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NON-INVASIVE MEASUREMENT OF DEEP TISSUE TEMPERATURE CHANGES CAUSED BY APOPTOSIS DURING BREAST CANCER NEOADjUVANT CHEMOTHERAPY:A CASE STUDY

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journal of Innovative Optical Health Sciences 2011年第4期4卷 361-372页

作者： SO HYUN CHUNG RITA MEHTA bruce j.tromberg A.G.YODH Department of Physics and Astronomy University of Pennsylvania 209 S.33rd StPhiladelphiaPA 19104USA Department of Medicine UC Irvine Healthcare 101 The City Drive SouthOrangeCA 92868USA Beckman Laser Institute Department of Biomedical Engineering University of CaliforniaIrvine1002 Health Sciences Rd IrvineCA 92612USA

Treatment-induced apoptosis of cancer cells is one goal of cancer ***,more heat is generated by mitochondria during apoptosis,especially the uncoupled apoptotic state,^(1,2) compared to the resting *** this case study,we explore these thermal effects by longitudinally measuring temperature variations in a breast lesion of a pathological complete responder during neoadjuvant chemotherapy(NAC).Diffuse Optical Spectroscopic Imaging(DOSI)was employed to derive absolute deep tissue temperature using subtle spectral features of the water peak at 975 nm.^(3)A significant temperature increase was observed in time windows during the anthracycline and cyclophosphamide(AC)regimen but not in the paclitaxel and bevacizumab *** concentration changes generally did not follow temperature,suggesting the measured temperature increases were likely due to mitochondrial uncoupling rather than a direct vascular effect.A simultaneous increase of tissue oxygen saturation with temperature was observed,suggesting that oxidative stress also contributes to *** preliminary,this study indicates longitudinal DOSI tissue temperature monitoring provides information that can improve our understanding of the mechanisms of tissue response during NAC.

关键词： Deep tissue temperature Diffuse Optical Spectroscopic Imaging apoptosis neoadjuvant chemotherapy breast cancer Bound Water Index NIR water absorption spectrum

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PROBING THE IMPACT OF GAMMA-IRRADIATION ON THE METABOLIC STATE OF NEURAL STEM AND PRECURSOR CELLS USING DUAL-WAVELENGTH INTRINSIC SIGNAL TWO-PHOTON EXCITED FLUORESCENCE

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journal of Innovative Optical Health Sciences 2011年第3期4卷 289-300页

作者： TATIANA B.KRASIEVA ERICH GIEDZINSKI KATHERINE TRAN MARY LAN CHARLES L.LIMOLI bruce j.tromberg Laser Microbeam and Medical Program Beckman Laser Institute University of California Irvine1002 Health Sciences Road EastIrvineCA 92612USA Department of Radiation Oncology University of California IrvineCalifornia 92697USA

Two-photon excitedfluorescence(TPEF)spectroscopy and imaging were used to investigate the effects of gamma-irradiation on neural stem and precursor cells(NSPCs).While the observed signal from reduced nicotinamide adenine dinucleotide(NADH)was localized to the mitochondria,the signal typically associated with oxidizedflavoproteins(Fp)was distributed diffusely throughout the *** measured TPEF emission and excitation spectra were similar to the established spectra of NAD(P)H and *** intensity was markedly increased by addition of the electron transport chain(ETC)modulator menadione to the medium,along with a concomitant decrease in the NAD(P)H ***-dimensional(3D)neurospheres were imaged to obtain the cellular metabolic index(CMI),calculated as the ratio of Fp to NAD(P)Hfluorescence *** effects were found to differ between low-dose(50 cGy)and high-dose(50 cGy)***-dose irradiation caused a marked drop in CMI values accompanied by increased cellular *** higher doses,both NAD(P)H and Fp signals increased,leading to an overall elevation in CMI *** underscore the complex relationship between radiation dose,metabolic state,and proliferation status in NSPCs and highlight the ability of TPEF spectroscopy and imaging to characterize metabolism in 3D spheroids.

关键词： Multiphoton microscopy cellular metabolic index gamma radiation brain tumors NAD(P)H flavoproteins

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