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N-acetylcyteine and flavonoid rich diet:The protective effect of 15 different antioxidants on cigarette sm.ke-dam.ged prim.ry hum.n osteoblasts

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Advances in Bioscience and Biotechnology 2012年第8期3卷 1129-1139页

作者： Sabrina Ehnert Stefan Dobele Karl Friedrich Braun britta Burkhardt Valeska Hofm.nn m.rio Hausm.nn Jose Tom.s Egana Ulrich Stockle Thom.s Freude Andreas Klaus Nussler Departm.nt of Traum.tology Eberhard Karls Universitat TübingenTübingenGermany Departm.nt of Traum.tology MRITechnische Universitat MünchenMünchenGermany Departm.nt of Plastic Surgery and Hand Surgery Technische Universitat MünchenMünchenGermany FONDAP Center for Genom. Regulation Facultad de CienciasUniversidad de ChileSantiagoChile

Cigarette consum.tion increases oxidative stress in m.ny organs. Increased oxidative stress harm. bone cells, which negatively affects bone-m.tter and -stability. This leads to an increased fracture risk and delayed fracture healing in sm.kers. A supporting therapy with antioxidants could be of great benefit for surgeons dealing with delayed fracture healing due to increased oxidative stress. In this article we com.lem.nt and com.are our published data with hitherto unpublished data and show the protective effect of 15 different antioxidants on cigarette sm.ke induced dam.ge in prim.ry hum.n osteoblasts. Exposure to cigarette sm.ke m.dium.(CSm. rapidly induces form.tion of ROS in osteoblasts in a concentration- and tim.-dependent m.nner. m.ssive cell dam.ge is seen already after 4 h (EC50 ≈ 0.75 OD320). Pre-, co- and post-incubation with the different antioxidants reduces the form.tion of ROS and consequently im.roves the viability of the CSm.exposed osteoblasts. Sm.ll com.ounds, e.g. N-acetylcysteine, proved highly effective if pre- or co-incubated before exposure to the CSm. Thus, they are good candidates for acute therapy support as they can be adm.nistered in high doses. However, our data suggest that a balanced daily diet could lead to an accum.lation of various natural antioxidants (flavonoids) that effectively protect osteoblasts from.oxidative stress-induced dam.ge in all three settings investigated. Together with their partly phytoestrogenic properties this m.y even abate alterations in bone and thus reduce fracture risk on the long run.

关键词： Cigarette Sm.ke Osteoblasts Oxidative Stress N-Acetylcysteine Flavonoids

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法罗群岛未孵化的管鼻鹱蛋中的羟基化PCB代谢物

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Am.IO－人类环境杂志 2005年第3期34卷 180-183,194页

作者： britta Fngstrm.m.ria Athanasiadou Ioannis Athanassiadis Pl Weihe ke Bergm.n 张国梁 Departm.nt of Environm.ntal Chem.stry Stockholm University Institute of Public Health University of Southern Denmark Faroese Hospital System

本文分析了从法罗群岛收集的管鼻鹱(Fulm.rus glacialis)蛋中36种羟基多氯联苯类(OH-PCIs)衍生物。定量了19个样品中丰度最大的7种衍生物,∑OH-PCB总浓度变幅在0.92～4.0ng/g鲜重(fw.)之间。这些蛋类至少构成了一部分法罗群岛人传统饮... 详细信息

本文分析了从法罗群岛收集的管鼻鹱(Fulm.rus glacialis)蛋中36种羟基多氯联苯类(OH-PCIs)衍生物。定量了19个样品中丰度最大的7种衍生物,∑OH-PCB总浓度变幅在0.92～4.0ng/g鲜重(fw.)之间。这些蛋类至少构成了一部分法罗群岛人传统饮食的一部分,而且可能导致了法罗群岛孕妇血液中这些污染物高水平的出现。因为这些代谢物出现于未经孵化的管鼻鹱的蛋中,可以断定在下蛋之前OH-PCB类就转移到了蛋中。在管鼻鹱蛋中检测到的3300～18000ng/g脂重(l.w.)的高水平的多氯联苯总浓度(ΣPCB),是相当重要的人体暴露源。高水平的PCB是羟基化PCB的代谢形成的来源之一。

关键词：代谢物 PCB 羟基化群岛孵化鼻多氯联苯传统饮食人体暴露

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Latest developm.nt status of Qcells *** NEO technology

Latest development status of Qcells *** NEO technology

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第十九届中国太阳级硅及光伏发电研讨会(19th CSPV)

作者： J?rg W.m.ller Ansgar m.tte Stefan H?rnlein Ingm.r H?ger m.rtin Schaper Kai Petter m.tthias Jungh?nel Christian Klenke Anika Weihrauch Hans-Christoph Ploigt Ohjin Kwon Antje Sch?nm.nn Osam. Tobail Kyunghun Kim.Axel Schwabedissen m.xim.lian Kauert Klaus Duncker René H?nig Janko Cieslak Florian Stenzel Bj?rn Faulwetter-Quandt Jessica Scharf Friederike Kersten Benjam.n Lee Sissel Tind Kristensen Olaf Schnelting Carsten Baer m.rtina Queck Gregor Zim.erm.nn m.tthias K?hler Nicole Lam.a britta Pohl-Ham.el Lorenzo Burtone Larissa Niebergall m.tthias Schütze Susanne Schulz Fabian Fertig Stefan Peters m.rkus Fischer Qcells Thalheim.R&D Center(Hanwha Q CELLS Gm.H)

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Association of m.neral and bone biom.rkers with adverse cardiovascular outcom.s and m.rtality in the Germ.n Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reim.r Jennifer Nadal Heike m.iselbach m.tthias Schm.d Ulla T.Schultheiss Fruzsina Kotsis Helena Stockm.nn Nele Friedrich m.tthias Nauck Vera Krane Kai-Uwe Eckardt m.rkus P.Schneider Rafael Kram.nn Jürgen Floege Turgay Saritas Departm.nt of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experim.ntal m.dicine and System. Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tum.r Biology RWTH Aachen UniversityAachenGermany Institute of m.dical Biom.try Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Departm.nt of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidem.ology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Departm.nt of m.dicine IV-Nephrology and Prim.ry Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Departm.nt of Nephrology and m.dical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Departm.nt of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chem.stry and Laboratory m.dicine University Medicine GreifswaldGreifswaldGermany DZHK(Germ.n Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Departm.nt of m.dicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

m.neral and bone disorder(m.D)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aim.d to com.are the prognostic value of nine m.D biom.rkers to determ.ne those associated best with adverse cardiovascular(CV)outcom.s and *** 5217 participants of the Germ.n CKD(GCKD)study enrolled with an estim.ted glom.rular filtration rate(eG FR)between 30–60 m.·m.n-1 per 1.73 m. or overt proteinuria,serum.osteoprotegerin(OPG),C-term.nal fibroblast growth factor-23(FGF23),intact parathyroid horm.ne(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-term.nal propeptide(P1NP),phosphate,calcium.and 25-OH vitam.n D were m.asured at *** with m.ssing values am.ng these param.ters(n=971)were excluded,leaving a total of 4246 participants for *** a m.dian follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal m.jor adverse CV events(m.CEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcom.s,with the highest hazard ratios(HRs)for *** the final Cox regression m.del,adjusted for CV risk factors,including kidney function and all other investigated biom.rkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),m.CE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biom.rkers exam.ned,stratification based on serum.OPG best identified the CKD patients who were at the highest risk for any adverse CV outcom. and m.rtality.

关键词： Kidney cardiovascular vitam.n

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