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Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding:A Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2021年第8期27卷 589-596页

作者： ZHANG Qun LI Yu-xin LIU Yao HOU Yi-xin ZHU Bing-bing HUANG Yun-yi SHI Ke WANG xian-bo Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing100015China Department of Gastroenterology Third Affiliated HospitalBeijing University of Chinese MedicineBeijing100029China Department of Gastroenterology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China

Objective To assess whether adjuvant Chinese patent medicines(CPMs)to standard treatment could reduce recurrent bleeding after variceal bleeding in cirrhotic *** This study retrospectively collected 555 consecutive patients who recovered from variceal bleeding.A population-based cohort study was established depending on if adjuvant CPMs were administered to prevent rebleeding.A total of 139 patients who had taken⩾28 cumulative defined daily doses(cDDDs)of CPMs were included in the CPMs cohort,and 416 patients who usedhe non-CPMs *** evaluation of rebleeding incidence,1:2 propensity score matched was used to estimate for reducing *** were followed for at least 12 *** end-point of this study was clinically significant esophagogastric variceal *** Following multivariate analysis,CPMs therapy was an independent factor for variceal rebleeding[adjusted hazard ratio(AHR)=0.657;95%confidence interval=0.497-0.868;P=0.003].After the 1:2 propensity score matching,a significant reduction(23.5%)in the incidence of variceal rebleeding in patients was observed,from 58.3%in the non-CPMs cohort to 44.6%in the CPMs cohort(modified log-rank test,P=0.002)within a *** AHRs for rebleeding were 0.928,0.553,and 0.105,for 28-90 cDDDs,91-180 cDDDs,and>180 cDDDs of CPMs,*** median rebleeding interval in the CPMs cohort was significantly larger compared with the non-CPMs cohort(113.5 vs.93.0 days;P=0.008).Conclusion Adjuvant CPMs to standard therapy can significantly reduce the incidence of variceal rebleeding and delay the time to rebleeding.

关键词： adjuvant therapy Chinese patent medicine variceal bleeding variceal rebleeding

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环渤海港口物流协同发展研究

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物流工程与管理 2013年第4期35卷 24-25页

作者：何娴天津青年职业学院天津300191

环渤海经济的发展,带动了港口的发展。随着港口水平不断提高,许多问题日益显现。文中以环渤海湾内湾的港口为研究对象,在对物流发展的整体环境进行SWOT分析的基础上,提出港口物流的协同发展战略,并从政府和港口两方面提出实施建议。

关键词：港口物流 SWOT分析协同发展

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Improved Corrosion Resistance in AZ61 Magnesium Alloys Induced by Impurity Reduction

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 225-232页

作者： Yan Dai xian-Hua Chen Tao Yan Ai-Tao Tang Di Zhao Zhu Luo Chun-Quan Liu Ren-Ju Cheng Fu-Sheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400045China Chongqing Academy of Science and Technology Chongqing 401123China

The effect of impurity element Fe on corrosion behavior of AZ61 magnesium alloys in various states has been investigated by immersion test and hydrogen evolution measurements in 3.5% sodium chloride *** corrosion rate is found to relay on the impurity Fe concentration in the alloys and decreases with decreasing Fe *** Fe content drops from 150 ppm to 10 ppm,the corresponding corrosion rates under as-cast and solution treatment conditions are reduced from 8.54 mm/a and 8.61 mm/a to 2.54 mm/a and 0.21 mm/a,*** corrosion pattern of the AZ61 alloys is the localized corrosion,and the galvanic couples are formed among the impurity particles,second-phase particles and the *** Fe impurity particles tend to act as main cathodic to form micro-galvanic cell with the α-Mg matrix,which is harmful for corrosion resistance of AZ61 alloy.

关键词： AZ61 magnesium alloy Impurity Fe Corrosion rate

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Role of CD8^(+) regulatory T cells in organ transplantation

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burns & Trauma 2014年第1期2卷 18-23页

作者： Jiyan Su Qingfeng Xie Yang Xu xian C.Li Zhenhua Dai Center for Regenerative and Translational Medicine Guangdong Provincial Academy of Chinese Medical SciencesGuangdong Provincial Hospital of Chinese Medicine and Guangzhou University of Chinese Medicine School of Chinese Material MedicaGuangzhouGuangdongChina Immunobiology and Transplantation Research Center Houston Methodist Research InstituteHoustonTexasUSA

CD8^(+)T cells are regulatory T cells(Tregs)that suppress both alloimmunity and autoimmunity in many animal *** class of regulatory cells includes the CD8^(+)CD28^(-),CD8^(+)CD103^(+),CD8^(+)FoxP3^(+)and CD8^(+)CD122^(+)*** mechanisms of action of these regulatory cells are not fully understood;however,the secretion of immunosuppressive cytokines,such as interleukin(IL)-4,IL-10 and transforming growth factor beta(TGF-β)as well as the direct killing of target cells via Fas L/Fas and the perforin/granzyme B pathways have been demonstrated in various *** studies are necessary to fully understand the mechanisms underlying the suppressive effects of Tregs and to provide experimental support for potential clinical *** recently observed that CD8^(+)CD122^(+)Tregs more potently suppressed allograft rejection compared to their CD4^(+)CD25^(+)counterparts,supporting the hypothesis that CD8^(+)Tregs may represent a new and promising Treg family that can be targeted to prevent allograft rejection in the *** this review,we summarize the progress in the field during the past 7-10 years and discuss CD8^(+)Treg phenotypes,mechanisms of action,and their potential clinical applications;particularly in composite tissue transplants in burn and trauma patients.

关键词： Tolerance transplantation CD8^(+)regulatory T cell immune regulation

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A review on the application,phytochemistry and pharmacology of Polygonatum odoratum,an edible medicinal plant

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Journal of Future Foods 2023年第3期3卷 240-251页

作者： Jingyi Bi Huiyong Fang Jianyun Zhang Litao Lu xian Gu Yuguang Zheng Traditional Chinese Medicine Processing Technology Innovation Center of hebei Province International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei ProvinceHebei University of Chinese MedicineShijiazhuang 050200China hebei Chemical and Pharmaceutical College Shijiazhuang 050026China

Polygonatum odoratum is distributed in several countries around the world as a medicinal and dual-use plant,and its rhizomes are used in China as a traditional Chinese medicine,also as vegetables,foods,functional foods or tea,with a history of application for more than 2000 years,with precise efficacy and no toxic side ***,few reviews are published on its chemical composition and its pharmacological *** are many components of ***,including steroidal saponins,homoisoflavanones,isoflavones,flavonoids,alkaloids,lignin,volatile oil,polysaccharides and *** this review,recent advances of the history and consumption of ***,the types of chemical components,and the pharmacological effects manifested in antitumour and anticancer,antioxidant,slowing senescence,relieving fatigue and immune regulation are summarized and ***,the main active ingredients of the plant are homoisoflavanones,polysaccharides,saponins,and *** review provides a reference for its development and utilization in the field of functional food and medicine in the future.

关键词： Polygonatum odoratum Phytochemistry Pharmacology Edible medicinal plant

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New Oscillatory Criterias of Certain Second Order Neutral Functional Differential Equations

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Chinese Quarterly Journal of Mathematics 2005年第4期20卷 418-422页

作者： LIN Wen-xian Department of Mathematics Hanshan Normal College Chaozhou 521041 China

In this paper, the sufficient conditions for the oscillation of all solutions of certain second order nonlinea neutral equations with continuous distributed delay.

关键词： differential equation oscillation continuous distributed delay

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Quantitative‑Profling Method of Serum Steroid Hormones by Hydroxylamine‑Derivatization HPLC-MS

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Natural Products and Bioprospecting 2019年第3期9卷 201-208页

作者： Qi Liu Quan Chi Ru-Ting Fan Hui-Dong Tian xian Wang Key Laboratory of Analytical Chemistry of the State Ethnic Afairs Commission College of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan 430074HubeiPeople’s Republic of China

A sensitive and rapid high performance liquid chromatography-mass spectrometry(HPLC-MS)method was developed and validated for simultaneous quantifcation of ten steroid hormones,including estrogens,androgens,progesterones,and corticosteroids four classes of *** following ten steroid hormones were analyzed:progesterone,21-deoxycortisol,estrone,4-androstenedione,testosterone,dihydro-testosterone,androstenone,dehydroepiandrosterone,corticosterone and *** deuterated isotopes were used as internal standards for *** preparation with and without derivatization were performed after liquid-liquid extraction,and the corresponding results were compared according to sensitivity and *** derivatization was found to improve the ionization efciency of the analytes for electrospray ionization MS *** gradient of mobile phase and experimental parameters for HPLC separation were *** lower limits of quantifcation were in the range of 0.05-5 ng mL^(−1) with wide linear range for the ten steroid *** intra-day precisionhere within the acceptance limits of the FDA *** HPLC-MS analysis time was 6 *** method enables simultaneous quantifcation of steroids in human *** will be helpful for the serum steroid profling in order to understand various endocrinology diseases.

关键词： Steroids Derivatization High performance liquid chromatography–mass spectrometry(HPLC-MS) Quantitative-profling

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Mass spectrum and strong decays of strangeonium in a constituent quark model

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Chinese Physics C 2021年第2期45卷 282-318页

作者： Qi Li Long-Cheng Gui Ming-Sheng Liu Qi-Fang Lü xian-Hui Zhong Department of Physics Hunan Normal UniversityChangsha 410081China Synergetic Innovation Center for Quantum Effects and Applications(SICQEA) Changsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Changsha 410081China

In this work we calculate the mass spectrum of strangeonium up to the 3D multiplet within a nonrelativistic linear potential quark ***,using the obtained wave functions,we also evaluate the strong decays of the strangeonium states with the ^3P_0 *** on our successful explanations of the well established states φ(1020) , φ(1680) , h_1(1415) , f'_2(1525) ,and φ_3(1850) ,we further discuss the possible assignments of strangeonium-like states from experiments by combining our theoretical results with *** is found that some resonances,such as f_2(2010) and f_2(2150) ,listed by the Particle Data Group,and X(2062) and X(2500) ,newly observed by BESIII,may be interpreted as strangeonium *** possibility of φ(2170) as a candidate for φ(3S) or φ(2D) cannot be *** expect our results to provide useful references for looking for the missing s\bar{s} states in future experiments.

关键词： mass spectrum strangeonium strong decay

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Gravitational Wave Detection Based on Squeeze-and-excitation Shrinkage Networks and Multiple Detector Coherent SNR

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Research in Astronomy and Astrophysics 2022年第11期22卷 84-96页

作者： Rui-Qing Yan Wei Liu Zong-Yao Yin Rong Ma Si-Ying Chen Dan Hu Dan Wu xian-Chuan Yu School of Artificial Intelligence Beijing Normal UniversityBeijing 100875China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Radiology and BRIC University of North Carolina at Chapel HillChapel HillNC 27599 United States of America National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Deep learning techniques have been applied to the detection of gravitational wave signals in the past few *** existing methods focus on the data obtained by a single ***,the signal-to-noise ratio(SNR)of gravitational wave signals in a single detector is pretty low,making it hard for deep neural networks to learn effective ***,how to use the observation signals obtained by multiple detectors in deep learning methods is a serious *** simulate binary neutron star signals from multiple detectors,including the Advanced LIGO and Virgo *** calculate coherent SNR of multiple detectors using a fully coherent allsky search method and obtain the coherent SNR data required for our proposed deep learning *** by the principle of attention network Squeeze-and-Excitation Networks(SENet)and the soft thresholding shrinkage function,we propose a novel Squeeze-and-Excitation Shrinkage(SES)module to better extract effective *** we use this module to establish a gravitational wave squeeze-and-excitation shrinkage network(GWSESNet)detection *** train and validate the performance of our model on the coherent SNR data *** model obtains satisfactory classification accuracy and can excellently complete the task of gravitational wave detection.

关键词： methods:data analysis methods:statistical gravitational waves

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Protocol of Jidong Women health Cohort Study: Rationale, Design, and Baseline Characteristics

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Biomedical and Environmental Sciences 2019年第2期32卷 144-152页

作者： QIU Meng Si WANG xian Wei YAO Yan GE Si Qi LIU Hua Min DAI Ying Chun ZHOU Yong Department of Epidemiology School of Public health Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research) Sanbo Brain Institute Sanbo Brain Hospital Capital Medical University Department of Cardiology Beijing Anzhen Hospital Capital Medical University Department of Neuroepidemiology Beijing Neurosurgical Institute Capital Medical University School of Public health Taishan Medical University

Objective The Jidong Women health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P he Jidong Women health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD.

关键词： Cardiovascular disease Menopause Women Protocol Chinese population-based

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