assay showed that downregulation of PRR11 inhibited the cell proliferation associated with cell cycle related genes *** our data suggested that PRR11 depletion expression enhanced the autophagosomes formation,followed with downregulation of P62 and upregulation of LC3-II ***,the immunoblotting results indicated that silencing of PRR11 inactivated the Akt/mTOR signaling ***,these results demonstrated PRR11 had an effective role in autophagy in NSCLC cells through Akt/mTOR autophagy signaling ***,it is helpful to clarify the function of PRR11 in tumorigenesis of NSCLC.

关键词： Akt/mTOR Autophagy Cell proliferation Non-small-cell lung cancer PRR11

Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

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Translational Neurodegeneration 2023年第1期12卷 745-765页

作者： yi Lu Fa-Qian bu Fang Wang Li Liu Shuai Zhang Guan Wang Xiu-ying Hu West China School of Nursing Sichuan University/Innovation Center of Nursing ResearchNursing Key Laboratory of Sichuan ProvinceState Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

Physical exercise is of great significance for maintaining human *** can provide varying degrees of benefits to cognitive function at all stages of life ***,with the aging of the world’s population and increase of life expectancy,cognitive dysfunction has gradually become a disease of high incidence,which is accompanied by neurodegenerative diseases in elderly *** often exhibit memory loss,aphasia and weakening of orientation once diagnosed,and are unable to have a normal *** dysfunction largely affects the physical and mental health,reduces the quality of life,and causes a great economic burden to the *** present,most of the interventions are aimed to maintain the current cognitive level and delay deterioration of *** contrast,exercise as a nonpharmacological therapy has great advantages in its nontoxicity,low cost and universal *** molecular mechanisms underlying the effect of exercise on cognition are complex,and studies have been extensively centered on neural plasticity,the direct target of exercise in the *** addition,mitochondrial stability and energy metabolism are essential for brain ***,the organ-brain axis responds to exercise and induces release of cytokines related to *** this review,we summarize the latest evidence on the molecular mechanisms underlying the effects of exercise on cognition,and point out directions for future research.

关键词： Exercise Cognitive function Molecular mechanism Neurodegenerative disease Nonpharmacological therapy